Peripheral and spinal TRPA1 channels contribute to formalin-induced long-lasting mechanical hypersensitivity.

abstract：Objective:Chronic pain is a highly prevalent and costly condition with few proven treatment options. Since 2014, Geisinger's Department of Pain Medicine has implemented the Multidisciplinary Pain Program (MPP), which consists of a 3-day educational seminar followed by 12 months of comprehensive care. This study examine...

journal_title：Journal of pain research

authors： Maeng DD,Baylor K,Bulger JB,Han JJ

更新日期：2018-10-18 00:00:00

abstract：:Calcitonin gene-related peptide (CGRP) is a major player in migraine pathophysiology, and CGRP monoclonal antibodies including fremanezumab may be a safe effective preventive therapy. Phase IIb studies in episodic migraine (EM) and chronic migraine (CM) demonstrated efficacy at both the monthly 225 mg and quarterly 67...

journal_title：Journal of pain research

authors： Robblee J,VanderPluym J

更新日期：2019-08-22 00:00:00

abstract：Background:Many aspects of study conduct impact the observed effect size of treatment. Data were utilized from a recently published meta-analysis of randomized, double-blind, placebo-controlled, clinical trials performed for the United States Food and Drug Administration (FDA) approval of full mu-agonist opioids for th...

journal_title：Journal of pain research

authors： Meske DS,Vaughn BJ,Kopecky EA,Katz N

更新日期：2019-11-20 00:00:00

abstract：Purpose:Epidural analgesia provides safe and effective labor pain relief. However, labor episodic pain can occur during epidural analgesia, requiring epidural top-ups, and may result in decreased patient satisfaction. The primary aim of our study was to investigate the factors associated with labor episodic pain during...

journal_title：Journal of pain research

authors： Chan JJI,Gan YY,Dabas R,Han NR,Sultana R,Sia ATH,Sng BL

更新日期：2019-02-15 00:00:00

abstract：Background:It has been reported that N-cadherin and cAMP response element binding protein (CREB) in the spinal cord are critical for synaptogenesis and regulation of excitatory synapse function, which could underlie chronic pain development. The aim of the present study was to investigate the role of spinal N-cadherin/...

journal_title：Journal of pain research

authors： Ma Y,Zhang X,Li C,Liu S,Xing Y,Tao F

更新日期：2020-08-12 00:00:00

abstract：Purposes:To investigate the prevalence of pain-related diagnoses in patients with dementia and evaluate the association of pain-related diagnoses with demographic characteristics and dementia subtypes. Patients and methods:In this population-based retrospective cohort study, participants were recruited from a cohort o...

journal_title：Journal of pain research

authors： Lin PC,Li CH,Chou PL,Chen YM,Lin LC

更新日期：2018-09-03 00:00:00

abstract：OBJECTIVE:To characterize the steady-state pharmacokinetic profile of hydromorphone extended-release (ER) in patients with chronic pain taking concomitant medications. METHODS:This open-label repeat-dose study enrolled 22 patients (mean age, 51.4 years; 81.8% female). All patients were receiving at least one concomita...

journal_title：Journal of pain research

authors： Vandenbossche J,Richarz U,Richards HM

更新日期：2012-01-01 00:00:00

abstract：Background:Regional variations of opioid use have been reported from many countries. The objective of this study was to examine opioid prescribing patterns in Germany including low- and high-potency opioids (LPO and HPO) focusing on regional differences. Methods:Data source was the "Information system for health care ...

journal_title：Journal of pain research

authors： Jobski K,Dörks M,Bantel C,Hoffmann F

更新日期：2020-10-07 00:00:00

abstract：BACKGROUND:One form of self-medication is sharing of medications, defined as borrowing or lending medications in situations where the receiver of these drugs is not the individual to whom the medications were allocated. OBJECTIVE:To explore experiences and opinions of patients about sharing prescription analgesics, re...

journal_title：Journal of pain research

authors： Markotic F,Vrdoljak D,Puljiz M,Puljak L

更新日期：2017-02-10 00:00:00

abstract：Background:Despite the increasing prevalence of opioid use disorder (OUD) in pregnant women, there are limited studies on their anesthesia care and analgesic outcomes after cesarean delivery (CD). Methods:Patients with OUD on either buprenorphine or methadone maintenance therapy who underwent CD at our institution fro...

journal_title：Journal of pain research

authors： Reno JL,Kushelev M,Coffman JH,Prasad MR,Meyer AM,Carpenter KM,Palettas MS,Coffman JC

更新日期：2020-12-30 00:00:00

abstract：:Purpose: One of the main factor of cervical foraminal stenosis (CFS) is the hypertrophic change of the cervical facet joint. In order to analyze the connection between CFS and the facet joint hypertrophy, we devised a new morphological parameter, called the cervical facet joint cross-sectional area (CFJA). The CFJA ha...

journal_title：Journal of pain research

authors： An SJ,Hong SJ,Kim YU,Lee YK

更新日期：2019-04-24 00:00:00

abstract：Purpose:To investigate the ameliorative effects of Vitellaria paradoxa (VP) nut extract for an anterior cruciate ligament transection with medial meniscectomy (ACLT+MMx)-induced osteoarthritis (OA) in high-fat diet (HFD)-induced obese rats. Methods:The rats were fed by HFD for 5 weeks before surgery-induced OA. Rats w...

journal_title：Journal of pain research

authors： Sudirman S,Chen CK,Long BT,Chang HW,Tsou D,Kong ZL

更新日期：2020-01-30 00:00:00

abstract：PURPOSE:The treatment of central neuropathic pain remains amongst the biggest challenges for pain specialists. The main objective of this study was to assess gabapentin (GBP), amitriptyline (AMI), and carbamazepine (CARBA) for the treatment of a rodent central neuropathic pain model. METHODS:Male Sprague Dawley rats w...

journal_title：Journal of pain research

authors： Castel A,Vachon P

更新日期：2013-12-17 00:00:00

abstract：:A 41-year-old woman presented with burning and erythema in her extremities triggered by warmth and activity, which was relieved by applying ice. Extensive workup was consistent with adult-onset primary erythromelalgia (EM). Several pharmacological treatments were tried including local anesthetics, capsaicin, ziconotid...

journal_title：Journal of pain research

authors： Low SA,Robbins W,Tawfik VL

更新日期：2017-04-27 00:00:00

abstract：:Neuromuscular blockade is a desirable or even essential component of general anesthesia for major surgical operations. As the population continues to age, and more operations are conducted in the elderly, due consideration must be given to neuromuscular blockade in these patients to avoid possible complications. This ...

journal_title：Journal of pain research

authors： Lee LA,Athanassoglou V,Pandit JJ

更新日期：2016-06-17 00:00:00

abstract：:Osteoarthritis (OA) is the most prevalent arthritis worldwide and is characterized by chronic pain and impaired physical function. We hypothesized that heightened pain in hand OA could be reduced with duloxetine or pregabalin. In this prospective, randomized clinical study, we recruited 65 participants, aged 40-75 yea...

journal_title：Journal of pain research

authors： Sofat N,Harrison A,Russell MD,Ayis S,Kiely PD,Baker EH,Barrick TR,Howe FA

更新日期：2017-10-10 00:00:00

abstract：:This open-label, phase 3b study (ClinicalTrials.gov Identifier: NCT00983073) evaluated the effectiveness, and tolerability of tapentadol for severe, chronic osteoarthritis knee pain that was inadequately managed with World Health Organization (WHO) Step I or II analgesics or co-analgesics, or that was not treated with...

journal_title：Journal of pain research

authors： Steigerwald I,Müller M,Kujawa J,Balblanc JC,Calvo-Alén J

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:No proof of efficacy, in the form of a randomized controlled trial (RCT), exists to support pulsed radiofrequency (PRF) treatment of the dorsal root ganglion (DRG) for chronic lumbar radicular (CLR) pain. We determined the feasibility of a larger trial (primary objective), and also explored the efficacy of P...

journal_title：Journal of pain research

authors： Shanthanna H,Chan P,McChesney J,Thabane L,Paul J

更新日期：2014-01-10 00:00:00

abstract：OBJECTIVE:This systematic review aimed to assess the efficacy, effectiveness, safety, and tolerability of osteopathic manipulative treatment (OMT) in patients with headache. BACKGROUND:Migraine is one of the most common and disabling medical conditions. It affects more than 15% of the general population, causing high ...

journal_title：Journal of pain research

authors： Cerritelli F,Lacorte E,Ruffini N,Vanacore N

更新日期：2017-03-14 00:00:00

abstract：Purpose:Exercise-induced hypoalgesia (EIH) is the short-term reduction of pain sensitivity after a single bout of exercise. Descending pain inhibition has been proposed to at least partly underlie EIH. Cognitive inhibition is the ability to inhibit a pre-potent response and has in turn been associated with descending p...

journal_title：Journal of pain research

authors： Gajsar H,Titze C,Konietzny K,Meyer M,Vaegter HB,Hasenbring MI

更新日期：2020-04-29 00:00:00

abstract：:It is broadly accepted that children of all age groups including (preterm) neonates and young infants can perceive pain and that there is an absolute need to treat their pain safely and effectively. The approved treatment options for children, particularly (preterm) neonates and young infants, are very limited with on...

journal_title：Journal of pain research

authors： Eerdekens M,Beuter C,Lefeber C,van den Anker J

更新日期：2019-05-23 00:00:00

abstract：INTRODUCTION:Heat/capsaicin skin sensitization is a well-characterized human experimental model to induce hyperalgesia and allodynia. Using this model, gabapentin, among other drugs, was shown to significantly reduce cutaneous hyperalgesia compared to placebo. Since the larger thermal probes used in the original studie...

journal_title：Journal of pain research

authors： Cavallone LF,Frey K,Montana MC,Joyal J,Regina KJ,Petersen KL,Gereau RW 4th

更新日期：2013-11-07 00:00:00

abstract：Background:Chronic shoulder pain (CSP) is a common disease causing pain and functional limitation, which is highly prevalent and has substantial negative effects on the quality of life. Acupuncture has gained popularity and has been accepted gradually by many countries because it can successfully treat patients with ch...

journal_title：Journal of pain research

authors： Zhang S,Wang X,Yan CQ,Hu SQ,Huo JW,Wang ZY,Zhou P,Liu CH,Liu CZ

更新日期：2018-03-07 00:00:00

abstract：OBJECTIVE:The generic STarT Back 5-item screening tool (STarT-G) is used to manage chronic pain in the lower back and elsewhere. This study evaluated the validity of the Japanese version of this generic screening tool. MATERIALS AND METHODS:Japanese participants between the ages of 20 and 64 years completed online sur...

journal_title：Journal of pain research

authors： Oka H,Matsudaira K,Fujii T,Kikuchi N,Haga Y,Sawada T,Katsuhira J,Yoshimoto T,Kawamata K,Tonosu J,Sumitani M,Kasahara S,Tanaka S

更新日期：2017-02-24 00:00:00

abstract：OBJECTIVE:To evaluate the analgesic effectiveness of intra-articular botulinum toxin Type B (BoNT/B) in a murine model of chronic degenerative arthritis pain. METHODS AND MATERIALS:Chronic arthritis was produced in adult C57Bl6 mice by intra-articular injection of Type IV collagenase into the left knee. Following indu...

journal_title：Journal of pain research

authors： Anderson S,Krug H,Dorman C,McGarraugh P,Frizelle S,Mahowald M

更新日期：2010-09-06 00:00:00

abstract：PURPOSE:Medical clowning has proven effective for reducing pain, anxiety, and stress, however, its differential effects on children from different cultures have not yet been researched. This study evaluated the effects of medical-clowning intervention on anxiety and pain among Jewish and Bedouin children, and anxiety a...

journal_title：Journal of pain research

authors： Gilboa-Negari Z,Abu-Kaf S,Huss E,Hain G,Moser A

更新日期：2017-07-05 00:00:00

abstract：OBJECTIVE:The aim of this study was to compare the efficacy of percutaneous vertebroplasty (PVP) and interventional tumor removal (ITR), with PVP alone for malignant vertebral compression fractures and/or spinal metastatic tumor with epidural involvement. PATIENTS AND METHODS:A total of 124 patients were selected for ...

journal_title：Journal of pain research

authors： Gu YF,Tian QH,Li YD,Wu CG,Su Y,Song HM,He CJ,Chen D

更新日期：2017-01-20 00:00:00

abstract：OBJECTIVE:To evaluate the safety and efficacy of ketoprofen in Transfersome® gel (IDEA-033) in comparison with a ketoprofen-free vehicle (TDT 064) for the treatment of osteoarthritis (OA) of the knee. METHODS:Patients with knee OA (N = 866) were randomly assigned to receive topical IDEA-033 containing 100, 50, or 25 m...

journal_title：Journal of pain research

authors： Kneer W,Rother M,Mazgareanu S,Seidel EJ,European IDEA-033 study group.

更新日期：2013-10-25 00:00:00

abstract：OBJECTIVES:Chronic neuropathic pain and chronic complex regional pain syndrome (CRPS), in particular, are debilitating and difficult-to-treat conditions that have a strong impact on patient's quality of life. The aim of this study was to evaluate the effectiveness of 5% lidocaine-medicated plaster as add-on therapy in ...

journal_title：Journal of pain research

authors： Calderón E,Calderón-Seoane ME,García-Hernández R,Torres LM

更新日期：2016-10-06 00:00:00

abstract：Introduction:Sickle cell disease (SCD) is an inherited blood disorder characterized by abnormally shaped sickle cells. The hallmark of this disease is intermittent, painful vaso-occlusive episodes (VOE), but a subset of individuals with SCD experience chronic pain. The mechanism of transition to chronic pain is not wel...

journal_title：Journal of pain research

authors： Bakshi N,Lukombo I,Belfer I,Krishnamurti L

更新日期：2018-02-23 00:00:00