Abstract:
:A 41-year-old woman presented with burning and erythema in her extremities triggered by warmth and activity, which was relieved by applying ice. Extensive workup was consistent with adult-onset primary erythromelalgia (EM). Several pharmacological treatments were tried including local anesthetics, capsaicin, ziconotide, and dantrolene, all providing 24-48 hours of relief followed by symptom flare. Interventional therapies, including peripheral and sympathetic ganglion blocks, also failed. Thus far, clonidine and ketamine have been the only effective agents for our patient. Genetic testing was negative for an EM-associated mutation in the SCN9A gene, encoding the NaV1.7 sodium channel, suggesting a mutation in an alternate gene.
journal_name
J Pain Resjournal_title
Journal of pain researchauthors
Low SA,Robbins W,Tawfik VLdoi
10.2147/JPR.S129661subject
Has Abstractpub_date
2017-04-27 00:00:00pages
973-977issn
1178-7090pii
jpr-10-973journal_volume
10pub_type
abstract::Recently, attention to the lifestyle of patients has been rapidly increasing in the field of pain therapy, particularly with regard to the role of nutrition in pain development and its management. In this review, we summarize the latest findings on the role of nutrition and nutraceuticals, microbiome, obesity, soy, om...
journal_title:Journal of pain research
pub_type: 杂志文章,评审
doi:10.2147/JPR.S115068
更新日期:2016-12-08 00:00:00
abstract:BACKGROUND:No proof of efficacy, in the form of a randomized controlled trial (RCT), exists to support pulsed radiofrequency (PRF) treatment of the dorsal root ganglion (DRG) for chronic lumbar radicular (CLR) pain. We determined the feasibility of a larger trial (primary objective), and also explored the efficacy of P...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S55749
更新日期:2014-01-10 00:00:00
abstract:Purpose:Brachial plexopathy can sometimes cause severe chronic pain. There are many possible treatments for such neuropathic pain, including neuromodulation. However, rigorous scientific evidence on the usefulness of spinal cord stimulation (SCS) is still scarce. Here, we report the use of high-frequency (10 kHz) SCS (...
journal_title:Journal of pain research
pub_type:
doi:10.2147/JPR.S168031
更新日期:2018-11-27 00:00:00
abstract::Cancer and cancer treatment-related chronic pain affect a significant number of patients. The etiology of this pain is diverse and may include nociceptive and/or neuropathic characteristics. Treatment is often multifactorial and may require advanced interventional techniques, such as spinal cord stimulation (SCS). Thi...
journal_title:Journal of pain research
pub_type: 杂志文章,评审
doi:10.2147/JPR.S263857
更新日期:2020-12-07 00:00:00
abstract:BACKGROUND:Several studies have illustrated that multisite pain is more frequent than single pain site, and it is associated with an array of negative consequences. However, there is limited knowledge available about the potential factors associated with multisite pain in the elderly general population. OBJECTIVE:This...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S143060
更新日期:2017-08-23 00:00:00
abstract:INTRODUCTION:Although the majority of opioids in the US are prescribed by nonpain specialists, these providers often report inadequate training in chronic pain management and opioid prescribing. The extent of health care providers' knowledge of opioid prescribing for chronic pain has not been well established. The purp...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S98273
更新日期:2016-03-10 00:00:00
abstract:OBJECTIVE:To characterize the steady-state pharmacokinetic profile of hydromorphone extended-release (ER) in patients with chronic pain taking concomitant medications. METHODS:This open-label repeat-dose study enrolled 22 patients (mean age, 51.4 years; 81.8% female). All patients were receiving at least one concomita...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S33807
更新日期:2012-01-01 00:00:00
abstract:Purpose:The quadratus lumborum block (QLB) is a relatively new regional analgesic technique that could provide analgesia to the abdominal wall and reduce postoperative opioid consumption. We investigated the opioid-sparing effect of a unilateral lateral QLB in laparoscopic nephrectomy. Patients and Methods:A total of ...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S257466
更新日期:2020-07-03 00:00:00
abstract:Purpose:Complex regional pain syndrome (CRPS) is a rare but refractory pain disorder. Recent advanced information retrieval studies using text-mining and network analysis have suggested nuclear factor kappa B (NFκB) as a possible central mediator of CRPS. The brain is also known to play important roles in CRPS. The aim...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S166270
更新日期:2019-03-06 00:00:00
abstract:BACKGROUND:Opioids are the most important pharmacological treatment for moderate-to-severe cancer pain, but side effects limit their use. Transdermal fentanyl (TDF) and oral prolonged-release oxycodone-naloxone (OXN-PR) are effective in controlling chronic pain, with less constipation compared to other opioids. However...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S141928
更新日期:2017-09-04 00:00:00
abstract::This paper reviews the current clinical data for the role of transdermal buprenorphine (BUP TDS) in the treatment of diverse acute and chronic pain syndromes. Literature searches were carried out using PubMed (1988 to June 2009). The published findings seem to support hypotheses regarding the rather unique analgesic m...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/jpr.s6503
更新日期:2009-09-15 00:00:00
abstract::Objectives: To classify patients suffering from low back pain (LBP) into two different groups - patients with lumbar disc herniation (LDH) and patients without this disease based on simple questions and without magnetic resonance imaging (MRI) procedure - and to diagnose the most effective risk factors of LDH. Methods...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S189927
更新日期:2019-04-15 00:00:00
abstract::Pain is the most common reason people visit emergency rooms. Pain does not discriminate on the basis of gender, race or age. The state of pain management in the emergency department (ED) is disturbing. ED physicians often do not provide adequate analgesia to their patients, do not meet patients' expectations in treati...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:
更新日期:2008-12-09 00:00:00
abstract::Adolescent low back pain (ALBP) is a common form of adolescent morbidity which remains poorly understood. When attempting a meta-analysis of observational studies into ALBP, in an effort to better understand associated risk factors, it is important that the studies involved are homogenic, particularly in terms of the ...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/jpr.s10025
更新日期:2010-05-17 00:00:00
abstract:OBJECTIVE:Lymphocyte apoptosis in critical illness is associated with immunosuppression. We explored for the first time the associations between pain ratings and expression of the apoptotic receptor Fas on B and T cells in critically ill patients and the potential mediating effects of adrenocorticotropic hormone (ACTH)...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S118105
更新日期:2017-01-13 00:00:00
abstract::Generalized joint hypermobility (GJH) is highly prevalent among patients diagnosed with chronic pain. When GJH is accompanied by pain in ≥4 joints over a period ≥3 months in the absence of other conditions that cause chronic pain, the hypermobility syndrome (HMS) may be diagnosed. In addition, GJH is also a clinical s...
journal_title:Journal of pain research
pub_type: 杂志文章,评审
doi:10.2147/JPR.S64251
更新日期:2015-08-20 00:00:00
abstract::Osteoarthritis (OA) is the most prevalent arthritis worldwide and is characterized by chronic pain and impaired physical function. We hypothesized that heightened pain in hand OA could be reduced with duloxetine or pregabalin. In this prospective, randomized clinical study, we recruited 65 participants, aged 40-75 yea...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S147640
更新日期:2017-10-10 00:00:00
abstract:Background:Many aspects of study conduct impact the observed effect size of treatment. Data were utilized from a recently published meta-analysis of randomized, double-blind, placebo-controlled, clinical trials performed for the United States Food and Drug Administration (FDA) approval of full mu-agonist opioids for th...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S201751
更新日期:2019-11-20 00:00:00
abstract:Objectives:Estimate the prevalence of neuropathic pain (NeP) among chronic pain patients attending Brazilian hospitals and pain clinics in São Paulo, Ceara, and Bahia and explore clinical characteristics by subtypes: painful diabetic peripheral neuropathy (pDPN), central neuropathic pain (CNP), chronic low back pain wi...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S160504
更新日期:2019-01-07 00:00:00
abstract:Purpose:Primary dysmenorrhea (PD; menstrual pain without an identified organic cause) has been proposed as a possible risk factor for the development of chronic pelvic pain, but the mechanism through which this process occurs is unknown. One possible mechanism is central sensitization - alterations in the central nervo...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S283363
更新日期:2020-12-22 00:00:00
abstract::This study describes the cultural adaptation and testing of the behavioral pain scale (BPS) and the critical-care pain observation tools (CPOT) for pain assessment in Taiwan. The cross-cultural adaptation followed the steps of translation, including forward translation, back-translation, evaluation of the translations...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S91036
更新日期:2016-09-15 00:00:00
abstract:OBJECTIVE:Patient controlled analgesia (PCA) is commonly used to provide analgesia following surgical procedures in the pediatric population. Morphine and hydromorphone remain the most commonly used opioids for PCA. Although both are effective, adverse effects may occur. When these adverse effects are unremitting or se...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S64497
更新日期:2014-08-13 00:00:00
abstract::Pain is highly prevalent, but frequently untreated or under-treated, and health care professionals are faced with a range of treatment challenges. Multimodal therapy is recommended and can be achieved using open combinations (ie, concomitant administration) of individual agents, fixed-dose combinations (FDCs), or mult...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S208082
更新日期:2019-09-04 00:00:00
abstract::Background: Chronic neuropathic pain (NP) is a complex disease that results from damage or presumed damage to the somatosensory nervous system. Current treatment regimens are often ineffective. The major impediment in developing effective treatments is our limited understanding of the underlying mechanisms. Preclinica...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S209657
更新日期:2019-08-02 00:00:00
abstract::The objective of this study was to evaluate the relationship between magnetic resonance imaging (MRI) findings and previous low back pain (LBP) in participants without current LBP. Current LBP was defined as LBP during the past month. Previous LBP was defined as a history of medical consultation for LBP. Ninety-one pa...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S122380
更新日期:2016-12-29 00:00:00
abstract:BACKGROUND:Low back pain is often called nonspecific pain. In this type of low back pain, various emotions and stress are known to strongly affect pain perception. The purpose of this study is to investigate how the degree of low back pain changes in people with chronic mild low back pain when they are inside and outsi...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S36960
更新日期:2012-01-01 00:00:00
abstract:Background:Transient receptor potential ankyrin 1 (TRPA1) is a non-selective cation channel expressed by a subset of nociceptive neurons that acts as a multimodal receptor. Its activity contributes to modulate nociceptive transmission in acute inflammatory pain. However, the role of this channel in chronic pain has bee...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S153671
更新日期:2017-12-27 00:00:00
abstract:BACKGROUND/OBJECTIVE:Previous studies have already reported an independent effect of light-load eccentric exercise (10% eccentric exercise contraction [EEC]) and low-level laser therapy (LLLT) as a protective measure against more strenuous eccentric exercise. However, the difference between these two interventions is l...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S139615
更新日期:2017-09-11 00:00:00
abstract::Mechanisms of postherpetic neuralgia (PHN) are still not clear. Transcripts such as microRNA (miRNA) and circular RNA (circRNA) in the affected skin may take part in the initiation and development of this neuropathic pain; however, their expression profiles in skins of PHN patients have not been reported. The PHN affe...
journal_title:Journal of pain research
pub_type:
doi:10.2147/JPR.S221615
更新日期:2019-10-16 00:00:00
abstract::Lumbar epidural steroid injections (LESIs) are commonly used for managing lower back pain (LBP) and radicular pain. LESIs are generally considered safe with only rare serious complication. One very rare complication that is frequently cited in the literature is adhesive arachnoiditis. However, a literature search fail...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S192706
更新日期:2019-01-29 00:00:00