Abstract:
:Rotator-cuff tears (RCTs) are typically associated with chronic pain. The most common treatment for reducing pain is the injection of cortisone into the injury site. An alternative and increasingly used technique is the injection of autologous platelet-rich plasma (PRP). A limitation of cortisone is its pain relief is short-lived, while PRP has the limitation of providing pain relief to only about 50% of patients, making its efficacy questioned, although when it is effective, its efficacy is longer than cortisone. Little is known about what accounts for these limitations. This paper presents results from a patient with RCTs causing excruciating pain who received an injection of PRP into that shoulder resulting in complete pain elimination that was ongoing at 2 years and 2 months. When 7-month severe posttrauma pain associated with the RCT developed in the contralateral shoulder, PRP prepared the same way and injected by the same person who performed the first injection provided no pain relief. However, a subsequent single cortisone injection resulted in complete pain elimination, which was ongoing at >15 months. These observations indicate that PRP can have inconsistent effects in reducing pain, not only between patients but also within the same patient. Further, although the pain relief induced by cortisone is normally not long-lasting, when given following a PRP injection, it can induce complete pain relief lasting >15 months. This paper discusses possible reasons for the variability in PRP efficacy on pain relief and addresses the possibility that when administered together, PRP and cortisone may act in a complementary manner, leading to significantly greater and longer-lasting pain relief.
journal_name
J Pain Resjournal_title
Journal of pain researchauthors
Kuffler DPdoi
10.2147/JPR.S169647subject
Has Abstractpub_date
2018-10-09 00:00:00pages
2239-2245issn
1178-7090pii
jpr-11-2239journal_volume
11pub_type
abstract:INTRODUCTION:Heat/capsaicin skin sensitization is a well-characterized human experimental model to induce hyperalgesia and allodynia. Using this model, gabapentin, among other drugs, was shown to significantly reduce cutaneous hyperalgesia compared to placebo. Since the larger thermal probes used in the original studie...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S53437
更新日期:2013-11-07 00:00:00
abstract:BACKGROUND:Large interindividual differences in clinical responses to opioids and the variable susceptibility to abuse of this class of drugs make their use problematic. We lack a full understanding of the factors responsible for these differences. Dietary factors including methyl donor content have been noted to alter...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S42561
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Several studies have illustrated that multisite pain is more frequent than single pain site, and it is associated with an array of negative consequences. However, there is limited knowledge available about the potential factors associated with multisite pain in the elderly general population. OBJECTIVE:This...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S143060
更新日期:2017-08-23 00:00:00
abstract::Paced breathing has shown efficacy in fibromyalgia (FM), but the mechanisms associated with symptom change are largely unknown. We investigated whether changes in respiratory rate (RR) alone resulted in autonomic changes during normal, paced, and mechanically assisted breathing in untrained FM patients and controls. P...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S139642
更新日期:2017-12-08 00:00:00
abstract:PURPOSE:The aim of this study was to examine the health and economic burden associated with fibromyalgia among adults in Japan. MATERIALS AND METHODS:Data from the 2011-2014 Japan National Health and Wellness Survey (n=115,271), a nationally representative survey of adults, were analyzed. The greedy matching algorithm...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S110707
更新日期:2016-11-04 00:00:00
abstract:BACKGROUND:Detecting the efficacy of novel analgesic agents in neuropathic pain is challenging. There is a critical need for study designs with the desirable characteristics of assay sensitivity, low placebo response, reliable pain recordings, low cost, short duration of exposure to test drug and placebo, and relevant ...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S34098
更新日期:2012-01-01 00:00:00
abstract::Generalized joint hypermobility (GJH) is highly prevalent among patients diagnosed with chronic pain. When GJH is accompanied by pain in ≥4 joints over a period ≥3 months in the absence of other conditions that cause chronic pain, the hypermobility syndrome (HMS) may be diagnosed. In addition, GJH is also a clinical s...
journal_title:Journal of pain research
pub_type: 杂志文章,评审
doi:10.2147/JPR.S64251
更新日期:2015-08-20 00:00:00
abstract:Background:Suspecting carpal tunnel syndrome (CTS) in patients with hand pain is usual. Considering the variable rate of false-negative results in nerve conduction study (NCS), as a frequent reference confirmatory standard test, we aimed to evaluate the diagnostic accuracy of neuromuscular ultrasound in patients with c...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S164004
更新日期:2018-07-10 00:00:00
abstract:Background:It is becoming increasingly important to understand the mechanisms of spinal cord stimulation (SCS) in alleviating neuropathic pain as novel stimulation paradigms arise. Purpose:Additionally, the small anatomic scale of current SCS animal models is a barrier to more translational research. Methods:Using ch...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S139843
更新日期:2018-06-15 00:00:00
abstract:INTRODUCTION:Frequent chronic local pain can develop into chronic widespread pain (CWP). The spread of pain is correlated with pain intensity, anxiety, and depression, conditions that ultimately lead to a poor quality of life. Knowledge is incomplete about CWP's etiology, although it has been suggested that both centra...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S125667
更新日期:2017-03-13 00:00:00
abstract::Adolescent low back pain (ALBP) is a common form of adolescent morbidity which remains poorly understood. When attempting a meta-analysis of observational studies into ALBP, in an effort to better understand associated risk factors, it is important that the studies involved are homogenic, particularly in terms of the ...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/jpr.s10025
更新日期:2010-05-17 00:00:00
abstract::This study describes the cultural adaptation and testing of the behavioral pain scale (BPS) and the critical-care pain observation tools (CPOT) for pain assessment in Taiwan. The cross-cultural adaptation followed the steps of translation, including forward translation, back-translation, evaluation of the translations...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S91036
更新日期:2016-09-15 00:00:00
abstract:OBJECTIVE:Patient controlled analgesia (PCA) is commonly used to provide analgesia following surgical procedures in the pediatric population. Morphine and hydromorphone remain the most commonly used opioids for PCA. Although both are effective, adverse effects may occur. When these adverse effects are unremitting or se...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S64497
更新日期:2014-08-13 00:00:00
abstract:OBJECTIVE:The aim of this study was to compare the efficacy of percutaneous vertebroplasty (PVP) and interventional tumor removal (ITR), with PVP alone for malignant vertebral compression fractures and/or spinal metastatic tumor with epidural involvement. PATIENTS AND METHODS:A total of 124 patients were selected for ...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S122211
更新日期:2017-01-20 00:00:00
abstract:Objective:To report a rare case of spontaneous fusion (SF) following cervical disc arthroplasty (CDA), to review the related literature, and to propose a new measure to prevent it. Methods:The course of a patient with SF is described here. The potential causes, risk factors, and preventive measure of SF after CDA publ...
journal_title:Journal of pain research
pub_type:
doi:10.2147/JPR.S242646
更新日期:2020-04-21 00:00:00
abstract:Background:Despite the increasing prevalence of opioid use disorder (OUD) in pregnant women, there are limited studies on their anesthesia care and analgesic outcomes after cesarean delivery (CD). Methods:Patients with OUD on either buprenorphine or methadone maintenance therapy who underwent CD at our institution fro...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S284874
更新日期:2020-12-30 00:00:00
abstract:Objectives:Pain is reported as one of the most common and burdensome symptoms for children with cancer. Pain catastrophizing is clearly related to pain intensity and disability. Catastrophizing in parents is associated with both child functioning and parent distress. The Pain Catastrophizing Scale for Parents (PCS-P) r...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S193164
更新日期:2019-03-18 00:00:00
abstract::Phantom-limb pain (PLP) belongs among difficult-to-treat chronic pain syndromes. Treatment options for PLP are to a large degree implicated by the level of understanding the mechanisms and nature of PLP. Research and clinical findings acknowledge the neuropathic nature of PLP and also suggest that both peripheral as w...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S16733
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Opioids and other controlled substances prescribed for chronic pain are associated with abuse, addiction, and death, prompting national initiatives to identify safe and effective pain management strategies including topical analgesics. METHODS:This prospective, observational study evaluated changes from bas...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S143513
更新日期:2017-10-03 00:00:00
abstract::Multisite pain, or pain that occurs simultaneously at >1 anatomical site, is more prevalent than single-site pain. While multisite pain affects over half of older adults, it remains an understudied pain entity that may have important functional implications in an aging population. Greater understanding of this complex...
journal_title:Journal of pain research
pub_type: 杂志文章,评审
doi:10.2147/JPR.S192755
更新日期:2019-03-29 00:00:00
abstract:Purpose:Epidural analgesia provides safe and effective labor pain relief. However, labor episodic pain can occur during epidural analgesia, requiring epidural top-ups, and may result in decreased patient satisfaction. The primary aim of our study was to investigate the factors associated with labor episodic pain during...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S185073
更新日期:2019-02-15 00:00:00
abstract:BACKGROUND:It has been demonstrated that N-ethyl-lidocaine (QX-314) can target the transient receptor protein vanilloid 1 (TRPV1) nociceptors when coadministered with capsaicin, resulting in a selective block of the nociceptors. Capsaicin is problematic in therapeutic use because it induces firing of nociceptors. The p...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S41614
更新日期:2013-01-01 00:00:00
abstract:INTRODUCTION:Although the majority of opioids in the US are prescribed by nonpain specialists, these providers often report inadequate training in chronic pain management and opioid prescribing. The extent of health care providers' knowledge of opioid prescribing for chronic pain has not been well established. The purp...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S98273
更新日期:2016-03-10 00:00:00
abstract:Background:Transversus abdominis plane (TAP) block can provide effective analgesia for abdominal surgery. However, many randomized controlled trials (RCTs) have shown controversial results in hysterectomy. We conducted a meta-analysis of RCTs to investigate the effectiveness of TAP block after hysterectomy. Methods:St...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S172828
更新日期:2018-10-18 00:00:00
abstract:Background:Regional variations of opioid use have been reported from many countries. The objective of this study was to examine opioid prescribing patterns in Germany including low- and high-potency opioids (LPO and HPO) focusing on regional differences. Methods:Data source was the "Information system for health care ...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S259009
更新日期:2020-10-07 00:00:00
abstract::Recently, attention to the lifestyle of patients has been rapidly increasing in the field of pain therapy, particularly with regard to the role of nutrition in pain development and its management. In this review, we summarize the latest findings on the role of nutrition and nutraceuticals, microbiome, obesity, soy, om...
journal_title:Journal of pain research
pub_type: 杂志文章,评审
doi:10.2147/JPR.S115068
更新日期:2016-12-08 00:00:00
abstract:Aim:Operant conditioning has long been believed to influence the pain experience through a psychological reward pathway. This study was formulated to test the hypothesis that pain sensitivity may be enhanced >3 months if a monetary reward works as a reinforcement. Methods:Forty healthy subjects volunteered to particip...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S175494
更新日期:2018-10-04 00:00:00
abstract:Purpose:Brachial plexopathy can sometimes cause severe chronic pain. There are many possible treatments for such neuropathic pain, including neuromodulation. However, rigorous scientific evidence on the usefulness of spinal cord stimulation (SCS) is still scarce. Here, we report the use of high-frequency (10 kHz) SCS (...
journal_title:Journal of pain research
pub_type:
doi:10.2147/JPR.S168031
更新日期:2018-11-27 00:00:00
abstract::Purpose: The study aimed to evaluate the analgesic efficiency of dexmedetomidine (DEX) when added to levobupivacaine in continuous ultrasound-guided serratus anterior plane block (SAPB) performed at the end of major thoracic surgery. Methods: This randomized, double-blind trial included 50 adults undergoing thoracic s...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S195431
更新日期:2019-04-30 00:00:00
abstract::Diabetic peripheral neuropathy (DPN) represents significant burdens to many patients and the public health-care system. Patients with diabetes in rural areas have higher risk of developing complications and having less access to proper treatment. We studied a rural population of patients with diabetes who attended a p...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S129139
更新日期:2017-04-07 00:00:00