Abstract:
:For many years, the medical treatment of breast cancer was reliant solely on cytotoxic chemotherapy. However, over the past twenty years, treatment has evolved to a more target-directed approach. We now employ tailored therapy based on the presence or absence of receptors for estrogen, progesterone, and human epidermal growth factor 2 (HER2). We expect this trend to continue, as agents that use novel approaches to target HER2, as well as targeting different portions of the HER signaling pathway, are in various stages of development. Notably, pertuzumab, a humanized monoclonal antibody that binds to a different domain of the extracellular portion of the HER2 receptor than trastuzumab, was recently approved for use, as was lapatinib, a small-molecule tyrosine kinase inhibitor. Patients with triple negative breast cancer, particularly those with the BRCA mutation, have more limited treatment options and carry a worse prognosis than those who are hormone receptor positive. However, recent data has shown that PARP inhibitors may have significant anti-tumor effect in those with this subtype of breast cancer. Novel agents that inhibit mTOR, PI3K, the insulin-like growth factor, heat shock protein 90, and histone deacetylase have shown promise in phase I-III trials and offer exciting new possibilities for the treatment of this often fatal disease. As we are presented with an ever increasing number of treatment options, the timing and combinations of therapeutic agents used becomes ever more complex in the age of personalized care, but we are hopeful that ultimately this will lead to improved patient outcomes.
journal_name
J Cancerjournal_title
Journal of Cancerauthors
Tinoco G,Warsch S,Glück S,Avancha K,Montero AJdoi
10.7150/jca.4925subject
Has Abstractpub_date
2013-01-01 00:00:00pages
117-32issue
2issn
1837-9664pii
jcav04p0117journal_volume
4pub_type
杂志文章abstract::In this bi-institutional study, twenty-three stage IIIC-IV MAGE-A3(+) melanoma patients were vaccinated with M3TK-GML biweekly at three dose levels, with a subsequent phase of vaccinations at the maximum dose level. Anti-MAGE-A3 and anti-TK T cells were assessed by in vitro assay and delayed-type hypersensitivity skin...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.2.329
更新日期:2011-01-01 00:00:00
abstract::RBP7 is a member of the cellular retinol-binding protein (CRBP) family and previous data suggested a link between CRBPs and the malignant transformation of colon cancer cells. Here, we investigated the potential of RBP7 as a predictive biomarker for patients with colon cancer and determined its functional relevance fo...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.35180
更新日期:2019-08-27 00:00:00
abstract::Background: The Aldehyde dehydrogenase 2 (ALDH2) mutant genotypes contain an allele encoding defective ALDH2 with reduced efficacy of alcohol metabolism leading to accumulation of highly toxic and carcinogenic acetaldehyde. It can induce unpleasant "Asian flush syndrome" and associate with increased risk of cancers. H...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.33221
更新日期:2019-10-03 00:00:00
abstract::Objective: To develop and validate a prediction model for the pathological complete response (pCR) to neoadjuvant chemotherapy (NCT) of triple-negative breast cancer (TNBC). Methods: We systematically searched Gene Expression Omnibus, ArrayExpress, and PubMed for the gene expression profiles of operable TNBC accessibl...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.52439
更新日期:2021-01-01 00:00:00
abstract::Galectins are the member of soluble proteins that bind with β-galactoside containing glycans. These proteins have been considered to be associated in various important events such as different types of cancers. It has been found that galectins could contribute to neoplastic transformation or regulate cell growth, cell...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.23628
更新日期:2018-11-25 00:00:00
abstract:PURPOSE:Our study is designed to develop and certify a promising prognostic signature for hepatocellular carcinoma (HCC). Materials and methods: We retrospectively analyzed mRNA expression profiles and clinicopathological data fetched from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) datasets. We fo...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.44573
更新日期:2020-07-31 00:00:00
abstract::Aim: Skin cutaneous melanoma (SKCM) is one of the most life-threatening malignancies damaging human health. APOBEC3G (A3G) has been found in several cancers; however, the role of A3G in SKCM is rarely studied. This study aimed to investigate the expression of A3G in tumor tissue and its prognostic value in SKCM patien...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.46383
更新日期:2020-07-06 00:00:00
abstract::Hedgehog (Hh) signalling plays an important role in cancer; however, its mechanism in ovarian cancer migration and invasion remains unclear. In the present study, we aimed to clarify the effect of the Hh signalling pathway on ovarian cancer migration and invasion through the regulation of CD24 expression, both in vitr...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.17712
更新日期:2017-02-25 00:00:00
abstract::Glioblastoma (GBM) is a common malignant brain tumor of the central nervous system with a poor prognosis. In order to identify the prognostic signatures of GBM, we screened differentially expressed genes (DEGs) that were based on a single-cell RNA sequencing (scRNA-seq) dataset. These genes characteristically represen...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.44034
更新日期:2020-04-06 00:00:00
abstract::Butyrate, a product of dietary fiber and a histone deacetylase inhibitor, induces apoptosis of colorectal cancer cells; this effect of butyrate is in part mediated by its ability to hyperactivate Wnt signaling, and may in part explain the preventive action of dietary fiber against colorectal cancer. However, the mecha...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.37864
更新日期:2020-01-01 00:00:00
abstract::Dysbindin has been reported to be correlated with several malignancies. However, the clinical significance and biological role of dysbindin in epithelial ovarian cancer remains largely unknown. Here we demonstrated that the mRNA and protein levels of dysbindin were significantly upregulated in EOC tissues compared wit...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.39269
更新日期:2020-02-21 00:00:00
abstract::Long non-coding RNAs (LncRNAs) have been reported to be involved in tumorigenesis and tumor progression. Single nucleotide polymorphisms (SNPs) in the lncRNAs also play a vital role in carcinogenesis. The aim of this study was to assess the relationships between the four selected tagSNPs (rs944289, rs3787016, rs145631...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.18055
更新日期:2017-04-09 00:00:00
abstract::The highly conserved Hippo signaling pathway is an important pathway involved in tumorigenesis and development. In previous studies, YAP, the transcription coactivator of Hippo pathway, is found to be highly expressed in many clinical bladder cancer samples. To investigate the function of YAP and its cofactor Mask2 in...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.16438
更新日期:2016-10-23 00:00:00
abstract::Background: The most common metastatic site in cervical cancers is lung. The aim of this study is to identify cervical cancer patients with high risk for developing lung metastasis and further explore their prognosis. Materials and Methods: At first, patients diagnosed with cervical cancer from 2010 to 2015 were ident...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.46258
更新日期:2020-08-08 00:00:00
abstract::Endometrial carcinoma (EC) is the most common malignant tumors in female derived from the endometrial epithelium. Several previous studies have described estrogen receptors (ER), progesterone Receptor (PR) and phosphatase and tensin homolog (PTEN) are associated with clinicopathological factors and prognosis in EC pat...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.33720
更新日期:2020-01-13 00:00:00
abstract::Background: Immune cells recognize tumor antigens presented on major histocompatibility complex class I (MHC-I) molecule. Increase of MHC-I molecular expression makes tumor cells more susceptible to lysis by immune cells. Methods: Tumor lysate vaccine was prepared to damage glioma cells including cell lines and primar...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.34471
更新日期:2019-09-07 00:00:00
abstract:BACKGROUND:To identify predictors for development of mastoiditis after intensity-modulated radiation therapy (IMRT) in nasopharyngeal carcinoma (NPC). METHODS:Data for 146 NPC patients treated with IMRT was retrospectively reviewed under institutional ethics committee approval. Clinical factors associated with mastoid...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.13183
更新日期:2016-01-08 00:00:00
abstract::Background: Our previous study demonstrated that the peroxiredoxin 6 (PRDX6) protein was downregulated in squamous cervical cancer samples after neoadjuvant chemotherapy compared with the expression level before chemotherapy. However, the effect of PRDX6 on the biological behavior of cervical cancer is still uncertain...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.39892
更新日期:2020-02-10 00:00:00
abstract:PURPOSE:To evaluate acute hypersensitivity reactions at the UCSD Moores Cancer Center in San Diego, compare our findings to those reported previously in the literature, and examine the effectiveness of the objective grading scale as represented by the Common Terminology Criteria for Adverse Events (CTCAE). PATIENTS AN...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.2.153
更新日期:2011-03-10 00:00:00
abstract::Melanoma is the most aggressive and treatment-resistant form of skin cancer. Curcumol is a Chinese medicinal herb traditionally used as a cancer remedy. However, the molecular mechanisms underlying the anticancer activity of curcumol in melanoma remains largely unknown. In the present study, we observed that Curcumol ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.38624
更新日期:2020-01-14 00:00:00
abstract::Cancer-associated fibroblasts (CAFs), which are an important component of the tumor microenvironment, have been identified in the blood circulation of patients with cancer metastasis, and metastatic cancer cells can recruit circulating CAFs. However, primary carcinoma sites usually regulate the behavior of metastatic ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.27590
更新日期:2019-07-23 00:00:00
abstract::[This retracts the article DOI: 10.7150/jca.29953.]. ...
journal_title:Journal of Cancer
pub_type: 撤回出版物
doi:10.7150/jca.38671
更新日期:2019-09-02 00:00:00
abstract::We use pulmonary interventional procedures for the diagnosis of pulmonary diseases either for benign or malignant lesions. Flexible bronchoscopy with or without radial endobronchial ultrasound, convex-probe endobronchial ultrasound and electromagnetic navigation are procedures performed in centers with experience in d...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.23737
更新日期:2018-02-12 00:00:00
abstract::Background: Proverbially, the incidence rate of papillary thyroid carcinoma (PTC) has increased year by year. Many long noncoding RNAs (lncRNAs) have been discovered having a relationship with tumor genesis tightly recently. Thanks to the previous researches, we found long intergenic noncoding RNA 00511 (LINC00511) is...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.35364
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:Most prostate cancers originate from the prostatic peripheral zone (PZ). We tested the hypothesis that the stromal cells from PZ and transitional zone (TZ) have differential effects on the ability of tumorigenesis. METHODS:Stromal cells isolated from the PZ and TZ of normal human prostates mixed with DU145 c...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.9961
更新日期:2015-07-03 00:00:00
abstract::Cisplatin chemoresistance is a clinical obstacle in the treatment of gastric cancer (GC). Enhanced DNA repair capacity may lead to cisplatin resistance. However, the detailed molecular mechanism of GC cisplatin resistance specifically involving nucleotide excision repair (NER) is not clear. However, the mechanism thro...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.25814
更新日期:2019-01-29 00:00:00
abstract::Cancer is a genetic disease where genetic variations cause abnormally functioning genes that appear to alter expression. Proteins, the final products of gene expression, determine the phenotypes and biological processes. Therefore, detecting gene expression levels can be used for cancer diagnosis, prognosis, and treat...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.24744
更新日期:2018-06-05 00:00:00
abstract::Purpose: Systemic therapy has often been used for patients with advanced hepatocellular carcinoma (HCC). However, due to drug resistance, the use of cytotoxic chemotherapy in the treatment of patients with advanced HCC has typically demonstrated low response rates. Secretory clusterin (sCLU) is expressed in aggressive...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.23849
更新日期:2018-04-06 00:00:00
abstract::Objective: Liposarcoma is a mesenchymal malignant tumor characterized by adipocyte differentiation which is divided into four subtypes with different prognosis. Accurate histopathological diagnosis is essential for precise treatment. Perilipins, including PLIN1, PLIN2, PLIN3, PLIN4, PLIN5, is a family of lipid droplet...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.41736
更新日期:2020-04-07 00:00:00
abstract::Non epithelial ovarian tumors represent a small group of rare gynecological cancers but they have a high incidence in young childbearing women. The recent years fertility preservation surgeries have become a common practice in specific ovarian malignancies when the patients wish to maintain their fertility. Specific t...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.26674
更新日期:2018-11-24 00:00:00