Abstract:
Background:Previous studies have shown the efficacy of tapentadol (TP) for chronic cancer pain. We evaluated multiple effectiveness aspects of TP prolonged release on moderate-severe cancer-related pain, neuropathic pain (NeP), patient satisfaction, and quality of life. Methods:An observational prospective study was conducted on 80 cancer patients. Opioid-naïve patients received a starting dose of prolonged-release TP 50 mg twice daily, and opioid-experienced patients were switched to TP, not to exceed 500 mg/day. Treatment response was evaluated at 3, 6, 30-40, and 60-70 days through response rate, numeric rating-scale scoring, survival analysis (time to event for response), pain-intensity difference, TP escalation-index percentage, and effects on NeP. The drug-sparing effect on concomitant therapies was evaluated. Results:Seventy of 80 patients (88%) were responders to treatment (95% CI 78%-94%). Compared to T0, pain-intensity reductions were statistically significant for all intervals (P<0.01), with better results at T3/T4. NeP was significantly reduced at T4 (P<0.01). The probability of response was low at the initial stages and increased during the study. Pain-intensity differences decreased during the study, though without significance. Two patients (2.5%) left the study for TP-induced side effects. A significant improvement in quality of life was observed after 30-40 days (P<0.01). The majority of patients were "satisfied", "very satisfied", or "extremely satisfied" (T3-T4). Conclusion:TP was effective in terms of drug-sparing effect, response rate, TP escalation-index percentage, and NeP management. By comparing data from the survival analysis with the response rate and time to response (numeric rating scale from T0 to T4), we found that although TP induced a quick response, a longer period of therapy and higher doses were needed to improve the positive result.
journal_name
J Pain Resjournal_title
Journal of pain researchauthors
Cascella M,Forte CA,Bimonte S,Esposito G,Romano C,Costanzo R,Morabito A,Cuomo Adoi
10.2147/JPR.S181079subject
Has Abstractpub_date
2018-12-24 00:00:00pages
117-125issn
1178-7090pii
jpr-12-117journal_volume
12pub_type
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journal_title:Journal of pain research
pub_type: 杂志文章
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更新日期:2020-01-08 00:00:00
abstract:Objective:To examine the influence of anxiety and pain-related catastrophizing on the time course of acute interleukin-6 (IL-6) responses to standardized noxious stimulation among patients with chronic pain. Methods:Data were collected from 48 participants in the following demographically matched groups: patients with...
journal_title:Journal of pain research
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journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S258433
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journal_title:Journal of pain research
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journal_title:Journal of pain research
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doi:10.2147/JPR.S131104
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doi:10.2147/JPR.S189927
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journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S150066
更新日期:2018-02-23 00:00:00
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journal_title:Journal of pain research
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journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S51054
更新日期:2013-10-25 00:00:00
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journal_title:Journal of pain research
pub_type: 杂志文章,评审
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更新日期:2018-10-25 00:00:00
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journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S21085
更新日期:2011-01-01 00:00:00
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pub_type: 杂志文章
doi:10.2147/JPR.S146916
更新日期:2018-02-19 00:00:00
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journal_title:Journal of pain research
pub_type:
doi:10.2147/JPR.S249493
更新日期:2020-05-05 00:00:00
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journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S177231
更新日期:2018-10-18 00:00:00
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journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S238718
更新日期:2020-04-29 00:00:00
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journal_title:Journal of pain research
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doi:10.2147/JPR.S248056
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journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S125667
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journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S12520
更新日期:2010-09-06 00:00:00
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journal_title:Journal of pain research
pub_type: 杂志文章
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更新日期:2020-06-02 00:00:00
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journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S267778
更新日期:2020-08-12 00:00:00
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journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S227212
更新日期:2020-01-21 00:00:00
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journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S53437
更新日期:2013-11-07 00:00:00
abstract:Objective:To report a rare case of spontaneous fusion (SF) following cervical disc arthroplasty (CDA), to review the related literature, and to propose a new measure to prevent it. Methods:The course of a patient with SF is described here. The potential causes, risk factors, and preventive measure of SF after CDA publ...
journal_title:Journal of pain research
pub_type:
doi:10.2147/JPR.S242646
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journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S257071
更新日期:2020-06-15 00:00:00
abstract::Advances in intrathecal analgesia and intrathecal drug delivery systems have allowed for a range of medications to be used in the control of pain and spasticity. This technique allows for reduced medication doses that can decrease the side effects typically associated with oral or parenteral drug delivery. Recent expe...
journal_title:Journal of pain research
pub_type: 杂志文章,评审
doi:10.2147/JPR.S37591
更新日期:2014-11-06 00:00:00