Combined untargeted and targeted metabolomic profiling reveals urinary biomarkers for discriminating obese from normal-weight adolescents.

Abstract:

BACKGROUND:Childhood and adolescent obesity may lead to obesity and related complications in adulthood. Biomarkers of obesity can be useful for screening for obesity complications and promoting early intervention during school age. Thus, the metabolomic differences in obese children and adolescents should be investigated for identification of potential biomarkers. OBJECTIVES:We investigated urinary biomarkers to distinguish metabolomic characteristics between obesity and normal weight in adolescents. METHODS:Adolescent subjects were divided into non-obese (n = 91) and obese (n = 93) groups according to body mass index. Untargeted and targeted metabolomic profiling of urine was performed using high-performance liquid chromatography (LC)-quadrupole time-of-flight mass spectrometry (MS), LC-MS/MS and flow injection analysis-MS/MS systems, respectively. RESULTS:Multivariate statistical analysis showed clear discrimination between the untargeted metabolomes of non-obese and obese groups. Seven endogenous metabolites were distinguished in the obese group, and inflammation-related metabolite markers showed strong predictive power for group classification. From targeted metabolomics, 45 metabolites mostly related to inflammation were significantly different in the obese group. CONCLUSIONS:Significantly different metabolome signatures were identified between normal-weight and obese adolescents. Combined untargeted and targeted metabolomics demonstrated that inflammation-driven insulin resistance, ammonia toxicity and oxidative stress may represent crucial metabolomic signatures in obese adolescents.

journal_name

Pediatr Obes

journal_title

Pediatric obesity

authors

Cho K,Moon JS,Kang JH,Jang HB,Lee HJ,Park SI,Yu KS,Cho JY

doi

10.1111/ijpo.12114

subject

Has Abstract

pub_date

2017-04-01 00:00:00

pages

93-101

issue

2

eissn

2047-6302

issn

2047-6310

journal_volume

12

pub_type

杂志文章
  • Self-reported waist circumference: a screening tool for classifying children with overweight/obesity and cardiometabolic risk factor clustering.

    abstract:OBJECTIVES:The objectives of this study were twofold - (i) to assess the agreement between self-reported waist circumference (SRWC) and assessor measured waist circumference (MWC) and (ii) to evaluate the diagnostic ability of SRWC for classifying (i) a clustering of cardiometabolic risk factors (CMRFs) and (ii) overwe...

    journal_title:Pediatric obesity

    pub_type: 杂志文章

    doi:10.1111/j.2047-6310.2011.00017.x

    authors: Chan NP,Choi KC,Nelson EA,Sung RY,Chan JC,Kong AP

    更新日期:2012-04-01 00:00:00

  • Prevention and treatment of pediatric obesity using mobile and wireless technologies: a systematic review.

    abstract::Mobile health (mHealth) is a relatively nascent field, with a variety of technologies being explored and developed. Because of the explosive growth in this field, it is of interest to examine the design, development and efficacy of various interventions as research becomes available. This systematic review examines cu...

    journal_title:Pediatric obesity

    pub_type: 杂志文章,评审

    doi:10.1111/ijpo.12002

    authors: Turner T,Spruijt-Metz D,Wen CK,Hingle MD

    更新日期:2015-12-01 00:00:00

  • Adherence to the Mediterranean diet during pregnancy and offspring adiposity and cardiometabolic traits in childhood.

    abstract:BACKGROUND:In adults, adherence to the Mediterranean diet has been inversely associated with cardiovascular risk, but the extent to which diet in pregnancy is associated with offspring adiposity is unclear. We aimed to investigate the association between adherence to Mediterranean diet in pregnancy and offspring cardio...

    journal_title:Pediatric obesity

    pub_type: 杂志文章

    doi:10.1111/ijpo.12191

    authors: Chatzi L,Rifas-Shiman SL,Georgiou V,Joung KE,Koinaki S,Chalkiadaki G,Margioris A,Sarri K,Vassilaki M,Vafeiadi M,Kogevinas M,Mantzoros C,Gillman MW,Oken E

    更新日期:2017-08-01 00:00:00

  • Depressive symptoms are associated with fasting insulin resistance in obese youth.

    abstract:BACKGROUND:In adults, depressive symptoms are positively associated with insulin resistance. OBJECTIVE:To determine whether an association exists between depressive symptoms and markers of insulin resistance in youth. METHODS:This study used a retrospective review of data from an obesity clinic. We evaluated the asso...

    journal_title:Pediatric obesity

    pub_type: 杂志文章

    doi:10.1111/ijpo.237

    authors: Hannon TS,Li Z,Tu W,Huber JN,Carroll AE,Lagges AM,Gupta S

    更新日期:2014-10-01 00:00:00

  • Pitfalls of the self-regulation of advertisements directed at children on Mexican television.

    abstract:BACKGROUND:There are no academic studies that characterize advertisements directed at children from the companies that signed the self-regulation. OBJECTIVE:The aim of this paper was to assess the extent and nature of food advertisements and the persuasive techniques used to market unhealthy food and beverages (UFB) t...

    journal_title:Pediatric obesity

    pub_type: 杂志文章

    doi:10.1111/ijpo.12144

    authors: Théodore FL,Tolentino-Mayo L,Hernández-Zenil E,Bahena L,Velasco A,Popkin B,Rivera JA,Barquera S

    更新日期:2017-08-01 00:00:00

  • Efficacy of repeated exposure and flavour-flavour learning as mechanisms to increase preschooler's vegetable intake and acceptance.

    abstract:BACKGROUND:Dutch children's diets, like the diets of many children in Europe and the US are not balanced, do not contain enough vegetables and have been associated with a high prevalence of childhood obesity. Promoting children's vegetable intake is challenging. OBJECTIVE:We investigated the relative effectiveness of ...

    journal_title:Pediatric obesity

    pub_type: 杂志文章,多中心研究

    doi:10.1111/ijpo.244

    authors: de Wild V,de Graaf C,Jager G

    更新日期:2015-06-01 00:00:00

  • Breakfast consumption and meal frequency interaction with childhood obesity.

    abstract:OBJECTIVES:Increased meal frequency and daily breakfast consumption have been inversely associated with childhood obesity. The purpose of the study was to examine the possible interaction effect between meal frequency and breakfast consumption on childhood obesity. METHODS:Seven hundred children (323 boys) aged 10-12 ...

    journal_title:Pediatric obesity

    pub_type: 杂志文章

    doi:10.1111/j.2047-6310.2011.00006.x

    authors: Antonogeorgos G,Panagiotakos DB,Papadimitriou A,Priftis KN,Anthracopoulos M,Nicolaidou P

    更新日期:2012-02-01 00:00:00

  • Effects of air pollution exposure on glucose metabolism in Los Angeles minority children.

    abstract:OBJECTIVES:Growing evidence indicates that ambient (AAP: NO2 , PM2.5 and O3 ) and traffic-related air pollutants (TRAP) contribute to metabolic disease risk in adults; however, few studies have examined these relationships in children. METHODS:Metabolic profiling was performed in 429 overweight and obese African-Ameri...

    journal_title:Pediatric obesity

    pub_type: 杂志文章

    doi:10.1111/ijpo.12188

    authors: Toledo-Corral CM,Alderete TL,Habre R,Berhane K,Lurmann FW,Weigensberg MJ,Goran MI,Gilliland FD

    更新日期:2018-01-01 00:00:00

  • Lifestyle intervention improves lipoprotein particle size and distribution without weight loss in obese Latino adolescents.

    abstract::Childhood obesity is associated with a pro-atherogenic phenotype contributing to increased cardiovascular disease (CVD) risk. This single-arm pilot study examined the effects of a lifestyle intervention on lipoprotein particle size and cholesterol distribution in obese Latino adolescents. Fifteen obese Latino adolesce...

    journal_title:Pediatric obesity

    pub_type: 杂志文章

    doi:10.1111/j.2047-6310.2013.00162.x

    authors: Ryder JR,Vega-López S,Ortega R,Konopken Y,Shaibi GQ

    更新日期:2013-10-01 00:00:00

  • Effect of a responsive parenting intervention on child emotional overeating is mediated by reduced maternal use of food to soothe: The INSIGHT RCT.

    abstract:BACKGROUND:Child emotional overeating is a risk factor for obesity that is learned in the home environment. Parents' use of food to soothe child distress may contribute to the development of children's emotional overeating. OBJECTIVES:To examine the effect of a responsive parenting (RP) intervention on mother-reported...

    journal_title:Pediatric obesity

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/ijpo.12645

    authors: Harris HA,Anzman-Frasca S,Marini ME,Paul IM,Birch LL,Savage JS

    更新日期:2020-10-01 00:00:00

  • Dietary fibre linked to decreased inflammation in overweight minority youth.

    abstract:OBJECTIVE:The objective of this study was to examine the relationship between diet and inflammation, and adiposity in minority youth. DESIGN AND METHODS:The study was designed as a cross-sectional analysis of 142 overweight (≥85th body mass index percentile) Hispanic and African-American adolescents (14-18 years) with...

    journal_title:Pediatric obesity

    pub_type: 杂志文章

    doi:10.1111/ijpo.12017

    authors: Miller SJ,Batra AK,Shearrer GE,House BT,Cook LT,Pont SJ,Goran MI,Davis JN

    更新日期:2016-02-01 00:00:00

  • Body composition at birth in preterm infants between 30 and 36 weeks gestation.

    abstract:BACKGROUND:The American Academy of Pediatrics calls for aggressive management of preterm infants to achieve body composition approximating that of the healthy infant in utero. Air displacement plethysmography (ADP) has been validated for assessment of body composition in preterm infants and could be used to monitor the...

    journal_title:Pediatric obesity

    pub_type: 杂志文章

    doi:10.1111/j.2047-6310.2013.00215.x

    authors: Ramel SE,Gray HL,Davern BA,Demerath EW

    更新日期:2015-02-01 00:00:00

  • Effect of the patatin-like phospholipase domain containing 3 gene (PNPLA3) I148M polymorphism on the risk and severity of nonalcoholic fatty liver disease and metabolic syndromes: A meta-analysis of paediatric and adolescent individuals.

    abstract:BACKGROUND:The effect of the patatin-like phospholipase domain containing 3 gene (PNPLA3) I148M polymorphism on the risk and severity of paediatric and adolescent nonalcoholic fatty liver disease (NAFLD) remains inconclusive. OBJECTIVES:We aimed to estimate the effect of this polymorphism not only on early-onset NAFLD...

    journal_title:Pediatric obesity

    pub_type: 杂志文章,meta分析

    doi:10.1111/ijpo.12615

    authors: Li J,Hua W,Ji C,Rui J,Zhao Y,Xie C,Shi B,Yang X

    更新日期:2020-06-01 00:00:00

  • Obesity status transitions across the elementary years: use of Markov chain modelling.

    abstract:OBJECTIVE:The objective of this study was to assess overweight and obesity status transition probabilities using first-order Markov transition models applied to elementary school children. METHOD:Complete longitudinal data across 11 assessments were available from 1494 elementary school children (from 7599 students in...

    journal_title:Pediatric obesity

    pub_type: 杂志文章

    doi:10.1111/ijpo.12025

    authors: Chen TA,Baranowski T,Moreno JP,O'Connor TM,Hughes SO,Baranowski J,Woehler D,Kimbro RT,Johnston CA

    更新日期:2016-04-01 00:00:00

  • Recruitment outcomes, challenges and lessons learned: the Healthy Communities Study.

    abstract:BACKGROUND:The Healthy Communities Study (HCS) was a national study of community programs and policies that aimed to address childhood obesity; it necessitated recruitment of a large sample of children from communities throughout the United States. OBJECTIVE:The HCS aimed to complete visits with an average of 45 child...

    journal_title:Pediatric obesity

    pub_type: 杂志文章

    doi:10.1111/ijpo.12455

    authors: Sagatov RDF,John LV,Gregoriou M,Arteaga SS,Weber S,Payn B,Strauss W,Weinstein N,Collie-Akers V,Healthy Communities Study Team.

    更新日期:2018-10-01 00:00:00

  • The sequence of prenatal growth restraint and post-natal catch-up growth leads to a thicker intima-media and more pre-peritoneal and hepatic fat by age 3-6 years.

    abstract:BACKGROUND:Infants born small-for-gestational-age (SGA) who develop post-natal weight catch-up are at risk for insulin resistance, central adiposity and cardiovascular disease in later life, even in the absence of overweight. OBJECTIVE:In young (age 3-6 years) non-obese SGA children, we assessed arterial health (as ju...

    journal_title:Pediatric obesity

    pub_type: 杂志文章

    doi:10.1111/ijpo.12053

    authors: Sebastiani G,Díaz M,Bassols J,Aragonés G,López-Bermejo A,de Zegher F,Ibáñez L

    更新日期:2016-08-01 00:00:00

  • Pacific Islands Families Study: Physical growth to age 14 and metabolic risk.

    abstract:BACKGROUND:The relationships between the trajectories of weight gain from early childhood to adolescence and risk for metabolic disease are not well understood. OBJECTIVE:The objective of the study is to examine the relationships between weight gain from 2 to 14 years and metabolic risk factors at age 14 years in Paci...

    journal_title:Pediatric obesity

    pub_type: 杂志文章

    doi:10.1111/ijpo.12497

    authors: Plank LD,Obolonkin V,Smith M,Savila F,Jalili-Moghaddam S,Tautolo ES,Rush EC

    更新日期:2019-05-01 00:00:00

  • Is gestational weight gain associated with offspring obesity at 36 months?

    abstract:OBJECTIVE:We examined the association between gestational weight gain (GWG) and offspring obesity at age 36 months. METHODS:Mother-infant dyads (n = 609) were followed from a first study visit (mean [standard deviation]: 18.8 [2.7] weeks gestation) to 36 months postpartum. Total GWG over the entire pregnancy was defin...

    journal_title:Pediatric obesity

    pub_type: 杂志文章

    doi:10.1111/ijpo.262

    authors: Diesel JC,Eckhardt CL,Day NL,Brooks MM,Arslanian SA,Bodnar LM

    更新日期:2015-08-01 00:00:00

  • Changes in pediatric waist circumference percentiles despite reported pediatric weight stabilization in the United States.

    abstract:BACKGROUND:Obesity is a global health concern but the United States has reported a leveling in obesity rates in the pediatric population. OBJECTIVE:To provide updated waist circumference (WC) percentile values, identify differences across time and discuss differences within the context of reported weight stabilization...

    journal_title:Pediatric obesity

    pub_type: 杂志文章

    doi:10.1111/ijpo.12150

    authors: Fernández JR,Bohan Brown M,López-Alarcón M,Dawson JA,Guo F,Redden DT,Allison DB

    更新日期:2017-10-01 00:00:00

  • The concurrent and longitudinal associations of temperament and nutritional risk factors in early childhood.

    abstract:BACKGROUND:Early childhood temperament is increasingly recognized as an important attribute that may impact screen time use, outdoor play and childhood obesity. The relationship between temperament and nutrition in preschool children is less clear. OBJECTIVE:The objective of the study is to investigate if temperament ...

    journal_title:Pediatric obesity

    pub_type: 杂志文章

    doi:10.1111/ijpo.12161

    authors: van den Heuvel M,Chen Y,Abdullah K,Maguire JL,Parkin PC,Birken CS,TARGet Kids! Collaboration.

    更新日期:2017-12-01 00:00:00

  • Associations of nitric oxide with obesity and psychological traits among children and adolescents in Taiwan.

    abstract:BACKGROUND:Findings concerning nitric oxide (NO) in children and adolescents with obesity are scant. OBJECTIVE:This study examined the links of NO with obesity and psychological traits (ie, self-concept, anxiety, depression, anger and disruptive behaviour) in children and adolescents in Taiwan. METHODS:A total of 564...

    journal_title:Pediatric obesity

    pub_type: 杂志文章

    doi:10.1111/ijpo.12593

    authors: Chung KH,Chiou HY,Chang JS,Chen YH

    更新日期:2020-03-01 00:00:00

  • Prevalence of obesity among 10-11-year-old Maltese children using four established standards.

    abstract:OBJECTIVE:The objective of this study was to establish, through measured height and weight, the prevalence of overweight and obesity in a representative sample of Maltese children aged 10-11 years. METHODS:Height and weight were measured in a sample, stratified by sex, region and type of school, of 874 year 6 children...

    journal_title:Pediatric obesity

    pub_type: 杂志文章

    doi:10.1111/j.2047-6310.2013.00191.x

    authors: Decelis A,Fox K,Jago R

    更新日期:2013-10-01 00:00:00

  • The association between allostatic load and anthropometric measurements among a multiethnic cohort of children.

    abstract:OBJECTIVE:This study investigated if levels of allostatic load (ALoad) differed according to race/ethnicity in children and if ALoad was associated with obesity-related measures. METHODS:A multiethnic sample of 307 children aged seven to 12 was evaluated, composed of 39% European American (EA), 35% African American (A...

    journal_title:Pediatric obesity

    pub_type: 杂志文章

    doi:10.1111/ijpo.12501

    authors: Cedillo YE,Murillo AL,Fernández JR

    更新日期:2019-06-01 00:00:00

  • Pediatric obesity treatment, self-esteem, and body image: A systematic review with meta-analysis.

    abstract:BACKGROUND:Pediatric obesity impacts on multiple domains of psychological health, including self-esteem and body image. OBJECTIVE:To determine the effect of multicomponent pediatric obesity treatment interventions on self-esteem and body image. METHODS:A systematic search of published literature up to June 2019 was u...

    journal_title:Pediatric obesity

    pub_type: 杂志文章,meta分析

    doi:10.1111/ijpo.12600

    authors: Gow ML,Tee MSY,Garnett SP,Baur LA,Aldwell K,Thomas S,Lister NB,Paxton SJ,Jebeile H

    更新日期:2020-03-01 00:00:00

  • Young microbes for adult obesity.

    abstract::Gut microbes are active participants of host metabolism. At birth, child physiology is committed towards healthiness or sickness depending, in part, on maternal condition (i.e. lean vs obesity) and delivery. Finally, changes from breastfeeding to solid food also account to define gut microbiota ecology in adulthood. N...

    journal_title:Pediatric obesity

    pub_type: 杂志文章,评审

    doi:10.1111/ijpo.12146

    authors: Serino M,Nicolas S,Trabelsi MS,Burcelin R,Blasco-Baque V

    更新日期:2017-08-01 00:00:00

  • No influence of sugar, snacks and fast food intake on the degree of obesity or treatment effect in childhood obesity.

    abstract:BACKGROUND:Increased consumption of sweetened beverages has previously been linked to the degree of childhood obesity. OBJECTIVE:The aim of the present study was to assess whether the intake of sweetened beverages, candy, snacks or fast food at baseline in a multidisciplinary childhood obesity treatment program was as...

    journal_title:Pediatric obesity

    pub_type: 杂志文章

    doi:10.1111/ijpo.12094

    authors: Trier C,Fonvig CE,Bøjsøe C,Mollerup PM,Gamborg M,Pedersen O,Hansen T,Holm JC

    更新日期:2016-12-01 00:00:00

  • Adipose tissue insulin resistance in adolescents with and without type 2 diabetes.

    abstract:BACKGROUND:The incidence of type 2 diabetes mellitus (T2D) is increasing in youth, yet little is known about the underlying pathophysiology. Decreased insulin suppression of lipolysis and elevated non-esterified free fatty acid (NEFA) concentrations are known to be associated with insulin resistance and T2D in adults, ...

    journal_title:Pediatric obesity

    pub_type: 杂志文章

    doi:10.1111/j.2047-6310.2013.00189.x

    authors: Kelsey MM,Forster JE,Van Pelt RE,Reusch JE,Nadeau KJ

    更新日期:2014-10-01 00:00:00

  • Prevalence of obesity and extreme obesity in children aged 3-5 years.

    abstract:BACKGROUND:Early childhood adiposity may have significant later health effects. This study examines the prevalence and recognition of obesity and severe obesity among preschool-aged children. METHODS:The electronic medical record was used to examine body mass index (BMI), height, sex and race/ethnicity in 42,559 child...

    journal_title:Pediatric obesity

    pub_type: 杂志文章

    doi:10.1111/j.2047-6310.2013.00154.x

    authors: Lo JC,Maring B,Chandra M,Daniels SR,Sinaiko A,Daley MF,Sherwood NE,Kharbanda EO,Parker ED,Adams KF,Prineas RJ,Magid DJ,O'Connor PJ,Greenspan LC

    更新日期:2014-06-01 00:00:00

  • Breathprints of childhood obesity: changes in volatile organic compounds in obese children compared with lean controls.

    abstract:OBJECTIVE:The objective of this study was to investigate changes in volatile organic compounds (VOCs) in exhaled breath in overweight/obese children compared with their lean counterparts. STUDY DESIGN:Single exhaled breath was collected and analyzed per protocol using selective ion flow tube mass spectrometry (SIFT-MS...

    journal_title:Pediatric obesity

    pub_type: 杂志文章

    doi:10.1111/j.2047-6310.2014.221.x

    authors: Alkhouri N,Eng K,Cikach F,Patel N,Yan C,Brindle A,Rome E,Hanouneh I,Grove D,Lopez R,Hazen SL,Dweik RA

    更新日期:2015-02-01 00:00:00

  • Laser beam measurement of abdominal sagittal diameter in obese children: a validation study.

    abstract:OBJECTIVES:Sagittal diameter (SAD) has been reported to correlate to visceral fat and cardiovascular risk factors. SAD is measured with the individual lying down, halfway between the lower rib margin and the iliac crest; it represents the mid-height of the abdomen. The aim of this study was to validate SAD measured usi...

    journal_title:Pediatric obesity

    pub_type: 杂志文章

    doi:10.1111/j.2047-6310.2012.00095.x

    authors: Flodmark CE,Shen W,Punyanitya M,Leander P,Lanke J,Pietrobelli A

    更新日期:2013-04-01 00:00:00