Duloxetine in the treatment of chronic pain due to fibromyalgia and diabetic neuropathy.

abstract：Purpose:The upregulation of spinal NMDA receptor is a crucial mechanism in remifentanil-induced hyperalgesia (RIH). Wnt3a/β-catenin pathway plays an important role in neuropathic pain. We hypothesized that wnt3a inhibitor (iwp-2) could downregulate the expression of NR2B subunit in NMDA receptor, in order to relieve R...

journal_title：Journal of pain research

authors： Gao Y,Zhou S,Pan Y,Gu L,He Y,Sun J

更新日期：2020-05-19 00:00:00

abstract：:Ultrasound-guided cervical nerve root block is the technique of injecting local anesthetic or steroid into the intertubercular groove outside of the cervical foramen under real-time ultrasound guidance. It has established diagnostic and therapeutic employment for patients suffering symptoms caused by cervical disc dis...

journal_title：Journal of pain research

authors： Zhang S,Fan L,Mei W

更新日期：2020-10-14 00:00:00

abstract：Background:Previous studies have shown the efficacy of tapentadol (TP) for chronic cancer pain. We evaluated multiple effectiveness aspects of TP prolonged release on moderate-severe cancer-related pain, neuropathic pain (NeP), patient satisfaction, and quality of life. Methods:An observational prospective study was c...

journal_title：Journal of pain research

authors： Cascella M,Forte CA,Bimonte S,Esposito G,Romano C,Costanzo R,Morabito A,Cuomo A

更新日期：2018-12-24 00:00:00

abstract：OBJECTIVE:Lymphocyte apoptosis in critical illness is associated with immunosuppression. We explored for the first time the associations between pain ratings and expression of the apoptotic receptor Fas on B and T cells in critically ill patients and the potential mediating effects of adrenocorticotropic hormone (ACTH)...

journal_title：Journal of pain research

authors： Papathanassoglou E,Mpouzika MD,Giannakopoulou M,Bozas E,Middleton N,Tsiaousis G,Karabinis A

更新日期：2017-01-13 00:00:00

abstract：Purposes:To investigate the prevalence of pain-related diagnoses in patients with dementia and evaluate the association of pain-related diagnoses with demographic characteristics and dementia subtypes. Patients and methods:In this population-based retrospective cohort study, participants were recruited from a cohort o...

journal_title：Journal of pain research

authors： Lin PC,Li CH,Chou PL,Chen YM,Lin LC

更新日期：2018-09-03 00:00:00

abstract：Purpose:Post-herpetic neuralgia (PHN) is a common herpes zoster (HZ) complication, where pain persists 90 days after the initial HZ diagnosis. Evaluating PHN risk is essential for determining the burden on patients and health-care systems, but research shows variable estimates. The extent to which these differences are...

journal_title：Journal of pain research

authors： Tanenbaum HC,Lawless A,Sy LS,Hong V,Ackerson B,Bruxvoort K,Luo Y,Tseng HF

更新日期：2020-07-13 00:00:00

abstract：:Recently, attention to the lifestyle of patients has been rapidly increasing in the field of pain therapy, particularly with regard to the role of nutrition in pain development and its management. In this review, we summarize the latest findings on the role of nutrition and nutraceuticals, microbiome, obesity, soy, om...

journal_title：Journal of pain research

authors： De Gregori M,Muscoli C,Schatman ME,Stallone T,Intelligente F,Rondanelli M,Franceschi F,Arranz LI,Lorente-Cebrián S,Salamone M,Ilari S,Belfer I,Allegri M

更新日期：2016-12-08 00:00:00

abstract：:Purpose: It has been reported that neck pain is more prevalent in episodic migraineurs (EM) than in the general population. Subjects with episodic migraine exhibited widespread hypersensitivity in cranio-cervical region. Our objectives were to explore the potential factors associated with the presence of neck pain for...

journal_title：Journal of pain research

authors： Yu Z,Wang R,Ao R,Yu S

更新日期：2019-05-20 00:00:00

abstract：Background:Regional variations of opioid use have been reported from many countries. The objective of this study was to examine opioid prescribing patterns in Germany including low- and high-potency opioids (LPO and HPO) focusing on regional differences. Methods:Data source was the "Information system for health care ...

journal_title：Journal of pain research

authors： Jobski K,Dörks M,Bantel C,Hoffmann F

更新日期：2020-10-07 00:00:00

abstract：BACKGROUND:In Japan, there are limited options for switching opioid analgesics. Hydromorphone is an opioid analgesic that is routinely used instead of morphine for cancer pain; however, it is not yet available in Japan. The aim of this study was to assess the efficacy and safety of hydromorphone (DS-7113b) extended-rel...

journal_title：Journal of pain research

authors： Inoue S,Saito Y,Tsuneto S,Aruga E,Ide A,Kakurai Y

更新日期：2017-08-18 00:00:00

abstract：OBJECTIVES:Chronic neuropathic pain and chronic complex regional pain syndrome (CRPS), in particular, are debilitating and difficult-to-treat conditions that have a strong impact on patient's quality of life. The aim of this study was to evaluate the effectiveness of 5% lidocaine-medicated plaster as add-on therapy in ...

journal_title：Journal of pain research

authors： Calderón E,Calderón-Seoane ME,García-Hernández R,Torres LM

更新日期：2016-10-06 00:00:00

abstract：Purpose:The aim of this study was to evaluate postoperative discomfort in patients undergoing ambulatory strabismus under general anesthesia, and to identify risk factors associated with the discomfort. Patients and Methods:A cross-sectional study was conducted among 210 consecutive patients undergoing ambulatory stra...

journal_title：Journal of pain research

authors： Huang J,Lin J,Xiong Y,Wang Z,Zhu Y,Ye H,Guo W

更新日期：2020-05-05 00:00:00

abstract：:A 41-year-old woman presented with burning and erythema in her extremities triggered by warmth and activity, which was relieved by applying ice. Extensive workup was consistent with adult-onset primary erythromelalgia (EM). Several pharmacological treatments were tried including local anesthetics, capsaicin, ziconotid...

journal_title：Journal of pain research

authors： Low SA,Robbins W,Tawfik VL

更新日期：2017-04-27 00:00:00

abstract：Background:Neuroplastic changes in nociceptive pathways contribute to severity of symptoms in knee osteoarthritis (KOA). A new look at neuroplastic changes management includes modulation of the primary motor cortex by transcranial direct current stimulation (tDCS). Objectives:We investigated whether tDCS combined with...

journal_title：Journal of pain research

authors： da Graca-Tarragó M,Lech M,Angoleri LDM,Santos DS,Deitos A,Brietzke AP,Torres IL,Fregni F,Caumo W

更新日期：2019-01-03 00:00:00

abstract：BACKGROUND:The objective of this study was to assess the safety, tolerability, and preliminary efficacy of NGX-4010, a capsaicin 8% patch, following pretreatment with three different topical anesthetics in patients with peripheral neuropathic pain. METHODS:This open-label, multicenter study enrolled 117 patients with ...

journal_title：Journal of pain research

authors： Webster LR,Peppin JF,Murphy FT,Tobias JK,Vanhove GF

更新日期：2012-01-01 00:00:00

abstract：Background:The objective of this study was to compare the clinical and radiological outcomes between patients with or without axial symptoms (AS) and investigate the risk factors associated with AS by multivariate regression analysis in anterior cervical discectomy and fusion (ACDF). Materials and methods:The records ...

journal_title：Journal of pain research

authors： Zhou J,Li L,Li T,Xue Y

更新日期：2018-10-26 00:00:00

abstract：OBJECTIVE:Patients with chronic fatigue syndrome (CFS) complain of long-lasting fatigue and pain which are not relieved by rest and worsened by physical exertion. Previous research has implicated metaboreceptors of muscles to play an important role for chronic fatigue and pain. Therefore, we hypothesized that blocking ...

journal_title：Journal of pain research

authors： Staud R,Kizer T,Robinson ME

更新日期：2017-06-26 00:00:00

abstract：:Low back pain in patients with myofascial pain syndrome is characterized by painful active myofascial trigger points (ATPs) in muscles. This article reviews a novel, noninvasive modality that combines simultaneous imaging and treatment, thus taking advantage of the electrodermal information available from imaged ATPs ...

journal_title：Journal of pain research

authors： Gorenberg M,Schwartz K

更新日期：2013-06-25 00:00:00

abstract：Purpose:Exercise-induced hypoalgesia (EIH) is the short-term reduction of pain sensitivity after a single bout of exercise. Descending pain inhibition has been proposed to at least partly underlie EIH. Cognitive inhibition is the ability to inhibit a pre-potent response and has in turn been associated with descending p...

journal_title：Journal of pain research

authors： Gajsar H,Titze C,Konietzny K,Meyer M,Vaegter HB,Hasenbring MI

更新日期：2020-04-29 00:00:00

abstract：:Purpose: Thirty percent of patients with postherpetic neuralgia (PHN) receiving conservative treatment report unsatisfactory pain relief. Epidural steroid injections (ESIs) are commonly used as a therapeutic intervention in these patients. In this study, we aimed to determine if there are variables that predict the ef...

journal_title：Journal of pain research

authors： Ghanavatian S,Wie CS,Low RS,Butterfield RJ,Zhang N,Dhaliwal GS,Montoya JM,Swanson DL

更新日期：2019-04-23 00:00:00

abstract：OBJECTIVE:The aim of this study was to compare the efficacy of percutaneous vertebroplasty (PVP) and interventional tumor removal (ITR), with PVP alone for malignant vertebral compression fractures and/or spinal metastatic tumor with epidural involvement. PATIENTS AND METHODS:A total of 124 patients were selected for ...

journal_title：Journal of pain research

authors： Gu YF,Tian QH,Li YD,Wu CG,Su Y,Song HM,He CJ,Chen D

更新日期：2017-01-20 00:00:00

abstract：:Adolescent low back pain (ALBP) is a common form of adolescent morbidity which remains poorly understood. When attempting a meta-analysis of observational studies into ALBP, in an effort to better understand associated risk factors, it is important that the studies involved are homogenic, particularly in terms of the ...

journal_title：Journal of pain research

authors： Milanese S,Grimmer-Somers K

更新日期：2010-05-17 00:00:00

abstract：Purpose:Spinal cord stimulation (SCS) is a drug-free treatment for chronic neuropathic pain. Recent SCS technology can record evoked compound action potentials (ECAPs) in the spinal cord during therapy and utilize features of the sensed ECAP to optimize the SCS. The purpose of this work is to characterize the relevant ...

journal_title：Journal of pain research

authors： Chakravarthy K,Bink H,Dinsmoor D

更新日期：2020-12-04 00:00:00

abstract：:Pain is highly prevalent, but frequently untreated or under-treated, and health care professionals are faced with a range of treatment challenges. Multimodal therapy is recommended and can be achieved using open combinations (ie, concomitant administration) of individual agents, fixed-dose combinations (FDCs), or mult...

journal_title：Journal of pain research

authors： Almansa C,Frampton CS,Vela JM,Whitelock S,Plata-Salamán CR

更新日期：2019-09-04 00:00:00

abstract：Background:Pancreatic cancer is a malignant disease with a high mortality rate and severe pain that is challenging to manage. To reduce the excruciating abdominal pain, opioids and adjuvant agents are conventionally used. Objectives:PRNCPB is a treatment of neural therapy. The number of studies assessing the effect on...

journal_title：Journal of pain research

authors： Molnár I,Hegyi G,Zsom L,Saahs C,Vagedes J,Kapócs G,Kovács Z,Sterner MG,Szőke H

更新日期：2019-01-14 00:00:00

abstract：Background:While the concomitant administration of painful and rewarding stimuli tends to reduce the perception of one another, recent evidence shows that pleasant pain relief is experience after the interruption of noxious stimuli. On neurobiological grounds, these opponent processes should translate into decreased ac...

journal_title：Journal of pain research

authors： Bitar N,Dugré JR,Marchand S,Potvin S

更新日期：2020-06-08 00:00:00

abstract：Background:Despite the increasing prevalence of opioid use disorder (OUD) in pregnant women, there are limited studies on their anesthesia care and analgesic outcomes after cesarean delivery (CD). Methods:Patients with OUD on either buprenorphine or methadone maintenance therapy who underwent CD at our institution fro...

journal_title：Journal of pain research

authors： Reno JL,Kushelev M,Coffman JH,Prasad MR,Meyer AM,Carpenter KM,Palettas MS,Coffman JC

更新日期：2020-12-30 00:00:00

abstract：Purpose:Complex regional pain syndrome (CRPS) is a rare but refractory pain disorder. Recent advanced information retrieval studies using text-mining and network analysis have suggested nuclear factor kappa B (NFκB) as a possible central mediator of CRPS. The brain is also known to play important roles in CRPS. The aim...

journal_title：Journal of pain research

authors： Nahm FS,Nahm SS,Han WK,Gil HY,Choi E,Lee PB

更新日期：2019-03-06 00:00:00

abstract：PURPOSE:The treatment of central neuropathic pain remains amongst the biggest challenges for pain specialists. The main objective of this study was to assess gabapentin (GBP), amitriptyline (AMI), and carbamazepine (CARBA) for the treatment of a rodent central neuropathic pain model. METHODS:Male Sprague Dawley rats w...

journal_title：Journal of pain research

authors： Castel A,Vachon P

更新日期：2013-12-17 00:00:00

abstract：BACKGROUND:Opioids are the most important pharmacological treatment for moderate-to-severe cancer pain, but side effects limit their use. Transdermal fentanyl (TDF) and oral prolonged-release oxycodone-naloxone (OXN-PR) are effective in controlling chronic pain, with less constipation compared to other opioids. However...

journal_title：Journal of pain research

authors： Roberto A,Greco MT,Legramandi L,Galli F,Galli M,Corli O

更新日期：2017-09-04 00:00:00