Abstract:
:Purpose: The present study aims to explore the potential mechanisms contributing to prostate cancer (PCa), screen the hub genes, and identify potential biomarkers and correlated pathways of PCa progression. Methods: The PCa gene expression profile GSE3325 was operated to analyze the differentially expressed genes (DEGs). DAVID was used to evaluate Gene ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses. A protein-protein interaction (PPI) network was constructed to visualize interactions of the hub genes. The prognostic and diagnostic analysis of these hub genes was carried out to evaluate their potential effects on PCa. Results: A total of 847 DEGs were identified (427 upregulated genes and 420 downregulated genes). Meanwhile, top15 hub genes were showed. GO analysis displayed that the DEGs were mainly enriched in cell cycle, DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest and proteinaceous extracellular matrix. KEGG analysis indicated the DEGs were enriched in the p53 signaling pathway and cell cycle pathway. The GO and KEGG enrichment analyses for the DEGs disclosed important biological features of PCa. PPI network showed the interaction of top 15 hub genes. Gene Set Enrichment Analysis (GSEA) revealed that some of the hub genes were associated with biochemical recurrence (BCR) and metastasis of PCa. Some top hub genes were distinctive and new discoveries compared with that of the existing associated researches. Conclusions: Our analysis revealed that the changes of cell cycle and p53 signaling pathway are two major signatures of PCa. CENPA, KIF20A and CDCA8 might promote the tumorigenesis and progression of PCa, especially in BCR and metastasis, which could be novel therapeutic targets and biomarkers for diagnosis, prognosis of PCa.
journal_name
J Cancerjournal_title
Journal of Cancerauthors
Song Z,Huang Y,Zhao Y,Ruan H,Yang H,Cao Q,Liu D,Zhang X,Chen Kdoi
10.7150/jca.29571subject
Has Abstractpub_date
2019-02-23 00:00:00pages
1398-1408issue
6issn
1837-9664pii
jcav10p1398journal_volume
10pub_type
杂志文章abstract::Background: The incidence and mortality rate of gastric cancer has markedly declined over the past few decades, due to the progress and advances in the development of diagnostic and treatment regimens. However, there is still a large portion of patients who are first diagnosed during the advanced stage of gastric canc...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.31303
更新日期:2019-10-06 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Journal of Cancer
pub_type: 杂志文章,评审
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journal_title:Journal of Cancer
pub_type: 杂志文章
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更新日期:2015-09-16 00:00:00
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doi:10.7150/jca.26101
更新日期:2018-09-08 00:00:00
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pub_type: 杂志文章
doi:10.7150/jca.25569
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