Abstract:
BACKGROUND:Childhood and adolescent obesity may lead to obesity and related complications in adulthood. Biomarkers of obesity can be useful for screening for obesity complications and promoting early intervention during school age. Thus, the metabolomic differences in obese children and adolescents should be investigated for identification of potential biomarkers. OBJECTIVES:We investigated urinary biomarkers to distinguish metabolomic characteristics between obesity and normal weight in adolescents. METHODS:Adolescent subjects were divided into non-obese (n = 91) and obese (n = 93) groups according to body mass index. Untargeted and targeted metabolomic profiling of urine was performed using high-performance liquid chromatography (LC)-quadrupole time-of-flight mass spectrometry (MS), LC-MS/MS and flow injection analysis-MS/MS systems, respectively. RESULTS:Multivariate statistical analysis showed clear discrimination between the untargeted metabolomes of non-obese and obese groups. Seven endogenous metabolites were distinguished in the obese group, and inflammation-related metabolite markers showed strong predictive power for group classification. From targeted metabolomics, 45 metabolites mostly related to inflammation were significantly different in the obese group. CONCLUSIONS:Significantly different metabolome signatures were identified between normal-weight and obese adolescents. Combined untargeted and targeted metabolomics demonstrated that inflammation-driven insulin resistance, ammonia toxicity and oxidative stress may represent crucial metabolomic signatures in obese adolescents.
journal_name
Pediatr Obesjournal_title
Pediatric obesityauthors
Cho K,Moon JS,Kang JH,Jang HB,Lee HJ,Park SI,Yu KS,Cho JYdoi
10.1111/ijpo.12114subject
Has Abstractpub_date
2017-04-01 00:00:00pages
93-101issue
2eissn
2047-6302issn
2047-6310journal_volume
12pub_type
杂志文章abstract:OBJECTIVES:The objectives of this study were twofold - (i) to assess the agreement between self-reported waist circumference (SRWC) and assessor measured waist circumference (MWC) and (ii) to evaluate the diagnostic ability of SRWC for classifying (i) a clustering of cardiometabolic risk factors (CMRFs) and (ii) overwe...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/j.2047-6310.2011.00017.x
更新日期:2012-04-01 00:00:00
abstract::Mobile health (mHealth) is a relatively nascent field, with a variety of technologies being explored and developed. Because of the explosive growth in this field, it is of interest to examine the design, development and efficacy of various interventions as research becomes available. This systematic review examines cu...
journal_title:Pediatric obesity
pub_type: 杂志文章,评审
doi:10.1111/ijpo.12002
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:In adults, adherence to the Mediterranean diet has been inversely associated with cardiovascular risk, but the extent to which diet in pregnancy is associated with offspring adiposity is unclear. We aimed to investigate the association between adherence to Mediterranean diet in pregnancy and offspring cardio...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12191
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:In adults, depressive symptoms are positively associated with insulin resistance. OBJECTIVE:To determine whether an association exists between depressive symptoms and markers of insulin resistance in youth. METHODS:This study used a retrospective review of data from an obesity clinic. We evaluated the asso...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.237
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:There are no academic studies that characterize advertisements directed at children from the companies that signed the self-regulation. OBJECTIVE:The aim of this paper was to assess the extent and nature of food advertisements and the persuasive techniques used to market unhealthy food and beverages (UFB) t...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12144
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:Dutch children's diets, like the diets of many children in Europe and the US are not balanced, do not contain enough vegetables and have been associated with a high prevalence of childhood obesity. Promoting children's vegetable intake is challenging. OBJECTIVE:We investigated the relative effectiveness of ...
journal_title:Pediatric obesity
pub_type: 杂志文章,多中心研究
doi:10.1111/ijpo.244
更新日期:2015-06-01 00:00:00
abstract:OBJECTIVES:Increased meal frequency and daily breakfast consumption have been inversely associated with childhood obesity. The purpose of the study was to examine the possible interaction effect between meal frequency and breakfast consumption on childhood obesity. METHODS:Seven hundred children (323 boys) aged 10-12 ...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/j.2047-6310.2011.00006.x
更新日期:2012-02-01 00:00:00
abstract:OBJECTIVES:Growing evidence indicates that ambient (AAP: NO2 , PM2.5 and O3 ) and traffic-related air pollutants (TRAP) contribute to metabolic disease risk in adults; however, few studies have examined these relationships in children. METHODS:Metabolic profiling was performed in 429 overweight and obese African-Ameri...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12188
更新日期:2018-01-01 00:00:00
abstract::Childhood obesity is associated with a pro-atherogenic phenotype contributing to increased cardiovascular disease (CVD) risk. This single-arm pilot study examined the effects of a lifestyle intervention on lipoprotein particle size and cholesterol distribution in obese Latino adolescents. Fifteen obese Latino adolesce...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/j.2047-6310.2013.00162.x
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND:Child emotional overeating is a risk factor for obesity that is learned in the home environment. Parents' use of food to soothe child distress may contribute to the development of children's emotional overeating. OBJECTIVES:To examine the effect of a responsive parenting (RP) intervention on mother-reported...
journal_title:Pediatric obesity
pub_type: 杂志文章,随机对照试验
doi:10.1111/ijpo.12645
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to examine the relationship between diet and inflammation, and adiposity in minority youth. DESIGN AND METHODS:The study was designed as a cross-sectional analysis of 142 overweight (≥85th body mass index percentile) Hispanic and African-American adolescents (14-18 years) with...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12017
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:The American Academy of Pediatrics calls for aggressive management of preterm infants to achieve body composition approximating that of the healthy infant in utero. Air displacement plethysmography (ADP) has been validated for assessment of body composition in preterm infants and could be used to monitor the...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/j.2047-6310.2013.00215.x
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:The effect of the patatin-like phospholipase domain containing 3 gene (PNPLA3) I148M polymorphism on the risk and severity of paediatric and adolescent nonalcoholic fatty liver disease (NAFLD) remains inconclusive. OBJECTIVES:We aimed to estimate the effect of this polymorphism not only on early-onset NAFLD...
journal_title:Pediatric obesity
pub_type: 杂志文章,meta分析
doi:10.1111/ijpo.12615
更新日期:2020-06-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to assess overweight and obesity status transition probabilities using first-order Markov transition models applied to elementary school children. METHOD:Complete longitudinal data across 11 assessments were available from 1494 elementary school children (from 7599 students in...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12025
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:The Healthy Communities Study (HCS) was a national study of community programs and policies that aimed to address childhood obesity; it necessitated recruitment of a large sample of children from communities throughout the United States. OBJECTIVE:The HCS aimed to complete visits with an average of 45 child...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12455
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:Infants born small-for-gestational-age (SGA) who develop post-natal weight catch-up are at risk for insulin resistance, central adiposity and cardiovascular disease in later life, even in the absence of overweight. OBJECTIVE:In young (age 3-6 years) non-obese SGA children, we assessed arterial health (as ju...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12053
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:The relationships between the trajectories of weight gain from early childhood to adolescence and risk for metabolic disease are not well understood. OBJECTIVE:The objective of the study is to examine the relationships between weight gain from 2 to 14 years and metabolic risk factors at age 14 years in Paci...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12497
更新日期:2019-05-01 00:00:00
abstract:OBJECTIVE:We examined the association between gestational weight gain (GWG) and offspring obesity at age 36 months. METHODS:Mother-infant dyads (n = 609) were followed from a first study visit (mean [standard deviation]: 18.8 [2.7] weeks gestation) to 36 months postpartum. Total GWG over the entire pregnancy was defin...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.262
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:Obesity is a global health concern but the United States has reported a leveling in obesity rates in the pediatric population. OBJECTIVE:To provide updated waist circumference (WC) percentile values, identify differences across time and discuss differences within the context of reported weight stabilization...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12150
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND:Early childhood temperament is increasingly recognized as an important attribute that may impact screen time use, outdoor play and childhood obesity. The relationship between temperament and nutrition in preschool children is less clear. OBJECTIVE:The objective of the study is to investigate if temperament ...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12161
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:Findings concerning nitric oxide (NO) in children and adolescents with obesity are scant. OBJECTIVE:This study examined the links of NO with obesity and psychological traits (ie, self-concept, anxiety, depression, anger and disruptive behaviour) in children and adolescents in Taiwan. METHODS:A total of 564...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12593
更新日期:2020-03-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to establish, through measured height and weight, the prevalence of overweight and obesity in a representative sample of Maltese children aged 10-11 years. METHODS:Height and weight were measured in a sample, stratified by sex, region and type of school, of 874 year 6 children...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/j.2047-6310.2013.00191.x
更新日期:2013-10-01 00:00:00
abstract:OBJECTIVE:This study investigated if levels of allostatic load (ALoad) differed according to race/ethnicity in children and if ALoad was associated with obesity-related measures. METHODS:A multiethnic sample of 307 children aged seven to 12 was evaluated, composed of 39% European American (EA), 35% African American (A...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12501
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:Pediatric obesity impacts on multiple domains of psychological health, including self-esteem and body image. OBJECTIVE:To determine the effect of multicomponent pediatric obesity treatment interventions on self-esteem and body image. METHODS:A systematic search of published literature up to June 2019 was u...
journal_title:Pediatric obesity
pub_type: 杂志文章,meta分析
doi:10.1111/ijpo.12600
更新日期:2020-03-01 00:00:00
abstract::Gut microbes are active participants of host metabolism. At birth, child physiology is committed towards healthiness or sickness depending, in part, on maternal condition (i.e. lean vs obesity) and delivery. Finally, changes from breastfeeding to solid food also account to define gut microbiota ecology in adulthood. N...
journal_title:Pediatric obesity
pub_type: 杂志文章,评审
doi:10.1111/ijpo.12146
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:Increased consumption of sweetened beverages has previously been linked to the degree of childhood obesity. OBJECTIVE:The aim of the present study was to assess whether the intake of sweetened beverages, candy, snacks or fast food at baseline in a multidisciplinary childhood obesity treatment program was as...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12094
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:The incidence of type 2 diabetes mellitus (T2D) is increasing in youth, yet little is known about the underlying pathophysiology. Decreased insulin suppression of lipolysis and elevated non-esterified free fatty acid (NEFA) concentrations are known to be associated with insulin resistance and T2D in adults, ...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/j.2047-6310.2013.00189.x
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:Early childhood adiposity may have significant later health effects. This study examines the prevalence and recognition of obesity and severe obesity among preschool-aged children. METHODS:The electronic medical record was used to examine body mass index (BMI), height, sex and race/ethnicity in 42,559 child...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/j.2047-6310.2013.00154.x
更新日期:2014-06-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to investigate changes in volatile organic compounds (VOCs) in exhaled breath in overweight/obese children compared with their lean counterparts. STUDY DESIGN:Single exhaled breath was collected and analyzed per protocol using selective ion flow tube mass spectrometry (SIFT-MS...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/j.2047-6310.2014.221.x
更新日期:2015-02-01 00:00:00
abstract:OBJECTIVES:Sagittal diameter (SAD) has been reported to correlate to visceral fat and cardiovascular risk factors. SAD is measured with the individual lying down, halfway between the lower rib margin and the iliac crest; it represents the mid-height of the abdomen. The aim of this study was to validate SAD measured usi...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/j.2047-6310.2012.00095.x
更新日期:2013-04-01 00:00:00