Abstract：
:Many studies, using different chemical agents, have shown excellent cancer prevention efficacy in mice and rats. However, equivalent tests of cancer prevention in humans require decades of intake of the agents while the rodents' short lifespans cannot give us information of the long-term safety. Therefore, animals with a much longer lifespan should be used to bridge the lifespan gap between the rodents and humans. There are many transgenic mouse models of carcinogenesis available, in which DNA promoters are used to activate transgenes. One promoter may activate the transgene in multiple cell types while different promoters are activated at different ages of the mice. These spatial and temporal aspects of transgenes are often neglected and may be pitfalls or weaknesses in chemoprevention studies. The variation in the copy number of the transgene may widen data variation and requires use of more animals. Models of chemically-induced carcinogenesis do not have these transgene-related defects, but chemical carcinogens usually damage metabolic organs or tissues, thus affecting the metabolism of the chemopreventive agents. Moreover, many genetically edited and some chemically-induced carcinogenesis models produce tumors that exhibit cancerous histology but are not cancers because the tumor cells are still mortal, inducer-dependent, and unable to metastasize, and thus should be used with caution in chemoprevention studies. Lastly, since mice prefer an ambient temperature of 30-32°C, it should be debated whether future mouse studies should be performed at this temperature, but not at 21-23°C that cold-stresses the animals.
journal_name
J Cancerjournal_title
Journal of Cancerauthors
Ma Y,Jia Y,Chen L,Ezeogu L,Yu B,Xu N,Liao DJdoi
10.7150/jca.12519subject
Has Abstractpub_date
2015-09-01 00:00:00pages
1058-65issue
10issn
1837-9664pii
jcav06p1058journal_volume
6pub_type
杂志文章,评审abstract：:Background: Docetaxel (DOC), or Taxotere, is an anthracycline antibiotic used to treat multiple types of cancer. It is a first-line chemotherapy treatment for patients with metastasized, hormone-resistant prostate cancer (PCa) or for patients with high-risk, localized PCa that could benefit from early chemotherapy tre...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.26681
更新日期：2018-11-11 00:00:00
abstract：:Thyroid transcription factor-1 (TTF-1) is overexpressed in up to 95% of primary lung adenocarcinoma while negative for almost all squamous cell carcinomas. TTF-1 expression has been investigated as a prognostic factor in non-small-cell lung cancer (NSCLC) with conflicting results. We conducted this meta-analysis to ga...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.26830
更新日期：2018-10-20 00:00:00
abstract：:We studied combinatorial interactions of two phytochemicals, curcumin and silymarin, in their action against cancer cell proliferation. Curcumin is the major component of the spice turmeric. Silymarin is a bioactive component of milk thistle used as a protective supplement against liver disease. We studied antiprolife...
journal_title：Journal of Cancer
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doi：10.7150/jca.15690
更新日期：2016-06-23 00:00:00
abstract：:Studies have indicated the significance of tumor associated macrophages (TAMs) in breast cancer; however, inconsistent results still exist. We retrospectively reviewed the macrophage distribution in 1579 breast cancer specimens with anti-CD68 or anti-CD163 immunohistochemical staining, and further analyzed the overall...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.33914
更新日期：2019-07-23 00:00:00
abstract：:Oral cancer is one of the most frequent malignant diseases worldwide, and areca nut is a primary carcinogen causing this cancer in Southeast Asia. It has been widely reported that areca nut induced several cytotoxic effects in oral cells, including ROS generation, inflammation, tissue hypoxia, DNA damage, and cell inv...
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pub_type： 杂志文章,评审
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更新日期：2019-07-08 00:00:00
abstract：: Purpose: Differentiated thyroid cancer (DTC) accounts for approximately 95% of thyroid carcinomas. In the metastatic RAI-refractory disease, chemotherapy has very limited efficacy and is associated with substantial toxicity. With increasing knowledge of the molecular patho...
journal_title：Journal of Cancer
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doi：10.7150/jca.22318
更新日期：2018-01-01 00:00:00
abstract：:Galectins are the member of soluble proteins that bind with β-galactoside containing glycans. These proteins have been considered to be associated in various important events such as different types of cancers. It has been found that galectins could contribute to neoplastic transformation or regulate cell growth, cell...
journal_title：Journal of Cancer
pub_type： 杂志文章,评审
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更新日期：2018-11-25 00:00:00
abstract：:Background: Protein kinase C zeta/lambda (PKCζ/λ) is a family of protein kinase enzymes that contributes to cell proliferation and regulation, which are important for cancer development. PKCζ/λ has been shown to be an important regulator of tumorigenesis in intestinal cancer. The phosphorylated form of PKCζ/λ, p-PKCζ/...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.20983
更新日期：2017-09-20 00:00:00
abstract：:Even with the technological advances of dose-escalated IMRT with the addition of the latest image guidance technologies, local failures still occur. The combination of MRI-based imaging techniques can yield quantitative information that reflects on the biological properties of prostatic tissues. These techniques provi...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.5419
更新日期：2013-01-01 00:00:00
abstract：:Neural invasion (NI) is one of the important routes for local spread of gastric cancer (GC) correlated with poor prognosis. However, the exact cellular characteristics and molecular mechanisms of NI in GC are still unclear. Netrin-1(NTN1) as an axon guidance molecule was firstly found during neural system development....
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.30230
更新日期：2019-06-02 00:00:00
abstract：BACKGROUND:This study was performed to assess the impact of irradiation on the tissue penetration depth of doxorubicin delivered during Pressurized Intra-Peritoneal Aerosol Chemotherapy (PIPAC). METHODS:Fresh post mortem swine peritoneum was cut into 10 proportional sections. Except for 2 control samples, all received...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.14714
更新日期：2016-05-07 00:00:00
abstract：:[This retracts the article DOI: 10.7150/jca.29953.]. ...
journal_title：Journal of Cancer
pub_type： 撤回出版物
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更新日期：2019-09-02 00:00:00
abstract：:Nasopharyngeal carcinoma (NPC), is one of the most common malignant tumor in southern China and southeast Asia. MYH10 is a coding gene of the NMMHC-IIB protein. Previous studies have shown that MYH10 expression was up-regulated in breast cancer, glioma and meningioma. Moreover, it was targeted by miR200 family. Howeve...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.40438
更新日期：2020-03-04 00:00:00
abstract：:Background: Hepatitis B virus infection had been identified its relationship with liver diseases, including liver tumors. We aimed to explore diagnostic and prognostic values between the Human Leukocyte Antigen (HLA) complex and hepatocellular carcinoma (HCC). Methods: We used the GSE14520 dataset to explore diagnosti...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.29655
更新日期：2019-08-28 00:00:00
abstract：OBJECTIVE(S):To assess skeletal wide fracture location and time of fracture after cancer treatment Study Design: One hundred thirty-nine women diagnosed with breast or gynecologic cancer between 2003 and 2012 that subsequently had a radiologic diagnosis of fracture were identified retrospectively using electronic medic...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.10288
更新日期：2015-01-01 00:00:00
abstract：:Transarterial chemoembolization (TACE) has been considered the standard treatment for intermediate-stage hepatocellular carcinoma according to BCLC algorithm. However, it has been unclear about the TACE-related predictive bio-markers and underlying molecular mechanisms. This investigation revealed that HCCs with highe...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.35631
更新日期：2020-01-01 00:00:00
abstract：:For hepatocellular carcinoma (HCC) patients with macrovascular invasion (MaVI), hepatectomy and transcatheter arterial chemoembolization (TACE) remain the main treatment options in Asia. However, which could achieve better survivals remains controversial. In present study, we conducted a meta-analysis to clarify the s...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.20978
更新日期：2017-08-25 00:00:00
abstract：:Stromal fibroblasts are suggested to be a key determinant in the malignant progression of breast cancer. To find an in vitro culture model that best mimics the in vivo tumor microenvironment so we can study the effects of stromal fibroblasts on breast cancer progression, we evaluated several three-dimensional (3D) co-...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.2.458
更新日期：2011-01-01 00:00:00
abstract：:Aims: To compare the long-term prognosis of younger and elderly patients with combined hepatocellular-cholangiocarcinoma (CHC) who underwent curative resection between 1993 and 2014 at our center. Methods: Two hundred and thirteen patients who underwent liver resection for CHC were enrolled in our study. The overall s...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.23921
更新日期：2018-02-28 00:00:00
abstract：:Background: Cancers may arise from cells with dysregulated telomeric functions due to shorten telomere length. We and others previously found that short leukocyte telomere length was associated with markedly evaluated risk of esophageal squamous cell carcinoma (ESCC). Hence, we hypothesized that single nucleotide poly...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.45165
更新日期：2020-06-23 00:00:00
abstract：:Objectives: Lung cancer in young adults is a distinct disease with particular socioeconomic implications. This study aimed to clarify the clinicopathological characteristics, best interventions, and outcomes of this distinctive entity. Methods: A retrospective review of patients with lung cancer was performed in our i...
journal_title：Journal of Cancer
pub_type： 杂志文章,评审
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更新日期：2019-06-09 00:00:00
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pub_type： 杂志文章
doi：10.7150/jca.37610
更新日期：2019-10-15 00:00:00
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journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.25136
更新日期：2018-09-08 00:00:00
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journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.15737
更新日期：2016-11-25 00:00:00
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journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.48365
更新日期：2020-08-27 00:00:00
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journal_title：Journal of Cancer
pub_type： 杂志文章,评审
doi：10.7150/jca.14031
更新日期：2016-05-25 00:00:00
abstract：:Cisplatin-based chemotherapy is the foundation of treatment for major non-small cell lung cancer (NSCLC) patients. However, cisplatin resistance is still a challenging issue, and the molecular mechanisms underlying this resistance remain to be fully explored. CLEC4M, a Ca2+-dependent C-type lectin, has recently been f...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.30139
更新日期：2019-10-19 00:00:00
abstract：:In this bi-institutional study, twenty-three stage IIIC-IV MAGE-A3(+) melanoma patients were vaccinated with M3TK-GML biweekly at three dose levels, with a subsequent phase of vaccinations at the maximum dose level. Anti-MAGE-A3 and anti-TK T cells were assessed by in vitro assay and delayed-type hypersensitivity skin...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.2.329
更新日期：2011-01-01 00:00:00
abstract：:Background: The transfusion of blood that has been stored for some time was found to be associated with transfusion-related immune modulation (TRIM) responses in cancer patients, which could result in poor clinical outcomes, such as tumor recurrence, metastasis and reduced survival rate. Given the prior observation of...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.31360
更新日期：2019-06-02 00:00:00
abstract：:Background: The purpose of this study was to examine and compare the prognostic value of different immunization-based scoring systems in patients with soft tissue sarcoma (STS). Methods: We conducted a retrospective study evaluating a cohort of 165 patients diagnosed with STS between July 2007 and July 2014. The relat...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.17356
更新日期：2017-02-25 00:00:00
