Abstract:
:For unresectable Hepatocellular carcinoma (HCC), chemotherapy is still an important treatment strategy. Oxaliplatin (Oxa) is an effective treatment of HCC after sorafenib treatment failure. However, the intrinsic or acquired resistance of Oxa affected the chemotherapeutic sensitivity. By analyzing the data of GEO Database, we found that Oxa aberrantly increased the expression of Cysteine-rich61 (Cyr61) in HCC cell lines. Subsequently, in Bel-7404 and SMMC-7721 cells after treated with Oxa, it was verified that the expression of Cyr61 and Yes-associated protein (YAP) was increased. Moreover, we found that blockade of YAP promoted Oxa-induced cell apoptosis for the first time. Meanwhile, our previous study demonstrated that Huaier (HE) inhibited the expression of YAP. Further study found that combination treatment of Oxa and HE had a significantly synergistic anti-cancer effect and significantly inhibited the expression of YAP and apoptosis related proteins. Taken together, we have observed that overexpression of YAP significantly reduced the chemotherapeutic sensitivity of Oxa in HCC for the first time. Combination treatment of Oxa and HE solved this problem.
journal_name
J Cancerjournal_title
Journal of Cancerauthors
Tao Y,Shan L,Xu X,Jiang H,Chen R,Qian Z,Yang Z,Liang B,Zheng H,Cai F,Yu Y,Ma Ldoi
10.7150/jca.25909subject
Has Abstractpub_date
2018-10-10 00:00:00pages
3962-3970issue
21issn
1837-9664pii
jcav09p3962journal_volume
9pub_type
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doi:10.7150/jca.30507
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pub_type: 杂志文章
doi:10.7150/jca.7123
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journal_title:Journal of Cancer
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pub_type: 杂志文章
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更新日期:2014-07-17 00:00:00
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journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.11403
更新日期:2015-04-02 00:00:00
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journal_title:Journal of Cancer
pub_type: 杂志文章
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更新日期:2017-04-09 00:00:00
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更新日期:2020-09-30 00:00:00
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更新日期:2019-06-02 00:00:00
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