New topical treatment of vulvodynia based on the pathogenetic role of cross talk between nociceptors, immunocompetent cells, and epithelial cells.

abstract：:Nocebo hyperalgesia has received sparse experimental attention compared to placebo analgesia. The aim of the present study was to investigate if personality traits and fear of pain could predict experimental nocebo hyperalgesia. One hundred and eleven healthy volunteers (76 females) participated in an experimental stu...

journal_title：Journal of pain research

authors： Aslaksen PM,Lyby PS

更新日期：2015-10-12 00:00:00

abstract：:Duloxetine is a serotonin-norepinephrine reuptake inhibitor approved by the US Food and Drug Administration for the treatment of fibromyalgia and painful diabetic neuropathy at doses of 60 mg daily. Duloxetine has been shown to significantly improve the symptoms of chronic pain associated with these disorders, as meas...

journal_title：Journal of pain research

authors： Wright A,Luedtke KE,Vandenberg C

更新日期：2010-12-16 00:00:00

abstract：BACKGROUND:Low back pain is often called nonspecific pain. In this type of low back pain, various emotions and stress are known to strongly affect pain perception. The purpose of this study is to investigate how the degree of low back pain changes in people with chronic mild low back pain when they are inside and outsi...

journal_title：Journal of pain research

authors： Sakakibara T,Wang Z,Kasai Y

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:No proof of efficacy, in the form of a randomized controlled trial (RCT), exists to support pulsed radiofrequency (PRF) treatment of the dorsal root ganglion (DRG) for chronic lumbar radicular (CLR) pain. We determined the feasibility of a larger trial (primary objective), and also explored the efficacy of P...

journal_title：Journal of pain research

authors： Shanthanna H,Chan P,McChesney J,Thabane L,Paul J

更新日期：2014-01-10 00:00:00

abstract：:Cervical intervertebral disc has long been considered a common source of neck pain. However, the pain caused by the disc itself has not been clearly defined so far, and its diagnosis and treatment has always been controversial. Degenerative cervical disc has a rich supply of nerve fibers, is prone to inflammatory reac...

journal_title：Journal of pain research

authors： Peng B,DePalma MJ

更新日期：2018-11-14 00:00:00

abstract：Objective:To describe the rate and demographics of pain among Vietnamese people in 48 provinces and describe the impact of pain on individuals, levels of satisfaction with treatment results, and behavior of pain sufferers. Methods:The cross-sectional study was conducted in adults presenting to outpatient clinics throu...

journal_title：Journal of pain research

authors： Chuong NV,Pho DC,Thuy NTT,Nguyen DT,Luan NT,Minh LH,Khai LT,Linh NT,Kien NT

更新日期：2019-02-25 00:00:00

abstract：:Objectives: To classify patients suffering from low back pain (LBP) into two different groups - patients with lumbar disc herniation (LDH) and patients without this disease based on simple questions and without magnetic resonance imaging (MRI) procedure - and to diagnose the most effective risk factors of LDH. Methods...

journal_title：Journal of pain research

authors： Jafari S,Dehesh T,Iranmanesh F

更新日期：2019-04-15 00:00:00

abstract：Purpose:Pregabalin is indicated for postherpetic neuralgia (PHN) in multiple countries, including China. This analysis compared pregabalin efficacy and safety in Chinese and international patients with PHN. Patients and methods:Data from Chinese and international randomized, double-blind, placebo-controlled trials wer...

journal_title：Journal of pain research

authors： Parsons B,Pan X,Xie L,Chen Y,Ortiz M,Whalen E

更新日期：2018-09-03 00:00:00

abstract：Background:Transversus abdominis plane (TAP) block can provide effective analgesia for abdominal surgery. However, many randomized controlled trials (RCTs) have shown controversial results in hysterectomy. We conducted a meta-analysis of RCTs to investigate the effectiveness of TAP block after hysterectomy. Methods:St...

journal_title：Journal of pain research

authors： Zhou H,Ma X,Pan J,Shuai H,Liu S,Luo X,Li R

更新日期：2018-10-18 00:00:00

abstract：Purpose:The aim of this prospective study was to assess the behavior of emergency department (ED) nurses with regard to pain and their role in pain management in a real-life clinical setting. Methods:A total of 509 consecutive patients were enrolled during a 6-week period. A case-report form was used to collect data o...

journal_title：Journal of pain research

authors： Sardo S,Galletta M,Coni E,Aviles Gonzalez CI,Piras I,Pia G,Evangelista M,Musu M,Finco G

更新日期：2020-09-22 00:00:00

abstract：Background:The objective of this study was to compare the efficacy of calcitonin with diclofenac sodium in the treatment of patients with nonspecific low back pain (LBP) and type I Modic changes (MC1). Patients and methods:The study was a retrospective observational study with 109 patients who had nonspecific LBP and ...

journal_title：Journal of pain research

authors： Zhou J,Li T,Li L,Xue Y

更新日期：2018-07-17 00:00:00

abstract：Purpose:The upregulation of spinal NMDA receptor is a crucial mechanism in remifentanil-induced hyperalgesia (RIH). Wnt3a/β-catenin pathway plays an important role in neuropathic pain. We hypothesized that wnt3a inhibitor (iwp-2) could downregulate the expression of NR2B subunit in NMDA receptor, in order to relieve R...

journal_title：Journal of pain research

authors： Gao Y,Zhou S,Pan Y,Gu L,He Y,Sun J

更新日期：2020-05-19 00:00:00

abstract：Objective:To report a rare case of spontaneous fusion (SF) following cervical disc arthroplasty (CDA), to review the related literature, and to propose a new measure to prevent it. Methods:The course of a patient with SF is described here. The potential causes, risk factors, and preventive measure of SF after CDA publ...

journal_title：Journal of pain research

authors： Ge CY,Wang J,Zhang BF,Hui H,Shan LQ,Zhao QP,Hao DJ

更新日期：2020-04-21 00:00:00

abstract：Background:Femoral nerve block (FNB) has been considered as an excellent analgesic modality in total knee arthroplasty (TKA) pain control. However, relatively high concentration of ropivacaine could lead to quadriceps muscle weakness and increase the risk of postoperative falls. Objective:This double-blinded randomize...

journal_title：Journal of pain research

authors： Yang X,Kang W,Xiong W,Lu D,Zhou Z,Chen X,Zhou X,Feng X

更新日期：2019-12-17 00:00:00

abstract：BACKGROUND:The purpose of this study was to assess the attitudes of maternal health care providers to pain relief during labor in Zaria, Nigeria. METHODS:This was a multicenter, collaborative, cross-sectional pilot study of provider perspectives concerning pain relief during labor. A structured, self-administered, que...

journal_title：Journal of pain research

authors： Ogboli-Nwasor E,Adaji S,Bature S,Shittu O

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Chronic low back pain (CLBP) and chronic neck pain (CNP) have become a serious medical and socioeconomic problem in recent decades. Patients suffering from chronic pain seem to have a higher prevalence of sleep disorders. PURPOSE:To calculate the prevalence of sleep deprivation in patients with CLBP and CNP...

journal_title：Journal of pain research

authors： Artner J,Cakir B,Spiekermann JA,Kurz S,Leucht F,Reichel H,Lattig F

更新日期：2013-01-01 00:00:00

abstract：:Purpose: Although amiodarone is classified as a Vaughan-Williams class Ⅲ antiarrhythmic drug, it has inhibitory effects on voltage-gated sodium and calcium channels and on β-adrenergic receptors. Given these pharmacological profiles, amiodarone may have analgesic properties. Most patients who are prescribed amiodarone...

journal_title：Journal of pain research

authors： Kotoda M,Ino H,Kumakura Y,Iijima T,Ishiyama T,Matsukawa T

更新日期：2019-06-06 00:00:00

abstract：:This paper reviews the current clinical data for the role of transdermal buprenorphine (BUP TDS) in the treatment of diverse acute and chronic pain syndromes. Literature searches were carried out using PubMed (1988 to June 2009). The published findings seem to support hypotheses regarding the rather unique analgesic m...

journal_title：Journal of pain research

authors： Hans G,Robert D

更新日期：2009-09-15 00:00:00

abstract：PURPOSE:Conditioned pain modulation (CPM) is an experimental approach for probing endogenous analgesia by which one painful stimulus (the conditioning stimulus) may inhibit the perceived pain of a subsequent stimulus (the test stimulus). Animal studies suggest that CPM is mediated by a spino-bulbo-spinal loop using obj...

journal_title：Journal of pain research

authors： Bernaba M,Johnson KA,Kong JT,Mackey S

更新日期：2014-11-26 00:00:00

abstract：Background:Pancreatic cancer is a malignant disease with a high mortality rate and severe pain that is challenging to manage. To reduce the excruciating abdominal pain, opioids and adjuvant agents are conventionally used. Objectives:PRNCPB is a treatment of neural therapy. The number of studies assessing the effect on...

journal_title：Journal of pain research

authors： Molnár I,Hegyi G,Zsom L,Saahs C,Vagedes J,Kapócs G,Kovács Z,Sterner MG,Szőke H

更新日期：2019-01-14 00:00:00

abstract：PURPOSE:This paper aimed to investigate motor proficiency in fine and gross motor function, with a focus on reaction time (RT) and movement skill, in patients with fibromyalgia (FM) and chronic fatigue syndrome (CFS) compared to healthy controls (HC). METHODS:A total of 60 individuals (20 CFS, 20 FM, and 20 HC), age 1...

journal_title：Journal of pain research

authors： Rasouli O,Fors EA,Borchgrevink PC,Öhberg F,Stensdotter AK

更新日期：2017-02-07 00:00:00

abstract：Background:Neuroplastic changes in nociceptive pathways contribute to severity of symptoms in knee osteoarthritis (KOA). A new look at neuroplastic changes management includes modulation of the primary motor cortex by transcranial direct current stimulation (tDCS). Objectives:We investigated whether tDCS combined with...

journal_title：Journal of pain research

authors： da Graca-Tarragó M,Lech M,Angoleri LDM,Santos DS,Deitos A,Brietzke AP,Torres IL,Fregni F,Caumo W

更新日期：2019-01-03 00:00:00

abstract：Purpose:No final conclusion has yet been reached on characteristics of postoperative pain and pain-related factors after video-assisted thoracoscopic surgery (VATS). This study was designed to explore features of acute severe pain and chronic post-surgical pain (CPSP), and the pain-related factors of VATS. Patients an...

journal_title：Journal of pain research

authors： Tong Y,Wei P,Wang S,Sun Q,Cui Y,Ning N,Chen S,He X

更新日期：2020-07-21 00:00:00

abstract：Purpose:To explore the role of cervical sagittal alignment in the occurrence of adjacent-level ossification development (ALOD) in patients who underwent anterior cervical discectomy fusion with self-locking stand-alone polyetheretherketone cage, and the relationship between cervical sagittal alignment and clinical outc...

journal_title：Journal of pain research

authors： Liu W,Rong Y,Chen J,Luo Y,Tang P,Zhou Z,Fan J,Cai W

更新日期：2018-07-20 00:00:00

abstract：Background:Thoracoscopic surgery (TS) has been performed as a minimally invasive procedure since the beginning of the 1990s. This has led to a dramatic change in the postoperative condition of these patients, facilitating early ambulation and easier management of postoperative pain. However, empirical evidence on posto...

journal_title：Journal of pain research

authors： Kuroda H,Mizuno H,Dejima H,Watanabe K,Yoshida T,Naito Y,Sakao Y

更新日期：2017-11-15 00:00:00

abstract：:Paced breathing has shown efficacy in fibromyalgia (FM), but the mechanisms associated with symptom change are largely unknown. We investigated whether changes in respiratory rate (RR) alone resulted in autonomic changes during normal, paced, and mechanically assisted breathing in untrained FM patients and controls. P...

journal_title：Journal of pain research

authors： Schmidt JE,O'Brien TG,Hooten WM,Joyner MJ,Johnson BD

更新日期：2017-12-08 00:00:00

abstract：:Purpose: The study aimed to evaluate the analgesic efficiency of dexmedetomidine (DEX) when added to levobupivacaine in continuous ultrasound-guided serratus anterior plane block (SAPB) performed at the end of major thoracic surgery. Methods: This randomized, double-blind trial included 50 adults undergoing thoracic s...

journal_title：Journal of pain research

authors： Abdallah NM,Bakeer AH,Youssef RB,Zaki HV,Abbas DN

更新日期：2019-04-30 00:00:00

abstract：:The objective of this study was to evaluate the relationship between magnetic resonance imaging (MRI) findings and previous low back pain (LBP) in participants without current LBP. Current LBP was defined as LBP during the past month. Previous LBP was defined as a history of medical consultation for LBP. Ninety-one pa...

journal_title：Journal of pain research

authors： Tonosu J,Oka H,Matsudaira K,Higashikawa A,Okazaki H,Tanaka S

更新日期：2016-12-29 00:00:00

abstract：:Generalized joint hypermobility (GJH) is highly prevalent among patients diagnosed with chronic pain. When GJH is accompanied by pain in ≥4 joints over a period ≥3 months in the absence of other conditions that cause chronic pain, the hypermobility syndrome (HMS) may be diagnosed. In addition, GJH is also a clinical s...

journal_title：Journal of pain research

authors： Scheper MC,de Vries JE,Verbunt J,Engelbert RH

更新日期：2015-08-20 00:00:00

abstract：OBJECTIVES:Effective postoperative pain management is crucial in the care of surgical patients. Opioids, which are commonly used in managing postoperative pain, have a potential for tolerance and addiction, along with sedating side effects. Gabapentin's use as a multimodal analgesic regimen to treat neuropathic pain ha...

journal_title：Journal of pain research

authors： Arumugam S,Lau CS,Chamberlain RS

更新日期：2016-09-12 00:00:00