Gabapentin reverses central pain sensitization following a collagenase-induced intrathalamic hemorrhage in rats.

abstract：Background:It is becoming increasingly important to understand the mechanisms of spinal cord stimulation (SCS) in alleviating neuropathic pain as novel stimulation paradigms arise. Purpose:Additionally, the small anatomic scale of current SCS animal models is a barrier to more translational research. Methods:Using ch...

journal_title：Journal of pain research

authors： Reddy CG,Miller JW,Abode-Iyamah KO,Safayi S,Wilson S,Dalm BD,Fredericks DC,Gillies GT,Howard MA 3rd,Brennan TJ

更新日期：2018-06-15 00:00:00

abstract：Background:G protein-gated inwardly rectifying potassium (GIRK) channels are involved in the regulation of neuronal excitability. Four GIRK subunits (GIRK1-4) are expressed in rat dorsal root ganglia (DRGs). Recently, we have characterized the expression of GIRK1 and -2, and both are downregulated in rat DRGs and spina...

journal_title：Journal of pain research

authors： Lyu C,Lyu GW,Mulder J,Martinez A,Shi TS

更新日期：2020-02-17 00:00:00

abstract：Purpose:The study aimed at the evaluation of the impact of intravenous (IV) dexamethasone on efficacy and duration of analgesia of paravertebral block (PVB) in patients undergoing modified radical mastectomy (MRM). Patients and methods:This randomized, double-blind controlled trial included 50 patients with breast can...

journal_title：Journal of pain research

authors： Bakeer AH,Abdallah NM,Kamel MA,Abbas DN,Ragab AS

更新日期：2018-12-19 00:00:00

abstract：:Topical treatments of localized neuropathic pain syndromes in general are mostly neglected, mainly due to the fact that most pain physicians expect that a topical formulation needs to result in a transdermal delivery of the active compounds. On the basis of the practical experience, this study brings forth a new, some...

journal_title：Journal of pain research

authors： Keppel Hesselink JM,Kopsky DJ,Sajben N

更新日期：2016-10-03 00:00:00

abstract：PURPOSE:The aim of this study was to examine the health and economic burden associated with fibromyalgia among adults in Japan. MATERIALS AND METHODS:Data from the 2011-2014 Japan National Health and Wellness Survey (n=115,271), a nationally representative survey of adults, were analyzed. The greedy matching algorithm...

journal_title：Journal of pain research

authors： Lee LK,Ebata N,Hlavacek P,DiBonaventura M,Cappelleri JC,Sadosky A

更新日期：2016-11-04 00:00:00

abstract：Background:Pancreatic cancer is a malignant disease with a high mortality rate and severe pain that is challenging to manage. To reduce the excruciating abdominal pain, opioids and adjuvant agents are conventionally used. Objectives:PRNCPB is a treatment of neural therapy. The number of studies assessing the effect on...

journal_title：Journal of pain research

authors： Molnár I,Hegyi G,Zsom L,Saahs C,Vagedes J,Kapócs G,Kovács Z,Sterner MG,Szőke H

更新日期：2019-01-14 00:00:00

abstract：OBJECTIVE:To characterize the steady-state pharmacokinetic profile of hydromorphone extended-release (ER) in patients with chronic pain taking concomitant medications. METHODS:This open-label repeat-dose study enrolled 22 patients (mean age, 51.4 years; 81.8% female). All patients were receiving at least one concomita...

journal_title：Journal of pain research

authors： Vandenbossche J,Richarz U,Richards HM

更新日期：2012-01-01 00:00:00

abstract：:The objective of this study was to evaluate the relationship between magnetic resonance imaging (MRI) findings and previous low back pain (LBP) in participants without current LBP. Current LBP was defined as LBP during the past month. Previous LBP was defined as a history of medical consultation for LBP. Ninety-one pa...

journal_title：Journal of pain research

authors： Tonosu J,Oka H,Matsudaira K,Higashikawa A,Okazaki H,Tanaka S

更新日期：2016-12-29 00:00:00

abstract：BACKGROUND:Cutaneous allodynia (CA) is a common feature of migraine, which has a complex underlying pathophysiology that is not well understood. In addition to pain, photophobia, phonophobia, osmophobia, nausea, and vomiting, CA can contribute to the overall disability caused by migraine. The presence of CA can be esta...

journal_title：Journal of pain research

authors： Mathew PG,Cutrer FM,Garza I

更新日期：2016-02-24 00:00:00

abstract：BACKGROUND:Very few studies have discussed transforaminal endoscopic discectomy (TED) in the treatment of common peroneal nerve paralysis induced by lumbar disk herniation (LDH). This study aimed to evaluate the efficacy of TED in the treatment of LDH combined with common peroneal nerve paralysis. MATERIALS AND METHOD...

journal_title：Journal of pain research

authors： Wang YP,Zhang W,Zhang J,Sun YP,An JL,Ding WY

更新日期：2017-01-05 00:00:00

abstract：Background:Chronic shoulder pain (CSP) is a common disease causing pain and functional limitation, which is highly prevalent and has substantial negative effects on the quality of life. Acupuncture has gained popularity and has been accepted gradually by many countries because it can successfully treat patients with ch...

journal_title：Journal of pain research

authors： Zhang S,Wang X,Yan CQ,Hu SQ,Huo JW,Wang ZY,Zhou P,Liu CH,Liu CZ

更新日期：2018-03-07 00:00:00

abstract：Purpose:Primary dysmenorrhea (PD; menstrual pain without an identified organic cause) has been proposed as a possible risk factor for the development of chronic pelvic pain, but the mechanism through which this process occurs is unknown. One possible mechanism is central sensitization - alterations in the central nervo...

journal_title：Journal of pain research

authors： Seidman LC,Temme CR,Zeltzer LK,Rapkin AJ,Naliboff BD,Payne LA

更新日期：2020-12-22 00:00:00

abstract：:Purpose: The objective for this clinical pilot study was to evaluate changes to chronic pain, vascular health, and inflammatory markers when consuming a dietary supplement blend (DSB, CytoQuel®), containing curcumin, resveratrol, tocotrienols, N-Acetylcysteine, and epigallocatechin gallate. Materials and methods: An o...

journal_title：Journal of pain research

authors： Hamilton DE,Jensen GS

更新日期：2019-05-15 00:00:00

abstract：Purpose:To explore the role of cervical sagittal alignment in the occurrence of adjacent-level ossification development (ALOD) in patients who underwent anterior cervical discectomy fusion with self-locking stand-alone polyetheretherketone cage, and the relationship between cervical sagittal alignment and clinical outc...

journal_title：Journal of pain research

authors： Liu W,Rong Y,Chen J,Luo Y,Tang P,Zhou Z,Fan J,Cai W

更新日期：2018-07-20 00:00:00

abstract：Background:Low back pain is a prevalent symptom that occurs in all age of people, whereas the pathogenesis is unknown. Iliopsoas tendinopathy is an increasingly recognized hip disorder that may contribute to low back pain. Our purpose is to evaluate the effect of ultrasound-guided local injection of anesthetic and ster...

journal_title：Journal of pain research

authors： Zhu Z,Zhang J,Sheng J,Zhang C,Xie Z

更新日期：2020-11-20 00:00:00

abstract：:Pain is considered a multidimensional conscious experience that includes a sensory component and a negative affective-motivational component. The negative affective-motivational component of pain is different from the sensory component and amplifies the pain experience. Nowadays, a significant number of preclinical re...

journal_title：Journal of pain research

authors： Wu Y,Yao X,Jiang Y,He X,Shao X,Du J,Shen Z,He Q,Fang J

更新日期：2017-11-06 00:00:00

abstract：:Multisite pain, or pain that occurs simultaneously at >1 anatomical site, is more prevalent than single-site pain. While multisite pain affects over half of older adults, it remains an understudied pain entity that may have important functional implications in an aging population. Greater understanding of this complex...

journal_title：Journal of pain research

authors： Butera KA,Roff SR,Buford TW,Cruz-Almeida Y

更新日期：2019-03-29 00:00:00

abstract：Background:Neuroplastic changes in nociceptive pathways contribute to severity of symptoms in knee osteoarthritis (KOA). A new look at neuroplastic changes management includes modulation of the primary motor cortex by transcranial direct current stimulation (tDCS). Objectives:We investigated whether tDCS combined with...

journal_title：Journal of pain research

authors： da Graca-Tarragó M,Lech M,Angoleri LDM,Santos DS,Deitos A,Brietzke AP,Torres IL,Fregni F,Caumo W

更新日期：2019-01-03 00:00:00

abstract：Background:Pain is a common and undertreated non-motor symptom in patients with Parkinson's disease (PD). Opioids have been seldom used in PD because they could worsen cognitive and motor functions. Objective:We aimed to assess efficacy and tolerability of tapentadol in PD patients. Methods:We retrospectively reviewe...

journal_title：Journal of pain research

authors： Freo U,Furnari M,Ori C

更新日期：2018-09-13 00:00:00

abstract：Purposes:To investigate the prevalence of pain-related diagnoses in patients with dementia and evaluate the association of pain-related diagnoses with demographic characteristics and dementia subtypes. Patients and methods:In this population-based retrospective cohort study, participants were recruited from a cohort o...

journal_title：Journal of pain research

authors： Lin PC,Li CH,Chou PL,Chen YM,Lin LC

更新日期：2018-09-03 00:00:00

abstract：Purpose:To examine the trends of analgesic prescribing at public tertiary hospital outpatient settings and explore the patterns of their utilization in nonsteroidal anti-inflammatory drugs (NSAIDs), tramadol, and opioid patients. Patients and methods:This cross-sectional study was conducted from 2010 to 2016 using the...

journal_title：Journal of pain research

authors： Zin CS,Nazar NI,Rahman NS,Alias NE,Ahmad WR,Rani NS,Cardosa MS,Ng KS,Ye FL

更新日期：2018-09-20 00:00:00

abstract：OBJECTIVES:To determine whether X-ray, computed tomography (CT), bone scan, and clinical impression accurately reflect the level of vertebral fracture in patients about to undergo vertebroplasty. DESIGN:Retrospective observational study, utilizing patient inpatient notes, referral correspondence, and clinicians' priva...

journal_title：Journal of pain research

authors： Graziotti PJ,Graziotti CR,Sangster AM

更新日期：2013-05-10 00:00:00

abstract：:Ultrasound-guided cervical nerve root block is the technique of injecting local anesthetic or steroid into the intertubercular groove outside of the cervical foramen under real-time ultrasound guidance. It has established diagnostic and therapeutic employment for patients suffering symptoms caused by cervical disc dis...

journal_title：Journal of pain research

authors： Zhang S,Fan L,Mei W

更新日期：2020-10-14 00:00:00

abstract：Purpose:Fabry disease belongs to lysosomal storage disorders and can be successfully treated today. On the contrary, the correct diagnostic classification of its symptoms can be challenging and most patients suffer from pain for years, until they are diagnosed correctly. The aim of this project was to characterize pati...

journal_title：Journal of pain research

authors： Forstenpointner J,Moeller P,Sendel M,Reimer M,Hüllemann P,Baron R

更新日期：2019-07-23 00:00:00

abstract：:Purpose: It has been reported that neck pain is more prevalent in episodic migraineurs (EM) than in the general population. Subjects with episodic migraine exhibited widespread hypersensitivity in cranio-cervical region. Our objectives were to explore the potential factors associated with the presence of neck pain for...

journal_title：Journal of pain research

authors： Yu Z,Wang R,Ao R,Yu S

更新日期：2019-05-20 00:00:00

abstract：Background:The objective of this study was to compare the clinical and radiological outcomes between patients with or without axial symptoms (AS) and investigate the risk factors associated with AS by multivariate regression analysis in anterior cervical discectomy and fusion (ACDF). Materials and methods:The records ...

journal_title：Journal of pain research

authors： Zhou J,Li L,Li T,Xue Y

更新日期：2018-10-26 00:00:00

abstract：Background:Central post-stroke pain (CPSP) is refractory to pharmacotherapy (eg, NSAIDs, opioids, antidepressants, and anticonvulsants), and may require transcranial or deep brain stimulation. Case Presentation:A 67-year-old woman presented with severe paroxysmal cramp-like pain on the right side, including the head a...

journal_title：Journal of pain research

authors： Liu Q,Zhong Q,Tang G,Ye L

更新日期：2020-02-26 00:00:00

abstract：Aim:In chronic pain, habituation is believed to be impaired, and pain hypervigilance can enhance the pain experience. The goal of this study was to determine whether pain hypervigilance further worsens habituation of event-related potentials, measured in a pain-rating protocol of 25 painful somatosensory electrical sti...

journal_title：Journal of pain research

authors： Vossen CJ,Luijcks R,van Os J,Joosten EA,Lousberg R

更新日期：2018-02-19 00:00:00

abstract：OBJECTIVE:Lymphocyte apoptosis in critical illness is associated with immunosuppression. We explored for the first time the associations between pain ratings and expression of the apoptotic receptor Fas on B and T cells in critically ill patients and the potential mediating effects of adrenocorticotropic hormone (ACTH)...

journal_title：Journal of pain research

authors： Papathanassoglou E,Mpouzika MD,Giannakopoulou M,Bozas E,Middleton N,Tsiaousis G,Karabinis A

更新日期：2017-01-13 00:00:00

abstract：:This paper reviews the current clinical data for the role of transdermal buprenorphine (BUP TDS) in the treatment of diverse acute and chronic pain syndromes. Literature searches were carried out using PubMed (1988 to June 2009). The published findings seem to support hypotheses regarding the rather unique analgesic m...

journal_title：Journal of pain research

authors： Hans G,Robert D

更新日期：2009-09-15 00:00:00