Abstract:
:Livedoid vasculopathy (LV) is a chronic prothrombotic disease of cutaneous micro-circulation resulting in cutaneous ischemia and infarction. As a rare disease, LV has an estimated incidence of ten cases per million. Not only correct diagnosis but also effective treatments are very difficult for patients with LV. Due to the lack of large-scale studies in this rare disease, LV poses a great challenge to the doctors, and existing treatment has always been an individual attempt with off-label application. The main goals in the treatment of patients with LV are to avoid the repeated occurrence of active cutaneous lesions and prevent painful ulceration and irreversible scarring. The current report describes the cases of three Chinese patients with LV receiving rivaroxaban treatment, an oral direct inhibitor of factor Xa inhibitor, and observes the treatment effect of rivaroxaban during the follow-up. As an injection-free alternative to low-molecular-weight heparin (LMWP) and monitoring-free alternative to warfarin, rivaroxaban improves the quality of life and enhances the compliance of patients. All patients consider rivaroxaban as more tolerable than previous drugs and, therefore, continue the application of rivaroxaban, effectively improving the treatment effect of drugs and successfully avoiding the repeated occurrence of active cutaneous lesions. Treatment application of rivaroxaban in Chinese patients with LV successfully avoids the recurrence of active cutaneous lesions and prevents the progressive ulceration and scarring.
journal_name
J Pain Resjournal_title
Journal of pain researchauthors
Chen W,Fan L,Wang Y,Deng Xdoi
10.2147/JPR.S133462subject
Has Abstractpub_date
2017-03-17 00:00:00pages
621-624issn
1178-7090pii
jpr-10-621journal_volume
10pub_type
杂志文章abstract:BACKGROUND:Opioid analgesics are effective for postsurgical pain but are associated with opioid-related adverse events, creating a significant clinical and economic burden. Gastrointestinal surgery patients are at high risk for opioid-related adverse events. We conducted a study to assess the impact of an opioid-sparin...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S46467
更新日期:2013-07-18 00:00:00
abstract:OBJECTIVE:The aim of this study was to compare the efficacy of percutaneous vertebroplasty (PVP) and interventional tumor removal (ITR), with PVP alone for malignant vertebral compression fractures and/or spinal metastatic tumor with epidural involvement. PATIENTS AND METHODS:A total of 124 patients were selected for ...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S122211
更新日期:2017-01-20 00:00:00
abstract:Purpose:Despite the rise in opioid-related hospitalizations, there has been little research regarding opioid-related healthcare utilization. The objective of this study was to estimate the mean adjusted hospital costs, payments, and length of stay (LOS) for opioid-related visits for the nation and each of the nine US c...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S184724
更新日期:2018-12-04 00:00:00
abstract:Purpose:Primary dysmenorrhea (PD; menstrual pain without an identified organic cause) has been proposed as a possible risk factor for the development of chronic pelvic pain, but the mechanism through which this process occurs is unknown. One possible mechanism is central sensitization - alterations in the central nervo...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S283363
更新日期:2020-12-22 00:00:00
abstract::Phantom-limb pain (PLP) belongs among difficult-to-treat chronic pain syndromes. Treatment options for PLP are to a large degree implicated by the level of understanding the mechanisms and nature of PLP. Research and clinical findings acknowledge the neuropathic nature of PLP and also suggest that both peripheral as w...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S16733
更新日期:2012-01-01 00:00:00
abstract:Background:The objective of this study was to compare the clinical and radiological outcomes between patients with or without axial symptoms (AS) and investigate the risk factors associated with AS by multivariate regression analysis in anterior cervical discectomy and fusion (ACDF). Materials and methods:The records ...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S172953
更新日期:2018-10-26 00:00:00
abstract::This open-label, phase 3b study (ClinicalTrials.gov Identifier: NCT00983073) evaluated the effectiveness, and tolerability of tapentadol for severe, chronic osteoarthritis knee pain that was inadequately managed with World Health Organization (WHO) Step I or II analgesics or co-analgesics, or that was not treated with...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S30540
更新日期:2012-01-01 00:00:00
abstract:Introduction:Sickle cell disease (SCD) is an inherited blood disorder characterized by abnormally shaped sickle cells. The hallmark of this disease is intermittent, painful vaso-occlusive episodes (VOE), but a subset of individuals with SCD experience chronic pain. The mechanism of transition to chronic pain is not wel...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S150066
更新日期:2018-02-23 00:00:00
abstract::Generalized joint hypermobility (GJH) is highly prevalent among patients diagnosed with chronic pain. When GJH is accompanied by pain in ≥4 joints over a period ≥3 months in the absence of other conditions that cause chronic pain, the hypermobility syndrome (HMS) may be diagnosed. In addition, GJH is also a clinical s...
journal_title:Journal of pain research
pub_type: 杂志文章,评审
doi:10.2147/JPR.S64251
更新日期:2015-08-20 00:00:00
abstract:BACKGROUND:Diagnosis of fibromyalgia (FM), a chronic musculoskeletal condition characterized by widespread pain and a constellation of symptoms, remains challenging and is often delayed. METHODS:Random forest modeling of electronic medical records was used to identify variables that may facilitate earlier FM identific...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/jpr.s8256
更新日期:2015-06-10 00:00:00
abstract:PURPOSE:The aim of this study was to examine the health and economic burden associated with fibromyalgia among adults in Japan. MATERIALS AND METHODS:Data from the 2011-2014 Japan National Health and Wellness Survey (n=115,271), a nationally representative survey of adults, were analyzed. The greedy matching algorithm...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S110707
更新日期:2016-11-04 00:00:00
abstract::Pain is highly prevalent, but frequently untreated or under-treated, and health care professionals are faced with a range of treatment challenges. Multimodal therapy is recommended and can be achieved using open combinations (ie, concomitant administration) of individual agents, fixed-dose combinations (FDCs), or mult...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S208082
更新日期:2019-09-04 00:00:00
abstract::Duloxetine is a serotonin-norepinephrine reuptake inhibitor approved by the US Food and Drug Administration for the treatment of fibromyalgia and painful diabetic neuropathy at doses of 60 mg daily. Duloxetine has been shown to significantly improve the symptoms of chronic pain associated with these disorders, as meas...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S12866
更新日期:2010-12-16 00:00:00
abstract:Purpose:Dysmenorrhea is a common disorder that substantially disrupts the lives of young women. The frequency of 14 associated symptoms both within and outside the pelvis was determined. Patients and methods:Symptom questionnaires were completed by 168 women with dysmenorrhea, allocated to three groups based on their ...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S179409
更新日期:2018-12-13 00:00:00
abstract:BACKGROUND:Detecting the efficacy of novel analgesic agents in neuropathic pain is challenging. There is a critical need for study designs with the desirable characteristics of assay sensitivity, low placebo response, reliable pain recordings, low cost, short duration of exposure to test drug and placebo, and relevant ...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S34098
更新日期:2012-01-01 00:00:00
abstract::Nocebo hyperalgesia has received sparse experimental attention compared to placebo analgesia. The aim of the present study was to investigate if personality traits and fear of pain could predict experimental nocebo hyperalgesia. One hundred and eleven healthy volunteers (76 females) participated in an experimental stu...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S91923
更新日期:2015-10-12 00:00:00
abstract:Objective:To examine the influence of anxiety and pain-related catastrophizing on the time course of acute interleukin-6 (IL-6) responses to standardized noxious stimulation among patients with chronic pain. Methods:Data were collected from 48 participants in the following demographically matched groups: patients with...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S147735
更新日期:2018-03-28 00:00:00
abstract:BACKGROUND:One form of self-medication is sharing of medications, defined as borrowing or lending medications in situations where the receiver of these drugs is not the individual to whom the medications were allocated. OBJECTIVE:To explore experiences and opinions of patients about sharing prescription analgesics, re...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S123554
更新日期:2017-02-10 00:00:00
abstract:OBJECTIVES:Effective postoperative pain management is crucial in the care of surgical patients. Opioids, which are commonly used in managing postoperative pain, have a potential for tolerance and addiction, along with sedating side effects. Gabapentin's use as a multimodal analgesic regimen to treat neuropathic pain ha...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S112626
更新日期:2016-09-12 00:00:00
abstract:Background:Pain is a common and undertreated non-motor symptom in patients with Parkinson's disease (PD). Opioids have been seldom used in PD because they could worsen cognitive and motor functions. Objective:We aimed to assess efficacy and tolerability of tapentadol in PD patients. Methods:We retrospectively reviewe...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S164939
更新日期:2018-09-13 00:00:00
abstract:Purpose:To examine the trends of analgesic prescribing at public tertiary hospital outpatient settings and explore the patterns of their utilization in nonsteroidal anti-inflammatory drugs (NSAIDs), tramadol, and opioid patients. Patients and methods:This cross-sectional study was conducted from 2010 to 2016 using the...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S164774
更新日期:2018-09-20 00:00:00
abstract:Objectives:Estimate the prevalence of neuropathic pain (NeP) among chronic pain patients attending Brazilian hospitals and pain clinics in São Paulo, Ceara, and Bahia and explore clinical characteristics by subtypes: painful diabetic peripheral neuropathy (pDPN), central neuropathic pain (CNP), chronic low back pain wi...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S160504
更新日期:2019-01-07 00:00:00
abstract::The observation of pain in others may enhance or reduce self-pain, yet the boundary conditions and factors that determine the direction of such effects are poorly understood. The current study set out to show that visual stimulus awareness plays a crucial role in determining whether vicarious pain primarily activates ...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S132744
更新日期:2017-07-31 00:00:00
abstract:BACKGROUND/OBJECTIVE:Previous studies have already reported an independent effect of light-load eccentric exercise (10% eccentric exercise contraction [EEC]) and low-level laser therapy (LLLT) as a protective measure against more strenuous eccentric exercise. However, the difference between these two interventions is l...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S139615
更新日期:2017-09-11 00:00:00
abstract::Low back pain in patients with myofascial pain syndrome is characterized by painful active myofascial trigger points (ATPs) in muscles. This article reviews a novel, noninvasive modality that combines simultaneous imaging and treatment, thus taking advantage of the electrodermal information available from imaged ATPs ...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S47540
更新日期:2013-06-25 00:00:00
abstract:Objective:To describe the rate and demographics of pain among Vietnamese people in 48 provinces and describe the impact of pain on individuals, levels of satisfaction with treatment results, and behavior of pain sufferers. Methods:The cross-sectional study was conducted in adults presenting to outpatient clinics throu...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S184713
更新日期:2019-02-25 00:00:00
abstract::Mechanisms of postherpetic neuralgia (PHN) are still not clear. Transcripts such as microRNA (miRNA) and circular RNA (circRNA) in the affected skin may take part in the initiation and development of this neuropathic pain; however, their expression profiles in skins of PHN patients have not been reported. The PHN affe...
journal_title:Journal of pain research
pub_type:
doi:10.2147/JPR.S221615
更新日期:2019-10-16 00:00:00
abstract::This paper reviews the current clinical data for the role of transdermal buprenorphine (BUP TDS) in the treatment of diverse acute and chronic pain syndromes. Literature searches were carried out using PubMed (1988 to June 2009). The published findings seem to support hypotheses regarding the rather unique analgesic m...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/jpr.s6503
更新日期:2009-09-15 00:00:00
abstract:BACKGROUND:Even though pain is a subjective phenomenon, its objective evaluation in humans is important because subjects requiring pain evaluation may be unable to describe their pain intensity because of decreased awareness or impaired cognitive function. Previous reports indicate that the perfusion index (PI), which ...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S57140
更新日期:2014-02-10 00:00:00
abstract::Rotator-cuff tears (RCTs) are typically associated with chronic pain. The most common treatment for reducing pain is the injection of cortisone into the injury site. An alternative and increasingly used technique is the injection of autologous platelet-rich plasma (PRP). A limitation of cortisone is its pain relief is...
journal_title:Journal of pain research
pub_type:
doi:10.2147/JPR.S169647
更新日期:2018-10-09 00:00:00