GDF15/GFRAL Pathway as a Metabolic Signature for Cachexia in Patients with Cancer.

abstract：:RBP7 is a member of the cellular retinol-binding protein (CRBP) family and previous data suggested a link between CRBPs and the malignant transformation of colon cancer cells. Here, we investigated the potential of RBP7 as a predictive biomarker for patients with colon cancer and determined its functional relevance fo...

journal_title：Journal of Cancer

authors： Elmasry M,Brandl L,Engel J,Jung A,Kirchner T,Horst D

更新日期：2019-08-27 00:00:00

abstract：:Background and aims. Cyclin-dependent kinase inhibitor 3 (CDKN3) has been found playing a varying role in carcinogenesis, but its biological function in esophageal squamous cell carcinoma (ESCC) is unclear. The aim of this study was to demonstrate the role of CDKN3 in ESCC. Materials and Methods: Real-time PCR and Wes...

journal_title：Journal of Cancer

authors： Liu J,Min L,Zhu S,Guo Q,Li H,Zhang Z,Zhao Y,Xu C,Zhang S

更新日期：2019-04-21 00:00:00

abstract：:Introduction: Preoperative risk stratification is crucial for clinical treatment of endometrial cancer (EC). This study aimed to establish a model based on magnetic resonance imaging (MRI) and clinical factors for risk classification of EC. Materials and Methods: A total of 102 patients with pathologically proven Stag...

journal_title：Journal of Cancer

authors： Chen J,Gu H,Fan W,Wang Y,Chen S,Chen X,Wang Z

更新日期：2021-01-01 00:00:00

abstract：:Early detection and accurate evaluation were both critical to improving the prognosis of clear cell Renal Cell Carcinoma (ccRCC) patients. More importantly, RNA Binding Proteins (RBPs) play a vital role in the tumorigenesis and progression of numerous cancers. However, the relationship between RBPs and ccRCC is still ...

journal_title：Journal of Cancer

authors： Zhu Z,He A,Lin L,Xu C,Cai T,Lin J

更新日期：2020-09-23 00:00:00

abstract：:Lung cancer is the most common malignancy in China and is associated with a poor survival rate amongst Han Chinese. The high mortality is largely attributed to late-stage diagnosis, when treatment is largely ineffective. Identification of genetic variants could potentially assist with earlier diagnosis and thus more e...

journal_title：Journal of Cancer

authors： Hu W,Tang CH,Chen HT,Zhao J,Jin L,Kang L,Wu Y,Ying P,Wang CQ,Su CM

更新日期：2019-06-02 00:00:00

abstract：:Objective: The purpose of this study was to evaluate the efficacy and feasibility of the R.E.N.A.L. Nephrometry Score to postoperatively predict high-grade clear-cell renal carcinoma (ccRCC). Methods: The study included 288 patients diagnosed with ccRCC who had complete CT/CTA data and R.E.N.A.L. Nephrometry Scores an...

journal_title：Journal of Cancer

authors： Chen SH,Wu YP,Li XD,Lin T,Guo QY,Chen YH,Huang JB,Wei Y,Xue XY,Zheng QS,Xu N

更新日期：2017-10-17 00:00:00

abstract：:Purpose Neuroblastoma is an embryonic solid tumor derived from the progenitors of the sympathetic nervous system. More than half of the patients developed metastatic disease at the time of initial diagnosis and had poor outcome with current therapeutic approaches. In recent years, some obligate and facultative anaerob...

journal_title：Journal of Cancer

authors： Ning BT,Yu B,Chan S,Chan JL,Huang JD,Chan GC

更新日期：2017-06-03 00:00:00

abstract：:Background: The Aldehyde dehydrogenase 2 (ALDH2) mutant genotypes contain an allele encoding defective ALDH2 with reduced efficacy of alcohol metabolism leading to accumulation of highly toxic and carcinogenic acetaldehyde. It can induce unpleasant "Asian flush syndrome" and associate with increased risk of cancers. H...

journal_title：Journal of Cancer

authors： Huang PH,Hu CC,Chien CH,Chen LW,Chien RN,Lin YS,Chao M,Lin CL,Yeh CT

更新日期：2019-10-03 00:00:00

abstract：:MPHOSPH1, which is one of the kinesin superfamily proteins, has been reported to play an essential role in the carcinogenesis and progression of several kinds of cancers. MPHOSPH1 has also been suggested to be involved in STAT3 phosphorylation in hepatocellular carcinoma. However, the biological behavior of MPHOSPH1 i...

journal_title：Journal of Cancer

authors： Abe T,Kohashi K,Takemoto J,Kinoshita F,Eto M,Oda Y

更新日期：2018-10-31 00:00:00

abstract：:The hemagglutinin-neuraminidase (HN) protein of Newcastle disease virus (NDV) with its immunotherapeutic activities and sialic acid binding abilities is a promising cancer adjuvant. The HN was surfaced displayed on Lactococcus lactis and its cancer targeting ability was investigated via attachment to the MDA-MB231 bre...

journal_title：Journal of Cancer

authors： Baradaran A,Yusoff K,Shafee N,Rahim RA

更新日期：2016-01-29 00:00:00

abstract：:Purpose: MicroRNAs (miRNAs) are key regulators of the growth and development of a wide range of cancer types such as colorectal cancer (CRC). A number of previously studies have observed that the levels of miR-365a-3p expression are dysregulated in many cancers, but the specific role of this miRNA in CRC and its assoc...

journal_title：Journal of Cancer

authors： Hong YG,Xin C,Zheng H,Huang ZP,Yang Y,Zhou JD,Gao XH,Hao L,Liu QZ,Zhang W,Hao LQ

更新日期：2020-03-26 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) is one of the most common types of aggressive cancer. The tumor tissue, which shows an active angiogenesis, is composed of neoplastic and stromal cells, and an abundant inflammatory infiltrate. Angiogenesis is important to support tumor growth, while infiltrating cells contribute to ...

journal_title：Journal of Cancer

authors： Rivas-Fuentes S,Salgado-Aguayo A,Pertuz Belloso S,Gorocica Rosete P,Alvarado-Vásquez N,Aquino-Jarquin G

更新日期：2015-08-07 00:00:00

abstract：:Ovarian cancer is a highly lethal malignancy in the female reproductive system. Platinum drugs, represented by cisplatin, are the first-line chemotherapeutic agents for treatment of various malignancies including ovarian cancer, but drug resistance leads to chemotherapy failure. MicroRNAs emerged as promising molecule...

journal_title：Journal of Cancer

authors： Xiang Y,Chen YJ,Yan YB,Liu Y,Qiu J,Tan RQ,Tian Q,Guan L,Niu SS,Xin HW

更新日期：2020-03-13 00:00:00

abstract：:Yes-associated protein (YAP) is a transcriptional coactivator that promotes cell proliferation, migration, and tissue homeostasis in colorectal cancer (CRC). Here, we established 5-Fu resistant CRC cell line (SW620R) and examined the role of YAP in chemotherapy resistance. We showed that YAP promoted cell proliferatio...

journal_title：Journal of Cancer

authors： Huang C,Chen Z,Yang C,Chen L,Lai C,Zhang Y,Yuan W,Jeong JH

更新日期：2020-07-11 00:00:00

abstract：:Objective: There are controversial indications for neoadjuvant chemotherapy (NAT) in the treatment of locally advanced gastric cancer (LAGC). Here, we aimed to identify indications for NAT based on pre-treatment clinicopathological and laboratory parameters. Methods: This study included a retrospective cohort of 1083 ...

journal_title：Journal of Cancer

authors： Wang Y,Zhang J,Guo S,Meng XY,Zheng ZC,Zhao Y

更新日期：2020-08-18 00:00:00

abstract：:Cellular compartmentalization of biochemical processes in eukaryotic cells is critical for many functions including shuttling of reducing equivalents across membranes. Although coordination of metabolic flux between different organelles is vital for cell physiology, its impact on tumor cell survival is not well unders...

journal_title：Journal of Cancer

authors： Zhang B,Tornmalm J,Widengren J,Vakifahmetoglu-Norberg H,Norberg E

更新日期：2017-07-05 00:00:00

abstract：:Background: To develop and validate a radiomic nomogram incorporating radiomic features with clinical variables for individual local recurrence risk assessment in nasopharyngeal carcinoma (NPC) patients before initial treatment. Methods: One hundred and forty patients were randomly divided into a training cohort (n = ...

journal_title：Journal of Cancer

authors： Zhang L,Zhou H,Gu D,Tian J,Zhang B,Dong D,Mo X,Liu J,Luo X,Pei S,Dong Y,Huang W,Chen Q,Liang C,Lian Z,Zhang S

更新日期：2019-07-10 00:00:00

abstract：:Background: Topoisomerase IIA (TOP2A) gene encodes DNA topoisomerase enzyme and has been reported that TOP2A is broadly expressed in many types of cancers. Our study aims to investigate the prognostic effect of TOP2A on lung adenocarcinoma (LUAD) and the potential molecular mechanism of TOP2A to tumorigenesis. Methods...

journal_title：Journal of Cancer

authors： Kou F,Sun H,Wu L,Li B,Zhang B,Wang X,Yang L

更新日期：2020-02-10 00:00:00

abstract：PURPOSE:We conducted a meta-analysis to evaluate and compare the short- and long-term results of laparoscopic colorectal surgery (LCRS) and conventional open surgery (OCRS) for colorectal cancer (CRC). METHODS:We searched relevant papers published between January 1990 and May 2011. We analyzed the outcomes of each typ...

journal_title：Journal of Cancer

authors： Ohtani H,Tamamori Y,Arimoto Y,Nishiguchi Y,Maeda K,Hirakawa K

更新日期：2011-01-01 00:00:00

abstract：:Oncogenic activation of the ETS Related Gene (ERG) in humans was originally identified in subsets of Ewing sarcomas, myeloid leukemias and, recently, in the majority of prostate cancers. Expression of human ERG protein and consequently its functions in normal and disease states needs to be better understood in light o...

journal_title：Journal of Cancer

authors： Mohamed AA,Tan SH,Mikhalkevich N,Ponniah S,Vasioukhin V,Bieberich CJ,Sesterhenn IA,Dobi A,Srivastava S,Sreenath TL

更新日期：2010-10-25 00:00:00

abstract：:Several studies have reported the association between MAPK signaling pathway gene polymorphisms and papillary thyroid carcinoma (PTC). KRAS gene, an oncogene from the mammalian RAS gene family plays an important role in the MAPK pathway. This study aimed to identify the potential association of KRAS gene polymorphisms...

journal_title：Journal of Cancer

authors： Ning L,Rao W,Yu Y,Liu X,Pan Y,Ma Y,Liu R,Zhang S,Sun H,Yu Q

更新日期：2016-12-09 00:00:00

abstract：:Junctional adhesion molecule B (JAM-B) is a multifunctional transmembrane protein that plays an important role in tumor progression. JAM-B is significantly upregulated in gastric cancer, melanoma cell metastasis and oral squamous cell carcinoma. JAM-2 may also function as a putative tumor suppressor in the progression...

journal_title：Journal of Cancer

authors： Zhang W,He R,Chen S,Zhang L,Cao G,Yang W,Li J

更新日期：2020-03-05 00:00:00

abstract：:Purpose: The present study aims to explore the potential mechanisms contributing to prostate cancer (PCa), screen the hub genes, and identify potential biomarkers and correlated pathways of PCa progression. Methods: The PCa gene expression profile GSE3325 was operated to analyze the differentially expressed genes (DEG...

journal_title：Journal of Cancer

authors： Song Z,Huang Y,Zhao Y,Ruan H,Yang H,Cao Q,Liu D,Zhang X,Chen K

更新日期：2019-02-23 00:00:00

abstract：:Centromere protein N (CENP-N), an important member of the centromere protein family, is essential for kinetochore assembly and chromosome segregation; however, the relevance of CENP-N in cancers remains unknown. The aim of this study was to investigate CENP-N expression and its functional mechanisms in oral squamous c...

journal_title：Journal of Cancer

authors： Oka N,Kasamatsu A,Endo-Sakamoto Y,Eizuka K,Wagai S,Koide-Ishida N,Miyamoto I,Iyoda M,Tanzawa H,Uzawa K

更新日期：2019-06-09 00:00:00

abstract：:Background: The effect of adjuvant chemotherapy on stage II colon cancer remains constantly controversial. Recently, however, several studies have reported the definite survival benefit of adjuvant chemotherapy (ACT) in T4 disease (stage IIB and IIC) among stage II colon cancer patients. The following study investigat...

journal_title：Journal of Cancer

authors： Liu Q,Luo D,An H,Zhang S,Cai S,Li Q,Li X

更新日期：2019-01-29 00:00:00

abstract：:Objectives: Chordomas are slow-growing malignancies that commonly affect vital neurological structures. These neoplasms are highly resistant to current chemotherapeutic regimens and often recur after surgical intervention. Therefore, there is an urgent need to identify molecular targets and more robust drugs to improv...

journal_title：Journal of Cancer

authors： Shen S,Dean DC,Yu Z,Hornicek F,Kan Q,Duan Z

更新日期：2020-01-01 00:00:00

abstract：:Background: Docetaxel (DOC), or Taxotere, is an anthracycline antibiotic used to treat multiple types of cancer. It is a first-line chemotherapy treatment for patients with metastasized, hormone-resistant prostate cancer (PCa) or for patients with high-risk, localized PCa that could benefit from early chemotherapy tre...

journal_title：Journal of Cancer

authors： Mansour M,van Ginkel S,Dennis JC,Mason B,Elhussin I,Abbott K,Pondugula SR,Samuel T,Morrison E

更新日期：2018-11-11 00:00:00

abstract：:Background. Esophageal cancer is ranked in the top ten of diagnosed tumors worldwide. Even though improvements in survival could be noticed over the last years, prognosis remains poor. ETS translocation variant 1 (ETV1) is a member of a family of transcription factors and is phosphorylated by mitogen-activated protein...

journal_title：Journal of Cancer

authors： Jomrich G,Maroske F,Stieger J,Preusser M,Ilhan-Mutlu A,Winkler D,Kristo I,Paireder M,Schoppmann SF

更新日期：2018-01-01 00:00:00

abstract：:The use of polyADPribose polymerase inhibitors in cancer treatment provides a unique opportunity to target DNA repair processes in cancer cells while leaving normal tissue intact. The PARP-1 enzyme repairs DNA single strand breaks (SSB). Therefore PARP-1 inhibition in BRCA1 negative cancers results in the formation of...

journal_title：Journal of Cancer

authors： Bourton EC,Ahorner PA,Plowman PN,Zahir SA,Al-Ali H,Parris CN

更新日期：2017-10-23 00:00:00

abstract：:Despite advancement in the treatment of diffuse large B-cell lymphoma (DLBCL), many patients tend to relapse or become refractory after initial therapy. Therefore, it is essential to identify novel therapeutic targets and drugs, understand the molecular pathogenesis mechanism of DLBCL, and find ways to prevent and tre...

journal_title：Journal of Cancer

authors： Xu L,Gao X,Yang P,Sang W,Jiao J,Niu M,Liu M,Qin Y,Yan D,Song X,Sun C,Tian Y,Zhu F,Sun X,Zeng L,Li Z,Xu K

更新日期：2021-01-01 00:00:00