Abstract：
PURPOSE:Conditioned pain modulation (CPM) is an experimental approach for probing endogenous analgesia by which one painful stimulus (the conditioning stimulus) may inhibit the perceived pain of a subsequent stimulus (the test stimulus). Animal studies suggest that CPM is mediated by a spino-bulbo-spinal loop using objective measures such as neuronal firing. In humans, pain ratings are often used as the end point. Because pain self-reports are subject to cognitive influences, we tested whether cognitive factors would impact on CPM results in healthy humans. METHODS:We conducted a within-subject, crossover study of healthy adults to determine the extent to which CPM is affected by 1) threatening and reassuring evaluation and 2) imagery alone of a cold conditioning stimulus. We used a heat stimulus individualized to 5/10 on a visual analog scale as the testing stimulus and computed the magnitude of CPM by subtracting the postconditioning rating from the baseline pain rating of the heat stimulus. RESULTS:We found that although evaluation can increase the pain rating of the conditioning stimulus, it did not significantly alter the magnitude of CPM. We also found that imagery of cold pain alone did not result in statistically significant CPM effect. CONCLUSION:Our results suggest that CPM is primarily dependent on sensory input, and that the cortical processes of evaluation and imagery have little impact on CPM. These findings lend support for CPM as a useful tool for probing endogenous analgesia through subcortical mechanisms.
journal_name
J Pain Resjournal_title
Journal of pain researchauthors
Bernaba M,Johnson KA,Kong JT,Mackey Sdoi
10.2147/JPR.S65607subject
Has Abstractpub_date
2014-11-26 00:00:00pages
689-97issn
1178-7090pii
jpr-7-689journal_volume
7pub_type
杂志文章abstract：Background:Suspecting carpal tunnel syndrome (CTS) in patients with hand pain is usual. Considering the variable rate of false-negative results in nerve conduction study (NCS), as a frequent reference confirmatory standard test, we aimed to evaluate the diagnostic accuracy of neuromuscular ultrasound in patients with c...
journal_title：Journal of pain research
pub_type： 杂志文章
doi：10.2147/JPR.S164004
更新日期：2018-07-10 00:00:00
abstract：:Recently, attention to the lifestyle of patients has been rapidly increasing in the field of pain therapy, particularly with regard to the role of nutrition in pain development and its management. In this review, we summarize the latest findings on the role of nutrition and nutraceuticals, microbiome, obesity, soy, om...
journal_title：Journal of pain research
pub_type： 杂志文章,评审
doi：10.2147/JPR.S115068
更新日期：2016-12-08 00:00:00
abstract：Background:Millions of people worldwide are suffering from pain. Non-pharmacological therapy has an important role in the treatment of pain and is recognized as a valuable, simple help to lower the dosage of analgesic drugs needed, decreasing the side effects, reducing drug dependency and reducing health care costs; ho...
journal_title：Journal of pain research
pub_type： 杂志文章
doi：10.2147/JPR.S265544
更新日期：2020-11-16 00:00:00
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journal_title：Journal of pain research
pub_type： 杂志文章
doi：10.2147/JPR.S53437
更新日期：2013-11-07 00:00:00
abstract：Introduction:Cannabidiol (CBD) is reported to produce pain relief, but the clinically relevant cellular and molecular mechanisms remain uncertain. The TRPV1 receptor integrates noxious stimuli and plays a key role in pain signaling. Hence, we conducted in vitro studies, to elucidate the efficacy and mechanisms of CBD f...
journal_title：Journal of pain research
pub_type： 杂志文章
doi：10.2147/JPR.S258433
更新日期：2020-09-11 00:00:00
abstract：Objective:Chronic pain is a highly prevalent and costly condition with few proven treatment options. Since 2014, Geisinger's Department of Pain Medicine has implemented the Multidisciplinary Pain Program (MPP), which consists of a 3-day educational seminar followed by 12 months of comprehensive care. This study examine...
journal_title：Journal of pain research
pub_type： 杂志文章
doi：10.2147/JPR.S177231
更新日期：2018-10-18 00:00:00
abstract：Background:The objective of this study was to compare the efficacy of calcitonin with diclofenac sodium in the treatment of patients with nonspecific low back pain (LBP) and type I Modic changes (MC1). Patients and methods:The study was a retrospective observational study with 109 patients who had nonspecific LBP and ...
journal_title：Journal of pain research
pub_type： 杂志文章
doi：10.2147/JPR.S158718
更新日期：2018-07-17 00:00:00
abstract：OBJECTIVE:The generic STarT Back 5-item screening tool (STarT-G) is used to manage chronic pain in the lower back and elsewhere. This study evaluated the validity of the Japanese version of this generic screening tool. MATERIALS AND METHODS:Japanese participants between the ages of 20 and 64 years completed online sur...
journal_title：Journal of pain research
pub_type： 杂志文章
doi：10.2147/JPR.S129585
更新日期：2017-02-24 00:00:00
abstract：OBJECTIVE:To evaluate the safety and efficacy of ketoprofen in Transfersome® gel (IDEA-033) in comparison with a ketoprofen-free vehicle (TDT 064) for the treatment of osteoarthritis (OA) of the knee. METHODS:Patients with knee OA (N = 866) were randomly assigned to receive topical IDEA-033 containing 100, 50, or 25 m...
journal_title：Journal of pain research
pub_type： 杂志文章
doi：10.2147/JPR.S51054
更新日期：2013-10-25 00:00:00
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journal_title：Journal of pain research
pub_type： 杂志文章
doi：10.2147/JPR.S199950
更新日期：2019-07-16 00:00:00
abstract：:Advances in intrathecal analgesia and intrathecal drug delivery systems have allowed for a range of medications to be used in the control of pain and spasticity. This technique allows for reduced medication doses that can decrease the side effects typically associated with oral or parenteral drug delivery. Recent expe...
journal_title：Journal of pain research
pub_type： 杂志文章,评审
doi：10.2147/JPR.S37591
更新日期：2014-11-06 00:00:00
abstract：:It is broadly accepted that children of all age groups including (preterm) neonates and young infants can perceive pain and that there is an absolute need to treat their pain safely and effectively. The approved treatment options for children, particularly (preterm) neonates and young infants, are very limited with on...
journal_title：Journal of pain research
pub_type： 杂志文章
doi：10.2147/JPR.S195788
更新日期：2019-05-23 00:00:00
abstract：:Patients with chronic non-malignant pain report impairments of physical, social, and psychological well-being. The goal of pain management should include reducing pain and improving quality of life. Patients with chronic pain require medications that are able to provide adequate pain relief, have minimum dosing interv...
journal_title：Journal of pain research
pub_type： 杂志文章,评审
doi：10.2147/JPR.S49502
更新日期：2014-03-24 00:00:00
abstract：BACKGROUND:Waiting list management at chronic pain clinics has become a serious problem throughout Canada. We analyzed the waiting list at the Centre hospitalier de l'Université de Montréal (CHUM) Pain Centre. METHODS:The present study is an observational, prospective study. We used a specifically designed survey ques...
journal_title：Journal of pain research
pub_type： 杂志文章
doi：10.2147/JPR.S46118
更新日期：2013-07-08 00:00:00
abstract：:Purpose: It has been reported that neck pain is more prevalent in episodic migraineurs (EM) than in the general population. Subjects with episodic migraine exhibited widespread hypersensitivity in cranio-cervical region. Our objectives were to explore the potential factors associated with the presence of neck pain for...
journal_title：Journal of pain research
pub_type： 杂志文章
doi：10.2147/JPR.S200606
更新日期：2019-05-20 00:00:00
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journal_title：Journal of pain research
pub_type： 杂志文章
doi：10.2147/JPR.S115065
更新日期：2016-11-16 00:00:00
abstract：OBJECTIVES:To determine whether X-ray, computed tomography (CT), bone scan, and clinical impression accurately reflect the level of vertebral fracture in patients about to undergo vertebroplasty. DESIGN:Retrospective observational study, utilizing patient inpatient notes, referral correspondence, and clinicians' priva...
journal_title：Journal of pain research
pub_type： 杂志文章
doi：10.2147/JPR.S32151
更新日期：2013-05-10 00:00:00
abstract：Purpose:Brachial plexopathy can sometimes cause severe chronic pain. There are many possible treatments for such neuropathic pain, including neuromodulation. However, rigorous scientific evidence on the usefulness of spinal cord stimulation (SCS) is still scarce. Here, we report the use of high-frequency (10 kHz) SCS (...
journal_title：Journal of pain research
pub_type：
doi：10.2147/JPR.S168031
更新日期：2018-11-27 00:00:00
abstract：Objective:To describe the rate and demographics of pain among Vietnamese people in 48 provinces and describe the impact of pain on individuals, levels of satisfaction with treatment results, and behavior of pain sufferers. Methods:The cross-sectional study was conducted in adults presenting to outpatient clinics throu...
journal_title：Journal of pain research
pub_type： 杂志文章
doi：10.2147/JPR.S184713
更新日期：2019-02-25 00:00:00
abstract：Purpose:This study aimed to review and pool the current literature on intra-articular ozone injection in knee osteoarthritis (OA) patients. Methods:A systematic review of three big databases was performed to identify all English-language randomized clinical trials (RCTs) that evaluated the efficacy of intra-articular ...
journal_title：Journal of pain research
pub_type： 杂志文章,评审
doi：10.2147/JPR.S175441
更新日期：2018-10-25 00:00:00
abstract：Background:Femoral nerve block (FNB) has been considered as an excellent analgesic modality in total knee arthroplasty (TKA) pain control. However, relatively high concentration of ropivacaine could lead to quadriceps muscle weakness and increase the risk of postoperative falls. Objective:This double-blinded randomize...
journal_title：Journal of pain research
pub_type： 杂志文章
doi：10.2147/JPR.S217283
更新日期：2019-12-17 00:00:00
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journal_title：Journal of pain research
pub_type： 杂志文章
doi：10.2147/JPR.S208082
更新日期：2019-09-04 00:00:00
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journal_title：Journal of pain research
pub_type： 杂志文章
doi：10.2147/JPR.S122861
更新日期：2017-01-25 00:00:00
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journal_title：Journal of pain research
pub_type： 杂志文章
doi：10.2147/JPR.S186659
更新日期：2019-01-14 00:00:00
abstract：Objective:To report a rare case of spontaneous fusion (SF) following cervical disc arthroplasty (CDA), to review the related literature, and to propose a new measure to prevent it. Methods:The course of a patient with SF is described here. The potential causes, risk factors, and preventive measure of SF after CDA publ...
journal_title：Journal of pain research
pub_type：
doi：10.2147/JPR.S242646
更新日期：2020-04-21 00:00:00
abstract：Purpose:Post-herpetic neuralgia (PHN) is a common herpes zoster (HZ) complication, where pain persists 90 days after the initial HZ diagnosis. Evaluating PHN risk is essential for determining the burden on patients and health-care systems, but research shows variable estimates. The extent to which these differences are...
journal_title：Journal of pain research
pub_type： 杂志文章
doi：10.2147/JPR.S255238
更新日期：2020-07-13 00:00:00
abstract：BACKGROUND:The purpose of this study was to assess the attitudes of maternal health care providers to pain relief during labor in Zaria, Nigeria. METHODS:This was a multicenter, collaborative, cross-sectional pilot study of provider perspectives concerning pain relief during labor. A structured, self-administered, que...
journal_title：Journal of pain research
pub_type： 杂志文章
doi：10.2147/JPR.S21085
更新日期：2011-01-01 00:00:00
abstract：Purpose:Despite the rise in opioid-related hospitalizations, there has been little research regarding opioid-related healthcare utilization. The objective of this study was to estimate the mean adjusted hospital costs, payments, and length of stay (LOS) for opioid-related visits for the nation and each of the nine US c...
journal_title：Journal of pain research
pub_type： 杂志文章
doi：10.2147/JPR.S184724
更新日期：2018-12-04 00:00:00
abstract：:Purpose: Although amiodarone is classified as a Vaughan-Williams class Ⅲ antiarrhythmic drug, it has inhibitory effects on voltage-gated sodium and calcium channels and on β-adrenergic receptors. Given these pharmacological profiles, amiodarone may have analgesic properties. Most patients who are prescribed amiodarone...
journal_title：Journal of pain research
pub_type： 杂志文章
doi：10.2147/JPR.S196480
更新日期：2019-06-06 00:00:00
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journal_title：Journal of pain research
pub_type： 杂志文章
doi：10.2147/JPR.S138850
更新日期：2017-10-16 00:00:00
