Abstract:
UNLABELLED:Postsurgical pain management remains a significant challenge. Liposome bupivacaine, as part of a multimodal analgesic regimen, has been shown to significantly reduce postsurgical opioid consumption, hospital length of stay (LOS), and hospitalization costs in gastrointestinal (GI) surgery, compared with intravenous (IV) opioid-based patient-controlled analgesia (PCA). Pooled results from open-label studies comparing a liposome bupivacaine-based multimodal analgesic regimen with IV opioid PCA were analyzed. Patients (n=191) who underwent planned surgery and received study drug (IV opioid PCA, n=105; multimodal analgesia, n=86) were included. Liposome bupivacaine-based multimodal analgesia compared with IV opioid PCA significantly reduced mean (standard deviation [SD]) postsurgical opioid consumption (38 [55] mg versus [vs] 96 [85] mg; P<0.0001), postsurgical LOS (median 2.9 vs 4.3 days; P<0.0001), and mean hospitalization costs (US$8,271 vs US$10,726; P=0.0109). The multimodal analgesia group reported significantly fewer patients with opioid-related adverse events (AEs) than the IV opioid PCA group (P=0.0027); there were no significant between-group differences in patient satisfaction scores at 30 days. A liposome bupivacaine-based multimodal analgesic regimen was associated with significantly less opioid consumption, opioid-related AEs, and better health economic outcomes compared with an IV opioid PCA-based regimen in patients undergoing GI surgery. STUDY REGISTRATION:This pooled analysis is based on data from Phase IV clinical trials registered on the US National Institutes of Health www.ClinicalTrials.gov database under study identifiers NCT01460485, NCT01507220, NCT01507233, NCT01509638, NCT01509807, NCT01509820, NCT01461122, NCT01461135, NCT01534988, and NCT01507246.
journal_name
J Pain Resjournal_title
Journal of pain researchauthors
Cohen SM,Vogel JD,Marcet JE,Candiotti KAdoi
10.2147/JPR.S63764subject
Has Abstractpub_date
2014-06-24 00:00:00pages
359-66issn
1178-7090pii
jpr-7-359journal_volume
7pub_type
杂志文章abstract:Background:Despite the increasing prevalence of opioid use disorder (OUD) in pregnant women, there are limited studies on their anesthesia care and analgesic outcomes after cesarean delivery (CD). Methods:Patients with OUD on either buprenorphine or methadone maintenance therapy who underwent CD at our institution fro...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S284874
更新日期:2020-12-30 00:00:00
abstract::Duloxetine is a serotonin-norepinephrine reuptake inhibitor approved by the US Food and Drug Administration for the treatment of fibromyalgia and painful diabetic neuropathy at doses of 60 mg daily. Duloxetine has been shown to significantly improve the symptoms of chronic pain associated with these disorders, as meas...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S12866
更新日期:2010-12-16 00:00:00
abstract:Purpose:Spinal cord stimulation (SCS) is a drug-free treatment for chronic neuropathic pain. Recent SCS technology can record evoked compound action potentials (ECAPs) in the spinal cord during therapy and utilize features of the sensed ECAP to optimize the SCS. The purpose of this work is to characterize the relevant ...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S289098
更新日期:2020-12-04 00:00:00
abstract:INTRODUCTION:Pain is a common symptom presented in the emergency department (ED) although it is often underestimated, poorly evaluated and treated. The application of a protocol for timely pain management ensured by the nurse can avoid the delays in the analgesic treatment and improve the patient's quality of waiting. ...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S138850
更新日期:2017-10-16 00:00:00
abstract:Background:Previous studies have shown the efficacy of tapentadol (TP) for chronic cancer pain. We evaluated multiple effectiveness aspects of TP prolonged release on moderate-severe cancer-related pain, neuropathic pain (NeP), patient satisfaction, and quality of life. Methods:An observational prospective study was c...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S181079
更新日期:2018-12-24 00:00:00
abstract::Topical treatments of localized neuropathic pain syndromes in general are mostly neglected, mainly due to the fact that most pain physicians expect that a topical formulation needs to result in a transdermal delivery of the active compounds. On the basis of the practical experience, this study brings forth a new, some...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S115407
更新日期:2016-10-03 00:00:00
abstract:OBJECTIVE:To evaluate the analgesic effectiveness of intra-articular botulinum toxin Type B (BoNT/B) in a murine model of chronic degenerative arthritis pain. METHODS AND MATERIALS:Chronic arthritis was produced in adult C57Bl6 mice by intra-articular injection of Type IV collagenase into the left knee. Following indu...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S12520
更新日期:2010-09-06 00:00:00
abstract:Purpose:To explore the role of cervical sagittal alignment in the occurrence of adjacent-level ossification development (ALOD) in patients who underwent anterior cervical discectomy fusion with self-locking stand-alone polyetheretherketone cage, and the relationship between cervical sagittal alignment and clinical outc...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S160472
更新日期:2018-07-20 00:00:00
abstract:Introduction:Sickle cell disease (SCD) is an inherited blood disorder characterized by abnormally shaped sickle cells. The hallmark of this disease is intermittent, painful vaso-occlusive episodes (VOE), but a subset of individuals with SCD experience chronic pain. The mechanism of transition to chronic pain is not wel...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S150066
更新日期:2018-02-23 00:00:00
abstract:Purpose:The quadratus lumborum block (QLB) is a relatively new regional analgesic technique that could provide analgesia to the abdominal wall and reduce postoperative opioid consumption. We investigated the opioid-sparing effect of a unilateral lateral QLB in laparoscopic nephrectomy. Patients and Methods:A total of ...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S257466
更新日期:2020-07-03 00:00:00
abstract:Background:Many aspects of study conduct impact the observed effect size of treatment. Data were utilized from a recently published meta-analysis of randomized, double-blind, placebo-controlled, clinical trials performed for the United States Food and Drug Administration (FDA) approval of full mu-agonist opioids for th...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S201751
更新日期:2019-11-20 00:00:00
abstract:Background:Chronic shoulder pain (CSP) is a common disease causing pain and functional limitation, which is highly prevalent and has substantial negative effects on the quality of life. Acupuncture has gained popularity and has been accepted gradually by many countries because it can successfully treat patients with ch...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S152550
更新日期:2018-03-07 00:00:00
abstract::Pain is the most common reason people visit emergency rooms. Pain does not discriminate on the basis of gender, race or age. The state of pain management in the emergency department (ED) is disturbing. ED physicians often do not provide adequate analgesia to their patients, do not meet patients' expectations in treati...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:
更新日期:2008-12-09 00:00:00
abstract::Cervical intervertebral disc has long been considered a common source of neck pain. However, the pain caused by the disc itself has not been clearly defined so far, and its diagnosis and treatment has always been controversial. Degenerative cervical disc has a rich supply of nerve fibers, is prone to inflammatory reac...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S180018
更新日期:2018-11-14 00:00:00
abstract::Multisite pain, or pain that occurs simultaneously at >1 anatomical site, is more prevalent than single-site pain. While multisite pain affects over half of older adults, it remains an understudied pain entity that may have important functional implications in an aging population. Greater understanding of this complex...
journal_title:Journal of pain research
pub_type: 杂志文章,评审
doi:10.2147/JPR.S192755
更新日期:2019-03-29 00:00:00
abstract:Background:The ability to accurately diagnose and objectively localize pain generators in chronic pain sufferers remains a major clinical challenge since assessment relies on subjective patient complaints and relatively non-specific diagnostic tools. Developments in clinical molecular imaging, including advances in ima...
journal_title:Journal of pain research
pub_type:
doi:10.2147/JPR.S167839
更新日期:2018-10-12 00:00:00
abstract::Paced breathing has shown efficacy in fibromyalgia (FM), but the mechanisms associated with symptom change are largely unknown. We investigated whether changes in respiratory rate (RR) alone resulted in autonomic changes during normal, paced, and mechanically assisted breathing in untrained FM patients and controls. P...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S139642
更新日期:2017-12-08 00:00:00
abstract:Purpose:The aim of this study was to evaluate postoperative discomfort in patients undergoing ambulatory strabismus under general anesthesia, and to identify risk factors associated with the discomfort. Patients and Methods:A cross-sectional study was conducted among 210 consecutive patients undergoing ambulatory stra...
journal_title:Journal of pain research
pub_type:
doi:10.2147/JPR.S249493
更新日期:2020-05-05 00:00:00
abstract:Background:With the increase in life expectancy seen throughout the world, the prevalence of degenerative spinal pathology and surgery to treat it has increased. Spinal surgery under general anesthesia leads to various problems and complications, especially in patients with numerous medical comorbidities or elderly pat...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S227212
更新日期:2020-01-21 00:00:00
abstract:Purposes:To investigate the prevalence of pain-related diagnoses in patients with dementia and evaluate the association of pain-related diagnoses with demographic characteristics and dementia subtypes. Patients and methods:In this population-based retrospective cohort study, participants were recruited from a cohort o...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S172875
更新日期:2018-09-03 00:00:00
abstract:Background:The objective of this study was to compare the efficacy of calcitonin with diclofenac sodium in the treatment of patients with nonspecific low back pain (LBP) and type I Modic changes (MC1). Patients and methods:The study was a retrospective observational study with 109 patients who had nonspecific LBP and ...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S158718
更新日期:2018-07-17 00:00:00
abstract:Purpose:To investigate the ameliorative effects of Vitellaria paradoxa (VP) nut extract for an anterior cruciate ligament transection with medial meniscectomy (ACLT+MMx)-induced osteoarthritis (OA) in high-fat diet (HFD)-induced obese rats. Methods:The rats were fed by HFD for 5 weeks before surgery-induced OA. Rats w...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S228766
更新日期:2020-01-30 00:00:00
abstract:Purpose:Complex regional pain syndrome (CRPS) is a rare but refractory pain disorder. Recent advanced information retrieval studies using text-mining and network analysis have suggested nuclear factor kappa B (NFκB) as a possible central mediator of CRPS. The brain is also known to play important roles in CRPS. The aim...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S166270
更新日期:2019-03-06 00:00:00
abstract:OBJECTIVE:Patient controlled analgesia (PCA) is commonly used to provide analgesia following surgical procedures in the pediatric population. Morphine and hydromorphone remain the most commonly used opioids for PCA. Although both are effective, adverse effects may occur. When these adverse effects are unremitting or se...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S64497
更新日期:2014-08-13 00:00:00
abstract::Livedoid vasculopathy (LV) is a chronic prothrombotic disease of cutaneous micro-circulation resulting in cutaneous ischemia and infarction. As a rare disease, LV has an estimated incidence of ten cases per million. Not only correct diagnosis but also effective treatments are very difficult for patients with LV. Due t...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S133462
更新日期:2017-03-17 00:00:00
abstract:PURPOSE:Since receiving a warning from the US Food and Drug Administration (FDA) about injection of corticosteroids into the epidural space having serious adverse events, we have sought alternative medications for injection at this site. Hyaluronic acid (HA) has anti-adhesive, anti-inflammatory, and lubricating propert...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S122861
更新日期:2017-01-25 00:00:00
abstract:BACKGROUND:Waiting list management at chronic pain clinics has become a serious problem throughout Canada. We analyzed the waiting list at the Centre hospitalier de l'Université de Montréal (CHUM) Pain Centre. METHODS:The present study is an observational, prospective study. We used a specifically designed survey ques...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S46118
更新日期:2013-07-08 00:00:00
abstract:OBJECTIVE:Lymphocyte apoptosis in critical illness is associated with immunosuppression. We explored for the first time the associations between pain ratings and expression of the apoptotic receptor Fas on B and T cells in critically ill patients and the potential mediating effects of adrenocorticotropic hormone (ACTH)...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S118105
更新日期:2017-01-13 00:00:00
abstract::Purpose: Thirty percent of patients with postherpetic neuralgia (PHN) receiving conservative treatment report unsatisfactory pain relief. Epidural steroid injections (ESIs) are commonly used as a therapeutic intervention in these patients. In this study, we aimed to determine if there are variables that predict the ef...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S190646
更新日期:2019-04-23 00:00:00
abstract:Purpose:Post-herpetic neuralgia (PHN) is a common herpes zoster (HZ) complication, where pain persists 90 days after the initial HZ diagnosis. Evaluating PHN risk is essential for determining the burden on patients and health-care systems, but research shows variable estimates. The extent to which these differences are...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S255238
更新日期:2020-07-13 00:00:00