Determination of a novel photosensitizer sinoporphyrin sodium in human plasma by ultra-performance liquid chromatography-tandem mass spectrometry.

Abstract:

:Sinoporphyrin sodium (DVDMS) is a new photosensitizer (PS) and it is used in photodynamic therapy (PDT) against tumor. In this paper, a simple, rapid and specific ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method for the quantitation of DVDMS in human plasma was developed. The analytes were extracted from plasma samples using liquid-liquid extraction (LLE) after addition of testosterone (internal standard) and chromatographed on an AQUITY UPLC Protein BEH C4 column (50 × 2.1 mm, i.d. 1.7 μm) thermostatted at 40 °C with acetonitrile-water (0.1% formic acid and 0.1 mM K2EDTA) as the gradient mobile phase at flow rate of 0.5 mL/min. The detection was performed on an API 5500 mass spectrometer coupled with electrospray ionization (ESI) source in positive mode. The multiple reactions monitoring (MRM) transitions of m/z 1143.6→563.2 and m/z 289.3→109.1 were used to quantify DVDMS and IS, respectively. The assay was validated over the concentration range of 30-3000 ng/mL. Precision and accuracy are in accordance with the generally accepted criteria for bioanalytical methods. The extraction recovery and the matrix effect were investigated. This method was successfully applied to pharmacokinetic (PK) study of DVDMS in Chinese patients with solid tumor after treated with DVDMS-PDT for the first time.

journal_name

J Pharm Biomed Anal

authors

Zhou J,Yang F,Yuan JJ,Bo YH,Gong JF,Shen L

doi

10.1016/j.jpba.2020.113852

subject

Has Abstract

pub_date

2021-02-20 00:00:00

pages

113852

eissn

0731-7085

issn

1873-264X

pii

S0731-7085(20)31739-8

journal_volume

195

pub_type

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