abstract：:Ischemia/reperfusion injury (IRI) initiates from oxidative stress caused by lack of blood supply and subsequent reperfusion. It is often associated with sterile inflammation, cell death and microvascular dysfunction, which ultimately results in myocardial, cerebral and hepatic IRIs. Reportedly, deregulation of Nrf2 pa...

journal_title：Archives of biochemistry and biophysics

authors： Padmavathi G,Ramkumar KM

更新日期：2021-02-15 00:00:00

abstract：:In spite of the abundance of antifungal therapies, 75% of women in the world suffer from the second most common cause of vaginal infection named vulvovaginal candidiasis. This complication is characterized with overgrowth of Candida albicans. The low efficacy and side effects of current antifungal therapies have convi...

journal_title：Archives of biochemistry and biophysics

authors： Ebrahimi-Shaghaghi F,Noormohammadi Z,Atyabi SM,Razzaghi-Abyaneh M

更新日期：2021-01-22 00:00:00

abstract：:Ferroptosis is a type of iron-dependent, non-apoptotic cell death, which is typically induced by cysteine starvation or by the inhibition of glutathione peroxidase 4 (GPX4) activity with the accompanying elevation in lipid peroxidation product levels. Despite the central role of mitochondria in oxidative metabolism an...

journal_title：Archives of biochemistry and biophysics

authors： Homma T,Kobayashi S,Sato H,Fujii J

更新日期：2021-01-22 00:00:00

abstract：:A congenital diaphragmatic hernia (CDH) is an anomaly caused by defects in the diaphragm; the resulting limited thorax cavity in turn restricts lung growth (pulmonary hypoplasia). This condition is related to pulmonary hypertension. Despite advances in neonatal CDH therapy, the mortality for severe pulmonary hypoplasi...

journal_title：Archives of biochemistry and biophysics

authors： Ito Y,Tsuda H,Imai K,Miki R,Miura M,Tachi A,Tano S,Hirako-Takamura S,Moriyama Y,Ushida T,Kobayashi T,Sumigama S,Kajiyama H,Kikkawa F,Kotani T

更新日期：2021-01-20 00:00:00

abstract：:Flavin-dependent monooxygenases catalyze a wide variety of redox reactions in important biological processes and are responsible for the synthesis of highly complex natural products. Although much has been learned about FMO chemistry in the last ~80 years of research, several aspects of the reactions catalyzed by thes...

journal_title：Archives of biochemistry and biophysics

authors： Reis RAG,Li H,Johnson M,Sobrado P

更新日期：2021-01-16 00:00:00

abstract：:The Metabotropic glutamate receptor 2 (mGluR2) is involved in several neurological and psychiatric disorders and is an attractive drug target. It is believed to form a strict dimer and the dimeric assembly is necessary for glutamate induced activation. Although many studies have focused on glutamate induced conformati...

journal_title：Archives of biochemistry and biophysics

authors： Singh DR,Pandey K,Mishra AK,Pandey P,Vivcharuk V

更新日期：2021-01-15 00:00:00

abstract：:Nanomechanical properties of living cells, as measured with atomic force microscopy (AFM), are increasingly recognized as criteria that differentiate normal and pathologically altered cells. Locally measured cell elastic properties, described by the parameter known as Young's modulus, are currently proposed as a new d...

journal_title：Archives of biochemistry and biophysics

authors： Pogoda K,Pięta E,Roman M,Piergies N,Liberda D,Wróbel TP,Janmey PA,Paluszkiewicz C,Kwiatek WM

更新日期：2021-01-15 00:00:00

abstract：:Antimicrobial and cell-penetrating peptides have been the object of extensive studies for more than 60 years. Initially these two families were studied separately, and more recently parallels have been drawn. These studies have given rise to numerous methodological developments both in terms of observation techniques ...

journal_title：Archives of biochemistry and biophysics

authors： Emmanuelle S,Astrid W,Sandrine S,Sophie C,Nicolas R

更新日期：2021-01-07 00:00:00

abstract：:Multidrug resistance (MDR) caused by overexpressed permeability-glycoprotein (P-gp) in cancer cells is the main barrier for the cure of cancers. P-gp can pump many chemotherapeutic drugs, which is a viable target to overcome P-gp-mediated MDR by efficient inhibitors of P-gp. However, limited understanding of the efflu...

journal_title：Archives of biochemistry and biophysics

authors： Wang L,Sun Y

更新日期：2020-12-15 00:00:00

abstract：:Environmental pollution is a major cause of global mortality and burden of disease. All chemical pollution forms together may be responsible for up to 12 million annual excess deaths as estimated by the Lancet Commission on pollution and health as well as the World Health Organization. Ambient air pollution by particu...

journal_title：Archives of biochemistry and biophysics

authors： Daiber A,Kuntic M,Hahad O,Delogu LG,Rohrbach S,Di Lisa F,Schulz R,Münzel T

更新日期：2020-12-15 00:00:00

abstract：:Organic acidurias (OADs) are inherited disorders of amino acid metabolism biochemically characterized by accumulation of short-chain carboxylic acids in tissues and biological fluids of the affected patients and clinically by predominant neurological manifestations. Some of these disorders are amenable to treatment, w...

journal_title：Archives of biochemistry and biophysics

authors： Wajner M,Vargas CR,Amaral AU

更新日期：2020-12-15 00:00:00

abstract：:Podocytes and their foot processes interlinked by slit diaphragms, constitute a continuous outermost layer of the glomerular capillary and seem to be crucial for maintaining the integrity of the glomerular filtration barrier. Purinergic signaling is involved in a wide range of physiological processes in the renal syst...

journal_title：Archives of biochemistry and biophysics

authors： Szrejder M,Rachubik P,Rogacka D,Audzeyenka I,Rychłowski M,Angielski S,Piwkowska A

更新日期：2020-11-30 00:00:00

abstract：:Glucocorticoid (GCs) hormones exert their actions via their cognate steroid receptors the Glucocorticoid Receptors (GR), by genomic or non-genomic mechanisms of actions. GCs regulate many cellular functions among them growth, metabolism, immune response and apoptosis. Due to their cell type specific induction of apopt...

journal_title：Archives of biochemistry and biophysics

authors： Karra AG,Tziortziou M,Kylindri P,Georgatza D,Gorgogietas VA,Makiou A,Krokida A,Tsialtas I,Kalousi FD,Papadopoulos GE,Papadopoulou KΚ,Psarra AG

更新日期：2020-11-30 00:00:00

abstract：:Osteocytes sense extracellular mechanical stimuli and transduce them into biochemical signals to regulate bone remodeling. The function is also evidenced in orthodontic tooth movement. But the underlying mechanisms haven't been clarified. Autophagy is an evolutionarily conserved cellular catabolic process which affect...

journal_title：Archives of biochemistry and biophysics

authors： Li W,Zhao J,Sun W,Wang H,Pan Y,Wang L,Zhang WB

更新日期：2020-11-15 00:00:00

abstract：:Excessive proliferation, migration and dedifferentiation of vascular smooth muscle cells (VSMCs) are the center of intimal formation during in-stent restenosis and vein graft disease. Paeoniflorin-6'-O-benzene sulfonate (CP-25) is known to suppress inflammation and atherogenesis. However, the potential effect of CP-25...

journal_title：Archives of biochemistry and biophysics

authors： Zhang J,Liu Y,Long M,Li J,Zhao W,Su Q

更新日期：2020-11-15 00:00:00

abstract：:MicroRNA-885 (miR-885) has been shown to act as vital regulator of tumorigenesis and its tumor-suppressive role has been investigated in several human cancers. However, the role of miR-885 in regulation of epithelial mesenchymal transition of liver cancer cells yet unknown. This study was undertaken to investigate the...

journal_title：Archives of biochemistry and biophysics

authors： Feng L,Zhang Y,Yang Q,Guo L,Yang F

更新日期：2020-10-30 00:00:00

abstract：:Previous studies have suggested that pyroptosis may play an important role in LPS-induced acute lung injury (ALI), but the exact mechanism of pyroptosis induction and the role of Angiotensin-converting enzyme 2 (ACE2)/Ang (1-7)/Mas axis in pyroptosis has not been investigated yet. The present study aimed to establish ...

journal_title：Archives of biochemistry and biophysics

authors： Huang H,Wang J,Liu Z,Gao F

更新日期：2020-10-30 00:00:00

abstract：:Cancer cells exhibit extreme sensitivity to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) over normal cells, highlighting TRAIL's potential as a novel and effective cancer drug. However, the therapeutic effect of TRAIL is limited due to drug resistance. In the present study, we sought to investigate ...

journal_title：Archives of biochemistry and biophysics

authors： Wu B,Xiong J,Zhou Y,Wu Y,Song Y,Wang N,Chen L,Zhang J

更新日期：2020-10-15 00:00:00

abstract：:The relationships between conformational dynamics, stability and protein function are not obvious. Frataxin (FXN) is an essential protein that forms part of a supercomplex dedicated to the iron-sulfur (Fe-S) cluster assembly within the mitochondrial matrix. In humans, the loss of FXN expression or a decrease in its fu...

journal_title：Archives of biochemistry and biophysics

authors： Castro IH,Bringas M,Doni D,Noguera ME,Capece L,Aran M,Blaustein M,Costantini P,Santos J

更新日期：2020-09-30 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is emerging as the most common liver disease in industrialized countries. Because hepatic steatosis is an early pathogenesis of NAFLD, the discovery of food components that could ameliorate hepatic steatosis is of interest. Susabinori (Pyropia yezoensis) is recognized as one of...

journal_title：Archives of biochemistry and biophysics

authors： Yanagita T,Tsuge K,Koga M,Inoue N,Nagao K

更新日期：2020-09-30 00:00:00

abstract：:Calycosin, a functional phytoestrogen isoflavone isolated from Radix astragali, has been shown to possess multiple pharmacological properties including anti-cancer activity. However, up to now, the anti-cancer effect and the related mechanism of calycosin on cervical cancer (CC) cells have not been explored. It has be...

journal_title：Archives of biochemistry and biophysics

authors： Zhang D,Sun G,Peng L,Tian J,Zhang H

更新日期：2020-09-30 00:00:00

abstract：BACKGROUND:Proteomics is expected to provide novel insights in the underlying pathophysiology of type 2 diabetes mellitus. In the present study, we aimed to identify and biochemically characterize proteins associated with diabetes mellitus in a Qatari population. METHODS:In a diabetes case-control study (175 cases, 16...

journal_title：Archives of biochemistry and biophysics

authors： Noordam R,van Heemst D,Suhre K,Krumsiek J,Mook-Kanamori DO

更新日期：2020-08-15 00:00:00

abstract：:Cardiac hypertrophy is an adaptive response to hemodynamic stress to compensate for cardiac dysfunction. MicroRNAs can regulate cardiac function and play a vital role in the regulation of cardiac hypertrophy. In the current study, in vivo and vitro hypertrophy models are established to explore the role of miR-27b and ...

journal_title：Archives of biochemistry and biophysics

authors： Zhang M,Cheng K,Chen H,Tu J,Shen Y,Pang L,Wu W

更新日期：2020-08-15 00:00:00

abstract：:Selenoprotein I (SELENOI) is an ethanolamine phosphotransferase that catalyzes the third reaction of the Kennedy pathway for the synthesis of phosphatidylethanolamine. Since the role of SELENOI in murine embryogenesis has not been investigated, SELENOI-/+ mating pairs were used to generate global KO offspring. Of 323 ...

journal_title：Archives of biochemistry and biophysics

authors： Avery JC,Yamazaki Y,Hoffmann FW,Folgelgren B,Hoffmann PR

更新日期：2020-08-15 00:00:00

abstract：:Ringer's lactate solution irradiated by non-thermal plasma, comprised of radicals, electrons, and ions, is defined as plasma-activated lactate (PAL). PAL exhibited antitumor effects in glioblastoma U251SP cells, which we termed PAL-specific regulated cell death. In contrast to the oxidative stress condition typical of...

journal_title：Archives of biochemistry and biophysics

authors： Ishikawa K,Hosoi Y,Tanaka H,Jiang L,Toyokuni S,Nakamura K,Kajiyama H,Kikkawa F,Mizuno M,Hori M

更新日期：2020-07-30 00:00:00

abstract：:Vascular dysfunction and injurious stimuli such as oxidative stress is closely related to the risk of cardiovascular diseases (CVD). Dietary polyphenols is reported to exert the beneficial effects on reducing the risk of CVD. Black soybean is rich in polyphenols, including isoflavones, anthocyanidins and flavan-3-ols,...

journal_title：Archives of biochemistry and biophysics

authors： Yamashita Y,Wang L,Nakamura A,Nanba F,Saito S,Toda T,Nakagawa J,Ashida H

更新日期：2020-07-30 00:00:00

abstract：:MicroRNA-342-3p (miR-342) has been shown to act as a tumor-suppressor in different cancer types. However, the role and therapeutic implications of miR-342 via modulation of Cofilin 1 (CFL1) has not been studied in any type of cancer. Given the importance of Cofilin signalling in breast, this study was undertaken to ex...

journal_title：Archives of biochemistry and biophysics

authors： Liu C,Xing H,Luo X,Wang Y

更新日期：2020-07-15 00:00:00

abstract：:Polyphyllin I (PPI), a bioactive constituent extracted from the rhizomes of Paris polyphylla, is cytotoxic to several cancer types. This study was designed to explore whether PPI prevents non-small-cell lung cancer (NSCLC) growth and to investigate the molecular mechanism. AMP-activated protein kinase (AMPK) has been ...

journal_title：Archives of biochemistry and biophysics

authors： Wu Y,Si Y,Xiang Y,Zhou T,Liu X,Wu M,Li W,Zhang T,Xiang K,Zhang L,Zhao H,Liu Y

更新日期：2020-07-15 00:00:00

abstract：:Drought is one of the most serious factors affecting crop yields in the world. Macleaya cordata (Willd.) is a draught-tolerant medicinal plant that has been proposed as a pioneer crop to be cultivated in arid areas. However, the exact molecular mechanisms through which M. cordata responds to draught stress remain elus...

journal_title：Archives of biochemistry and biophysics

authors： Yu L,Zhou L,Liu W,Huang P,Jiang R,Tang Z,Cheng P,Zeng J

更新日期：2020-05-15 00:00:00

abstract：:Endometrial carcinoma is a type of gynecological cancer that originates in the endometrial epithelial tissue. Due to its high proliferation and ability to invade muscle tissue, it is one of the most common malignant tumors in the female reproductive system. Fatostatin is a small molecule non-sterol diarylthiazole deri...

journal_title：Archives of biochemistry and biophysics

authors： Yao L,Chen S,Li W

更新日期：2020-05-15 00:00:00

abstract：:Signal transducer and activator of transcription 3 (STAT3) is expressed aberrantly in multiple tumors, including gastric cancer (GC). STAT3 overexpression and excessive activation have been confirmed to play vital roles in tumorigenesis. Cucurbitacin B (CuB) is a natural product with potent anti-cancer activities in s...

journal_title：Archives of biochemistry and biophysics

authors： Xu J,Chen Y,Yang R,Zhou T,Ke W,Si Y,Yang S,Zhang T,Liu X,Zhang L,Xiang K,Guo Y,Liu Y

更新日期：2020-05-15 00:00:00

abstract：:Glaucoma is the leading cause of irreversible blindness in the world and trabeculectomy remains still the most commonly performed filtration surgery. Failure of trabeculectomy is due to the formation of scarring, which is associated with the increased fibroblast proliferation, activation, and collagen deposition at th...

journal_title：Archives of biochemistry and biophysics

authors： Wang L,Guo D,Wang Z,Yin X,Wei H,Hu W,Chen R,Chen C

更新日期：2020-04-15 00:00:00

abstract：:A Pseudomonas CoA ligase (BadA) biocatalyzed aroyl CoA thioesters used by a downstream N-benzoyltransferase (NDTNBT) in a cascade reaction made aroyl analogs of the anticancer drug paclitaxel. BadA kept the high-cost aroyl CoA substrates at saturation for the downstream NDTNBT by recycling CoA when it was added as the...

journal_title：Archives of biochemistry and biophysics

authors： Sullivan SA,Nawarathne IN,Walker KD

更新日期：2020-04-15 00:00:00

abstract：:We measured temporal oscillations of intracellular K+ concentration in yeast cells exhibiting glycolytic oscillations using fluorescence spectroscopy and microscopy methods. These oscillations showed the same period as those of glycolytic metabolites (NADH, ATP), indicating a strong coupling between them. We experimen...

journal_title：Archives of biochemistry and biophysics

authors： Olsen LF,Stock RP,Bagatolli LA

更新日期：2020-03-15 00:00:00

abstract：:The most common form of muscular dystrophy is known as Myotonic dystrophy Type 1 (DM1) in adults. It was aimed to investigate the relationship between antioxidant imbalance and diaphragm thickness with pulmonary function test results in peripheral blood of Myotonic Dystrophy Type 1 patients. In the prospective study, ...

journal_title：Archives of biochemistry and biophysics

authors： Koc F,Atli G,Menziletoglu SY,Kose S

更新日期：2020-02-15 00:00:00

abstract：:[3H]Diazonamide A ([3H]DZA), prepared from the natural product isolated from Diazona angulata, bound to tubulin in larger aberrant assembly products (>500 kDa by sizing HPLC) but not to the αβ-tubulin heterodimer. The binding reaction was rapid, but stoichiometry was low. Stoichiometry was enhanced up to 8-fold by pre...

journal_title：Archives of biochemistry and biophysics

authors： Bai R,Cruz-Monserrate Z,Fenical W,Pettit GR,Hamel E

更新日期：2020-02-15 00:00:00

abstract：:Experimental autoimmune encephalomyelitis (EAE) is a commonly used mouse model of multiple sclerosis, a chronic inflammatory disease of the central nervous system (CNS) characterized by demyelination leading to brain and spinal cord malfunctions. We postulate that not only biological but also biomechanical properties ...

journal_title：Archives of biochemistry and biophysics

authors： Pyka-Fościak G,Zemła J,Lis GJ,Litwin JA,Lekka M

更新日期：2020-02-15 00:00:00

abstract：:Excessive iron accumulation in the heart can lead to iron overload cardiomyopathy (IOC), the leading cause of death in hemochromatosis patients. Current understanding regarding the mechanism by which iron overload causes a deterioration in cardiac performance, mitochondrial dysfunction, and impaired mitochondrial dyna...

journal_title：Archives of biochemistry and biophysics

authors： Sumneang N,Siri-Angkul N,Kumfu S,Chattipakorn SC,Chattipakorn N

更新日期：2020-02-15 00:00:00

abstract：:Macrophages play a pivotal role in the defense response against harmful pathogens and stimuli by releasing various pro-inflammatory mediators. However, overproduction of pro-inflammatory mediators will do harm to the organism and cause inflammation-associated diseases. Omentin-1, which is a newly discovered adipokine,...

journal_title：Archives of biochemistry and biophysics

authors： Wang J,Gao Y,Lin F,Han K,Wang X

更新日期：2020-01-15 00:00:00

abstract：:Prostaglandin E2 (PGE2) plays a key role in inflammation-associated carcinogenesis. NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH) catalyzes the oxidation of the 15(S)-hydroxyl group of PGE2 to generate 15-keto PGE2. 15-PGDH has been known as a tumor suppressor in various malignancies including colon c...

journal_title：Archives of biochemistry and biophysics

authors： Lee JE,Zhong X,Lee JY,Surh YJ,Na HK

更新日期：2020-01-15 00:00:00