Pain aversion and anxiety-like behavior occur at different times during the course of chronic inflammatory pain in rats.

abstract：:Multisite pain, or pain that occurs simultaneously at >1 anatomical site, is more prevalent than single-site pain. While multisite pain affects over half of older adults, it remains an understudied pain entity that may have important functional implications in an aging population. Greater understanding of this complex...

journal_title：Journal of pain research

authors： Butera KA,Roff SR,Buford TW,Cruz-Almeida Y

更新日期：2019-03-29 00:00:00

abstract：:The observation of pain in others may enhance or reduce self-pain, yet the boundary conditions and factors that determine the direction of such effects are poorly understood. The current study set out to show that visual stimulus awareness plays a crucial role in determining whether vicarious pain primarily activates ...

journal_title：Journal of pain research

authors： Terrighena EL,Lu G,Yuen WP,Lee TM,Keuper K

更新日期：2017-07-31 00:00:00

abstract：:Calcitonin gene-related peptide (CGRP) is a major player in migraine pathophysiology, and CGRP monoclonal antibodies including fremanezumab may be a safe effective preventive therapy. Phase IIb studies in episodic migraine (EM) and chronic migraine (CM) demonstrated efficacy at both the monthly 225 mg and quarterly 67...

journal_title：Journal of pain research

authors： Robblee J,VanderPluym J

更新日期：2019-08-22 00:00:00

abstract：Purpose:Post-herpetic neuralgia (PHN) is a common herpes zoster (HZ) complication, where pain persists 90 days after the initial HZ diagnosis. Evaluating PHN risk is essential for determining the burden on patients and health-care systems, but research shows variable estimates. The extent to which these differences are...

journal_title：Journal of pain research

authors： Tanenbaum HC,Lawless A,Sy LS,Hong V,Ackerson B,Bruxvoort K,Luo Y,Tseng HF

更新日期：2020-07-13 00:00:00

abstract：:Generalized joint hypermobility (GJH) is highly prevalent among patients diagnosed with chronic pain. When GJH is accompanied by pain in ≥4 joints over a period ≥3 months in the absence of other conditions that cause chronic pain, the hypermobility syndrome (HMS) may be diagnosed. In addition, GJH is also a clinical s...

journal_title：Journal of pain research

authors： Scheper MC,de Vries JE,Verbunt J,Engelbert RH

更新日期：2015-08-20 00:00:00

abstract：:Livedoid vasculopathy (LV) is a chronic prothrombotic disease of cutaneous micro-circulation resulting in cutaneous ischemia and infarction. As a rare disease, LV has an estimated incidence of ten cases per million. Not only correct diagnosis but also effective treatments are very difficult for patients with LV. Due t...

journal_title：Journal of pain research

authors： Chen W,Fan L,Wang Y,Deng X

更新日期：2017-03-17 00:00:00

abstract：Background:Acupotomy, which involves the addition of a scalpel function to the conventional acupuncture treatment, has recently been applied as a conservative treatment method for lumbar disc herniation (LDH). This study investigated the effectiveness and safety of acupotomy, compared to manual acupuncture, for the tre...

journal_title：Journal of pain research

authors： Jeong JK,Kim E,Yoon KS,Jeon JH,Kim YI,Lee H,Kwon O,Jung SY,Lee JH,Yang C,Kang JH,Han CH

更新日期：2020-04-01 00:00:00

abstract：Objective:To report a rare case of spontaneous fusion (SF) following cervical disc arthroplasty (CDA), to review the related literature, and to propose a new measure to prevent it. Methods:The course of a patient with SF is described here. The potential causes, risk factors, and preventive measure of SF after CDA publ...

journal_title：Journal of pain research

authors： Ge CY,Wang J,Zhang BF,Hui H,Shan LQ,Zhao QP,Hao DJ

更新日期：2020-04-21 00:00:00

abstract：Background:Transversus abdominis plane (TAP) block can provide effective analgesia for abdominal surgery. However, many randomized controlled trials (RCTs) have shown controversial results in hysterectomy. We conducted a meta-analysis of RCTs to investigate the effectiveness of TAP block after hysterectomy. Methods:St...

journal_title：Journal of pain research

authors： Zhou H,Ma X,Pan J,Shuai H,Liu S,Luo X,Li R

更新日期：2018-10-18 00:00:00

abstract：OBJECTIVES:To determine whether X-ray, computed tomography (CT), bone scan, and clinical impression accurately reflect the level of vertebral fracture in patients about to undergo vertebroplasty. DESIGN:Retrospective observational study, utilizing patient inpatient notes, referral correspondence, and clinicians' priva...

journal_title：Journal of pain research

authors： Graziotti PJ,Graziotti CR,Sangster AM

更新日期：2013-05-10 00:00:00

abstract：Background:The objective of this study was to compare the efficacy of calcitonin with diclofenac sodium in the treatment of patients with nonspecific low back pain (LBP) and type I Modic changes (MC1). Patients and methods:The study was a retrospective observational study with 109 patients who had nonspecific LBP and ...

journal_title：Journal of pain research

authors： Zhou J,Li T,Li L,Xue Y

更新日期：2018-07-17 00:00:00

abstract：Background:The prevalence of neuropathic pain (NeP) has been estimated within specific health conditions; however, there are no published data on its broad prevalence in the US. The current exploratory study addresses this gap using the validated PainDetect questionnaire as a screener for probable NeP in a general-popu...

journal_title：Journal of pain research

authors： DiBonaventura MD,Sadosky A,Concialdi K,Hopps M,Kudel I,Parsons B,Cappelleri JC,Hlavacek P,Alexander AH,Stacey BR,Markman JD,Farrar JT

更新日期：2017-11-01 00:00:00

abstract：:Advances in intrathecal analgesia and intrathecal drug delivery systems have allowed for a range of medications to be used in the control of pain and spasticity. This technique allows for reduced medication doses that can decrease the side effects typically associated with oral or parenteral drug delivery. Recent expe...

journal_title：Journal of pain research

authors： Bottros MM,Christo PJ

更新日期：2014-11-06 00:00:00

abstract：Background:Pain is a common and undertreated non-motor symptom in patients with Parkinson's disease (PD). Opioids have been seldom used in PD because they could worsen cognitive and motor functions. Objective:We aimed to assess efficacy and tolerability of tapentadol in PD patients. Methods:We retrospectively reviewe...

journal_title：Journal of pain research

authors： Freo U,Furnari M,Ori C

更新日期：2018-09-13 00:00:00

abstract：:Cancer and cancer treatment-related chronic pain affect a significant number of patients. The etiology of this pain is diverse and may include nociceptive and/or neuropathic characteristics. Treatment is often multifactorial and may require advanced interventional techniques, such as spinal cord stimulation (SCS). Thi...

journal_title：Journal of pain research

authors： Hagedorn JM,Pittelkow TP,Hunt CL,D'Souza RS,Lamer TJ

更新日期：2020-12-07 00:00:00

abstract：Purpose:Despite the rise in opioid-related hospitalizations, there has been little research regarding opioid-related healthcare utilization. The objective of this study was to estimate the mean adjusted hospital costs, payments, and length of stay (LOS) for opioid-related visits for the nation and each of the nine US c...

journal_title：Journal of pain research

authors： Mallow PJ,Belk KW,Topmiller M,Strassels SA

更新日期：2018-12-04 00:00:00

abstract：:Duloxetine is a serotonin-norepinephrine reuptake inhibitor approved by the US Food and Drug Administration for the treatment of fibromyalgia and painful diabetic neuropathy at doses of 60 mg daily. Duloxetine has been shown to significantly improve the symptoms of chronic pain associated with these disorders, as meas...

journal_title：Journal of pain research

authors： Wright A,Luedtke KE,Vandenberg C

更新日期：2010-12-16 00:00:00

abstract：Purpose:Primary dysmenorrhea (PD; menstrual pain without an identified organic cause) has been proposed as a possible risk factor for the development of chronic pelvic pain, but the mechanism through which this process occurs is unknown. One possible mechanism is central sensitization - alterations in the central nervo...

journal_title：Journal of pain research

authors： Seidman LC,Temme CR,Zeltzer LK,Rapkin AJ,Naliboff BD,Payne LA

更新日期：2020-12-22 00:00:00

abstract：Background:Neuroplastic changes in nociceptive pathways contribute to severity of symptoms in knee osteoarthritis (KOA). A new look at neuroplastic changes management includes modulation of the primary motor cortex by transcranial direct current stimulation (tDCS). Objectives:We investigated whether tDCS combined with...

journal_title：Journal of pain research

authors： da Graca-Tarragó M,Lech M,Angoleri LDM,Santos DS,Deitos A,Brietzke AP,Torres IL,Fregni F,Caumo W

更新日期：2019-01-03 00:00:00

abstract：Background:Although the Eph receptor plays an important role in the development of neuropathic pain following nerve injury, there has been no evidence of the participation of the ephrin A4 receptor (EphA4) in the development of trigeminal neuropathic pain. The present study investigated the role of EphA4 in central noc...

journal_title：Journal of pain research

authors： Kim MJ,Son JY,Ju JS,Ahn DK

更新日期：2020-05-22 00:00:00

abstract：Objective:To examine the influence of anxiety and pain-related catastrophizing on the time course of acute interleukin-6 (IL-6) responses to standardized noxious stimulation among patients with chronic pain. Methods:Data were collected from 48 participants in the following demographically matched groups: patients with...

journal_title：Journal of pain research

authors： Lazaridou A,Martel MO,Cahalan CM,Cornelius MC,Franceschelli O,Campbell CM,Haythornthwaite JA,Smith M,Riley J,Edwards RR

更新日期：2018-03-28 00:00:00

abstract：OBJECTIVE:Patients with chronic fatigue syndrome (CFS) complain of long-lasting fatigue and pain which are not relieved by rest and worsened by physical exertion. Previous research has implicated metaboreceptors of muscles to play an important role for chronic fatigue and pain. Therefore, we hypothesized that blocking ...

journal_title：Journal of pain research

authors： Staud R,Kizer T,Robinson ME

更新日期：2017-06-26 00:00:00

abstract：INTRODUCTION:Heat/capsaicin skin sensitization is a well-characterized human experimental model to induce hyperalgesia and allodynia. Using this model, gabapentin, among other drugs, was shown to significantly reduce cutaneous hyperalgesia compared to placebo. Since the larger thermal probes used in the original studie...

journal_title：Journal of pain research

authors： Cavallone LF,Frey K,Montana MC,Joyal J,Regina KJ,Petersen KL,Gereau RW 4th

更新日期：2013-11-07 00:00:00

abstract：BACKGROUND:Very few studies have discussed transforaminal endoscopic discectomy (TED) in the treatment of common peroneal nerve paralysis induced by lumbar disk herniation (LDH). This study aimed to evaluate the efficacy of TED in the treatment of LDH combined with common peroneal nerve paralysis. MATERIALS AND METHOD...

journal_title：Journal of pain research

authors： Wang YP,Zhang W,Zhang J,Sun YP,An JL,Ding WY

更新日期：2017-01-05 00:00:00

abstract：Background:Transient receptor potential ankyrin 1 (TRPA1) is a non-selective cation channel expressed by a subset of nociceptive neurons that acts as a multimodal receptor. Its activity contributes to modulate nociceptive transmission in acute inflammatory pain. However, the role of this channel in chronic pain has bee...

journal_title：Journal of pain research

authors： Martínez-Rojas VA,García G,Noriega-Navarro R,Guzmán-Priego CG,Torres-López JE,Granados-Soto V,Murbartián J

更新日期：2017-12-27 00:00:00

abstract：:The objective of this study was to evaluate the relationship between magnetic resonance imaging (MRI) findings and previous low back pain (LBP) in participants without current LBP. Current LBP was defined as LBP during the past month. Previous LBP was defined as a history of medical consultation for LBP. Ninety-one pa...

journal_title：Journal of pain research

authors： Tonosu J,Oka H,Matsudaira K,Higashikawa A,Okazaki H,Tanaka S

更新日期：2016-12-29 00:00:00

abstract：BACKGROUND/OBJECTIVE:Previous studies have already reported an independent effect of light-load eccentric exercise (10% eccentric exercise contraction [EEC]) and low-level laser therapy (LLLT) as a protective measure against more strenuous eccentric exercise. However, the difference between these two interventions is l...

journal_title：Journal of pain research

authors： Nausheen S,Moiz JA,Raza S,Shareef MY,Anwer S,Alghadir AH

更新日期：2017-09-11 00:00:00

abstract：:Pulsed radiofrequency is an effective, safe, and nondestructive pain treatment technique that has been insufficiently reported in the treatment of supraorbital neuralgia. We report the successful use of pulsed radiofrequency to alleviate acute severe supraorbital neuralgia in a post-craniotomy patient. A 52-year-old f...

journal_title：Journal of pain research

authors： Xiao X,Ren H,Ji N,Luo F

更新日期：2018-08-08 00:00:00

abstract：OBJECTIVE:Patient controlled analgesia (PCA) is commonly used to provide analgesia following surgical procedures in the pediatric population. Morphine and hydromorphone remain the most commonly used opioids for PCA. Although both are effective, adverse effects may occur. When these adverse effects are unremitting or se...

journal_title：Journal of pain research

authors： DiGiusto M,Bhalla T,Martin D,Foerschler D,Jones MJ,Tobias JD

更新日期：2014-08-13 00:00:00

abstract：Background:To date, there has been no study on the effects of interleukin-10 (IL-10) on complex regional pain syndrome (CRPS) rodent models, despite the anti-allodynic effect of IL-10 in previous studies. Thus, the aim of this study was to investigate the effect of IL-10 in a CRPS mouse model and find whether early inh...

journal_title：Journal of pain research

authors： Kim JH,Park JS,Park D

更新日期：2018-09-04 00:00:00