Abstract:
:This paper reviews the current clinical data for the role of transdermal buprenorphine (BUP TDS) in the treatment of diverse acute and chronic pain syndromes. Literature searches were carried out using PubMed (1988 to June 2009). The published findings seem to support hypotheses regarding the rather unique analgesic mechanisms of buprenorphine as compared with pure μ-opioids like morphine and fentanyl. However, the exact mechanism of this analgesic efficacy still remains largely unknown despite recent advances in preclinical pharmacological studies. Such assessments have demonstrated the sustained antihyperalgesic effect of buprenorphine in diverse animal pain models. These findings are supported in a growing number of clinical studies of oral, intrathecal, intravenous, and Bup TDS. This review paper focuses almost entirely on the clinical experience concerning the transdermal administration of buprenorphine, although preclinical aspects are also addressed in order to provide a complete picture of the unique pharmacological properties of this analgesic drug. Mounting evidence indicates the appropriateness of Bup TDS in the treatment of diverse acute and chronic pain syndromes which have been less or not responsive to other opioids. Additionally, BUP TDS seems to hold great promise for other difficult-to-treat (pain) conditions, such as patients in the intensive care setting. However, its use is somewhat tempered by the occurrence of local skin reactions which have been shown to be often therapy resistant. Further studies are certainly warranted to identify even more precisely the clinical syndromes that are most sensitive to buprenorphine treatment, and to compare buprenorphine to other opioids in head-to-head trials of acute and chronic pain conditions.
journal_name
J Pain Resjournal_title
Journal of pain researchauthors
Hans G,Robert Ddoi
10.2147/jpr.s6503subject
Has Abstractpub_date
2009-09-15 00:00:00pages
117-34issn
1178-7090journal_volume
2pub_type
杂志文章abstract:Background:Erector spinae plane block (ESPB) as a new trunk fascia block technique was proposed in 2016. ESPB has aroused the interest of many nerve block experts. However, there are few clinical studies on ESPB for lumbar surgery, and its effectiveness and safety are controversial. The goal of this review is to summar...
journal_title:Journal of pain research
pub_type: 杂志文章,评审
doi:10.2147/JPR.S256205
更新日期:2020-07-01 00:00:00
abstract::Nocebo hyperalgesia has received sparse experimental attention compared to placebo analgesia. The aim of the present study was to investigate if personality traits and fear of pain could predict experimental nocebo hyperalgesia. One hundred and eleven healthy volunteers (76 females) participated in an experimental stu...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S91923
更新日期:2015-10-12 00:00:00
abstract:Purpose:This study aimed to review and pool the current literature on intra-articular ozone injection in knee osteoarthritis (OA) patients. Methods:A systematic review of three big databases was performed to identify all English-language randomized clinical trials (RCTs) that evaluated the efficacy of intra-articular ...
journal_title:Journal of pain research
pub_type: 杂志文章,评审
doi:10.2147/JPR.S175441
更新日期:2018-10-25 00:00:00
abstract::Paced breathing has shown efficacy in fibromyalgia (FM), but the mechanisms associated with symptom change are largely unknown. We investigated whether changes in respiratory rate (RR) alone resulted in autonomic changes during normal, paced, and mechanically assisted breathing in untrained FM patients and controls. P...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S139642
更新日期:2017-12-08 00:00:00
abstract::The observation of pain in others may enhance or reduce self-pain, yet the boundary conditions and factors that determine the direction of such effects are poorly understood. The current study set out to show that visual stimulus awareness plays a crucial role in determining whether vicarious pain primarily activates ...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S132744
更新日期:2017-07-31 00:00:00
abstract:Background and Aims:Plantar fasciitis (PF) is the leading cause of heel pain in adults. This study was designed to evaluate the effect of hyaluronic acid (HA) injection in reducing the symptoms of PF, compared with corticosteroid (CS) injection as a conventional treatment. Methods:In this triple-blind, randomized, cli...
journal_title:Journal of pain research
pub_type:
doi:10.2147/JPR.S217419
更新日期:2020-01-14 00:00:00
abstract:UNLABELLED:Postsurgical pain management remains a significant challenge. Liposome bupivacaine, as part of a multimodal analgesic regimen, has been shown to significantly reduce postsurgical opioid consumption, hospital length of stay (LOS), and hospitalization costs in gastrointestinal (GI) surgery, compared with intra...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S63764
更新日期:2014-06-24 00:00:00
abstract:OBJECTIVE:To characterize the steady-state pharmacokinetic profile of hydromorphone extended-release (ER) in patients with chronic pain taking concomitant medications. METHODS:This open-label repeat-dose study enrolled 22 patients (mean age, 51.4 years; 81.8% female). All patients were receiving at least one concomita...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S33807
更新日期:2012-01-01 00:00:00
abstract:Background:Previous studies have shown the efficacy of tapentadol (TP) for chronic cancer pain. We evaluated multiple effectiveness aspects of TP prolonged release on moderate-severe cancer-related pain, neuropathic pain (NeP), patient satisfaction, and quality of life. Methods:An observational prospective study was c...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S181079
更新日期:2018-12-24 00:00:00
abstract:Background:Millions of people worldwide are suffering from pain. Non-pharmacological therapy has an important role in the treatment of pain and is recognized as a valuable, simple help to lower the dosage of analgesic drugs needed, decreasing the side effects, reducing drug dependency and reducing health care costs; ho...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S265544
更新日期:2020-11-16 00:00:00
abstract:BACKGROUND:The purpose of this study was to assess the attitudes of maternal health care providers to pain relief during labor in Zaria, Nigeria. METHODS:This was a multicenter, collaborative, cross-sectional pilot study of provider perspectives concerning pain relief during labor. A structured, self-administered, que...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S21085
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:The generic STarT Back 5-item screening tool (STarT-G) is used to manage chronic pain in the lower back and elsewhere. This study evaluated the validity of the Japanese version of this generic screening tool. MATERIALS AND METHODS:Japanese participants between the ages of 20 and 64 years completed online sur...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S129585
更新日期:2017-02-24 00:00:00
abstract::Diabetic peripheral neuropathy (DPN) represents significant burdens to many patients and the public health-care system. Patients with diabetes in rural areas have higher risk of developing complications and having less access to proper treatment. We studied a rural population of patients with diabetes who attended a p...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S129139
更新日期:2017-04-07 00:00:00
abstract::Neuromuscular blockade is a desirable or even essential component of general anesthesia for major surgical operations. As the population continues to age, and more operations are conducted in the elderly, due consideration must be given to neuromuscular blockade in these patients to avoid possible complications. This ...
journal_title:Journal of pain research
pub_type: 杂志文章,评审
doi:10.2147/JPR.S85183
更新日期:2016-06-17 00:00:00
abstract:Purpose:To investigate the ameliorative effects of Vitellaria paradoxa (VP) nut extract for an anterior cruciate ligament transection with medial meniscectomy (ACLT+MMx)-induced osteoarthritis (OA) in high-fat diet (HFD)-induced obese rats. Methods:The rats were fed by HFD for 5 weeks before surgery-induced OA. Rats w...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S228766
更新日期:2020-01-30 00:00:00
abstract:OBJECTIVE:Patient controlled analgesia (PCA) is commonly used to provide analgesia following surgical procedures in the pediatric population. Morphine and hydromorphone remain the most commonly used opioids for PCA. Although both are effective, adverse effects may occur. When these adverse effects are unremitting or se...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S64497
更新日期:2014-08-13 00:00:00
abstract::[This corrects the article DOI: 10.2147/JPR.S203721.]. ...
journal_title:Journal of pain research
pub_type: 已发布勘误
doi:10.2147/JPR.S278204
更新日期:2020-08-26 00:00:00
abstract::Calcitonin gene-related peptide (CGRP) is a major player in migraine pathophysiology, and CGRP monoclonal antibodies including fremanezumab may be a safe effective preventive therapy. Phase IIb studies in episodic migraine (EM) and chronic migraine (CM) demonstrated efficacy at both the monthly 225 mg and quarterly 67...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S166427
更新日期:2019-08-22 00:00:00
abstract:Background:Suspecting carpal tunnel syndrome (CTS) in patients with hand pain is usual. Considering the variable rate of false-negative results in nerve conduction study (NCS), as a frequent reference confirmatory standard test, we aimed to evaluate the diagnostic accuracy of neuromuscular ultrasound in patients with c...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S164004
更新日期:2018-07-10 00:00:00
abstract:Purpose:Brachial plexopathy can sometimes cause severe chronic pain. There are many possible treatments for such neuropathic pain, including neuromodulation. However, rigorous scientific evidence on the usefulness of spinal cord stimulation (SCS) is still scarce. Here, we report the use of high-frequency (10 kHz) SCS (...
journal_title:Journal of pain research
pub_type:
doi:10.2147/JPR.S168031
更新日期:2018-11-27 00:00:00
abstract:Background:Thoracoscopic surgery (TS) has been performed as a minimally invasive procedure since the beginning of the 1990s. This has led to a dramatic change in the postoperative condition of these patients, facilitating early ambulation and easier management of postoperative pain. However, empirical evidence on posto...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S147691
更新日期:2017-11-15 00:00:00
abstract::It is broadly accepted that children of all age groups including (preterm) neonates and young infants can perceive pain and that there is an absolute need to treat their pain safely and effectively. The approved treatment options for children, particularly (preterm) neonates and young infants, are very limited with on...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S195788
更新日期:2019-05-23 00:00:00
abstract:Background:Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis patients often present with psychiatric symptoms, cognitive dysfunction, epilepsy and memory deficits. A previous study has suggested that headache can occurr during the early stages of anti-NMDAR encephalitis. However, the exact association between hea...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S189301
更新日期:2019-01-30 00:00:00
abstract:Objective:This study investigated psychological characteristics of patients with chronic complex regional pain syndrome (CRPS) and examined relationships between psychosocial factors and pain severity. Methods:In total, 76 patients with CRPS, 95 patients with other types of chronic pain, 171 healthy controls, and 66 p...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S230394
更新日期:2020-02-13 00:00:00
abstract:Purpose:Complex regional pain syndrome (CRPS) is a rare but refractory pain disorder. Recent advanced information retrieval studies using text-mining and network analysis have suggested nuclear factor kappa B (NFκB) as a possible central mediator of CRPS. The brain is also known to play important roles in CRPS. The aim...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S166270
更新日期:2019-03-06 00:00:00
abstract:Aim:In chronic pain, habituation is believed to be impaired, and pain hypervigilance can enhance the pain experience. The goal of this study was to determine whether pain hypervigilance further worsens habituation of event-related potentials, measured in a pain-rating protocol of 25 painful somatosensory electrical sti...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S146916
更新日期:2018-02-19 00:00:00
abstract::Background: Chronic neuropathic pain (NP) is a complex disease that results from damage or presumed damage to the somatosensory nervous system. Current treatment regimens are often ineffective. The major impediment in developing effective treatments is our limited understanding of the underlying mechanisms. Preclinica...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S209657
更新日期:2019-08-02 00:00:00
abstract:BACKGROUND:No proof of efficacy, in the form of a randomized controlled trial (RCT), exists to support pulsed radiofrequency (PRF) treatment of the dorsal root ganglion (DRG) for chronic lumbar radicular (CLR) pain. We determined the feasibility of a larger trial (primary objective), and also explored the efficacy of P...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S55749
更新日期:2014-01-10 00:00:00
abstract::Pain is the most common reason people visit emergency rooms. Pain does not discriminate on the basis of gender, race or age. The state of pain management in the emergency department (ED) is disturbing. ED physicians often do not provide adequate analgesia to their patients, do not meet patients' expectations in treati...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:
更新日期:2008-12-09 00:00:00
abstract:Background:Postherpetic neuralgia (PHN) refers to pain which remains after the healing of rashes from herpes zoster. Previous literatures have shown that acupuncture has potential benefits for PHN, but evidence remains lacking. Thus, we have performed a systematic review and meta-analysis to identify the effectiveness ...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S199950
更新日期:2019-07-16 00:00:00