Abstract:
:Neuromuscular blockade is a desirable or even essential component of general anesthesia for major surgical operations. As the population continues to age, and more operations are conducted in the elderly, due consideration must be given to neuromuscular blockade in these patients to avoid possible complications. This review considers the pharmacokinetics and pharmacodynamics of neuromuscular blockade that may be altered in the elderly. Compartment distribution, metabolism, and excretion of drugs may vary due to age-related changes in physiology, altering the duration of action with a need for reduced dosage (eg, aminosteroids). Other drugs (atracurium, cisatracurium) have more reliable duration of action and should perhaps be considered for use in the elderly. The range of interpatient variability that neuromuscular blocking drugs may exhibit is then considered and drugs with a narrower range, such as cisatracurium, may produce more predictable, and inherently safer, outcomes. Ultimately, appropriate neuromuscular monitoring should be used to guide the administration of muscle relaxants so that the risk of residual neuromuscular blockade postoperatively can be minimized. The reliability of various monitoring is considered. This paper concludes with a review of the various reversal agents, namely, anticholinesterase drugs and sugammadex, and the alterations in dosing of these that should be considered for the elderly patient.
journal_name
J Pain Resjournal_title
Journal of pain researchauthors
Lee LA,Athanassoglou V,Pandit JJdoi
10.2147/JPR.S85183subject
Has Abstractpub_date
2016-06-17 00:00:00pages
437-44issn
1178-7090pii
jpr-9-437journal_volume
9pub_type
杂志文章,评审abstract:Background:With the increase in life expectancy seen throughout the world, the prevalence of degenerative spinal pathology and surgery to treat it has increased. Spinal surgery under general anesthesia leads to various problems and complications, especially in patients with numerous medical comorbidities or elderly pat...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S227212
更新日期:2020-01-21 00:00:00
abstract:BACKGROUND:Waiting list management at chronic pain clinics has become a serious problem throughout Canada. We analyzed the waiting list at the Centre hospitalier de l'Université de Montréal (CHUM) Pain Centre. METHODS:The present study is an observational, prospective study. We used a specifically designed survey ques...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S46118
更新日期:2013-07-08 00:00:00
abstract:Background:Transversus abdominis plane (TAP) block can provide effective analgesia for abdominal surgery. However, many randomized controlled trials (RCTs) have shown controversial results in hysterectomy. We conducted a meta-analysis of RCTs to investigate the effectiveness of TAP block after hysterectomy. Methods:St...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S172828
更新日期:2018-10-18 00:00:00
abstract:BACKGROUND:Low back pain is often called nonspecific pain. In this type of low back pain, various emotions and stress are known to strongly affect pain perception. The purpose of this study is to investigate how the degree of low back pain changes in people with chronic mild low back pain when they are inside and outsi...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S36960
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Very few studies have discussed transforaminal endoscopic discectomy (TED) in the treatment of common peroneal nerve paralysis induced by lumbar disk herniation (LDH). This study aimed to evaluate the efficacy of TED in the treatment of LDH combined with common peroneal nerve paralysis. MATERIALS AND METHOD...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S120463
更新日期:2017-01-05 00:00:00
abstract:Purposes:To investigate the prevalence of pain-related diagnoses in patients with dementia and evaluate the association of pain-related diagnoses with demographic characteristics and dementia subtypes. Patients and methods:In this population-based retrospective cohort study, participants were recruited from a cohort o...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S172875
更新日期:2018-09-03 00:00:00
abstract:Purpose:To explore the role of cervical sagittal alignment in the occurrence of adjacent-level ossification development (ALOD) in patients who underwent anterior cervical discectomy fusion with self-locking stand-alone polyetheretherketone cage, and the relationship between cervical sagittal alignment and clinical outc...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S160472
更新日期:2018-07-20 00:00:00
abstract:Purpose:Exercise-induced hypoalgesia (EIH) is the short-term reduction of pain sensitivity after a single bout of exercise. Descending pain inhibition has been proposed to at least partly underlie EIH. Cognitive inhibition is the ability to inhibit a pre-potent response and has in turn been associated with descending p...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S238718
更新日期:2020-04-29 00:00:00
abstract:BACKGROUND:Diagnosis of fibromyalgia (FM), a chronic musculoskeletal condition characterized by widespread pain and a constellation of symptoms, remains challenging and is often delayed. METHODS:Random forest modeling of electronic medical records was used to identify variables that may facilitate earlier FM identific...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/jpr.s8256
更新日期:2015-06-10 00:00:00
abstract:BACKGROUND:Large interindividual differences in clinical responses to opioids and the variable susceptibility to abuse of this class of drugs make their use problematic. We lack a full understanding of the factors responsible for these differences. Dietary factors including methyl donor content have been noted to alter...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S42561
更新日期:2013-01-01 00:00:00
abstract:Background and Aims:Plantar fasciitis (PF) is the leading cause of heel pain in adults. This study was designed to evaluate the effect of hyaluronic acid (HA) injection in reducing the symptoms of PF, compared with corticosteroid (CS) injection as a conventional treatment. Methods:In this triple-blind, randomized, cli...
journal_title:Journal of pain research
pub_type:
doi:10.2147/JPR.S217419
更新日期:2020-01-14 00:00:00
abstract:Purpose:The INTERMED instrument, which was developed to measure patient's biopsychosocial (BPS) complexity, represents a powerful diagnostic and therapeutic tool. Epigenetic changes are the interface between signals from the environment and genetic modifications, affecting gene expression, in particular, by DNA methyla...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S251782
更新日期:2020-06-02 00:00:00
abstract:Purpose:Complex regional pain syndrome (CRPS) is a rare but refractory pain disorder. Recent advanced information retrieval studies using text-mining and network analysis have suggested nuclear factor kappa B (NFκB) as a possible central mediator of CRPS. The brain is also known to play important roles in CRPS. The aim...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S166270
更新日期:2019-03-06 00:00:00
abstract:Purpose:This study aimed to review and pool the current literature on intra-articular ozone injection in knee osteoarthritis (OA) patients. Methods:A systematic review of three big databases was performed to identify all English-language randomized clinical trials (RCTs) that evaluated the efficacy of intra-articular ...
journal_title:Journal of pain research
pub_type: 杂志文章,评审
doi:10.2147/JPR.S175441
更新日期:2018-10-25 00:00:00
abstract:Background:Chronic shoulder pain (CSP) is a common disease causing pain and functional limitation, which is highly prevalent and has substantial negative effects on the quality of life. Acupuncture has gained popularity and has been accepted gradually by many countries because it can successfully treat patients with ch...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S152550
更新日期:2018-03-07 00:00:00
abstract:Background:Pain is a common and undertreated non-motor symptom in patients with Parkinson's disease (PD). Opioids have been seldom used in PD because they could worsen cognitive and motor functions. Objective:We aimed to assess efficacy and tolerability of tapentadol in PD patients. Methods:We retrospectively reviewe...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S164939
更新日期:2018-09-13 00:00:00
abstract:Background:It has been reported that N-cadherin and cAMP response element binding protein (CREB) in the spinal cord are critical for synaptogenesis and regulation of excitatory synapse function, which could underlie chronic pain development. The aim of the present study was to investigate the role of spinal N-cadherin/...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S267778
更新日期:2020-08-12 00:00:00
abstract:OBJECTIVE:To evaluate the analgesic effectiveness of intra-articular botulinum toxin Type B (BoNT/B) in a murine model of chronic degenerative arthritis pain. METHODS AND MATERIALS:Chronic arthritis was produced in adult C57Bl6 mice by intra-articular injection of Type IV collagenase into the left knee. Following indu...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S12520
更新日期:2010-09-06 00:00:00
abstract::The observation of pain in others may enhance or reduce self-pain, yet the boundary conditions and factors that determine the direction of such effects are poorly understood. The current study set out to show that visual stimulus awareness plays a crucial role in determining whether vicarious pain primarily activates ...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S132744
更新日期:2017-07-31 00:00:00
abstract:Background:Erector spinae plane block (ESPB) as a new trunk fascia block technique was proposed in 2016. ESPB has aroused the interest of many nerve block experts. However, there are few clinical studies on ESPB for lumbar surgery, and its effectiveness and safety are controversial. The goal of this review is to summar...
journal_title:Journal of pain research
pub_type: 杂志文章,评审
doi:10.2147/JPR.S256205
更新日期:2020-07-01 00:00:00
abstract:PURPOSE:Since receiving a warning from the US Food and Drug Administration (FDA) about injection of corticosteroids into the epidural space having serious adverse events, we have sought alternative medications for injection at this site. Hyaluronic acid (HA) has anti-adhesive, anti-inflammatory, and lubricating propert...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S122861
更新日期:2017-01-25 00:00:00
abstract:BACKGROUND:Oliceridine (TRV130), a novel μ-receptor G-protein pathway selective (μ-GPS) modulator, was designed to improve the therapeutic window of conventional opioids by activating G-protein signaling while causing low β-arrestin recruitment to the μ receptor. This randomized, double-blind, patient-controlled analge...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S137952
更新日期:2017-10-06 00:00:00
abstract:Objective:To describe the rate and demographics of pain among Vietnamese people in 48 provinces and describe the impact of pain on individuals, levels of satisfaction with treatment results, and behavior of pain sufferers. Methods:The cross-sectional study was conducted in adults presenting to outpatient clinics throu...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S184713
更新日期:2019-02-25 00:00:00
abstract:Aim:Operant conditioning has long been believed to influence the pain experience through a psychological reward pathway. This study was formulated to test the hypothesis that pain sensitivity may be enhanced >3 months if a monetary reward works as a reinforcement. Methods:Forty healthy subjects volunteered to particip...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S175494
更新日期:2018-10-04 00:00:00
abstract:UNLABELLED:Postsurgical pain management remains a significant challenge. Liposome bupivacaine, as part of a multimodal analgesic regimen, has been shown to significantly reduce postsurgical opioid consumption, hospital length of stay (LOS), and hospitalization costs in gastrointestinal (GI) surgery, compared with intra...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S63764
更新日期:2014-06-24 00:00:00
abstract:Purpose:The aim of this prospective study was to assess the behavior of emergency department (ED) nurses with regard to pain and their role in pain management in a real-life clinical setting. Methods:A total of 509 consecutive patients were enrolled during a 6-week period. A case-report form was used to collect data o...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S266087
更新日期:2020-09-22 00:00:00
abstract:Introduction:Sickle cell disease (SCD) is an inherited blood disorder characterized by abnormally shaped sickle cells. The hallmark of this disease is intermittent, painful vaso-occlusive episodes (VOE), but a subset of individuals with SCD experience chronic pain. The mechanism of transition to chronic pain is not wel...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S150066
更新日期:2018-02-23 00:00:00
abstract:Background:Regional variations of opioid use have been reported from many countries. The objective of this study was to examine opioid prescribing patterns in Germany including low- and high-potency opioids (LPO and HPO) focusing on regional differences. Methods:Data source was the "Information system for health care ...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S259009
更新日期:2020-10-07 00:00:00
abstract::[This corrects the article DOI: 10.2147/JPR.S203721.]. ...
journal_title:Journal of pain research
pub_type: 已发布勘误
doi:10.2147/JPR.S278204
更新日期:2020-08-26 00:00:00
abstract::The objective of this study was to evaluate the relationship between magnetic resonance imaging (MRI) findings and previous low back pain (LBP) in participants without current LBP. Current LBP was defined as LBP during the past month. Previous LBP was defined as a history of medical consultation for LBP. Ninety-one pa...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S122380
更新日期:2016-12-29 00:00:00