Complex management of a patient with refractory primary erythromelalgia lacking a SCN9A mutation.

Abstract:

:A 41-year-old woman presented with burning and erythema in her extremities triggered by warmth and activity, which was relieved by applying ice. Extensive workup was consistent with adult-onset primary erythromelalgia (EM). Several pharmacological treatments were tried including local anesthetics, capsaicin, ziconotide, and dantrolene, all providing 24-48 hours of relief followed by symptom flare. Interventional therapies, including peripheral and sympathetic ganglion blocks, also failed. Thus far, clonidine and ketamine have been the only effective agents for our patient. Genetic testing was negative for an EM-associated mutation in the SCN9A gene, encoding the NaV1.7 sodium channel, suggesting a mutation in an alternate gene.

journal_name

J Pain Res

journal_title

Journal of pain research

authors

Low SA,Robbins W,Tawfik VL

doi

10.2147/JPR.S129661

subject

Has Abstract

pub_date

2017-04-27 00:00:00

pages

973-977

issn

1178-7090

pii

jpr-10-973

journal_volume

10

pub_type

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    pub_type:

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    更新日期:2019-10-16 00:00:00

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