abstract：:Acute myeloid leukemia (AML) is a malignant disease originating from bone marrow hematopoietic stem cells, characterized by anemia, hemorrhage, fever, and infection, with low survival rate. However, the pathogenesis of AML is not fully understood at present. In this work, an integrated approach based untargeted metabo...

authors： Yuan Y,Wu Q,Zhao J,Feng Z,Dong J,An M,Wu G,Qin F,Zhao L

更新日期：2021-02-20 00:00:00

abstract：:A new approach to the quantitative analysis of parabens (PBs) in cosmetics, based on microextraction by packed sorbent (MEPS) followed by HPLC-UV detection is proposed. The development of optimal conditions for the sample preparation step was carried out in two stages. The potentially important factors that could infl...

authors： Khesina ZB,Iartsev SD,Revelsky AI,Buryak AK

更新日期：2021-02-20 00:00:00

abstract：:Gel electrophoresis-based and shotgun approaches are the most employed proteomic platforms in plant biology research, with the latter replacing the former in the last years. We have compared 2-DE-MALDI-TOF/TOF and GeLC-Orbitrap/MS analyses using the same protein extracts from Quercus ilex cotyledons at different devel...

authors： Sghaier-Hammami B,Castillejo MÁ,Baazaoui N,Jorrín-Novo JV,Escandón M

更新日期：2021-02-20 00:00:00

abstract：:The pollen beetle is a major pest of oilseed rape. Although various resistance mechanisms have been identified, such as kdr (mutation in the sodium channel) and metabolic resistance (CYP overexpression), other "hidden" factors also exist. Some studies have stressed the importance of epistasis as a genetic background. ...

authors： Kocourek F,Stara J,Sopko B,Talacko P,Harant K,Hovorka T,Erban T

更新日期：2021-02-20 00:00:00

abstract：:Sinoporphyrin sodium (DVDMS) is a new photosensitizer (PS) and it is used in photodynamic therapy (PDT) against tumor. In this paper, a simple, rapid and specific ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method for the quantitation of DVDMS in human plasma was developed. The analyt...

authors： Zhou J,Yang F,Yuan JJ,Bo YH,Gong JF,Shen L

更新日期：2021-02-20 00:00:00

abstract：:Pregnane X receptor (PXR) is highly expressed in the liver and plays an integral role in the control of xenobiotic and endobiotic metabolism to maintain homeostasis. We previously reported that activation of PXR significantly induced liver enlargement. But the lipid profiling during PXR-induced hepatomegaly remains un...

authors： Jiang Y,Yao X,Fan S,Gao Y,Zhang H,Huang M,Bi H

更新日期：2021-02-20 00:00:00

abstract：:Hereditary angioedema (HAE) is a rare genetic disease caused by deficiency or dysfunction of C1 esterase inhibitor (C1-INH). Plasma C1-INH activity and concentrations of C1-INH and complement components 1q and 4 (C1q, C4) are critical to the HAE diagnosis. We describe a novel multiplexed assay to simultaneously measur...

authors： Lai Y,Zhang G,Inhaber N,Bernstein JA,Cwik M,Zhou Z,Chockalingam PS,Wu J

更新日期：2021-02-20 00:00:00

abstract：:In this work, a deep eutectic solvent (DES) composed of tetrabutylammonium bromide (TBABr) and acetic acid in a 1:2 M ratio was applied as the dispersive solvent for the dispersive liquid-liquid microextraction based on solidification of floating organic droplet (DLLME-SFO), using 1-decanol as extractant. Six preserva...

authors： Bian Y,Wang Y,Yu J,Zheng S,Qin F,Zhao L

更新日期：2021-02-20 00:00:00

abstract：:The metabolite profiling of plant extracts always represents an exciting challenge, as the chemical diversity of natural products is still far beyond the researchers' imagination, even focusing on a plant that is thought to have already been broadly investigated. Herein UHPLC-HRMS/MS techniques were applied to an alco...

authors： Brahmi-Chendouh N,Piccolella S,Nigro E,Hamri-Zeghichi S,Madani K,Daniele A,Pacifico S

更新日期：2021-02-20 00:00:00

abstract：: Significance: Excessive and prolonged proinflammatory responses are associated with oxidative stress, which is commonly observed during chronic tuberculosis (TB). Such condition favors tissue destruction and consequently bacterial spread. A tissue remodeling program is als...

authors： Amaral EP,Vinhaes CL,Oliveira-de-Souza D,Nogueira B,Akrami KM,Andrade BB

更新日期：2021-02-20 00:00:00

abstract：:The contribution of glutamatergic transmission to generation of initial convulsive seizures (CS) is debated. We tested whether pretreatment with a glutamine synthetase (GS) inhibitor, methionine sulfoximine (MSO), affects the onset and progression of initial CS by cholinergic stimulus in juvenile rats. Male rats (24 d...

authors： Pawlik MJ,Obara-Michlewska M,Popek MP,Czarnecka AM,Czuczwar SJ,Łuszczki J,Kołodziej M,Acewicz A,Wierzba-Bobrowicz T,Albrecht J

更新日期：2021-02-15 00:00:00

abstract：:Anxiety is a very common yet poorly understood symptom of Parkinson's disease. We investigated whether Parkinson's disease patients experiencing anxiety share neural mechanisms described in the general population with involvement of critical regions for the control of behaviour and movement. Thirty-nine patients with ...

authors： Criaud M,Kim JH,Zurowski M,Lobaugh N,Chavez S,Houle S,Strafella AP

更新日期：2021-02-15 00:00:00

abstract：Introduction:It is often quoted that 70% of clinical decisions are based on laboratory results, but the evidence to substantiate this claim is lacking. Since clinical guidelines aim to document best-practice decision making for specific disease conditions, inclusion of any laboratory test means that the best available ...

authors： Hicks AJ,Carwardine ZL,Hallworth MJ,Kilpatrick ES

更新日期：2021-02-15 00:00:00

abstract：BACKGROUND:Symptoms of grief vary by culture and societal reactions to death may be gender specific. We aimed to validate a Nepali language version of the Prolonged Grief-13 item scale (PG-13) among widows. METHODS:We tested two adapted versions of a Prolonged Grief Disorder (PGD) instrument with 204 Nepali-speaking w...

authors： Surkan PJ,Garrison-Desany HM,Rimal D,Luitel NP,Kim Y,Prigerson HG,Shrestha S,Tol W,Murray SM

更新日期：2021-02-15 00:00:00

abstract：BACKGROUND:Examining variability in the presenting symptoms of depression may be particularly important in characterizing depression in patients with comorbid conditions such as obesity. Identifying the underlying constructs of depression in such patients may produce phenotypic information to aid diagnosis and treatmen...

authors： Majd M,Smyth JM,Lv N,Xiao L,Snowden MB,Venditti EM,Williams LM,Ajilore OA,Suppes T,Ma J

更新日期：2021-02-15 00:00:00

abstract：BACKGROUND:Prior studies have established inconsistent associations between body weight and mental health. However, most work has relied on body mass index (BMI) and examination of a single mental health variable. The present study examined associations of BMI and waist circumference with multiple mental health variabl...

authors： Yusufov M,Kopeski LM,Silverman AL,Björgvinsson T

更新日期：2021-02-15 00:00:00

abstract：INTRODUCTION:Altered levels of acute-phase proteins are often described in different conditions in BD. Nevertheless, data on the association between lithium treatment and inflammatory markers in the long-term course of BD are still missing. The aim of the study was to examine the long-term course of BD concerning long-...

authors： Queissner R,Lenger M,Birner A,Dalkner N,Fellendorf F,Bengesser S,Platzer M,Hamm C,Maget A,Reininghaus B,Ratzenhofer M,Schuller J,Mangge H,Kapfhammer HP,Reininghaus EZ

更新日期：2021-02-15 00:00:00

abstract：:This study aimed to evaluate the effects of leptin, ghrelin and neuropeptide-Y on the development of nonconvulsive seizure activity and their role on combating oxidative stress and cytokines produced by the systemic immune response in the WAG/Rij rat model for genetic absence epilepsy. Current study showed that all th...

authors： Oztas B,Sahin D,Kir H,Kuskay S,Ates N

更新日期：2021-02-15 00:00:00

abstract：:Ischemia/reperfusion injury (IRI) initiates from oxidative stress caused by lack of blood supply and subsequent reperfusion. It is often associated with sterile inflammation, cell death and microvascular dysfunction, which ultimately results in myocardial, cerebral and hepatic IRIs. Reportedly, deregulation of Nrf2 pa...

authors： Padmavathi G,Ramkumar KM

更新日期：2021-02-15 00:00:00

abstract：INTRODUCTION:The objective of this randomized controlled trial (RCT) was to quantify the effects of eight weeks of World Health Organization and American College of Sports Medicine guidelines-based resistance exercise training (RET) among participants meeting criteria for subclinical, or analogue-GAD (AGAD) METHODS: Fo...

authors： Gordon BR,McDowell CP,Lyons M,Herring MP

更新日期：2021-02-15 00:00:00

abstract：BACKGROUND:Bipolar disorder (BD) might be associated in disturbances in brain networks. However, little is known about the abnormalities in structural brain connectivity which might be related to vulnerability to BD and predictive of the emergence of manic symptoms. No previous study has investigated the effect of subt...

authors： Bora E,Can G,Zorlu N,Ulas G,Inal N,Ozerdem A

更新日期：2021-02-15 00:00:00

abstract：BACKGROUND:The International Society for Bipolar Disorders Targeting Cognition Task Force recommends screening for and monitoring of cognitive impairments in patients with bipolar disorder (BD) with the Screen for Cognitive Impairment in Psychiatry (SCIP). The study aimed to provide the first demographically adjusted n...

authors： Ott CV,Knorr U,Jespersen A,Obenhausen K,Røen I,Purdon SE,Kessing LV,Miskowiak KW

更新日期：2021-02-15 00:00:00

abstract：BACKGROUND:Slower and suboptimal decision making has been identified in adults with schizophrenia and bipolar disorder. Owing to the limited evidence on decision making in first-degree relatives, we aimed to investigate, whether alterations in decision making are present in young children at familial high risk of bipol...

authors： Hemager N,Jepsen JRM,Thorup A,Christiani C,Ellersgaard D,Spang KS,Burton BK,Gregersen M,Søndergaard A,Greve AN,Gantriis DL,Mors O,Nordentoft M,Plessen KJ

更新日期：2021-02-15 00:00:00

abstract：BACKGROUND:Depression is a prevalent and disabling condition in youth. Treatment efficacy has been demonstrated for several therapeutic modalities. Acceptability of treatments is also important to explore and was addressed by investigating treatment dropout using meta-analyses. METHODS:A systematic search was conducte...

authors： Wright I,Mughal F,Bowers G,Meiser-Stedman R

更新日期：2021-02-15 00:00:00

abstract：BACKGROUND:Telephone-administered psychotherapy (tCBT) and internet-based treatments (iCBT) may overcome barriers to mental health treatment. TCBT has demonstrated efficacy similar to traditional psychotherapy, however, few studies have compared iCBT to efficacious interventions. This exploratory study examined the non...

authors： Nicholas J,Knapp AA,Vergara JL,Graham AK,Gray EL,Lattie EG,Kwasny MJ,Mohr DC

更新日期：2021-02-15 00:00:00

abstract：BACKGROUND:Default mode network (DMN) has been widely reported to be altered in bipolar disorder during major depressive episode (BDD). Recent studies supported the idea that DMN is not an unitary system, but composed of smaller and distinct functional subsystems. The current study aimed to investigate the abnormal fun...

authors： Yang Y,Cui Q,Lu F,Pang Y,Chen Y,Tang Q,Li D,Lei T,He Z,Hu S,Deng J,Chen H

更新日期：2021-02-15 00:00:00

abstract：LAY SUMMARY:During the coronavirus disease 2019 (COVID-19) pandemic, cancer screening decreased precipitously; home screening for colorectal cancer diminished less than that for colonoscopy and breast and cervical cancer screening. The authors have highlighted approaches for home cancer screening in addition to telemed...

authors： Gorin SNS,Jimbo M,Heizelman R,Harmes KM,Harper DM

更新日期：2021-02-15 00:00:00

abstract：BACKGROUND:The association of community factors and outcomes after hematopoietic cell transplantation (HCT) has not been comprehensively described. Using the County Health Rankings and Roadmaps (CHRR) and the Center for International Blood and Marrow Transplant Research (CIBMTR), this study evaluated the impact of comm...

authors： Hong S,Brazauskas R,Hebert KM,Ganguly S,Abdel-Azim H,Diaz MA,Beattie S,Ciurea SO,Szwajcer D,Badawy SM,Gratwohl AA,LeMaistre C,Aljurf MDSM,Olsson RF,Bhatt NS,Farhadfar N,Yared JA,Yoshimi A,Seo S,Gergis U,Beitinjane

更新日期：2021-02-15 00:00:00

abstract：:Animal models of alcohol drinking and dependence are a critical resource for understanding the neurobiological mechanisms and development of more effective treatments for alcohol use disorder (AUD). Because most rat strains do not voluntarily consume large enough quantities of alcohol to adequately model heavy drinkin...

authors： Glover EJ,Khan F,Clayton-Stiglbauer K,Chandler LJ

更新日期：2021-02-15 00:00:00

abstract：:Tobacco addiction is highly co-morbid with a variety of mental health conditions, including schizophrenia, mood and anxiety disorders. Nicotine, the primary psychoactive compound in tobacco-related products is known to functionally modulate brain circuits that are disturbed in these disorders. Nicotine can potently re...

authors： Laviolette SR

更新日期：2021-02-15 00:00:00

abstract：:Phosphodiesterases (PDE) are the only enzymes that degrade cAMP and cGMP which are second messengers crucial to memory consolidation. Different PDE inhibitors have been developed and tested for their memory-enhancing potential, but the occurrence of side effects has hampered clinical progression. As separate inhibitio...

authors： Paes D,Xie K,Wheeler DG,Zook D,Prickaerts J,Peters M

更新日期：2021-02-15 00:00:00

abstract：:Differences in overall cocaine intake can directly affect neuroadaptations, and this relationship can make it difficult to interpret neurobiological changes seen in drug-choice studies, since drug intake varies between subjects. Herein, a choice procedure that controls for cocaine intake was utilized to explore if neu...

authors： Chow JJ,Hofford RS,Beckmann JS

更新日期：2021-02-15 00:00:00

abstract：:The NLRP3 inflammasome regulates innate immune and inflammatory responses by promoting pro-inflammatory cytokines such as IL-18 and IL-1β. NLRP3 is one of the main factors restricting the activation of the inflammasome, which is closely related to the abundance and localization of NLRP3. A substantial number of studie...

authors： Ge Q,Chen X,Zhao Y,Mu H,Zhang J

更新日期：2021-02-15 00:00:00

abstract：:The scientific interest in irisin, a myokine discovered in 2012, has grown exponentially in recent years. Irisin, which is mainly produced in skeletal muscle, influences the browning process of adipose tissue and lipid and energy metabolism. Recent discoveries highlight that the potential of this hormone may have been...

authors： Flori L,Testai L,Calderone V

更新日期：2021-02-15 00:00:00

abstract：:Arsenic as a one of the most important toxic metals could induce hepatotoxicity. Previous reports revealed the significance of oxidative stress in promoting of arsenic-induced liver toxicity. The aim of the present investigation is to evaluate the effect of chrysin (CHR), a natural flavonoid with potent antioxidant ac...

authors： Fatemi I,Khalili H,Mehrzadi S,Basir Z,Malayeri A,Goudarzi M

更新日期：2021-02-15 00:00:00

abstract：:The prokaryotic CRISPR-Cas systems could be applied as revolutionized genome editing tool in live cells of various species to modify, visualize and identify definite sequences of DNA and RNA. CRISPR-Cas could edit the genome by homology-directed repair and non-homologous end joining mechanisms. Furthermore, DNA-target...

authors： Ghaemi A,Bagheri E,Abnous K,Taghdisi SM,Ramezani M,Alibolandi M

更新日期：2021-02-15 00:00:00

abstract：AIMS:Poly (ADP-ribose) polymerase- (PARP)-1 is predominantly triggered by DNA damage. Overexpression of PARP-1 is known for its association with the pathogenesis of several CNS disorders, such as Stroke, Parkinson's disease (PD), Alzheimer's disease (AD), Huntington (HD) and Amyotrophic lateral sclerosis (ALS). NAD+ de...

authors： Thapa K,Khan H,Sharma U,Grewal AK,Singh TG

更新日期：2021-02-15 00:00:00

abstract：:Brachyura is one of the most species rich and highly derived groups among extant crustaceans, with over 7250 known species. However, brachyuran phylogeny remains controversial and requires further study. Here, we combined 103 brachyuran mitogenomes from GenBank with 10 new mitogenomes to describe gene rearrangement pa...

authors： Wang Q,Wang J,Wu Q,Xu X,Wang P,Wang Z

更新日期：2021-02-15 00:00:00

abstract：:Having cotton fabrics with multifunctional properties is of the most research focused on using either different processes or new and different materials. Improving thermo - responsive and antibacterial properties of cotton fabrics decorated with silver nanoparticles and nanogel has been investigated. During this resea...

authors： Mohamed AL,Hassabo AG

更新日期：2021-02-15 00:00:00

abstract：:Modified biopolymer chitosan namely 2-hydroxy-1-naphthaldehyde chitosan (CTS-Nap) has been synthesized for the removal of toxic chromium from aqueous solutions. In an attempt to enhance the adsorption capacity of toxic chromium on the prepared modified biopolymer, magnetic Fe3O4 nanoparticles have been loaded on the m...

authors： Khalil TE,Elhusseiny AF,Ibrahim NM,El-Dissouky A

更新日期：2021-02-15 00:00:00