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The association between anti-inflammatory effects of long-term lithium treatment and illness course in Bipolar Disorder.

Abstract：

INTRODUCTION:Altered levels of acute-phase proteins are often described in different conditions in BD. Nevertheless, data on the association between lithium treatment and inflammatory markers in the long-term course of BD are still missing. The aim of the study was to examine the long-term course of BD concerning long-term lithium treatment, chronic inflammatory processes and symptom progression. Furthermore, the association between duration of lithium treatment and levels of hsCRP was explored. METHODS:267 individuals (males= 139, females= 128) with BD were included. Duration of lithium treatment as well as symptom progression, defined as the increase in severity of symptoms, number of episodes a year and duration of episodes within a period of 1.5 years in the past and hsCRP were evaluated. RESULTS:Male individuals with symptom progression over time had significantly lower duration of lithium treatment compared to individuals without symptoms progression (U= 47.4, p=.037). There were significantly higher levels of hsCRP in male individuals with symptom progression compared to males without symptom progression (U= 47.5, p=.027). Further, there was a significant negative correlation between the duration of lithium treatment and hsCRP levels in the whole sample (r= -.276, p<.05). CONCLUSION:Our results show that an altered inflammatory state may be associated with a more severe illness course in BD. Further, a longer duration of lithium treatment may be associated with lower symptom progression. The shown association between hsCRP-levels and lithium treatment duration suggests a potential anti-inflammatory effect of lithium as a mediator of its significant positive outcome effect in BD.

journal_name

J Affect Disord

journal_title

Journal of affective disorders

authors

Queissner R,Lenger M,Birner A,Dalkner N,Fellendorf F,Bengesser S,Platzer M,Hamm C,Maget A,Reininghaus B,Ratzenhofer M,Schuller J,Mangge H,Kapfhammer HP,Reininghaus EZ

doi

10.1016/j.jad.2020.11.063

subject

Has Abstract

pub_date

2021-02-15 00:00:00

pages

228-234

eissn

0165-0327

issn

1573-2517

pii

S0165-0327(20)32993-1

journal_volume

281

pub_type

杂志文章

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The association between anti-inflammatory effects of long-term lithium treatment and illness course in Bipolar Disorder.