Abstract:
BACKGROUND:Opioid analgesics are effective for postsurgical pain but are associated with opioid-related adverse events, creating a significant clinical and economic burden. Gastrointestinal surgery patients are at high risk for opioid-related adverse events. We conducted a study to assess the impact of an opioid-sparing multimodal analgesia regimen with liposome bupivacaine, compared with the standard of care (intravenous [IV] opioid-based, patient-controlled analgesia [PCA]) on postsurgical opioid use and health economic outcomes in patients undergoing ileostomy reversal. METHODS:In this open-label, multicenter study, sequential cohorts of patients undergoing ileostomy reversal received IV opioid PCA (first cohort); or multimodal analgesia including a single intraoperative administration of liposome bupivacaine (second cohort). Rescue analgesia was available to all patients. Primary outcome measures were postsurgical opioid use, hospital length of stay, and hospitalization costs. Incidence of opioid-related adverse events was also assessed. RESULTS:Twenty-seven patients were enrolled, underwent the planned surgery, and did not meet any intraoperative exclusion criteria; 16 received liposome bupivacaine-based multimodal analgesia and eleven received the standard IV opioid PCA regimen. The multimodal regimen was associated with significant reductions in opioid use compared with the IV opioid PCA regimen (mean, 20 mg versus 112 mg; median, 6 mg versus 48 mg, respectively; P < 0.01), postsurgical length of stay (median, 3.0 days versus 5.1 days, respectively; P < 0.001), and hospitalization costs (geometric mean, $6482 versus $9282, respectively; P = 0.01). CONCLUSION:A liposome bupivacaine-based multimodal analgesic regimen resulted in statistically significant and clinically meaningful reductions in opioid consumption, shorter length of stay, and lower inpatient costs than an IV opioid-based analgesic regimen.
journal_name
J Pain Resjournal_title
Journal of pain researchauthors
Marcet JE,Nfonsam VN,Larach Sdoi
10.2147/JPR.S46467subject
Has Abstractpub_date
2013-07-18 00:00:00pages
549-55issn
1178-7090pii
jpr-6-549journal_volume
6pub_type
杂志文章abstract:BACKGROUND/OBJECTIVE:Previous studies have already reported an independent effect of light-load eccentric exercise (10% eccentric exercise contraction [EEC]) and low-level laser therapy (LLLT) as a protective measure against more strenuous eccentric exercise. However, the difference between these two interventions is l...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S139615
更新日期:2017-09-11 00:00:00
abstract::Purpose: It has been reported that neck pain is more prevalent in episodic migraineurs (EM) than in the general population. Subjects with episodic migraine exhibited widespread hypersensitivity in cranio-cervical region. Our objectives were to explore the potential factors associated with the presence of neck pain for...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S200606
更新日期:2019-05-20 00:00:00
abstract:Background:Thoracoscopic surgery (TS) has been performed as a minimally invasive procedure since the beginning of the 1990s. This has led to a dramatic change in the postoperative condition of these patients, facilitating early ambulation and easier management of postoperative pain. However, empirical evidence on posto...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S147691
更新日期:2017-11-15 00:00:00
abstract:BACKGROUND:Diagnosis of fibromyalgia (FM), a chronic musculoskeletal condition characterized by widespread pain and a constellation of symptoms, remains challenging and is often delayed. METHODS:Random forest modeling of electronic medical records was used to identify variables that may facilitate earlier FM identific...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/jpr.s8256
更新日期:2015-06-10 00:00:00
abstract:BACKGROUND:Despite growing interest in the therapeutic use of cannabis to manage chronic pain, only limited data that address these issues are available. In recent years, a number of nations have introduced specific laws to allow patients to use cannabis preparations to treat a variety of medical conditions. In 2015, t...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S132814
更新日期:2017-05-22 00:00:00
abstract::Purpose: Thirty percent of patients with postherpetic neuralgia (PHN) receiving conservative treatment report unsatisfactory pain relief. Epidural steroid injections (ESIs) are commonly used as a therapeutic intervention in these patients. In this study, we aimed to determine if there are variables that predict the ef...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S190646
更新日期:2019-04-23 00:00:00
abstract:Background:It has been reported that N-cadherin and cAMP response element binding protein (CREB) in the spinal cord are critical for synaptogenesis and regulation of excitatory synapse function, which could underlie chronic pain development. The aim of the present study was to investigate the role of spinal N-cadherin/...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S267778
更新日期:2020-08-12 00:00:00
abstract:Purpose:Fabry disease belongs to lysosomal storage disorders and can be successfully treated today. On the contrary, the correct diagnostic classification of its symptoms can be challenging and most patients suffer from pain for years, until they are diagnosed correctly. The aim of this project was to characterize pati...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S206223
更新日期:2019-07-23 00:00:00
abstract:BACKGROUND:Low back pain is often called nonspecific pain. In this type of low back pain, various emotions and stress are known to strongly affect pain perception. The purpose of this study is to investigate how the degree of low back pain changes in people with chronic mild low back pain when they are inside and outsi...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S36960
更新日期:2012-01-01 00:00:00
abstract:Background:Transversus abdominis plane (TAP) block can provide effective analgesia for abdominal surgery. However, many randomized controlled trials (RCTs) have shown controversial results in hysterectomy. We conducted a meta-analysis of RCTs to investigate the effectiveness of TAP block after hysterectomy. Methods:St...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S172828
更新日期:2018-10-18 00:00:00
abstract:Background:Pancreatic cancer is a malignant disease with a high mortality rate and severe pain that is challenging to manage. To reduce the excruciating abdominal pain, opioids and adjuvant agents are conventionally used. Objectives:PRNCPB is a treatment of neural therapy. The number of studies assessing the effect on...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S186659
更新日期:2019-01-14 00:00:00
abstract:Background:The ability to accurately diagnose and objectively localize pain generators in chronic pain sufferers remains a major clinical challenge since assessment relies on subjective patient complaints and relatively non-specific diagnostic tools. Developments in clinical molecular imaging, including advances in ima...
journal_title:Journal of pain research
pub_type:
doi:10.2147/JPR.S167839
更新日期:2018-10-12 00:00:00
abstract:UNLABELLED:Postsurgical pain management remains a significant challenge. Liposome bupivacaine, as part of a multimodal analgesic regimen, has been shown to significantly reduce postsurgical opioid consumption, hospital length of stay (LOS), and hospitalization costs in gastrointestinal (GI) surgery, compared with intra...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S63764
更新日期:2014-06-24 00:00:00
abstract:Background:Despite the increasing prevalence of opioid use disorder (OUD) in pregnant women, there are limited studies on their anesthesia care and analgesic outcomes after cesarean delivery (CD). Methods:Patients with OUD on either buprenorphine or methadone maintenance therapy who underwent CD at our institution fro...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S284874
更新日期:2020-12-30 00:00:00
abstract:Introduction:Cannabidiol (CBD) is reported to produce pain relief, but the clinically relevant cellular and molecular mechanisms remain uncertain. The TRPV1 receptor integrates noxious stimuli and plays a key role in pain signaling. Hence, we conducted in vitro studies, to elucidate the efficacy and mechanisms of CBD f...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S258433
更新日期:2020-09-11 00:00:00
abstract:Purpose:Exercise-induced hypoalgesia (EIH) is the short-term reduction of pain sensitivity after a single bout of exercise. Descending pain inhibition has been proposed to at least partly underlie EIH. Cognitive inhibition is the ability to inhibit a pre-potent response and has in turn been associated with descending p...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S238718
更新日期:2020-04-29 00:00:00
abstract:Background:This study evaluates the reporting quality of randomized controlled trials (RCTs) on acupuncture use for the treatment of postherpetic neuralgia and explores related factors. Methods:The following six databases PubMed, Embase, Cochrane Library, VIP, CNKI, and SinoMed, were systematically searched from their...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S210471
更新日期:2019-07-29 00:00:00
abstract::Recently, attention to the lifestyle of patients has been rapidly increasing in the field of pain therapy, particularly with regard to the role of nutrition in pain development and its management. In this review, we summarize the latest findings on the role of nutrition and nutraceuticals, microbiome, obesity, soy, om...
journal_title:Journal of pain research
pub_type: 杂志文章,评审
doi:10.2147/JPR.S115068
更新日期:2016-12-08 00:00:00
abstract:OBJECTIVES:Chronic neuropathic pain and chronic complex regional pain syndrome (CRPS), in particular, are debilitating and difficult-to-treat conditions that have a strong impact on patient's quality of life. The aim of this study was to evaluate the effectiveness of 5% lidocaine-medicated plaster as add-on therapy in ...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S113517
更新日期:2016-10-06 00:00:00
abstract:Background:Suspecting carpal tunnel syndrome (CTS) in patients with hand pain is usual. Considering the variable rate of false-negative results in nerve conduction study (NCS), as a frequent reference confirmatory standard test, we aimed to evaluate the diagnostic accuracy of neuromuscular ultrasound in patients with c...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S164004
更新日期:2018-07-10 00:00:00
abstract::Low back pain in patients with myofascial pain syndrome is characterized by painful active myofascial trigger points (ATPs) in muscles. This article reviews a novel, noninvasive modality that combines simultaneous imaging and treatment, thus taking advantage of the electrodermal information available from imaged ATPs ...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S47540
更新日期:2013-06-25 00:00:00
abstract:Purpose:The study aimed at the evaluation of the impact of intravenous (IV) dexamethasone on efficacy and duration of analgesia of paravertebral block (PVB) in patients undergoing modified radical mastectomy (MRM). Patients and methods:This randomized, double-blind controlled trial included 50 patients with breast can...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S181788
更新日期:2018-12-19 00:00:00
abstract:Purpose:Although the use of opioids is increasing in South Korea, there have been no studies on the serious complications caused by the opioids. The aim of this study was to investigate the rare but serious complications through medicolegal analysis. Materials and Methods:From January 1994 to December 2019, we retrosp...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S256759
更新日期:2020-06-25 00:00:00
abstract:Background:Erector spinae plane block (ESPB) as a new trunk fascia block technique was proposed in 2016. ESPB has aroused the interest of many nerve block experts. However, there are few clinical studies on ESPB for lumbar surgery, and its effectiveness and safety are controversial. The goal of this review is to summar...
journal_title:Journal of pain research
pub_type: 杂志文章,评审
doi:10.2147/JPR.S256205
更新日期:2020-07-01 00:00:00
abstract:Purpose:The INTERMED instrument, which was developed to measure patient's biopsychosocial (BPS) complexity, represents a powerful diagnostic and therapeutic tool. Epigenetic changes are the interface between signals from the environment and genetic modifications, affecting gene expression, in particular, by DNA methyla...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S251782
更新日期:2020-06-02 00:00:00
abstract:PURPOSE:The aim of this study was to examine the health and economic burden associated with fibromyalgia among adults in Japan. MATERIALS AND METHODS:Data from the 2011-2014 Japan National Health and Wellness Survey (n=115,271), a nationally representative survey of adults, were analyzed. The greedy matching algorithm...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S110707
更新日期:2016-11-04 00:00:00
abstract:Background:The prevalence of neuropathic pain (NeP) has been estimated within specific health conditions; however, there are no published data on its broad prevalence in the US. The current exploratory study addresses this gap using the validated PainDetect questionnaire as a screener for probable NeP in a general-popu...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S127014
更新日期:2017-11-01 00:00:00
abstract::Osteoarthritis (OA) is a common degenerative disease that affects the vast majority of the elderly and may eventually embark on the road of the total knee arthroplasty (TKA), although controversy still exists in the medical community about the best therapies for osteoarthritis. Compared with physical therapy, oral ana...
journal_title:Journal of pain research
pub_type: 杂志文章,评审
doi:10.2147/JPR.S260878
更新日期:2020-08-04 00:00:00
abstract:BACKGROUND:Several studies have illustrated that multisite pain is more frequent than single pain site, and it is associated with an array of negative consequences. However, there is limited knowledge available about the potential factors associated with multisite pain in the elderly general population. OBJECTIVE:This...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S143060
更新日期:2017-08-23 00:00:00
abstract:OBJECTIVE:The generic STarT Back 5-item screening tool (STarT-G) is used to manage chronic pain in the lower back and elsewhere. This study evaluated the validity of the Japanese version of this generic screening tool. MATERIALS AND METHODS:Japanese participants between the ages of 20 and 64 years completed online sur...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S129585
更新日期:2017-02-24 00:00:00