Predictors of Mastoiditis after Intensity-Modulated Radiotherapy in Nasopharyngeal Carcinoma: A Dose-Volume Analysis.

abstract：:Background: Regulatory T cells (Tregs) and plasmacytoid dendritic cells (pDCs) are the main immunosuppressive cells in tumor microenvironment of gastric cancer (GC). In this prospective study, the association of prognosis with Tregs subsets and pDCs were further analyzed. Methods: pDCs, Tregs population and its expres...

journal_title：Journal of Cancer

authors： Liu X,Yu H,Yan C,Mei Y,Lin C,Hong Y,Lin X,Zhang Q,Yu J

更新日期：2019-10-22 00:00:00

abstract：:As a crucial event involved in the metastasis and relapse of esophageal cancer, c-Met overexpression has been considered as one of the culprits responsible for the failure in patients who received radiochemotherapy. Since c-Met has been confirmed to be pivotal for cell survival, proliferation and migration, little is ...

journal_title：Journal of Cancer

authors： Chen GZ,Dai WS,Zhu HC,Song HM,Yang X,Wang YD,Min H,Lu Q,Liu S,Sun XC,Zeng XN

更新日期：2017-03-12 00:00:00

abstract：:Background: The predictive roles of secreted protein acidic and rich in cysteine (SPARC) in pancreatic ductal adenocarcinoma (PDAC) patients after curative resection have not been clarified. We investigated the correlations between the SPARC expression and the postoperative prognosis. Methods: We retrospectively analy...

journal_title：Journal of Cancer

authors： Murakawa M,Aoyama T,Miyagi Y,Kobayashi S,Ueno M,Morimoto M,Numata M,Yamamoto N,Tamagawa H,Yukawa N,Rino Y,Masuda M,Morinaga S

更新日期：2019-01-01 00:00:00

abstract：:Background: Malnutrition and systemic inflammatory response are frequently associated with prognosis in patients with several types of cancer, including renal cell carcinoma (RCC). The study is aimed to investigate the ability of preoperative serum albumin to globulin ratio (AGR) to predict the long-term mortality of ...

journal_title：Journal of Cancer

authors： He X,Guo S,Chen D,Yang G,Chen X,Zhang Y,He Q,Qin Z,Liu Z,Xue Y,Zhang M,Liu R,Zhou F,Han H,Yao K

更新日期：2017-01-15 00:00:00

abstract：:Purpose: Aim of this study was to comprehensively analyze BRCA1-associated protein-1 (BAP1) somatic mutation in clear cell renal cell carcinoma (ccRCC) and explore potential therapeutic pathways and molecules. Patients and methods: In this study, we analyzed 445 ccRCC cases from The Cancer Genome Atlas (TCGA). Compreh...

journal_title：Journal of Cancer

authors： Jin S,Wu J,Zhu Y,Gu W,Wan F,Xiao W,Dai B,Zhang H,Shi G,Shen Y,Zhu Y,Ye D

更新日期：2018-10-18 00:00:00

abstract：:Objective: There are controversial indications for neoadjuvant chemotherapy (NAT) in the treatment of locally advanced gastric cancer (LAGC). Here, we aimed to identify indications for NAT based on pre-treatment clinicopathological and laboratory parameters. Methods: This study included a retrospective cohort of 1083 ...

journal_title：Journal of Cancer

authors： Wang Y,Zhang J,Guo S,Meng XY,Zheng ZC,Zhao Y

更新日期：2020-08-18 00:00:00

abstract：:Our results show that using an EBV-LCL feeder cell line, large numbers of pure populations of highly activated NK cells can be expanded ex vivo under GMP conditions. With the exception of thyroiditis and constitutional symptoms related to IL-2 therapy, infusions of up to 1 x 10(8) cells/kg of ex vivo expanded NK have ...

journal_title：Journal of Cancer

authors： Lundqvist A,Berg M,Smith A,Childs RW

更新日期：2011-01-01 00:00:00

abstract：:Background. Esophageal cancer is ranked in the top ten of diagnosed tumors worldwide. Even though improvements in survival could be noticed over the last years, prognosis remains poor. ETS translocation variant 1 (ETV1) is a member of a family of transcription factors and is phosphorylated by mitogen-activated protein...

journal_title：Journal of Cancer

authors： Jomrich G,Maroske F,Stieger J,Preusser M,Ilhan-Mutlu A,Winkler D,Kristo I,Paireder M,Schoppmann SF

更新日期：2018-01-01 00:00:00

abstract：:Purpose: Systemic therapy has often been used for patients with advanced hepatocellular carcinoma (HCC). However, due to drug resistance, the use of cytotoxic chemotherapy in the treatment of patients with advanced HCC has typically demonstrated low response rates. Secretory clusterin (sCLU) is expressed in aggressive...

journal_title：Journal of Cancer

authors： Wang X,Zou F,Zhong J,Yue L,Wang F,Wei H,Yang G,Jin T,Dong X,Li J,Xiu P

更新日期：2018-04-06 00:00:00

abstract：PURPOSE:Triple-negative breast cancer (TNBC) has attracted more attention both clinically and experimentally because of its high-risk biological characteristics and lacking of effective treatment method. The purpose of this retrospective study was to find out the incidence of triple-negative breast cancer (TNBC) in all...

journal_title：Journal of Cancer

authors： Qiu J,Xue X,Hu C,Xu H,Kou D,Li R,Li M

更新日期：2016-01-01 00:00:00

abstract：:Purpose: We examined the effect of GV1001 in castration castration-resistant prostate cancer (CRPC) cell growth and invasion and explored the potential molecular mechanisms of action. Materials and Methods: The in vitro anti-cancer effects of GV1001 in CRPC cells were examined using cell viability assay, TUNEL assay, ...

journal_title：Journal of Cancer

authors： Park YH,Jung AR,Kim GE,Kim MY,Sung JW,Shin D,Cho HJ,Ha US,Hong SH,Kim SW,Lee JY

更新日期：2019-10-17 00:00:00

abstract：:Our previous studies have demonstrated that the compound fuling granule (CFG), a traditional Chinese medicine, suppresses ovarian cancer cell growth, migration and metastasis. However, the underlying mechanisms remain to be fully elucidated. In this study, we found that CFG could induce mitochondrial fragmentation, mi...

journal_title：Journal of Cancer

authors： Ruan S,Zhang Z,Tian X,Huang D,Liu W,Yang B,Shen M,Tao F

更新日期：2018-09-08 00:00:00

abstract：:MPHOSPH1, which is one of the kinesin superfamily proteins, has been reported to play an essential role in the carcinogenesis and progression of several kinds of cancers. MPHOSPH1 has also been suggested to be involved in STAT3 phosphorylation in hepatocellular carcinoma. However, the biological behavior of MPHOSPH1 i...

journal_title：Journal of Cancer

authors： Abe T,Kohashi K,Takemoto J,Kinoshita F,Eto M,Oda Y

更新日期：2018-10-31 00:00:00

abstract：:Liquid biopsy is becoming a promising method for non-invasive cancer detection. In several proof-of-concept studies, long non-coding RNAs (lncRNAs) were found to be potential biomarkers for bladder cancer detection. The objective of this study was to discover a panel of cell-free, urinary lncRNAs as liquid biopsy biom...

journal_title：Journal of Cancer

authors： Yu X,Wang R,Han C,Wang Z,Jin X

更新日期：2020-01-01 00:00:00

abstract：:Background: The Matrix metalloproteinase-14 (MMP-14) expression has been shown to be overexpressed in different cancers. However, there is no comprehensive quantitative evaluation of the MMP-14 prognostic value in digestive system carcinoma (DSC). The aim of this study is to explore the correlation between the MMP-14 ...

journal_title：Journal of Cancer

authors： Duan F,Peng Z,Yin J,Yang Z,Shang J

更新日期：2020-01-01 00:00:00

abstract：:Amplified in breast cancer 1 (AIB1) gene, a coactivator for steroid receptor, is frequently amplified in diverse cancers and is considered as an oncogene in tumorigenesis. However, the prognostic significance of AIB1 amplification in gliomas remains totally unclear. In this study, 115 gliomas and 16 benign meningiomas...

journal_title：Journal of Cancer

authors： Chen L,Wang C,Zhang X,Gao K,Liu R,Shi B,Hou P

更新日期：2016-10-22 00:00:00

abstract：:Tumor progression is often associated with chronic inflammation in the tumor microenvironment, which is mediated by numerous cytokines, chemokines and growth factors produced by cancer and stroma cells. All these mediators support tumor development and immunosuppression in autocrine and/or paracrine ways. Neutralizati...

journal_title：Journal of Cancer

authors： Sevko A,Umansky V

更新日期：2013-01-01 00:00:00

abstract：:Background: To identify associated risk factors and develop a predictive nomogram for the early death of metastatic gastric cancer patients. Methods: A total of 4575 patients in the SEER cohort and 220 patients in the Chinese cohort diagnosed with metastatic gastric cancer in our Cancer Center were obtained. Univariat...

journal_title：Journal of Cancer

authors： Zhu Y,Fang X,Wang L,Zhang T,Yu D

更新日期：2020-07-14 00:00:00

abstract：:Objective: To develop and validate a prediction model for the pathological complete response (pCR) to neoadjuvant chemotherapy (NCT) of triple-negative breast cancer (TNBC). Methods: We systematically searched Gene Expression Omnibus, ArrayExpress, and PubMed for the gene expression profiles of operable TNBC accessibl...

journal_title：Journal of Cancer

authors： Han Y,Wang J,Xu B

更新日期：2021-01-01 00:00:00

abstract：:Colorectal cancer (CRC) is an important health issue worldwide, accounting for the third place of cancer incidence. Chronic inflammation, as seen in Crohn's disease and ulcerative colitis, is the most important risk factor for developing CRC, as it favours neoplastic transformation by enhancing epithelial cell turnove...

journal_title：Journal of Cancer

authors： Figueroa-González G,García-Castillo V,Coronel-Hernández J,López-Urrutia E,León-Cabrera S,Arias-Romero LE,Terrazas LI,Rodríguez-Sosa M,Campos-Parra AD,Zúñiga-Calzada E,Lopez-Camarillo C,Morales-González F,Jacobo-Herrera NJ,Pérez

更新日期：2016-07-25 00:00:00

abstract：:Background and aim: Understanding the molecular biological mechanisms underlying laryngeal squamous cell carcinoma (LSCC) invasion and metastasis is crucial for diagnosis, treatment, and prognosis. We aimed to examine the expression of the tumor suppressor microRNA-204-5p (miR-204-5p) and its target gene, forkhead box...

journal_title：Journal of Cancer

authors： Gao W,Wu Y,He X,Zhang C,Zhu M,Chen B,Liu Q,Qu X,Li W,Wen S,Wang B

更新日期：2017-07-21 00:00:00

abstract：:Inhibition of aberrantly activated pathways cross-talking with hormone receptor (HR) improves response to endocrine therapy in patients with HR-positive advanced breast cancer. We performed a Pubmed database systematic review to ascertain the existence of a better clinical response when combining endocrine therapy wit...

journal_title：Journal of Cancer

authors： Grassadonia A,Caporale M,Tinari N,Zilli M,DeTursi M,Gamucci T,Vici P,Natoli C

更新日期：2015-05-12 00:00:00

abstract：:To explore the role of phospholipase D1 (PLD1) mRNA in transition of prostate cancer (PCa) cells to androgen independence, we used Arraystar Human LncRNA Microarray V3.0 to detect and compare the differential expression of PLD1 and its signaling pathway-related gene in standard androgen dependence prostate cancer (ADP...

journal_title：Journal of Cancer

authors： Zhou W,Shi K,Ji L,Wu R,Chen Y,Tu H,Zhou B,Wang Z,Zhang M

更新日期：2018-09-08 00:00:00

abstract：PURPOSE:Our study is designed to develop and certify a promising prognostic signature for hepatocellular carcinoma (HCC). Materials and methods: We retrospectively analyzed mRNA expression profiles and clinicopathological data fetched from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) datasets. We fo...

journal_title：Journal of Cancer

authors： Xie H,Liu S,Zhang Z,Chen P,Tao Y

更新日期：2020-07-31 00:00:00

abstract：:Background: Lysosome-associated protein transmembrane-4β-35(LAPTM4B-35) has been observed overexpressed in multiple malignant tumors. However, the prognostic value of LAPTM4B-35 remains controversial. Therefore, we conducted a meta-analysis to evaluate the prognostic value of LAPTM4B-35 in human cancers. Methods: The ...

journal_title：Journal of Cancer

authors： Zhou L,Dai C,Tian T,Wang M,Lin S,Deng Y,Xu P,Hao Q,Wu Y,Yang T,Zhu W,Dai Z

更新日期：2018-10-21 00:00:00

abstract：BACKGROUND AND AIMS:We compared clinicopathologic data and long-term clinical outcomes among patients with non-B and non-C hepatocellular carcinoma (NBNC-HCC) who underwent curative resection (group A, n=129), those with hepatitis B virus-related HCC (group B, n=62) and those with hepatitis C virus-related HCC (group C...

journal_title：Journal of Cancer

authors： Nishikawa H,Arimoto A,Wakasa T,Kita R,Kimura T,Osaki Y

更新日期：2013-07-18 00:00:00

abstract：:Background: Topoisomerase IIA (TOP2A) gene encodes DNA topoisomerase enzyme and has been reported that TOP2A is broadly expressed in many types of cancers. Our study aims to investigate the prognostic effect of TOP2A on lung adenocarcinoma (LUAD) and the potential molecular mechanism of TOP2A to tumorigenesis. Methods...

journal_title：Journal of Cancer

authors： Kou F,Sun H,Wu L,Li B,Zhang B,Wang X,Yang L

更新日期：2020-02-10 00:00:00

abstract：:Background and aims. Cyclin-dependent kinase inhibitor 3 (CDKN3) has been found playing a varying role in carcinogenesis, but its biological function in esophageal squamous cell carcinoma (ESCC) is unclear. The aim of this study was to demonstrate the role of CDKN3 in ESCC. Materials and Methods: Real-time PCR and Wes...

journal_title：Journal of Cancer

authors： Liu J,Min L,Zhu S,Guo Q,Li H,Zhang Z,Zhao Y,Xu C,Zhang S

更新日期：2019-04-21 00:00:00

abstract：:Colorectal cancer is a commonly diagnosed malignancy and also the major cause of death worldwide. Chemotherapy is the primary therapy for advanced colorectal cancer. Although oxaliplatin has potential effect in colorectal cancer therapy, the molecular mechanisms involved in its cytotoxic effects are not well elucidate...

journal_title：Journal of Cancer

authors： Evert J,Pathak S,Sun XF,Zhang H

更新日期：2018-05-22 00:00:00

abstract：:We use pulmonary interventional procedures for the diagnosis of pulmonary diseases either for benign or malignant lesions. Flexible bronchoscopy with or without radial endobronchial ultrasound, convex-probe endobronchial ultrasound and electromagnetic navigation are procedures performed in centers with experience in d...

journal_title：Journal of Cancer

authors： Hohenforst-Schmidt W,Zarogoulidis P,Huang H,Man YG,Laskou S,Koulouris C,Giannakidis D,Mantalobas S,Florou MC,Amaniti A,Steinheimer M,Sinha A,Freitag L,Turner JF,Browning R,Vogl T,Roman A,Benhassen N,Kesisoglou I,Sap

更新日期：2018-02-12 00:00:00