The challenge of developing pain medications for children: therapeutic needs and future perspectives.

abstract：Purpose:The aim of this prospective study was to assess the behavior of emergency department (ED) nurses with regard to pain and their role in pain management in a real-life clinical setting. Methods:A total of 509 consecutive patients were enrolled during a 6-week period. A case-report form was used to collect data o...

journal_title：Journal of pain research

authors： Sardo S,Galletta M,Coni E,Aviles Gonzalez CI,Piras I,Pia G,Evangelista M,Musu M,Finco G

更新日期：2020-09-22 00:00:00

abstract：Purpose:Epidural analgesia provides safe and effective labor pain relief. However, labor episodic pain can occur during epidural analgesia, requiring epidural top-ups, and may result in decreased patient satisfaction. The primary aim of our study was to investigate the factors associated with labor episodic pain during...

journal_title：Journal of pain research

authors： Chan JJI,Gan YY,Dabas R,Han NR,Sultana R,Sia ATH,Sng BL

更新日期：2019-02-15 00:00:00

abstract：OBJECTIVE:Patients with chronic fatigue syndrome (CFS) complain of long-lasting fatigue and pain which are not relieved by rest and worsened by physical exertion. Previous research has implicated metaboreceptors of muscles to play an important role for chronic fatigue and pain. Therefore, we hypothesized that blocking ...

journal_title：Journal of pain research

authors： Staud R,Kizer T,Robinson ME

更新日期：2017-06-26 00:00:00

abstract：BACKGROUND:One form of self-medication is sharing of medications, defined as borrowing or lending medications in situations where the receiver of these drugs is not the individual to whom the medications were allocated. OBJECTIVE:To explore experiences and opinions of patients about sharing prescription analgesics, re...

journal_title：Journal of pain research

authors： Markotic F,Vrdoljak D,Puljiz M,Puljak L

更新日期：2017-02-10 00:00:00

abstract：:Purpose: Thirty percent of patients with postherpetic neuralgia (PHN) receiving conservative treatment report unsatisfactory pain relief. Epidural steroid injections (ESIs) are commonly used as a therapeutic intervention in these patients. In this study, we aimed to determine if there are variables that predict the ef...

journal_title：Journal of pain research

authors： Ghanavatian S,Wie CS,Low RS,Butterfield RJ,Zhang N,Dhaliwal GS,Montoya JM,Swanson DL

更新日期：2019-04-23 00:00:00

abstract：Background:Central post-stroke pain (CPSP) is refractory to pharmacotherapy (eg, NSAIDs, opioids, antidepressants, and anticonvulsants), and may require transcranial or deep brain stimulation. Case Presentation:A 67-year-old woman presented with severe paroxysmal cramp-like pain on the right side, including the head a...

journal_title：Journal of pain research

authors： Liu Q,Zhong Q,Tang G,Ye L

更新日期：2020-02-26 00:00:00

abstract：Background:Many aspects of study conduct impact the observed effect size of treatment. Data were utilized from a recently published meta-analysis of randomized, double-blind, placebo-controlled, clinical trials performed for the United States Food and Drug Administration (FDA) approval of full mu-agonist opioids for th...

journal_title：Journal of pain research

authors： Meske DS,Vaughn BJ,Kopecky EA,Katz N

更新日期：2019-11-20 00:00:00

abstract：:Patients with chronic non-malignant pain report impairments of physical, social, and psychological well-being. The goal of pain management should include reducing pain and improving quality of life. Patients with chronic pain require medications that are able to provide adequate pain relief, have minimum dosing interv...

journal_title：Journal of pain research

authors： Kizilbash A,Ngô-Minh CT

更新日期：2014-03-24 00:00:00

abstract：BACKGROUND:Diagnosis of fibromyalgia (FM), a chronic musculoskeletal condition characterized by widespread pain and a constellation of symptoms, remains challenging and is often delayed. METHODS:Random forest modeling of electronic medical records was used to identify variables that may facilitate earlier FM identific...

journal_title：Journal of pain research

authors： Emir B,Masters ET,Mardekian J,Clair A,Kuhn M,Silverman SL

更新日期：2015-06-10 00:00:00

abstract：Background:Thoracoscopic surgery (TS) has been performed as a minimally invasive procedure since the beginning of the 1990s. This has led to a dramatic change in the postoperative condition of these patients, facilitating early ambulation and easier management of postoperative pain. However, empirical evidence on posto...

journal_title：Journal of pain research

authors： Kuroda H,Mizuno H,Dejima H,Watanabe K,Yoshida T,Naito Y,Sakao Y

更新日期：2017-11-15 00:00:00

abstract：Purpose:Gabapentinoids are currently the mainstay of pharmacological treatments for patients with neuropathic pain. Little is known about the effects of this therapy on the integrity of neuronal networks, especially in patients with an already-damaged nervous system. Since gabapentinoids can worsen cognitive functions ...

journal_title：Journal of pain research

authors： Baldewig M,Goldbaum O,Richter-Landsberg C,Weyland A,Bantel C

更新日期：2018-06-20 00:00:00

abstract：:Objectives: To classify patients suffering from low back pain (LBP) into two different groups - patients with lumbar disc herniation (LDH) and patients without this disease based on simple questions and without magnetic resonance imaging (MRI) procedure - and to diagnose the most effective risk factors of LDH. Methods...

journal_title：Journal of pain research

authors： Jafari S,Dehesh T,Iranmanesh F

更新日期：2019-04-15 00:00:00

abstract：Purpose:To explore the role of cervical sagittal alignment in the occurrence of adjacent-level ossification development (ALOD) in patients who underwent anterior cervical discectomy fusion with self-locking stand-alone polyetheretherketone cage, and the relationship between cervical sagittal alignment and clinical outc...

journal_title：Journal of pain research

authors： Liu W,Rong Y,Chen J,Luo Y,Tang P,Zhou Z,Fan J,Cai W

更新日期：2018-07-20 00:00:00

abstract：:Pain is the most common reason people visit emergency rooms. Pain does not discriminate on the basis of gender, race or age. The state of pain management in the emergency department (ED) is disturbing. ED physicians often do not provide adequate analgesia to their patients, do not meet patients' expectations in treati...

journal_title：Journal of pain research

authors： Motov SM,Khan AN

更新日期：2008-12-09 00:00:00

abstract：:Background: Chronic neuropathic pain (NP) is a complex disease that results from damage or presumed damage to the somatosensory nervous system. Current treatment regimens are often ineffective. The major impediment in developing effective treatments is our limited understanding of the underlying mechanisms. Preclinica...

journal_title：Journal of pain research

authors： Alshelh Z,Mills EP,Kosanovic D,Di Pietro F,Macey PM,Vickers ER,Henderson LA

更新日期：2019-08-02 00:00:00

abstract：Background:Transient receptor potential ankyrin 1 (TRPA1) is a non-selective cation channel expressed by a subset of nociceptive neurons that acts as a multimodal receptor. Its activity contributes to modulate nociceptive transmission in acute inflammatory pain. However, the role of this channel in chronic pain has bee...

journal_title：Journal of pain research

authors： Martínez-Rojas VA,García G,Noriega-Navarro R,Guzmán-Priego CG,Torres-López JE,Granados-Soto V,Murbartián J

更新日期：2017-12-27 00:00:00

abstract：BACKGROUND:The purpose of this study was to assess the attitudes of maternal health care providers to pain relief during labor in Zaria, Nigeria. METHODS:This was a multicenter, collaborative, cross-sectional pilot study of provider perspectives concerning pain relief during labor. A structured, self-administered, que...

journal_title：Journal of pain research

authors： Ogboli-Nwasor E,Adaji S,Bature S,Shittu O

更新日期：2011-01-01 00:00:00

abstract：Background:Millions of people worldwide are suffering from pain. Non-pharmacological therapy has an important role in the treatment of pain and is recognized as a valuable, simple help to lower the dosage of analgesic drugs needed, decreasing the side effects, reducing drug dependency and reducing health care costs; ho...

journal_title：Journal of pain research

authors： Jira L,Weyessa N,Mulatu S,Alemayehu A

更新日期：2020-11-16 00:00:00

abstract：Background:Pain is a common and undertreated non-motor symptom in patients with Parkinson's disease (PD). Opioids have been seldom used in PD because they could worsen cognitive and motor functions. Objective:We aimed to assess efficacy and tolerability of tapentadol in PD patients. Methods:We retrospectively reviewe...

journal_title：Journal of pain research

authors： Freo U,Furnari M,Ori C

更新日期：2018-09-13 00:00:00

abstract：Purpose:Exercise-induced hypoalgesia (EIH) is the short-term reduction of pain sensitivity after a single bout of exercise. Descending pain inhibition has been proposed to at least partly underlie EIH. Cognitive inhibition is the ability to inhibit a pre-potent response and has in turn been associated with descending p...

journal_title：Journal of pain research

authors： Gajsar H,Titze C,Konietzny K,Meyer M,Vaegter HB,Hasenbring MI

更新日期：2020-04-29 00:00:00

abstract：:Livedoid vasculopathy (LV) is a chronic prothrombotic disease of cutaneous micro-circulation resulting in cutaneous ischemia and infarction. As a rare disease, LV has an estimated incidence of ten cases per million. Not only correct diagnosis but also effective treatments are very difficult for patients with LV. Due t...

journal_title：Journal of pain research

authors： Chen W,Fan L,Wang Y,Deng X

更新日期：2017-03-17 00:00:00

abstract：:Mechanisms of postherpetic neuralgia (PHN) are still not clear. Transcripts such as microRNA (miRNA) and circular RNA (circRNA) in the affected skin may take part in the initiation and development of this neuropathic pain; however, their expression profiles in skins of PHN patients have not been reported. The PHN affe...

journal_title：Journal of pain research

authors： Cao S,Zhang D,Yuan J,Liu C,Zhou W,Zhang L,Yu S,Qin B,Li Y,Deng W

更新日期：2019-10-16 00:00:00

abstract：OBJECTIVE:Chronic pelvic pain (CPP) is widely acknowledged as a common problem with significant consequences for those diagnosed with this condition. There is a lack of studies with good sample size that provide a comprehensive psychological profile of women presenting to specialist chronic pain clinics. Therefore, the...

journal_title：Journal of pain research

authors： Bryant C,Cockburn R,Plante AF,Chia A

更新日期：2016-11-16 00:00:00

abstract：Background:G protein-gated inwardly rectifying potassium (GIRK) channels are involved in the regulation of neuronal excitability. Four GIRK subunits (GIRK1-4) are expressed in rat dorsal root ganglia (DRGs). Recently, we have characterized the expression of GIRK1 and -2, and both are downregulated in rat DRGs and spina...

journal_title：Journal of pain research

authors： Lyu C,Lyu GW,Mulder J,Martinez A,Shi TS

更新日期：2020-02-17 00:00:00

abstract：:Cervical intervertebral disc has long been considered a common source of neck pain. However, the pain caused by the disc itself has not been clearly defined so far, and its diagnosis and treatment has always been controversial. Degenerative cervical disc has a rich supply of nerve fibers, is prone to inflammatory reac...

journal_title：Journal of pain research

authors： Peng B,DePalma MJ

更新日期：2018-11-14 00:00:00

abstract：OBJECTIVE:To evaluate the safety and efficacy of ketoprofen in Transfersome® gel (IDEA-033) in comparison with a ketoprofen-free vehicle (TDT 064) for the treatment of osteoarthritis (OA) of the knee. METHODS:Patients with knee OA (N = 866) were randomly assigned to receive topical IDEA-033 containing 100, 50, or 25 m...

journal_title：Journal of pain research

authors： Kneer W,Rother M,Mazgareanu S,Seidel EJ,European IDEA-033 study group.

更新日期：2013-10-25 00:00:00

abstract：Purpose:Despite the rise in opioid-related hospitalizations, there has been little research regarding opioid-related healthcare utilization. The objective of this study was to estimate the mean adjusted hospital costs, payments, and length of stay (LOS) for opioid-related visits for the nation and each of the nine US c...

journal_title：Journal of pain research

authors： Mallow PJ,Belk KW,Topmiller M,Strassels SA

更新日期：2018-12-04 00:00:00

abstract：:Pain is considered a multidimensional conscious experience that includes a sensory component and a negative affective-motivational component. The negative affective-motivational component of pain is different from the sensory component and amplifies the pain experience. Nowadays, a significant number of preclinical re...

journal_title：Journal of pain research

authors： Wu Y,Yao X,Jiang Y,He X,Shao X,Du J,Shen Z,He Q,Fang J

更新日期：2017-11-06 00:00:00

abstract：OBJECTIVE:The aim of this study was to compare the efficacy of percutaneous vertebroplasty (PVP) and interventional tumor removal (ITR), with PVP alone for malignant vertebral compression fractures and/or spinal metastatic tumor with epidural involvement. PATIENTS AND METHODS:A total of 124 patients were selected for ...

journal_title：Journal of pain research

authors： Gu YF,Tian QH,Li YD,Wu CG,Su Y,Song HM,He CJ,Chen D

更新日期：2017-01-20 00:00:00

abstract：PURPOSE:Conditioned pain modulation (CPM) is an experimental approach for probing endogenous analgesia by which one painful stimulus (the conditioning stimulus) may inhibit the perceived pain of a subsequent stimulus (the test stimulus). Animal studies suggest that CPM is mediated by a spino-bulbo-spinal loop using obj...

journal_title：Journal of pain research

authors： Bernaba M,Johnson KA,Kong JT,Mackey S

更新日期：2014-11-26 00:00:00