Abstract:
:The authors retrospectively examined the contralateral prophylactic mastectomy (CPM) rate among 100 women with ductal carcinoma in situ who are BRCA negative. Of 100 women with ductal carcinoma in situ, 31 elected contralateral prophylactic mastectomy (CPM). Factors associated with increased likelihood of undergoing contralateral prophylactic mastectomy (CPM) among this cohort were: family history of ovarian cancer, marital status, reconstruction, mastectomy of the affected breast, and tamoxifen use.
journal_name
J Cancerjournal_title
Journal of Cancerauthors
Elsayegh N,Profato J,Barrera AM,Lin H,Kuerer HM,Ardic C,Litton JK,Tripathy D,Arun BKdoi
10.7150/jca.11710subject
Has Abstractpub_date
2015-05-23 00:00:00pages
610-5issue
7issn
1837-9664pii
jcav06p0610journal_volume
6pub_type
杂志文章abstract:PURPOSE:Urothelial carcinoma (UC) is a type of tumor, especially of the urinary bladder, that affects people worldwide. Clarification of its detailed tumor biology and discovery of potential targets for developing treatment strategies are imperative because of frequent recurrences and poor prognosis of advanced UCs. By...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.15696
更新日期:2016-07-08 00:00:00
abstract::Early detection and accurate evaluation were both critical to improving the prognosis of clear cell Renal Cell Carcinoma (ccRCC) patients. More importantly, RNA Binding Proteins (RBPs) play a vital role in the tumorigenesis and progression of numerous cancers. However, the relationship between RBPs and ccRCC is still ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.49175
更新日期:2020-09-23 00:00:00
abstract::Cervical cancer is a commonly diagnosed cancer among females. Polymorphisms in pre-microRNAs have been demonstrated to play critical roles in cancer. However, the roles of pre-microRNA polymorphisms in the aetiology of cervical cancer have not been well documented. We genotyped eight pre-microRNA polymorphisms in 290 ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.39636
更新日期:2020-02-03 00:00:00
abstract::PURPOSE: Chronic obstructive pulmonary disease (COPD) is associated with an increased cancer risk. We evaluated the chemopreventive effect of statins against all cancers in COPD patients and identified the statin with the strongest chemopreventive effect. PATIENTS AND METHODS: All patients diagnosed with COPD at healt...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.15779
更新日期:2016-09-13 00:00:00
abstract::Oral cancer is one of the most frequent malignant diseases worldwide, and areca nut is a primary carcinogen causing this cancer in Southeast Asia. It has been widely reported that areca nut induced several cytotoxic effects in oral cells, including ROS generation, inflammation, tissue hypoxia, DNA damage, and cell inv...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.29765
更新日期:2019-07-08 00:00:00
abstract::Aim: BAP1 is frequently mutated in clear cell renal cell carcinoma (ccRCC) with a definitive role still unclear. Methods: In silico analysis of BAP1-mutant and wild-type gene enrichment and functional annotation in TCGA-KIRC dataset was performed. Target gene was studied based on functional clustering and was knowledg...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.26275
更新日期:2018-10-01 00:00:00
abstract::Circular RNAs (circRNAs), as a type of tissue specific RNA with more stable structure than linear RNAs, was poorly understood on its correlation with gastric cancer (GC). In this review, we outline the synthesis and characteristics of circRNAs and generalize their categories and functions. Through comprehensive analys...
journal_title:Journal of Cancer
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doi:10.7150/jca.32927
更新日期:2019-10-15 00:00:00
abstract::Glioblastoma (GBM) is a common malignant brain tumor of the central nervous system with a poor prognosis. In order to identify the prognostic signatures of GBM, we screened differentially expressed genes (DEGs) that were based on a single-cell RNA sequencing (scRNA-seq) dataset. These genes characteristically represen...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.44034
更新日期:2020-04-06 00:00:00
abstract::Background: Early gastric carcinoma (EGC) with pure signet ring cell carcinoma (pSRCC) has been reported to have favourable prognosis and low risk of lymph node metastasis (LNM). However, risk factors of LNM and clinicopathological features for early gastric mixed signet ring cell carcinoma (mSRCC) remain poorly inves...
journal_title:Journal of Cancer
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doi:10.7150/jca.29245
更新日期:2019-01-29 00:00:00
abstract::Non epithelial ovarian tumors represent a small group of rare gynecological cancers but they have a high incidence in young childbearing women. The recent years fertility preservation surgeries have become a common practice in specific ovarian malignancies when the patients wish to maintain their fertility. Specific t...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.26674
更新日期:2018-11-24 00:00:00
abstract::Lung cancer is the deadliest cancer in the world. Angiogenesis plays a crucial role of the incidence, progression, and metastasis in lung cancer. Angiogenesis inhibitors are used to treat non-small cell lung cancer (NSCLC) patients, and the molecular biomarkers are also being assessed to predict treatment response/the...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.22020
更新日期:2018-03-22 00:00:00
abstract::Liquid biopsy is becoming a promising method for non-invasive cancer detection. In several proof-of-concept studies, long non-coding RNAs (lncRNAs) were found to be potential biomarkers for bladder cancer detection. The objective of this study was to discover a panel of cell-free, urinary lncRNAs as liquid biopsy biom...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.37006
更新日期:2020-01-01 00:00:00
abstract::Angiogenesis, a highly regulated process, is exploited by tumors like breast cancer to ensure a constant supply of oxygen and nutrients and is key for tumor survival and progression. Estrogen and alcohol independently have been observed to contribute to angiogenesis in breast cancer but their combinatorial effects hav...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.25581
更新日期:2018-10-06 00:00:00
abstract::Hepatocellular carcinoma (HCC) cells exhibit multidrug resistance (MDR), but the underlying mechanisms remain unclear. Cancer cells that overexpress telomerase are resistant to chemotherapeutic drugs. This study aimed to determine the effects of mitochondrial translocation of telomerase on MDR in HCC cells. HepG2 cell...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.10419
更新日期:2015-01-05 00:00:00
abstract::Objectives: PD-1 and PD-L1 overexpression in malignant tumors in response to radiotherapy is correlated with a poor prognosis. Human papilloma virus (HPV) infection impacts intrinsic radiosensitivity of head and neck cancers (HNCs). Herein, this study aims to determine PD-1/PD-L1 expression differences in tumors with ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.27199
更新日期:2019-01-29 00:00:00
abstract::Cullin family proteins function as scaffolds to form numerous E3 ubiquitin ligases with RING proteins, adaptor proteins and substrate recognition receptors. These E3 ligases further recognize numerous substrates to participate in a variety of cellular processes, such as DNA damage and repair, cell death and cell cycle...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.11076
更新日期:2015-01-16 00:00:00
abstract:: Purpose: Differentiated thyroid cancer (DTC) accounts for approximately 95% of thyroid carcinomas. In the metastatic RAI-refractory disease, chemotherapy has very limited efficacy and is associated with substantial toxicity. With increasing knowledge of the molecular patho...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.22318
更新日期:2018-01-01 00:00:00
abstract::Myeloid-derived suppressor cells (MDSCs) have strong immunosuppressive functions and contribute to the formation of the tumor microenvironment. Long non-coding (Lnc) RNAs are highly important factors associated with tumors and may be used as markers for tumor diagnosis, which is valuable for targeted therapy. LncRNA M...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.24796
更新日期:2018-06-14 00:00:00
abstract::Background: Anti-EGFR therapies have been recommended for advanced colorectal cancer (CRC) with wild-type RAS and PIK3CA mutation. However, PIK3CA mutations are a poor prognostic marker and a negative predictor of response to anti-EGFR therapies in RAS wild-type CRC. Therefore, new and advanced treatment strategies ar...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.19458
更新日期:2017-08-22 00:00:00
abstract::We hypothesised that the blood levels of immune cells would be related to the progression of colorectal cancer and regional lymph node metastasis. We investigated the association between the blood levels of immune cells and regional lymph node metastasis in colorectal cancer patients. Patients with American Joint Comm...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.18230
更新日期:2017-05-10 00:00:00
abstract::Hepatocellular carcinoma (HCC) is a major malignancy of cancer-related mortality worldwide. Metastasis-associated in colon cancer-1 (MACC1) was suggested as a marker for vascular invasive HCC. This study investigated the MACC1 single-nucleotide polymorphisms (SNPs) to evaluate HCC susceptibility and clinicopathologica...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.38856
更新日期:2020-01-14 00:00:00
abstract:BACKGROUND:There is often a finite progression-free interval of time between one systemic therapy and the next when treating patients with advanced cancer. While it appears that progression-free survival (PFS) between systemic therapies tends to get shorter for a number of factors, there has not been a formal evaluatio...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.3.7
更新日期:2012-01-01 00:00:00
abstract::Purpose: The aberrant of fibroblast growth factors and their receptors (FGF/FGFR) is an emerging target in the treatment of solid tumors. This study aimed to explore the landscape of FGF/FGFR alterations in a large cohort of cancer patients. Material and Methods: The formalin-fixed paraffin-embedded specimens of cance...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.49269
更新日期:2020-09-23 00:00:00
abstract::Background: Identification of new predictive markers in melanoma is of great clinical importance. This study was aimed to analyze association between selected common variants in the cancer susceptibility genes and melanoma progression at the time of diagnosis. Material and Method: The study included 243 consecutive pa...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.26404
更新日期:2018-08-06 00:00:00
abstract::Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive human malignancies. The metabolomic approaches are developed to discover the novel biomarkers of PDAC. Methods: 550 preoperative, postoperative PDAC and normal controls (NCs) serums were employed to characterize metabolic alterations in ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.41250
更新日期:2020-05-19 00:00:00
abstract::Background: In the various cancer, mast cells (MCs) infiltration is correlated with a worse prognosis. There is an increasing evidence that MCs and their mediators are participated in remodeling of the tumor microenvironment and facilitate tumor growth, epithelial-to-mesenchymal transition (EMT) and metastasis. Method...
journal_title:Journal of Cancer
pub_type: 杂志文章,收录出版
doi:10.7150/jca.29953
更新日期:2019-06-09 00:00:00
abstract::Pancreatic ductal adenocarcinoma (PDAC) is currently one of the most intractable malignancies with a typical scirrhous pattern in histology. Due to its abundant tumor stroma and scant vascularization, chemotherapeutic agents are considered inefficiently permeable to cancer nests, making it highly difficult to cure the...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.24415
更新日期:2018-07-30 00:00:00
abstract::Background: Infiltration of immune cells and immune microenvironment determine the proliferative activity of the tumor and metastasis. The aim of this study was to analyze the influence of activation or suppression of the immune response mediators on the prognosis of biliary tract cancer (BTC). Methods: We searched Pu...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.16774
更新日期:2017-01-01 00:00:00
abstract::Background: Immune cells recognize tumor antigens presented on major histocompatibility complex class I (MHC-I) molecule. Increase of MHC-I molecular expression makes tumor cells more susceptible to lysis by immune cells. Methods: Tumor lysate vaccine was prepared to damage glioma cells including cell lines and primar...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.34471
更新日期:2019-09-07 00:00:00
abstract::Clinical outcomes of checkpoint blockade immunotherapy on colorectal cancer (CRC) are influenced by mismatch repair (MMR) gene status, which is associated with distinct tumor immune infiltrates and systemic inflammatory response status. However, the prognostic value of PD-L1 expression and the systemic inflammatory re...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.25187
更新日期:2019-04-05 00:00:00