Abstract:
BACKGROUND:Opioids are the most important pharmacological treatment for moderate-to-severe cancer pain, but side effects limit their use. Transdermal fentanyl (TDF) and oral prolonged-release oxycodone-naloxone (OXN-PR) are effective in controlling chronic pain, with less constipation compared to other opioids. However, TDF and OXN-PR have never been directly compared. PATIENTS AND METHODS:Cancer patients with moderate-to-severe chronic pain were consecutively enrolled in two prospective 28-day trials, received either TDF or OXN-PR, and were assessed at baseline and after 7, 14, 21, and 28 days. The primary endpoint was 28-day analgesic response rate (average pain intensity decrease ≥30% from baseline). Other outcome measures included opioid daily dose changes over time; need for adjuvant analgesics; number of switches; premature discontinuation; presence and severity of constipation; and other adverse drug reactions. To compare the efficacy and the safety of TDF and OXN-PR, we used the propensity score analysis to adjust for heterogeneity between the two patient groups. RESULTS:Three hundred ten out of 336 patients originally treated (119 TDF and 191 OXN-PR) were included in the comparative analysis. The amount of responders was comparable after TDF (75.3%) and OXN-PR administration (82.9%, not significant [NS]). The final opioid daily dose expressed as morphine equivalent was 113.6 mg for TDF and 44.5 mg for OXN-PR (p<0.0001). A daily opioid dose escalation >5% was less common after OXN-PR (19.3%) than after TDS administration (37.9%, p<0.0001). Opioid switches and discontinuation were similar in both groups. Severe constipation in the two groups was comparable (32.6% after TDF vs 24.7% after OXN-PR, NS). Nausea, vomiting, and dry mouth were significantly less frequent in the OXN-PR group than in the TDF group. CONCLUSION:Despite a similar analgesic activity in moderate-to-severe cancer pain, OXN-PR is characterized by lower daily dosages, less need for drug escalation, and fewer side effects compared to TDF.
journal_name
J Pain Resjournal_title
Journal of pain researchauthors
Roberto A,Greco MT,Legramandi L,Galli F,Galli M,Corli Odoi
10.2147/JPR.S141928subject
Has Abstractpub_date
2017-09-04 00:00:00pages
2123-2133issn
1178-7090pii
jpr-10-2123journal_volume
10pub_type
杂志文章abstract:Background:Cast immobilization is the primary treatment for children with forearm fractures. After emergency department (ED) discharge, some patients develop cast-related pain (CstRP) around the distal part of the upper extremity. We examined variables associated with ED revisits due to CstRP in children with forearm f...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S226447
更新日期:2020-01-08 00:00:00
abstract:OBJECTIVES:Chronic neuropathic pain and chronic complex regional pain syndrome (CRPS), in particular, are debilitating and difficult-to-treat conditions that have a strong impact on patient's quality of life. The aim of this study was to evaluate the effectiveness of 5% lidocaine-medicated plaster as add-on therapy in ...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S113517
更新日期:2016-10-06 00:00:00
abstract::Purpose: The objective for this clinical pilot study was to evaluate changes to chronic pain, vascular health, and inflammatory markers when consuming a dietary supplement blend (DSB, CytoQuel®), containing curcumin, resveratrol, tocotrienols, N-Acetylcysteine, and epigallocatechin gallate. Materials and methods: An o...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S189064
更新日期:2019-05-15 00:00:00
abstract::Background: Chronic neuropathic pain (NP) is a complex disease that results from damage or presumed damage to the somatosensory nervous system. Current treatment regimens are often ineffective. The major impediment in developing effective treatments is our limited understanding of the underlying mechanisms. Preclinica...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S209657
更新日期:2019-08-02 00:00:00
abstract:Background:With the increase in life expectancy seen throughout the world, the prevalence of degenerative spinal pathology and surgery to treat it has increased. Spinal surgery under general anesthesia leads to various problems and complications, especially in patients with numerous medical comorbidities or elderly pat...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S227212
更新日期:2020-01-21 00:00:00
abstract:Background:G protein-gated inwardly rectifying potassium (GIRK) channels are involved in the regulation of neuronal excitability. Four GIRK subunits (GIRK1-4) are expressed in rat dorsal root ganglia (DRGs). Recently, we have characterized the expression of GIRK1 and -2, and both are downregulated in rat DRGs and spina...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S233744
更新日期:2020-02-17 00:00:00
abstract:Objective:To report a rare case of spontaneous fusion (SF) following cervical disc arthroplasty (CDA), to review the related literature, and to propose a new measure to prevent it. Methods:The course of a patient with SF is described here. The potential causes, risk factors, and preventive measure of SF after CDA publ...
journal_title:Journal of pain research
pub_type:
doi:10.2147/JPR.S242646
更新日期:2020-04-21 00:00:00
abstract:OBJECTIVES:To determine whether X-ray, computed tomography (CT), bone scan, and clinical impression accurately reflect the level of vertebral fracture in patients about to undergo vertebroplasty. DESIGN:Retrospective observational study, utilizing patient inpatient notes, referral correspondence, and clinicians' priva...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S32151
更新日期:2013-05-10 00:00:00
abstract:BACKGROUND:The purpose of this study was to assess the attitudes of maternal health care providers to pain relief during labor in Zaria, Nigeria. METHODS:This was a multicenter, collaborative, cross-sectional pilot study of provider perspectives concerning pain relief during labor. A structured, self-administered, que...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S21085
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:The generic STarT Back 5-item screening tool (STarT-G) is used to manage chronic pain in the lower back and elsewhere. This study evaluated the validity of the Japanese version of this generic screening tool. MATERIALS AND METHODS:Japanese participants between the ages of 20 and 64 years completed online sur...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S129585
更新日期:2017-02-24 00:00:00
abstract:Purpose:The aim of this prospective study was to assess the behavior of emergency department (ED) nurses with regard to pain and their role in pain management in a real-life clinical setting. Methods:A total of 509 consecutive patients were enrolled during a 6-week period. A case-report form was used to collect data o...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S266087
更新日期:2020-09-22 00:00:00
abstract:UNLABELLED:Postsurgical pain management remains a significant challenge. Liposome bupivacaine, as part of a multimodal analgesic regimen, has been shown to significantly reduce postsurgical opioid consumption, hospital length of stay (LOS), and hospitalization costs in gastrointestinal (GI) surgery, compared with intra...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S63764
更新日期:2014-06-24 00:00:00
abstract:OBJECTIVE:To characterize the steady-state pharmacokinetic profile of hydromorphone extended-release (ER) in patients with chronic pain taking concomitant medications. METHODS:This open-label repeat-dose study enrolled 22 patients (mean age, 51.4 years; 81.8% female). All patients were receiving at least one concomita...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S33807
更新日期:2012-01-01 00:00:00
abstract::This paper reviews the current clinical data for the role of transdermal buprenorphine (BUP TDS) in the treatment of diverse acute and chronic pain syndromes. Literature searches were carried out using PubMed (1988 to June 2009). The published findings seem to support hypotheses regarding the rather unique analgesic m...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/jpr.s6503
更新日期:2009-09-15 00:00:00
abstract:Background:Low back pain is a prevalent symptom that occurs in all age of people, whereas the pathogenesis is unknown. Iliopsoas tendinopathy is an increasingly recognized hip disorder that may contribute to low back pain. Our purpose is to evaluate the effect of ultrasound-guided local injection of anesthetic and ster...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S281880
更新日期:2020-11-20 00:00:00
abstract:Background:Although the Eph receptor plays an important role in the development of neuropathic pain following nerve injury, there has been no evidence of the participation of the ephrin A4 receptor (EphA4) in the development of trigeminal neuropathic pain. The present study investigated the role of EphA4 in central noc...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S249185
更新日期:2020-05-22 00:00:00
abstract:Objective:To examine the influence of anxiety and pain-related catastrophizing on the time course of acute interleukin-6 (IL-6) responses to standardized noxious stimulation among patients with chronic pain. Methods:Data were collected from 48 participants in the following demographically matched groups: patients with...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S147735
更新日期:2018-03-28 00:00:00
abstract:BACKGROUND:While studies have demonstrated the economic burden of migraines in terms of quality of life, health care resource use (HRU), and costs, there exists a notable paucity of data comparing such outcomes among migraineurs with nausea and vomiting (N/V) and those without. The current study aimed to address this g...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S124683
更新日期:2017-03-24 00:00:00
abstract:Background:Chronic shoulder pain (CSP) is a common disease causing pain and functional limitation, which is highly prevalent and has substantial negative effects on the quality of life. Acupuncture has gained popularity and has been accepted gradually by many countries because it can successfully treat patients with ch...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S152550
更新日期:2018-03-07 00:00:00
abstract:OBJECTIVE:Patient controlled analgesia (PCA) is commonly used to provide analgesia following surgical procedures in the pediatric population. Morphine and hydromorphone remain the most commonly used opioids for PCA. Although both are effective, adverse effects may occur. When these adverse effects are unremitting or se...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S64497
更新日期:2014-08-13 00:00:00
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journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S196480
更新日期:2019-06-06 00:00:00
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journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S179409
更新日期:2018-12-13 00:00:00
abstract:BACKGROUND:Low back pain is often called nonspecific pain. In this type of low back pain, various emotions and stress are known to strongly affect pain perception. The purpose of this study is to investigate how the degree of low back pain changes in people with chronic mild low back pain when they are inside and outsi...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S36960
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Opioid analgesics are effective for postsurgical pain but are associated with opioid-related adverse events, creating a significant clinical and economic burden. Gastrointestinal surgery patients are at high risk for opioid-related adverse events. We conducted a study to assess the impact of an opioid-sparin...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S46467
更新日期:2013-07-18 00:00:00
abstract:Purpose:Exercise-induced hypoalgesia (EIH) is the short-term reduction of pain sensitivity after a single bout of exercise. Descending pain inhibition has been proposed to at least partly underlie EIH. Cognitive inhibition is the ability to inhibit a pre-potent response and has in turn been associated with descending p...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S238718
更新日期:2020-04-29 00:00:00
abstract:Background:To date, there has been no study on the effects of interleukin-10 (IL-10) on complex regional pain syndrome (CRPS) rodent models, despite the anti-allodynic effect of IL-10 in previous studies. Thus, the aim of this study was to investigate the effect of IL-10 in a CRPS mouse model and find whether early inh...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S166624
更新日期:2018-09-04 00:00:00
abstract::Temporal sensory summation of pain (TSSP) is a proxy measure of windup in humans and results in increased ratings of pain caused by a repetitive, low-frequency noxious stimulus. Aftersensations (ASs) are pain sensations that remain after TSSP has been induced. We examined the within-session and across-session variabil...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S18105
更新日期:2011-01-01 00:00:00
abstract:Background:Transient receptor potential ankyrin 1 (TRPA1) is a non-selective cation channel expressed by a subset of nociceptive neurons that acts as a multimodal receptor. Its activity contributes to modulate nociceptive transmission in acute inflammatory pain. However, the role of this channel in chronic pain has bee...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S153671
更新日期:2017-12-27 00:00:00
abstract:Background:Suspecting carpal tunnel syndrome (CTS) in patients with hand pain is usual. Considering the variable rate of false-negative results in nerve conduction study (NCS), as a frequent reference confirmatory standard test, we aimed to evaluate the diagnostic accuracy of neuromuscular ultrasound in patients with c...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S164004
更新日期:2018-07-10 00:00:00
abstract:Background:Previous studies have shown the efficacy of tapentadol (TP) for chronic cancer pain. We evaluated multiple effectiveness aspects of TP prolonged release on moderate-severe cancer-related pain, neuropathic pain (NeP), patient satisfaction, and quality of life. Methods:An observational prospective study was c...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S181079
更新日期:2018-12-24 00:00:00