Reduced GABAergic neuronal activity in zona incerta causes neuropathic pain in a rat sciatic nerve chronic constriction injury model.

abstract：:Purpose: The study aimed to evaluate the analgesic efficiency of dexmedetomidine (DEX) when added to levobupivacaine in continuous ultrasound-guided serratus anterior plane block (SAPB) performed at the end of major thoracic surgery. Methods: This randomized, double-blind trial included 50 adults undergoing thoracic s...

journal_title：Journal of pain research

authors： Abdallah NM,Bakeer AH,Youssef RB,Zaki HV,Abbas DN

更新日期：2019-04-30 00:00:00

abstract：Background:The ability to accurately diagnose and objectively localize pain generators in chronic pain sufferers remains a major clinical challenge since assessment relies on subjective patient complaints and relatively non-specific diagnostic tools. Developments in clinical molecular imaging, including advances in ima...

journal_title：Journal of pain research

authors： Cipriano PW,Lee SW,Yoon D,Shen B,Tawfik VL,Curtin CM,Dragoo JL,James ML,McCurdy CR,Chin FT,Biswal S

更新日期：2018-10-12 00:00:00

abstract：Background:While the concomitant administration of painful and rewarding stimuli tends to reduce the perception of one another, recent evidence shows that pleasant pain relief is experience after the interruption of noxious stimuli. On neurobiological grounds, these opponent processes should translate into decreased ac...

journal_title：Journal of pain research

authors： Bitar N,Dugré JR,Marchand S,Potvin S

更新日期：2020-06-08 00:00:00

abstract：:Duloxetine is a serotonin-norepinephrine reuptake inhibitor approved by the US Food and Drug Administration for the treatment of fibromyalgia and painful diabetic neuropathy at doses of 60 mg daily. Duloxetine has been shown to significantly improve the symptoms of chronic pain associated with these disorders, as meas...

journal_title：Journal of pain research

authors： Wright A,Luedtke KE,Vandenberg C

更新日期：2010-12-16 00:00:00

abstract：BACKGROUND:Large interindividual differences in clinical responses to opioids and the variable susceptibility to abuse of this class of drugs make their use problematic. We lack a full understanding of the factors responsible for these differences. Dietary factors including methyl donor content have been noted to alter...

journal_title：Journal of pain research

authors： Liang DY,Sun Y,Clark JD

更新日期：2013-01-01 00:00:00

abstract：Background:Femoral nerve block (FNB) has been considered as an excellent analgesic modality in total knee arthroplasty (TKA) pain control. However, relatively high concentration of ropivacaine could lead to quadriceps muscle weakness and increase the risk of postoperative falls. Objective:This double-blinded randomize...

journal_title：Journal of pain research

authors： Yang X,Kang W,Xiong W,Lu D,Zhou Z,Chen X,Zhou X,Feng X

更新日期：2019-12-17 00:00:00

abstract：Background and Aims:Plantar fasciitis (PF) is the leading cause of heel pain in adults. This study was designed to evaluate the effect of hyaluronic acid (HA) injection in reducing the symptoms of PF, compared with corticosteroid (CS) injection as a conventional treatment. Methods:In this triple-blind, randomized, cli...

journal_title：Journal of pain research

authors： Raeissadat SA,Nouri F,Darvish M,Esmaily H,Ghazihosseini P

更新日期：2020-01-14 00:00:00

abstract：Purpose:No final conclusion has yet been reached on characteristics of postoperative pain and pain-related factors after video-assisted thoracoscopic surgery (VATS). This study was designed to explore features of acute severe pain and chronic post-surgical pain (CPSP), and the pain-related factors of VATS. Patients an...

journal_title：Journal of pain research

authors： Tong Y,Wei P,Wang S,Sun Q,Cui Y,Ning N,Chen S,He X

更新日期：2020-07-21 00:00:00

abstract：PURPOSE:Conditioned pain modulation (CPM) is an experimental approach for probing endogenous analgesia by which one painful stimulus (the conditioning stimulus) may inhibit the perceived pain of a subsequent stimulus (the test stimulus). Animal studies suggest that CPM is mediated by a spino-bulbo-spinal loop using obj...

journal_title：Journal of pain research

authors： Bernaba M,Johnson KA,Kong JT,Mackey S

更新日期：2014-11-26 00:00:00

abstract：:Purpose: The objective for this clinical pilot study was to evaluate changes to chronic pain, vascular health, and inflammatory markers when consuming a dietary supplement blend (DSB, CytoQuel®), containing curcumin, resveratrol, tocotrienols, N-Acetylcysteine, and epigallocatechin gallate. Materials and methods: An o...

journal_title：Journal of pain research

authors： Hamilton DE,Jensen GS

更新日期：2019-05-15 00:00:00

abstract：Background:Transient receptor potential ankyrin 1 (TRPA1) is a non-selective cation channel expressed by a subset of nociceptive neurons that acts as a multimodal receptor. Its activity contributes to modulate nociceptive transmission in acute inflammatory pain. However, the role of this channel in chronic pain has bee...

journal_title：Journal of pain research

authors： Martínez-Rojas VA,García G,Noriega-Navarro R,Guzmán-Priego CG,Torres-López JE,Granados-Soto V,Murbartián J

更新日期：2017-12-27 00:00:00

abstract：:Topical treatments of localized neuropathic pain syndromes in general are mostly neglected, mainly due to the fact that most pain physicians expect that a topical formulation needs to result in a transdermal delivery of the active compounds. On the basis of the practical experience, this study brings forth a new, some...

journal_title：Journal of pain research

authors： Keppel Hesselink JM,Kopsky DJ,Sajben N

更新日期：2016-10-03 00:00:00

abstract：Purpose:Despite the rise in opioid-related hospitalizations, there has been little research regarding opioid-related healthcare utilization. The objective of this study was to estimate the mean adjusted hospital costs, payments, and length of stay (LOS) for opioid-related visits for the nation and each of the nine US c...

journal_title：Journal of pain research

authors： Mallow PJ,Belk KW,Topmiller M,Strassels SA

更新日期：2018-12-04 00:00:00

abstract：Background:Postherpetic neuralgia (PHN) refers to pain which remains after the healing of rashes from herpes zoster. Previous literatures have shown that acupuncture has potential benefits for PHN, but evidence remains lacking. Thus, we have performed a systematic review and meta-analysis to identify the effectiveness ...

journal_title：Journal of pain research

authors： Pei W,Zeng J,Lu L,Lin G,Ruan J

更新日期：2019-07-16 00:00:00

abstract：Background:Pain is a common and undertreated non-motor symptom in patients with Parkinson's disease (PD). Opioids have been seldom used in PD because they could worsen cognitive and motor functions. Objective:We aimed to assess efficacy and tolerability of tapentadol in PD patients. Methods:We retrospectively reviewe...

journal_title：Journal of pain research

authors： Freo U,Furnari M,Ori C

更新日期：2018-09-13 00:00:00

abstract：Purpose:The quadratus lumborum block (QLB) is a relatively new regional analgesic technique that could provide analgesia to the abdominal wall and reduce postoperative opioid consumption. We investigated the opioid-sparing effect of a unilateral lateral QLB in laparoscopic nephrectomy. Patients and Methods:A total of ...

journal_title：Journal of pain research

authors： Kwak KH,Baek SI,Kim JK,Kim TH,Yeo J

更新日期：2020-07-03 00:00:00

abstract：:This paper reviews the current clinical data for the role of transdermal buprenorphine (BUP TDS) in the treatment of diverse acute and chronic pain syndromes. Literature searches were carried out using PubMed (1988 to June 2009). The published findings seem to support hypotheses regarding the rather unique analgesic m...

journal_title：Journal of pain research

authors： Hans G,Robert D

更新日期：2009-09-15 00:00:00

abstract：:Generalized joint hypermobility (GJH) is highly prevalent among patients diagnosed with chronic pain. When GJH is accompanied by pain in ≥4 joints over a period ≥3 months in the absence of other conditions that cause chronic pain, the hypermobility syndrome (HMS) may be diagnosed. In addition, GJH is also a clinical s...

journal_title：Journal of pain research

authors： Scheper MC,de Vries JE,Verbunt J,Engelbert RH

更新日期：2015-08-20 00:00:00

abstract：:[This corrects the article DOI: 10.2147/JPR.S203721.]. ...

journal_title：Journal of pain research

authors：

更新日期：2020-08-26 00:00:00

abstract：BACKGROUND:Sports-related injuries, such as sprains and strains, commonly occur during exercise and athletic events. Current therapy includes nonsteroidal anti-inflammatory drugs (NSAIDs), which have a high incidence of upper gastrointestinal side effects. The present study assessed the efficacy and safety of the diclo...

journal_title：Journal of pain research

authors： Lionberger DR,Joussellin E,Lanzarotti A,Yanchick J,Magelli M

更新日期：2011-03-07 00:00:00

abstract：OBJECTIVE:Patient controlled analgesia (PCA) is commonly used to provide analgesia following surgical procedures in the pediatric population. Morphine and hydromorphone remain the most commonly used opioids for PCA. Although both are effective, adverse effects may occur. When these adverse effects are unremitting or se...

journal_title：Journal of pain research

authors： DiGiusto M,Bhalla T,Martin D,Foerschler D,Jones MJ,Tobias JD

更新日期：2014-08-13 00:00:00

abstract：:Different pericardial catheters have been suggested as an effective alternative method for drainage of pericardial effusion. The aim of this study was to determine the performance, pain, and quality of life on use of central venous catheter (CVC) for drainage of pericardial effusion in patients undergoing open heart s...

journal_title：Journal of pain research

authors： Ghods K,Razavi MR,Forozeshfard M

更新日期：2016-10-31 00:00:00

abstract：:Objectives: To classify patients suffering from low back pain (LBP) into two different groups - patients with lumbar disc herniation (LDH) and patients without this disease based on simple questions and without magnetic resonance imaging (MRI) procedure - and to diagnose the most effective risk factors of LDH. Methods...

journal_title：Journal of pain research

authors： Jafari S,Dehesh T,Iranmanesh F

更新日期：2019-04-15 00:00:00

abstract：:The objective of this study was to evaluate the relationship between magnetic resonance imaging (MRI) findings and previous low back pain (LBP) in participants without current LBP. Current LBP was defined as LBP during the past month. Previous LBP was defined as a history of medical consultation for LBP. Ninety-one pa...

journal_title：Journal of pain research

authors： Tonosu J,Oka H,Matsudaira K,Higashikawa A,Okazaki H,Tanaka S

更新日期：2016-12-29 00:00:00

abstract：Purpose:The aim of this study was to evaluate postoperative discomfort in patients undergoing ambulatory strabismus under general anesthesia, and to identify risk factors associated with the discomfort. Patients and Methods:A cross-sectional study was conducted among 210 consecutive patients undergoing ambulatory stra...

journal_title：Journal of pain research

authors： Huang J,Lin J,Xiong Y,Wang Z,Zhu Y,Ye H,Guo W

更新日期：2020-05-05 00:00:00

abstract：Background:Despite the increasing prevalence of opioid use disorder (OUD) in pregnant women, there are limited studies on their anesthesia care and analgesic outcomes after cesarean delivery (CD). Methods:Patients with OUD on either buprenorphine or methadone maintenance therapy who underwent CD at our institution fro...

journal_title：Journal of pain research

authors： Reno JL,Kushelev M,Coffman JH,Prasad MR,Meyer AM,Carpenter KM,Palettas MS,Coffman JC

更新日期：2020-12-30 00:00:00

abstract：BACKGROUND:It has been demonstrated that N-ethyl-lidocaine (QX-314) can target the transient receptor protein vanilloid 1 (TRPV1) nociceptors when coadministered with capsaicin, resulting in a selective block of the nociceptors. Capsaicin is problematic in therapeutic use because it induces firing of nociceptors. The p...

journal_title：Journal of pain research

authors： Nakagawa H,Hiura A

更新日期：2013-01-01 00:00:00

abstract：Purpose:Gabapentinoids are currently the mainstay of pharmacological treatments for patients with neuropathic pain. Little is known about the effects of this therapy on the integrity of neuronal networks, especially in patients with an already-damaged nervous system. Since gabapentinoids can worsen cognitive functions ...

journal_title：Journal of pain research

authors： Baldewig M,Goldbaum O,Richter-Landsberg C,Weyland A,Bantel C

更新日期：2018-06-20 00:00:00

abstract：Purpose:Spinal cord stimulation (SCS) is a drug-free treatment for chronic neuropathic pain. Recent SCS technology can record evoked compound action potentials (ECAPs) in the spinal cord during therapy and utilize features of the sensed ECAP to optimize the SCS. The purpose of this work is to characterize the relevant ...

journal_title：Journal of pain research

authors： Chakravarthy K,Bink H,Dinsmoor D

更新日期：2020-12-04 00:00:00

abstract：Introduction:Sickle cell disease (SCD) is an inherited blood disorder characterized by abnormally shaped sickle cells. The hallmark of this disease is intermittent, painful vaso-occlusive episodes (VOE), but a subset of individuals with SCD experience chronic pain. The mechanism of transition to chronic pain is not wel...

journal_title：Journal of pain research

authors： Bakshi N,Lukombo I,Belfer I,Krishnamurti L

更新日期：2018-02-23 00:00:00