Retrospective Analysis of Real-World Outcomes of 10 kHz SCS in Patients with Upper Limb and Neck Pain.

Abstract:

Background:Patients living with chronic upper limb and neck (ULN) pain are reliant on often ineffective therapies as they face limited options for effective long-term treatment. Objective:Prospective clinical studies have demonstrated that high-frequency spinal cord stimulation at 10 kHz (10 kHz SCS) is effective in treating chronic pain in multiple etiologies including ULN pain. This study aimed at validating the findings from clinical studies on ULN in a real-world cohort. Study Design:A retrospective, observational review. Setting:A multicenter review between April 2016 and August 2019. Patients and Methods:Anonymized data were extracted from a real-world database of 47 consecutive patients aged ≥18 years of age with chronic upper limb and/or neck pain who were trialed and permanently implanted with 10 kHz SCS. Patient-reported pain relief, quality of life, function, sleep and medication use were extracted from anonymised patient records where available. Responder rates, defined as the proportion of patients with at least 50% pain relief at the end of trial and the last visit after implantation, were calculated. Results:All patients reported successful response (≥50% pain relief) at the end of trial and >75% patients continued to respond to the therapy at the last follow-up period. Majority (72%) of patients reported improvement in function, about half of the patients (53%) reported improvement in sleep and one-third of the patients (36%) reported reducing their medication at last follow-up. Conclusion:10 kHz SCS provides durable pain relief to patients with chronic upper limb and neck pain.

journal_name

J Pain Res

journal_title

Journal of pain research

authors

Sayed D,Salmon J,Khan TW,Sack AM,Braun T,Barnard A,Rotte A

doi

10.2147/JPR.S257071

subject

Has Abstract

pub_date

2020-06-15 00:00:00

pages

1441-1448

issn

1178-7090

pii

257071

journal_volume

13

pub_type

杂志文章
  • Effects of transversus abdominis plane blocks after hysterectomy: a meta-analysis of randomized controlled trials.

    abstract:Background:Transversus abdominis plane (TAP) block can provide effective analgesia for abdominal surgery. However, many randomized controlled trials (RCTs) have shown controversial results in hysterectomy. We conducted a meta-analysis of RCTs to investigate the effectiveness of TAP block after hysterectomy. Methods:St...

    journal_title:Journal of pain research

    pub_type: 杂志文章

    doi:10.2147/JPR.S172828

    authors: Zhou H,Ma X,Pan J,Shuai H,Liu S,Luo X,Li R

    更新日期:2018-10-18 00:00:00

  • Epidemiology of physician-diagnosed neuropathic pain in Brazil.

    abstract:Objectives:Estimate the prevalence of neuropathic pain (NeP) among chronic pain patients attending Brazilian hospitals and pain clinics in São Paulo, Ceara, and Bahia and explore clinical characteristics by subtypes: painful diabetic peripheral neuropathy (pDPN), central neuropathic pain (CNP), chronic low back pain wi...

    journal_title:Journal of pain research

    pub_type: 杂志文章

    doi:10.2147/JPR.S160504

    authors: Udall M,Kudel I,Cappelleri JC,Sadosky A,King-Concialdi K,Parsons B,Hlavacek P,Hopps M,Salomon PA,DiBonaventura MD,Clark P,Garcia JBS

    更新日期:2019-01-07 00:00:00

  • The psychological profile of women presenting to a multidisciplinary clinic for chronic pelvic pain: high levels of psychological dysfunction and implications for practice.

    abstract:OBJECTIVE:Chronic pelvic pain (CPP) is widely acknowledged as a common problem with significant consequences for those diagnosed with this condition. There is a lack of studies with good sample size that provide a comprehensive psychological profile of women presenting to specialist chronic pain clinics. Therefore, the...

    journal_title:Journal of pain research

    pub_type: 杂志文章

    doi:10.2147/JPR.S115065

    authors: Bryant C,Cockburn R,Plante AF,Chia A

    更新日期:2016-11-16 00:00:00

  • Nurses' Behavior Regarding Pain Treatment in an Emergency Department: A Single-Center Observational Study.

    abstract:Purpose:The aim of this prospective study was to assess the behavior of emergency department (ED) nurses with regard to pain and their role in pain management in a real-life clinical setting. Methods:A total of 509 consecutive patients were enrolled during a 6-week period. A case-report form was used to collect data o...

    journal_title:Journal of pain research

    pub_type: 杂志文章

    doi:10.2147/JPR.S266087

    authors: Sardo S,Galletta M,Coni E,Aviles Gonzalez CI,Piras I,Pia G,Evangelista M,Musu M,Finco G

    更新日期:2020-09-22 00:00:00

  • Reproducibility of the heat/capsaicin skin sensitization model in healthy volunteers.

    abstract:INTRODUCTION:Heat/capsaicin skin sensitization is a well-characterized human experimental model to induce hyperalgesia and allodynia. Using this model, gabapentin, among other drugs, was shown to significantly reduce cutaneous hyperalgesia compared to placebo. Since the larger thermal probes used in the original studie...

    journal_title:Journal of pain research

    pub_type: 杂志文章

    doi:10.2147/JPR.S53437

    authors: Cavallone LF,Frey K,Montana MC,Joyal J,Regina KJ,Petersen KL,Gereau RW 4th

    更新日期:2013-11-07 00:00:00

  • A comparison between the administration of oral prolonged-release oxycodone-naloxone and transdermal fentanyl in patients with moderate-to-severe cancer pain: a propensity score analysis.

    abstract:BACKGROUND:Opioids are the most important pharmacological treatment for moderate-to-severe cancer pain, but side effects limit their use. Transdermal fentanyl (TDF) and oral prolonged-release oxycodone-naloxone (OXN-PR) are effective in controlling chronic pain, with less constipation compared to other opioids. However...

    journal_title:Journal of pain research

    pub_type: 杂志文章

    doi:10.2147/JPR.S141928

    authors: Roberto A,Greco MT,Legramandi L,Galli F,Galli M,Corli O

    更新日期:2017-09-04 00:00:00

  • Current and future options for the management of phantom-limb pain.

    abstract::Phantom-limb pain (PLP) belongs among difficult-to-treat chronic pain syndromes. Treatment options for PLP are to a large degree implicated by the level of understanding the mechanisms and nature of PLP. Research and clinical findings acknowledge the neuropathic nature of PLP and also suggest that both peripheral as w...

    journal_title:Journal of pain research

    pub_type: 杂志文章

    doi:10.2147/JPR.S16733

    authors: Knotkova H,Cruciani RA,Tronnier VM,Rasche D

    更新日期:2012-01-01 00:00:00

  • Conditioned pain modulation is minimally influenced by cognitive evaluation or imagery of the conditioning stimulus.

    abstract:PURPOSE:Conditioned pain modulation (CPM) is an experimental approach for probing endogenous analgesia by which one painful stimulus (the conditioning stimulus) may inhibit the perceived pain of a subsequent stimulus (the test stimulus). Animal studies suggest that CPM is mediated by a spino-bulbo-spinal loop using obj...

    journal_title:Journal of pain research

    pub_type: 杂志文章

    doi:10.2147/JPR.S65607

    authors: Bernaba M,Johnson KA,Kong JT,Mackey S

    更新日期:2014-11-26 00:00:00

  • Changes in pain and concurrent pain medication use following compounded topical analgesic treatment for chronic pain: 3- and 6-month follow-up results from the prospective, observational Optimizing Patient Experience and Response to Topical Analgesics stu

    abstract:BACKGROUND:Opioids and other controlled substances prescribed for chronic pain are associated with abuse, addiction, and death, prompting national initiatives to identify safe and effective pain management strategies including topical analgesics. METHODS:This prospective, observational study evaluated changes from bas...

    journal_title:Journal of pain research

    pub_type: 杂志文章

    doi:10.2147/JPR.S143513

    authors: Gudin JA,Brennan MJ,Harris ED,Hurwitz PL,Dietze DT,Strader JD

    更新日期:2017-10-03 00:00:00

  • Anxiety-induced hyperalgesia in female rats is mediated by cholecystokinin 2 receptor in rostral ventromedial medulla and spinal 5-hydroxytryptamine 2B receptor.

    abstract:Background:Preoperative anxiety is associated with postoperative hyperalgesia; however, few studies have investigated the mechanism underlying this association in female surgical patients. Research has suggested that ON cells in the rostral ventromedial medulla (RVM) receive nerve impulses via cholecystokinin 2 (CCK2) ...

    journal_title:Journal of pain research

    pub_type: 杂志文章

    doi:10.2147/JPR.S187715

    authors: Jiang M,Bo J,Lei Y,Hu F,Xia Z,Liu Y,Lu C,Sun Y,Hou B,Ni K,Ma Z,Gu X

    更新日期:2019-07-03 00:00:00

  • Analgesic effects of amiodarone in mouse models of pain.

    abstract::Purpose: Although amiodarone is classified as a Vaughan-Williams class Ⅲ antiarrhythmic drug, it has inhibitory effects on voltage-gated sodium and calcium channels and on β-adrenergic receptors. Given these pharmacological profiles, amiodarone may have analgesic properties. Most patients who are prescribed amiodarone...

    journal_title:Journal of pain research

    pub_type: 杂志文章

    doi:10.2147/JPR.S196480

    authors: Kotoda M,Ino H,Kumakura Y,Iijima T,Ishiyama T,Matsukawa T

    更新日期:2019-06-06 00:00:00

  • Effects of the glial modulator palmitoylethanolamide on chronic pain intensity and brain function.

    abstract::Background: Chronic neuropathic pain (NP) is a complex disease that results from damage or presumed damage to the somatosensory nervous system. Current treatment regimens are often ineffective. The major impediment in developing effective treatments is our limited understanding of the underlying mechanisms. Preclinica...

    journal_title:Journal of pain research

    pub_type: 杂志文章

    doi:10.2147/JPR.S209657

    authors: Alshelh Z,Mills EP,Kosanovic D,Di Pietro F,Macey PM,Vickers ER,Henderson LA

    更新日期:2019-08-02 00:00:00

  • Gross and fine motor function in fibromyalgia and chronic fatigue syndrome.

    abstract:PURPOSE:This paper aimed to investigate motor proficiency in fine and gross motor function, with a focus on reaction time (RT) and movement skill, in patients with fibromyalgia (FM) and chronic fatigue syndrome (CFS) compared to healthy controls (HC). METHODS:A total of 60 individuals (20 CFS, 20 FM, and 20 HC), age 1...

    journal_title:Journal of pain research

    pub_type: 杂志文章

    doi:10.2147/JPR.S127038

    authors: Rasouli O,Fors EA,Borchgrevink PC,Öhberg F,Stensdotter AK

    更新日期:2017-02-07 00:00:00

  • The Effect Of Dexmedetomidine As Adjuvant To Ropivacaine 0.1% For Femoral Nerve Block On Strength Of Quadriceps Muscle In Patients Undergoing Total Knee Arthroplasty: A Double-Blinded Randomized Controlled Trial.

    abstract:Background:Femoral nerve block (FNB) has been considered as an excellent analgesic modality in total knee arthroplasty (TKA) pain control. However, relatively high concentration of ropivacaine could lead to quadriceps muscle weakness and increase the risk of postoperative falls. Objective:This double-blinded randomize...

    journal_title:Journal of pain research

    pub_type: 杂志文章

    doi:10.2147/JPR.S217283

    authors: Yang X,Kang W,Xiong W,Lu D,Zhou Z,Chen X,Zhou X,Feng X

    更新日期:2019-12-17 00:00:00

  • Tolerability of NGX-4010, a capsaicin 8% patch, in conjunction with three topical anesthetic formulations for the treatment of neuropathic pain.

    abstract:BACKGROUND:The objective of this study was to assess the safety, tolerability, and preliminary efficacy of NGX-4010, a capsaicin 8% patch, following pretreatment with three different topical anesthetics in patients with peripheral neuropathic pain. METHODS:This open-label, multicenter study enrolled 117 patients with ...

    journal_title:Journal of pain research

    pub_type: 杂志文章

    doi:10.2147/JPR.S25272

    authors: Webster LR,Peppin JF,Murphy FT,Tobias JK,Vanhove GF

    更新日期:2012-01-01 00:00:00

  • Acupotomy versus Manual Acupuncture for the Treatment of Back and/or Leg Pain in Patients with Lumbar Disc Herniation: A Multicenter, Randomized, Controlled, Assessor-Blinded Clinical Trial.

    abstract:Background:Acupotomy, which involves the addition of a scalpel function to the conventional acupuncture treatment, has recently been applied as a conservative treatment method for lumbar disc herniation (LDH). This study investigated the effectiveness and safety of acupotomy, compared to manual acupuncture, for the tre...

    journal_title:Journal of pain research

    pub_type:

    doi:10.2147/JPR.S234761

    authors: Jeong JK,Kim E,Yoon KS,Jeon JH,Kim YI,Lee H,Kwon O,Jung SY,Lee JH,Yang C,Kang JH,Han CH

    更新日期:2020-04-01 00:00:00

  • Ultrasound-Guided Stellate Ganglion Block for Central Post-Stroke Pain: A Case Report and Review.

    abstract:Background:Central post-stroke pain (CPSP) is refractory to pharmacotherapy (eg, NSAIDs, opioids, antidepressants, and anticonvulsants), and may require transcranial or deep brain stimulation. Case Presentation:A 67-year-old woman presented with severe paroxysmal cramp-like pain on the right side, including the head a...

    journal_title:Journal of pain research

    pub_type:

    doi:10.2147/JPR.S236812

    authors: Liu Q,Zhong Q,Tang G,Ye L

    更新日期:2020-02-26 00:00:00

  • Spontaneous Fusion After Cervical Disc Arthroplasty: A Case Report and Literature Review.

    abstract:Objective:To report a rare case of spontaneous fusion (SF) following cervical disc arthroplasty (CDA), to review the related literature, and to propose a new measure to prevent it. Methods:The course of a patient with SF is described here. The potential causes, risk factors, and preventive measure of SF after CDA publ...

    journal_title:Journal of pain research

    pub_type:

    doi:10.2147/JPR.S242646

    authors: Ge CY,Wang J,Zhang BF,Hui H,Shan LQ,Zhao QP,Hao DJ

    更新日期:2020-04-21 00:00:00

  • Prevalence of sleep deprivation in patients with chronic neck and back pain: a retrospective evaluation of 1016 patients.

    abstract:BACKGROUND:Chronic low back pain (CLBP) and chronic neck pain (CNP) have become a serious medical and socioeconomic problem in recent decades. Patients suffering from chronic pain seem to have a higher prevalence of sleep disorders. PURPOSE:To calculate the prevalence of sleep deprivation in patients with CLBP and CNP...

    journal_title:Journal of pain research

    pub_type: 杂志文章

    doi:10.2147/JPR.S36386

    authors: Artner J,Cakir B,Spiekermann JA,Kurz S,Leucht F,Reichel H,Lattig F

    更新日期:2013-01-01 00:00:00

  • Real-life management of patients with breakthrough cancer pain caused by bone metastases in Spain.

    abstract::Purpose: We aimed to explore the characteristics, and real-life therapeutic management of patients with breakthrough cancer pain (BTcP) caused by bone metastases in Spain, and to evaluate physicians' opinion of and satisfaction with prescribed BTcP therapy. Participants and methods: For the purposes of this study, an ...

    journal_title:Journal of pain research

    pub_type: 杂志文章

    doi:10.2147/JPR.S194881

    authors: Ferrer Albiach C,Villegas Estévez F,López Alarcón MD,de Madariaga M,Carregal A,Arranz J,Trinidad Martín-Arroyo JM,Jiménez López AJ,Sanz Yagüe A

    更新日期:2019-07-12 00:00:00

  • Clinical efficacy of calcitonin compared to diclofenac sodium in chronic nonspecific low back pain with type I Modic changes: a retrospective study.

    abstract:Background:The objective of this study was to compare the efficacy of calcitonin with diclofenac sodium in the treatment of patients with nonspecific low back pain (LBP) and type I Modic changes (MC1). Patients and methods:The study was a retrospective observational study with 109 patients who had nonspecific LBP and ...

    journal_title:Journal of pain research

    pub_type: 杂志文章

    doi:10.2147/JPR.S158718

    authors: Zhou J,Li T,Li L,Xue Y

    更新日期:2018-07-17 00:00:00

  • The relationship between findings on magnetic resonance imaging and previous history of low back pain.

    abstract::The objective of this study was to evaluate the relationship between magnetic resonance imaging (MRI) findings and previous low back pain (LBP) in participants without current LBP. Current LBP was defined as LBP during the past month. Previous LBP was defined as a history of medical consultation for LBP. Ninety-one pa...

    journal_title:Journal of pain research

    pub_type: 杂志文章

    doi:10.2147/JPR.S122380

    authors: Tonosu J,Oka H,Matsudaira K,Higashikawa A,Okazaki H,Tanaka S

    更新日期:2016-12-29 00:00:00

  • Impact of a multidisciplinary pain management program on patient care utilization and cost of care.

    abstract:Objective:Chronic pain is a highly prevalent and costly condition with few proven treatment options. Since 2014, Geisinger's Department of Pain Medicine has implemented the Multidisciplinary Pain Program (MPP), which consists of a 3-day educational seminar followed by 12 months of comprehensive care. This study examine...

    journal_title:Journal of pain research

    pub_type: 杂志文章

    doi:10.2147/JPR.S177231

    authors: Maeng DD,Baylor K,Bulger JB,Han JJ

    更新日期:2018-10-18 00:00:00

  • Knowledge and Attitude Towards Non-Pharmacological Pain Management and Associated Factors Among Nurses Working in Benishangul Gumuz Regional State Hospitals in Western Ethiopia, 2018.

    abstract:Background:Millions of people worldwide are suffering from pain. Non-pharmacological therapy has an important role in the treatment of pain and is recognized as a valuable, simple help to lower the dosage of analgesic drugs needed, decreasing the side effects, reducing drug dependency and reducing health care costs; ho...

    journal_title:Journal of pain research

    pub_type: 杂志文章

    doi:10.2147/JPR.S265544

    authors: Jira L,Weyessa N,Mulatu S,Alemayehu A

    更新日期:2020-11-16 00:00:00

  • Intramuscular electrical stimulus potentiates motor cortex modulation effects on pain and descending inhibitory systems in knee osteoarthritis: a randomized, factorial, sham-controlled study.

    abstract:Background:Neuroplastic changes in nociceptive pathways contribute to severity of symptoms in knee osteoarthritis (KOA). A new look at neuroplastic changes management includes modulation of the primary motor cortex by transcranial direct current stimulation (tDCS). Objectives:We investigated whether tDCS combined with...

    journal_title:Journal of pain research

    pub_type: 杂志文章

    doi:10.2147/JPR.S181019

    authors: da Graca-Tarragó M,Lech M,Angoleri LDM,Santos DS,Deitos A,Brietzke AP,Torres IL,Fregni F,Caumo W

    更新日期:2019-01-03 00:00:00

  • Increased cerebral nuclear factor kappa B in a complex regional pain syndrome rat model: possible relationship between peripheral injury and the brain.

    abstract:Purpose:Complex regional pain syndrome (CRPS) is a rare but refractory pain disorder. Recent advanced information retrieval studies using text-mining and network analysis have suggested nuclear factor kappa B (NFκB) as a possible central mediator of CRPS. The brain is also known to play important roles in CRPS. The aim...

    journal_title:Journal of pain research

    pub_type: 杂志文章

    doi:10.2147/JPR.S166270

    authors: Nahm FS,Nahm SS,Han WK,Gil HY,Choi E,Lee PB

    更新日期:2019-03-06 00:00:00

  • Vitellaria paradoxa Nut Triterpene-Rich Extract Ameliorates Symptoms of Inflammation on Post-Traumatic Osteoarthritis in Obese Rats.

    abstract:Purpose:To investigate the ameliorative effects of Vitellaria paradoxa (VP) nut extract for an anterior cruciate ligament transection with medial meniscectomy (ACLT+MMx)-induced osteoarthritis (OA) in high-fat diet (HFD)-induced obese rats. Methods:The rats were fed by HFD for 5 weeks before surgery-induced OA. Rats w...

    journal_title:Journal of pain research

    pub_type: 杂志文章

    doi:10.2147/JPR.S228766

    authors: Sudirman S,Chen CK,Long BT,Chang HW,Tsou D,Kong ZL

    更新日期:2020-01-30 00:00:00

  • Low Back Pain Caused by Iliopsoas Tendinopathy Treated with Ultrasound-Guided Local Injection of Anesthetic and Steroid: A Retrospective Study.

    abstract:Background:Low back pain is a prevalent symptom that occurs in all age of people, whereas the pathogenesis is unknown. Iliopsoas tendinopathy is an increasingly recognized hip disorder that may contribute to low back pain. Our purpose is to evaluate the effect of ultrasound-guided local injection of anesthetic and ster...

    journal_title:Journal of pain research

    pub_type: 杂志文章

    doi:10.2147/JPR.S281880

    authors: Zhu Z,Zhang J,Sheng J,Zhang C,Xie Z

    更新日期:2020-11-20 00:00:00

  • Therapeutic effect of epidural hyaluronic acid in a rat model of foraminal stenosis.

    abstract:PURPOSE:Since receiving a warning from the US Food and Drug Administration (FDA) about injection of corticosteroids into the epidural space having serious adverse events, we have sought alternative medications for injection at this site. Hyaluronic acid (HA) has anti-adhesive, anti-inflammatory, and lubricating propert...

    journal_title:Journal of pain research

    pub_type: 杂志文章

    doi:10.2147/JPR.S122861

    authors: Nahm FS,Lee PB,Choe GY,Lim YJ,Kim YC

    更新日期:2017-01-25 00:00:00

  • CBD Effects on TRPV1 Signaling Pathways in Cultured DRG Neurons.

    abstract:Introduction:Cannabidiol (CBD) is reported to produce pain relief, but the clinically relevant cellular and molecular mechanisms remain uncertain. The TRPV1 receptor integrates noxious stimuli and plays a key role in pain signaling. Hence, we conducted in vitro studies, to elucidate the efficacy and mechanisms of CBD f...

    journal_title:Journal of pain research

    pub_type: 杂志文章

    doi:10.2147/JPR.S258433

    authors: Anand U,Jones B,Korchev Y,Bloom SR,Pacchetti B,Anand P,Sodergren MH

    更新日期:2020-09-11 00:00:00