Fear of pain potentiates nocebo hyperalgesia.

Abstract:

:Nocebo hyperalgesia has received sparse experimental attention compared to placebo analgesia. The aim of the present study was to investigate if personality traits and fear of pain could predict experimental nocebo hyperalgesia. One hundred and eleven healthy volunteers (76 females) participated in an experimental study in which personality traits and fear of pain were measured prior to induction of thermal heat pain. Personality traits were measured by the Big-Five Inventory-10. Fear of pain was measured by the Fear of Pain Questionnaire III. Heat pain was induced by a PC-controlled thermode. Pain was measured by a computerized visual analog scale. Stress levels during the experiment were measured by numerical rating scales. The participants were randomized to a Nocebo group or to a no-treatment Natural History group. The results revealed that pain and stress levels were significantly higher in the Nocebo group after nocebo treatment. Mediation analysis showed that higher levels of the Fear of Pain Questionnaire III factor "fear of medical pain" significantly increased stress levels after nocebo treatment and that higher stress levels were associated with increased nocebo hyperalgesic responses. There were no significant associations between any of the personality factors and the nocebo hyperalgesic effect. The results from the present study suggest that dispositional fear of pain might be a useful predictor for nocebo hyperalgesia and emotional states concomitant with expectations of increased pain. Furthermore, measurement of traits that are specific to pain experience is probably better suited for prediction of nocebo hyperalgesic responses compared to broad measures of personality.

journal_name

J Pain Res

journal_title

Journal of pain research

authors

Aslaksen PM,Lyby PS

doi

10.2147/JPR.S91923

subject

Has Abstract

pub_date

2015-10-12 00:00:00

pages

703-10

issn

1178-7090

pii

jpr-8-703

journal_volume

8

pub_type

杂志文章
  • Preoperative Modic changes are related to axial symptoms after anterior cervical discectomy and fusion.

    abstract:Background:The objective of this study was to compare the clinical and radiological outcomes between patients with or without axial symptoms (AS) and investigate the risk factors associated with AS by multivariate regression analysis in anterior cervical discectomy and fusion (ACDF). Materials and methods:The records ...

    journal_title:Journal of pain research

    pub_type: 杂志文章

    doi:10.2147/JPR.S172953

    authors: Zhou J,Li L,Li T,Xue Y

    更新日期:2018-10-26 00:00:00

  • Effects of tapentadol on pain, motor symptoms and cognitive functions in Parkinson's disease.

    abstract:Background:Pain is a common and undertreated non-motor symptom in patients with Parkinson's disease (PD). Opioids have been seldom used in PD because they could worsen cognitive and motor functions. Objective:We aimed to assess efficacy and tolerability of tapentadol in PD patients. Methods:We retrospectively reviewe...

    journal_title:Journal of pain research

    pub_type: 杂志文章

    doi:10.2147/JPR.S164939

    authors: Freo U,Furnari M,Ori C

    更新日期:2018-09-13 00:00:00

  • Current and future options for the management of phantom-limb pain.

    abstract::Phantom-limb pain (PLP) belongs among difficult-to-treat chronic pain syndromes. Treatment options for PLP are to a large degree implicated by the level of understanding the mechanisms and nature of PLP. Research and clinical findings acknowledge the neuropathic nature of PLP and also suggest that both peripheral as w...

    journal_title:Journal of pain research

    pub_type: 杂志文章

    doi:10.2147/JPR.S16733

    authors: Knotkova H,Cruciani RA,Tronnier VM,Rasche D

    更新日期:2012-01-01 00:00:00

  • The impact of multisite pain on functional outcomes in older adults: biopsychosocial considerations.

    abstract::Multisite pain, or pain that occurs simultaneously at >1 anatomical site, is more prevalent than single-site pain. While multisite pain affects over half of older adults, it remains an understudied pain entity that may have important functional implications in an aging population. Greater understanding of this complex...

    journal_title:Journal of pain research

    pub_type: 杂志文章,评审

    doi:10.2147/JPR.S192755

    authors: Butera KA,Roff SR,Buford TW,Cruz-Almeida Y

    更新日期:2019-03-29 00:00:00

  • The psychological profile of women presenting to a multidisciplinary clinic for chronic pelvic pain: high levels of psychological dysfunction and implications for practice.

    abstract:OBJECTIVE:Chronic pelvic pain (CPP) is widely acknowledged as a common problem with significant consequences for those diagnosed with this condition. There is a lack of studies with good sample size that provide a comprehensive psychological profile of women presenting to specialist chronic pain clinics. Therefore, the...

    journal_title:Journal of pain research

    pub_type: 杂志文章

    doi:10.2147/JPR.S115065

    authors: Bryant C,Cockburn R,Plante AF,Chia A

    更新日期:2016-11-16 00:00:00

  • Current Perspectives on Spinal Cord Stimulation for the Treatment of Cancer Pain.

    abstract::Cancer and cancer treatment-related chronic pain affect a significant number of patients. The etiology of this pain is diverse and may include nociceptive and/or neuropathic characteristics. Treatment is often multifactorial and may require advanced interventional techniques, such as spinal cord stimulation (SCS). Thi...

    journal_title:Journal of pain research

    pub_type: 杂志文章,评审

    doi:10.2147/JPR.S263857

    authors: Hagedorn JM,Pittelkow TP,Hunt CL,D'Souza RS,Lamer TJ

    更新日期:2020-12-07 00:00:00

  • A comparison between the administration of oral prolonged-release oxycodone-naloxone and transdermal fentanyl in patients with moderate-to-severe cancer pain: a propensity score analysis.

    abstract:BACKGROUND:Opioids are the most important pharmacological treatment for moderate-to-severe cancer pain, but side effects limit their use. Transdermal fentanyl (TDF) and oral prolonged-release oxycodone-naloxone (OXN-PR) are effective in controlling chronic pain, with less constipation compared to other opioids. However...

    journal_title:Journal of pain research

    pub_type: 杂志文章

    doi:10.2147/JPR.S141928

    authors: Roberto A,Greco MT,Legramandi L,Galli F,Galli M,Corli O

    更新日期:2017-09-04 00:00:00

  • Tolerability of NGX-4010, a capsaicin 8% patch, in conjunction with three topical anesthetic formulations for the treatment of neuropathic pain.

    abstract:BACKGROUND:The objective of this study was to assess the safety, tolerability, and preliminary efficacy of NGX-4010, a capsaicin 8% patch, following pretreatment with three different topical anesthetics in patients with peripheral neuropathic pain. METHODS:This open-label, multicenter study enrolled 117 patients with ...

    journal_title:Journal of pain research

    pub_type: 杂志文章

    doi:10.2147/JPR.S25272

    authors: Webster LR,Peppin JF,Murphy FT,Tobias JK,Vanhove GF

    更新日期:2012-01-01 00:00:00

  • Clear differences in cerebrospinal fluid proteome between women with chronic widespread pain and healthy women - a multivariate explorative cross-sectional study.

    abstract:INTRODUCTION:Frequent chronic local pain can develop into chronic widespread pain (CWP). The spread of pain is correlated with pain intensity, anxiety, and depression, conditions that ultimately lead to a poor quality of life. Knowledge is incomplete about CWP's etiology, although it has been suggested that both centra...

    journal_title:Journal of pain research

    pub_type: 杂志文章

    doi:10.2147/JPR.S125667

    authors: Olausson P,Ghafouri B,Bäckryd E,Gerdle B

    更新日期:2017-03-13 00:00:00

  • Intramuscular electrical stimulus potentiates motor cortex modulation effects on pain and descending inhibitory systems in knee osteoarthritis: a randomized, factorial, sham-controlled study.

    abstract:Background:Neuroplastic changes in nociceptive pathways contribute to severity of symptoms in knee osteoarthritis (KOA). A new look at neuroplastic changes management includes modulation of the primary motor cortex by transcranial direct current stimulation (tDCS). Objectives:We investigated whether tDCS combined with...

    journal_title:Journal of pain research

    pub_type: 杂志文章

    doi:10.2147/JPR.S181019

    authors: da Graca-Tarragó M,Lech M,Angoleri LDM,Santos DS,Deitos A,Brietzke AP,Torres IL,Fregni F,Caumo W

    更新日期:2019-01-03 00:00:00

  • Number Of Clinical Trial Study Sites Impacts Observed Treatment Effect Size: An Analysis Of Randomized Controlled Trials Of Opioids For Chronic Pain.

    abstract:Background:Many aspects of study conduct impact the observed effect size of treatment. Data were utilized from a recently published meta-analysis of randomized, double-blind, placebo-controlled, clinical trials performed for the United States Food and Drug Administration (FDA) approval of full mu-agonist opioids for th...

    journal_title:Journal of pain research

    pub_type: 杂志文章

    doi:10.2147/JPR.S201751

    authors: Meske DS,Vaughn BJ,Kopecky EA,Katz N

    更新日期:2019-11-20 00:00:00

  • Gross and fine motor function in fibromyalgia and chronic fatigue syndrome.

    abstract:PURPOSE:This paper aimed to investigate motor proficiency in fine and gross motor function, with a focus on reaction time (RT) and movement skill, in patients with fibromyalgia (FM) and chronic fatigue syndrome (CFS) compared to healthy controls (HC). METHODS:A total of 60 individuals (20 CFS, 20 FM, and 20 HC), age 1...

    journal_title:Journal of pain research

    pub_type: 杂志文章

    doi:10.2147/JPR.S127038

    authors: Rasouli O,Fors EA,Borchgrevink PC,Öhberg F,Stensdotter AK

    更新日期:2017-02-07 00:00:00

  • To what extent are patients with migraine able to predict attacks?

    abstract:Purpose:Premonitory symptoms (PSs) of migraine are those that precede pain in a migraine attack. Previous studies suggest that treatment during this phase may prevent the onset of pain; however, this approach requires that patients be able to recognize their PSs. Our objectives were to evaluate patients' actual ability...

    journal_title:Journal of pain research

    pub_type: 杂志文章

    doi:10.2147/JPR.S175602

    authors: Gago-Veiga AB,Pagán J,Henares K,Heredia P,González-García N,De Orbe MI,Ayala JL,Sobrado M,Vivancos J

    更新日期:2018-09-27 00:00:00

  • Treatment of pain post-brachial plexus injury using high-frequency spinal cord stimulation.

    abstract:Purpose:Brachial plexopathy can sometimes cause severe chronic pain. There are many possible treatments for such neuropathic pain, including neuromodulation. However, rigorous scientific evidence on the usefulness of spinal cord stimulation (SCS) is still scarce. Here, we report the use of high-frequency (10 kHz) SCS (...

    journal_title:Journal of pain research

    pub_type:

    doi:10.2147/JPR.S168031

    authors: Floridia D,Cerra F,Guzzo G,Marino S,Muscarà N,Corallo F,Bramanti A,Chillura A,Naro A

    更新日期:2018-11-27 00:00:00

  • Assessing the reporting quality in randomized controlled trials of acupuncture for postherpetic neuralgia using the CONSORT statement and STRICTA guidelines.

    abstract:Background:This study evaluates the reporting quality of randomized controlled trials (RCTs) on acupuncture use for the treatment of postherpetic neuralgia and explores related factors. Methods:The following six databases PubMed, Embase, Cochrane Library, VIP, CNKI, and SinoMed, were systematically searched from their...

    journal_title:Journal of pain research

    pub_type: 杂志文章

    doi:10.2147/JPR.S210471

    authors: Liu K,Zeng J,Pei W,Chen S,Luo Z,Lu L,Lin G

    更新日期:2019-07-29 00:00:00

  • Diclofenac epolamine topical patch relieves pain associated with ankle sprain.

    abstract:BACKGROUND:Sports-related injuries, such as sprains and strains, commonly occur during exercise and athletic events. Current therapy includes nonsteroidal anti-inflammatory drugs (NSAIDs), which have a high incidence of upper gastrointestinal side effects. The present study assessed the efficacy and safety of the diclo...

    journal_title:Journal of pain research

    pub_type: 杂志文章

    doi:10.2147/JPR.S15380

    authors: Lionberger DR,Joussellin E,Lanzarotti A,Yanchick J,Magelli M

    更新日期:2011-03-07 00:00:00

  • Risk Factors Associated with Postoperative Discomfort After Ambulatory Strabismus Surgery Under General Anesthesia.

    abstract:Purpose:The aim of this study was to evaluate postoperative discomfort in patients undergoing ambulatory strabismus under general anesthesia, and to identify risk factors associated with the discomfort. Patients and Methods:A cross-sectional study was conducted among 210 consecutive patients undergoing ambulatory stra...

    journal_title:Journal of pain research

    pub_type:

    doi:10.2147/JPR.S249493

    authors: Huang J,Lin J,Xiong Y,Wang Z,Zhu Y,Ye H,Guo W

    更新日期:2020-05-05 00:00:00

  • Spinal N-Cadherin/CREB Signaling Contributes to Chronic Alcohol Consumption-Enhanced Postsurgical Pain.

    abstract:Background:It has been reported that N-cadherin and cAMP response element binding protein (CREB) in the spinal cord are critical for synaptogenesis and regulation of excitatory synapse function, which could underlie chronic pain development. The aim of the present study was to investigate the role of spinal N-cadherin/...

    journal_title:Journal of pain research

    pub_type: 杂志文章

    doi:10.2147/JPR.S267778

    authors: Ma Y,Zhang X,Li C,Liu S,Xing Y,Tao F

    更新日期:2020-08-12 00:00:00

  • Repeat-dose steady-state pharmacokinetic evaluation of once-daily hydromorphone extended-release (OROS(®) hydromorphone ER) in patients with chronic pain.

    abstract:OBJECTIVE:To characterize the steady-state pharmacokinetic profile of hydromorphone extended-release (ER) in patients with chronic pain taking concomitant medications. METHODS:This open-label repeat-dose study enrolled 22 patients (mean age, 51.4 years; 81.8% female). All patients were receiving at least one concomita...

    journal_title:Journal of pain research

    pub_type: 杂志文章

    doi:10.2147/JPR.S33807

    authors: Vandenbossche J,Richarz U,Richards HM

    更新日期:2012-01-01 00:00:00

  • Cervical disc degeneration and neck pain.

    abstract::Cervical intervertebral disc has long been considered a common source of neck pain. However, the pain caused by the disc itself has not been clearly defined so far, and its diagnosis and treatment has always been controversial. Degenerative cervical disc has a rich supply of nerve fibers, is prone to inflammatory reac...

    journal_title:Journal of pain research

    pub_type: 杂志文章

    doi:10.2147/JPR.S180018

    authors: Peng B,DePalma MJ

    更新日期:2018-11-14 00:00:00

  • Parameters associated with efficacy of epidural steroid injections in the management of postherpetic neuralgia: the Mayo Clinic experience.

    abstract::Purpose: Thirty percent of patients with postherpetic neuralgia (PHN) receiving conservative treatment report unsatisfactory pain relief. Epidural steroid injections (ESIs) are commonly used as a therapeutic intervention in these patients. In this study, we aimed to determine if there are variables that predict the ef...

    journal_title:Journal of pain research

    pub_type: 杂志文章

    doi:10.2147/JPR.S190646

    authors: Ghanavatian S,Wie CS,Low RS,Butterfield RJ,Zhang N,Dhaliwal GS,Montoya JM,Swanson DL

    更新日期:2019-04-23 00:00:00

  • The impact of intravenous dexamethasone on the efficacy and duration of analgesia of paravertebral block in breast cancer surgery: a randomized controlled trial.

    abstract:Purpose:The study aimed at the evaluation of the impact of intravenous (IV) dexamethasone on efficacy and duration of analgesia of paravertebral block (PVB) in patients undergoing modified radical mastectomy (MRM). Patients and methods:This randomized, double-blind controlled trial included 50 patients with breast can...

    journal_title:Journal of pain research

    pub_type: 杂志文章

    doi:10.2147/JPR.S181788

    authors: Bakeer AH,Abdallah NM,Kamel MA,Abbas DN,Ragab AS

    更新日期:2018-12-19 00:00:00

  • Anatomy of the Pain Centre waiting list at the Centre hospitalier de l'Université de Montréal (CHUM).

    abstract:BACKGROUND:Waiting list management at chronic pain clinics has become a serious problem throughout Canada. We analyzed the waiting list at the Centre hospitalier de l'Université de Montréal (CHUM) Pain Centre. METHODS:The present study is an observational, prospective study. We used a specifically designed survey ques...

    journal_title:Journal of pain research

    pub_type: 杂志文章

    doi:10.2147/JPR.S46118

    authors: Vargas-Schaffer G,Rusnov A,Boulanger A

    更新日期:2013-07-08 00:00:00

  • Characteristics of Postoperative Pain After VATS and Pain-Related Factors: The Experience in National Cancer Center of China.

    abstract:Purpose:No final conclusion has yet been reached on characteristics of postoperative pain and pain-related factors after video-assisted thoracoscopic surgery (VATS). This study was designed to explore features of acute severe pain and chronic post-surgical pain (CPSP), and the pain-related factors of VATS. Patients an...

    journal_title:Journal of pain research

    pub_type: 杂志文章

    doi:10.2147/JPR.S249134

    authors: Tong Y,Wei P,Wang S,Sun Q,Cui Y,Ning N,Chen S,He X

    更新日期:2020-07-21 00:00:00

  • Sensing Evoked Compound Action Potentials from the Spinal Cord: Novel Preclinical and Clinical Considerations for the Pain Management Researcher and Clinician.

    abstract:Purpose:Spinal cord stimulation (SCS) is a drug-free treatment for chronic neuropathic pain. Recent SCS technology can record evoked compound action potentials (ECAPs) in the spinal cord during therapy and utilize features of the sensed ECAP to optimize the SCS. The purpose of this work is to characterize the relevant ...

    journal_title:Journal of pain research

    pub_type: 杂志文章

    doi:10.2147/JPR.S289098

    authors: Chakravarthy K,Bink H,Dinsmoor D

    更新日期:2020-12-04 00:00:00

  • Anti-allodynic effect of interleukin 10 in a mouse model of complex regional pain syndrome through reduction of NK1 receptor expression of microglia in the spinal cord.

    abstract:Background:To date, there has been no study on the effects of interleukin-10 (IL-10) on complex regional pain syndrome (CRPS) rodent models, despite the anti-allodynic effect of IL-10 in previous studies. Thus, the aim of this study was to investigate the effect of IL-10 in a CRPS mouse model and find whether early inh...

    journal_title:Journal of pain research

    pub_type: 杂志文章

    doi:10.2147/JPR.S166624

    authors: Kim JH,Park JS,Park D

    更新日期:2018-09-04 00:00:00

  • Complex management of a patient with refractory primary erythromelalgia lacking a SCN9A mutation.

    abstract::A 41-year-old woman presented with burning and erythema in her extremities triggered by warmth and activity, which was relieved by applying ice. Extensive workup was consistent with adult-onset primary erythromelalgia (EM). Several pharmacological treatments were tried including local anesthetics, capsaicin, ziconotid...

    journal_title:Journal of pain research

    pub_type:

    doi:10.2147/JPR.S129661

    authors: Low SA,Robbins W,Tawfik VL

    更新日期:2017-04-27 00:00:00

  • Impact of opioid dose reduction on individuals with chronic pain: results of an online survey.

    abstract:Background:In 2016, the Centers for Disease Control and Prevention (CDC) released a guideline on opioid prescribing for primary care physicians. Patients with chronic pain receiving long-term opioid therapy were surveyed to assess the incidence and impact of opioid dose reduction following this guideline's promulgation...

    journal_title:Journal of pain research

    pub_type: 杂志文章

    doi:10.2147/JPR.S175402

    authors: Twillman RK,Hemmenway N,Passik SD,Thompson CA,Shrum M,DeGeorge MK

    更新日期:2018-11-08 00:00:00

  • A 12-week randomized study of topical therapy with three dosages of ketoprofen in Transfersome® gel (IDEA-033) compared with the ketoprofen-free vehicle (TDT 064), in patients with osteoarthritis of the knee.

    abstract:OBJECTIVE:To evaluate the safety and efficacy of ketoprofen in Transfersome® gel (IDEA-033) in comparison with a ketoprofen-free vehicle (TDT 064) for the treatment of osteoarthritis (OA) of the knee. METHODS:Patients with knee OA (N = 866) were randomly assigned to receive topical IDEA-033 containing 100, 50, or 25 m...

    journal_title:Journal of pain research

    pub_type: 杂志文章

    doi:10.2147/JPR.S51054

    authors: Kneer W,Rother M,Mazgareanu S,Seidel EJ,European IDEA-033 study group.

    更新日期:2013-10-25 00:00:00

  • The Fear of Pain Questionnaire: psychometric properties of a Brazilian version for adolescents and its relationship with brain-derived neurotrophic factor (BDNF).

    abstract:Objectives:The primary aim was to assess the psychometric properties (including internal consistency, construct validity, criterion validity, criterion-group validity and responsiveness) of the Fear of Pain Questionnaire (FOPQ) for adolescents (FOPQ-A) and parents (FOPQ-P) translated to Brazilian Portuguese (BrP). The ...

    journal_title:Journal of pain research

    pub_type: 杂志文章

    doi:10.2147/JPR.S199120

    authors: Berniger Romariz JA,Nonnemacher C,Abreu M,Dickel Segabinazi J,Bandeira JS,Beltran G,Souza A,Torres IL,Caumo W

    更新日期:2019-08-07 00:00:00