Foretinib Enhances the Radiosensitivity in Esophageal Squamous Cell Carcinoma by Inhibiting Phosphorylation of c-Met.

abstract：:Nasopharyngeal carcinoma (NPC), is one of the most common malignant tumor in southern China and southeast Asia. MYH10 is a coding gene of the NMMHC-IIB protein. Previous studies have shown that MYH10 expression was up-regulated in breast cancer, glioma and meningioma. Moreover, it was targeted by miR200 family. Howeve...

journal_title：Journal of Cancer

authors： Liu W,Cai T,Li L,Chen H,Chen R,Zhang M,Zhang W,Zhao L,Xiong H,Qin P,Gao X,Jiang Q

更新日期：2020-03-04 00:00:00

abstract：:Endometrial carcinoma (EC) is the most common malignant tumors in female derived from the endometrial epithelium. Several previous studies have described estrogen receptors (ER), progesterone Receptor (PR) and phosphatase and tensin homolog (PTEN) are associated with clinicopathological factors and prognosis in EC pat...

journal_title：Journal of Cancer

authors： Liang Y,Lin B,Ye Z,Chen S,Yu H,Chen C,Zhang X,Zhou K,Zeng J

更新日期：2020-01-13 00:00:00

abstract：:Background: Cancers may arise from cells with dysregulated telomeric functions due to shorten telomere length. We and others previously found that short leukocyte telomere length was associated with markedly evaluated risk of esophageal squamous cell carcinoma (ESCC). Hence, we hypothesized that single nucleotide poly...

journal_title：Journal of Cancer

authors： Li Z,Song Y,Xu Y,Shen Y,Zhang N,Yang M,Yu D

更新日期：2020-06-23 00:00:00

abstract：:Circular RNAs (circRNAs), as a type of tissue specific RNA with more stable structure than linear RNAs, was poorly understood on its correlation with gastric cancer (GC). In this review, we outline the synthesis and characteristics of circRNAs and generalize their categories and functions. Through comprehensive analys...

journal_title：Journal of Cancer

authors： Fang X,Wen J,Sun M,Yuan Y,Xu Q

更新日期：2019-10-15 00:00:00

abstract：:Background: Population-based data on the prognosis of brain metastases at initial diagnosis of ovary cancer (OCBM) are currently lacking. Besides, the effective treatment for OCBM patients is still controversial now. The study aimed to explore the prognostic factors among OCBM. Methods: We retrospectively reviewed the...

journal_title：Journal of Cancer

authors： Xi S,Li Z,Guo Q,Lin W,Liang X,Ma L

更新日期：2020-05-18 00:00:00

abstract：:Background: Lysosome-associated protein transmembrane-4β-35(LAPTM4B-35) has been observed overexpressed in multiple malignant tumors. However, the prognostic value of LAPTM4B-35 remains controversial. Therefore, we conducted a meta-analysis to evaluate the prognostic value of LAPTM4B-35 in human cancers. Methods: The ...

journal_title：Journal of Cancer

authors： Zhou L,Dai C,Tian T,Wang M,Lin S,Deng Y,Xu P,Hao Q,Wu Y,Yang T,Zhu W,Dai Z

更新日期：2018-10-21 00:00:00

abstract：:Background: Colorectal cancer (CRC) remains to be one of the most common malignancies worldwide. Various studies have demonstrated that microRNAs (miRs) play a critical role in regulating cancer progression and sensitivity to chemoradiotherapy. miR-1 was found to be aberrantly expressed in CRC. However, it has not bee...

journal_title：Journal of Cancer

authors： Wu Y,Pu N,Su W,Yang X,Xing C

更新日期：2020-06-07 00:00:00

abstract：:Endocrine resistance in hormone receptor positive breast cancer patients urges us to develop novel approaches such as inhibitors of the cyclin-dependent kinases (CDK) 4/6 to reverse its resistance. Nowadays, three selective CDK4/6 inhibitors (Palbociclib, Ribociclib and Abemaciclib) are approved by Federal Drug Admini...

journal_title：Journal of Cancer

authors： Chen X,Xu D,Li X,Zhang J,Xu W,Hou J,Zhang W,Tang J

更新日期：2019-10-21 00:00:00

abstract：:Cisplatin-based chemotherapy is the foundation of treatment for major non-small cell lung cancer (NSCLC) patients. However, cisplatin resistance is still a challenging issue, and the molecular mechanisms underlying this resistance remain to be fully explored. CLEC4M, a Ca2+-dependent C-type lectin, has recently been f...

journal_title：Journal of Cancer

authors： Tan LM,Li X,Qiu CF,Zhu T,Hu CP,Yin JY,Zhang W,Zhou HH,Liu ZQ

更新日期：2019-10-19 00:00:00

abstract：:Purpose: Diffuse large B cell lymphoma (DLBCL) is one of the most common B cell lymphomas, which displays heterogeneous pathologies. Programmed cell death 1/ programmed cell death ligand 1 (PD-1/PD-L1) plays an essential role in immunosuppression in multiple malignancies. Signal transducer and activator of transcripti...

journal_title：Journal of Cancer

authors： Fei Y,Yu J,Li Y,Li L,Zhou S,Zhang T,Li L,Qiu L,Meng B,Pan Y,Ren X,Qian Z,Wang X,Zhang H

更新日期：2020-10-17 00:00:00

abstract：:Background: Topoisomerase IIA (TOP2A) gene encodes DNA topoisomerase enzyme and has been reported that TOP2A is broadly expressed in many types of cancers. Our study aims to investigate the prognostic effect of TOP2A on lung adenocarcinoma (LUAD) and the potential molecular mechanism of TOP2A to tumorigenesis. Methods...

journal_title：Journal of Cancer

authors： Kou F,Sun H,Wu L,Li B,Zhang B,Wang X,Yang L

更新日期：2020-02-10 00:00:00

abstract：:Background: Lung carcinoma is the leading cause of malignant tumor related mortality in China in recent decades, and the development of new and effective therapies for patients with advanced lung carcinoma is needed. We recently found that fluorofenidone (FD), a newly developed pyridine compound, reduced the activatio...

journal_title：Journal of Cancer

authors： Deng ZH,Meng J,Tang J,Hu GY,Tao LJ

更新日期：2017-07-04 00:00:00

abstract：:Background: To identify associated risk factors and develop a predictive nomogram for the early death of metastatic gastric cancer patients. Methods: A total of 4575 patients in the SEER cohort and 220 patients in the Chinese cohort diagnosed with metastatic gastric cancer in our Cancer Center were obtained. Univariat...

journal_title：Journal of Cancer

authors： Zhu Y,Fang X,Wang L,Zhang T,Yu D

更新日期：2020-07-14 00:00:00

abstract：:Cancer-associated fibroblasts (CAFs), which are an important component of the tumor microenvironment, have been identified in the blood circulation of patients with cancer metastasis, and metastatic cancer cells can recruit circulating CAFs. However, primary carcinoma sites usually regulate the behavior of metastatic ...

journal_title：Journal of Cancer

authors： Zhang YF,Zhou YZ,Zhang B,Huang SF,Li PP,He XM,Cao GD,Kang MX,Dong X,Wu YL

更新日期：2019-07-23 00:00:00

abstract：:Tyrosine phosphorylation is an important post-translation modification of proteins that is controlled by tyrosine kinases and phosphatases. Disruption of the balance between the activity of tyrosine kinases and phosphatases may result in diseases. Receptor type protein tyrosine phosphatase epsilon (PTPRE) is closely r...

journal_title：Journal of Cancer

authors： Liang J,Shi J,Wang N,Zhao H,Sun J

更新日期：2019-01-01 00:00:00

abstract：:Minichromosome Maintenance (MCM) proteins play essential roles in various cancers. We previously reported that MCM7 could be a prognostic biomarker in non-small cell lung cancer (NSCLC). The purpose of current study is to explore roles of other MCM proteins in NSCLC and their correlation with clinico-pathologic parame...

journal_title：Journal of Cancer

authors： Liu YZ,Wang BS,Jiang YY,Cao J,Hao JJ,Zhang Y,Xu X,Cai Y,Wang MR

更新日期：2017-10-09 00:00:00

abstract：:We found that microRNA-320a (miR-320a) was an attractive prognostic biomarker in breast cancer (BC) previously, whereas its regulatory mechanism in BC was not well understood. Our aim was to identify miR-320a target gene, examine the clinical relationship between miR-320a and its target, and further explore the functi...

journal_title：Journal of Cancer

authors： Yu J,Wang L,Yang H,Ding D,Zhang L,Wang J,Chen Q,Zou Q,Jin Y,Liu X

更新日期：2016-11-25 00:00:00

abstract：:Hepatocellular carcinoma (HCC) cells exhibit multidrug resistance (MDR), but the underlying mechanisms remain unclear. Cancer cells that overexpress telomerase are resistant to chemotherapeutic drugs. This study aimed to determine the effects of mitochondrial translocation of telomerase on MDR in HCC cells. HepG2 cell...

journal_title：Journal of Cancer

authors： Yan J,Zhou Y,Chen D,Li L,Yang X,You Y,Ling X

更新日期：2015-01-05 00:00:00

abstract：:Increasing studies indicate that long noncoding RNA (lncRNA) plays a critical role in aerobic glycolysis of various tumors. However, the contribution of lncRNA in gastric cancer (GC) cell glycolysis is still poorly understood. The objective of this research was to investigate the functional role and mechanism of lncRN...

journal_title：Journal of Cancer

authors： Qian C,Xu Z,Chen L,Wang Y,Yao J

更新日期：2020-08-27 00:00:00

abstract：:Ever since its discovery (1924) the Warburg effect (aerobic glycolysis) remains an unresolved puzzle: why the aggressive cancer cells "prefer" to use the energetically highly inefficient method of burning the glucose at the cellular level? While in the course of the last 90 years several hypotheses have been suggested...

journal_title：Journal of Cancer

authors： Devic S

更新日期：2016-04-26 00:00:00

abstract：:Background: Identification of new predictive markers in melanoma is of great clinical importance. This study was aimed to analyze association between selected common variants in the cancer susceptibility genes and melanoma progression at the time of diagnosis. Material and Method: The study included 243 consecutive pa...

journal_title：Journal of Cancer

authors： Sikora M,Rudnicka L,Borkowska B,Kardynał A,Słowińska M,Rakowska A,Warszawik-Hendzel O,Wiergowska A,Ługowska I,Rutkowski P,Dębniak T,Lubiński J,Olszewska M

更新日期：2018-08-06 00:00:00

abstract：:Hedgehog (Hh) signalling plays an important role in cancer; however, its mechanism in ovarian cancer migration and invasion remains unclear. In the present study, we aimed to clarify the effect of the Hh signalling pathway on ovarian cancer migration and invasion through the regulation of CD24 expression, both in vitr...

journal_title：Journal of Cancer

authors： Zeng C,Chen T,Zhang Y,Chen Q

更新日期：2017-02-25 00:00:00

abstract：PURPOSE:Triple-negative breast cancer (TNBC) has attracted more attention both clinically and experimentally because of its high-risk biological characteristics and lacking of effective treatment method. The purpose of this retrospective study was to find out the incidence of triple-negative breast cancer (TNBC) in all...

journal_title：Journal of Cancer

authors： Qiu J,Xue X,Hu C,Xu H,Kou D,Li R,Li M

更新日期：2016-01-01 00:00:00

abstract：:Objectives: Lung cancer in young adults is a distinct disease with particular socioeconomic implications. This study aimed to clarify the clinicopathological characteristics, best interventions, and outcomes of this distinctive entity. Methods: A retrospective review of patients with lung cancer was performed in our i...

journal_title：Journal of Cancer

authors： Liu B,Quan X,Xu C,Lv J,Li C,Dong L,Liu M

更新日期：2019-06-09 00:00:00

abstract：:Purpose Neuroblastoma is an embryonic solid tumor derived from the progenitors of the sympathetic nervous system. More than half of the patients developed metastatic disease at the time of initial diagnosis and had poor outcome with current therapeutic approaches. In recent years, some obligate and facultative anaerob...

journal_title：Journal of Cancer

authors： Ning BT,Yu B,Chan S,Chan JL,Huang JD,Chan GC

更新日期：2017-06-03 00:00:00

abstract：:Purpose: Systemic therapy has often been used for patients with advanced hepatocellular carcinoma (HCC). However, due to drug resistance, the use of cytotoxic chemotherapy in the treatment of patients with advanced HCC has typically demonstrated low response rates. Secretory clusterin (sCLU) is expressed in aggressive...

journal_title：Journal of Cancer

authors： Wang X,Zou F,Zhong J,Yue L,Wang F,Wei H,Yang G,Jin T,Dong X,Li J,Xiu P

更新日期：2018-04-06 00:00:00

abstract：:Objective: Citron Rho-Interacting Serine/Threonine Kinase (CIT) was originally identified as a binding partner of active forms of the small GTPases Rho and Rac. This kinase participated in the regulation of cytokinesis and loss of CIT was associated with chromosomal instability. Here, we assume that CIT might be a pot...

journal_title：Journal of Cancer

authors： Shou J,Yu C,Zhang D,Zhang Q

更新日期：2020-04-14 00:00:00

abstract：:Background: The most common metastatic site in cervical cancers is lung. The aim of this study is to identify cervical cancer patients with high risk for developing lung metastasis and further explore their prognosis. Materials and Methods: At first, patients diagnosed with cervical cancer from 2010 to 2015 were ident...

journal_title：Journal of Cancer

authors： Chen X,Chen L,Zhu H,Tao J

更新日期：2020-08-08 00:00:00

abstract：:Inhibition of aberrantly activated pathways cross-talking with hormone receptor (HR) improves response to endocrine therapy in patients with HR-positive advanced breast cancer. We performed a Pubmed database systematic review to ascertain the existence of a better clinical response when combining endocrine therapy wit...

journal_title：Journal of Cancer

authors： Grassadonia A,Caporale M,Tinari N,Zilli M,DeTursi M,Gamucci T,Vici P,Natoli C

更新日期：2015-05-12 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have been widely used to treat non-small cell lung cancer (NSCLC) because they inhibit tumour growth and metastasis. However, the underlying mechanisms are not fully understood. Here, we investigate whether anti-lymphangiogenesis mechanisms cont...

journal_title：Journal of Cancer

authors： Zhang Y,Yang X,Liu H,Cai M,Shentu Y

更新日期：2020-01-01 00:00:00