MicroRNA And Circular RNA Expression In Affected Skin Of Patients With Postherpetic Neuralgia.

Abstract:

:Mechanisms of postherpetic neuralgia (PHN) are still not clear. Transcripts such as microRNA (miRNA) and circular RNA (circRNA) in the affected skin may take part in the initiation and development of this neuropathic pain; however, their expression profiles in skins of PHN patients have not been reported. The PHN affected skin and the mirror skin were collected and subjected to miRNA and circRNA microarray, and expression profiles were comparatively analyzed. There were 317 differently expressed miRNAs in PHN affected skin compared with mirror skin (fold change ≥2.0), and 13 of them showed fold change >10 in the PHN skin. Only one circRNA, hsa_circRNA_405463 showed fold change >2 in PHN skin, however, 31 circRNAs with fold change ≥1.5. To evaluate functions of differential miRNAs, their target mRNAs were predicted and bioinformatics analyses including gene ontology, Kyoto Encyclopedia of Genes and Genomes pathway were conducted. Target mRNAs significantly (P<0.05) enriched in 85 pathways, such as FoxO, AMPK, MAPK and pathway. These data reported for the first time that miRNA and circRNA differentially expressed in the PHN skin and these transcripts with abnormal expression could be potential targets to treat PHN.

journal_name

J Pain Res

journal_title

Journal of pain research

authors

Cao S,Zhang D,Yuan J,Liu C,Zhou W,Zhang L,Yu S,Qin B,Li Y,Deng W

doi

10.2147/JPR.S221615

subject

Has Abstract

pub_date

2019-10-16 00:00:00

pages

2905-2913

issn

1178-7090

pii

221615

journal_volume

12

pub_type

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