Abstract:
OBJECTIVES:Growing evidence indicates that ambient (AAP: NO2 , PM2.5 and O3 ) and traffic-related air pollutants (TRAP) contribute to metabolic disease risk in adults; however, few studies have examined these relationships in children. METHODS:Metabolic profiling was performed in 429 overweight and obese African-American and Latino youth living in urban Los Angeles, California. This cross-sectional study estimated individual residential air pollution exposure and used linear regression to examine relationships between air pollution and metabolic outcomes. RESULTS:AAP and TRAP exposure were associated with adverse effects on glucose metabolism independent of body fat percent. PM2.5 was associated with 25.0% higher fasting insulin (p < 0.001), 8.3% lower insulin sensitivity (p < 0.001), 14.7% higher acute insulin response to glucose (p = 0.001) and 1.7% higher fasting glucose (p < 0.001). Similar associations were observed for increased NO2 exposure. TRAP from non-freeway roads was associated with 12.1% higher insulin (p < 0.001), 6.9% lower insulin sensitivity (p = 0.02), 10.8% higher acute insulin response to glucose (p = 0.003) and 0.7% higher fasting glucose (p = 0.047). CONCLUSIONS:Elevated air pollution exposure was associated with a metabolic profile that is characteristic of increased risk for type 2 diabetes. These results indicate that increased prior year exposure to air pollution may adversely affect type 2 diabetes-related pathophysiology in overweight and obese minority children.
journal_name
Pediatr Obesjournal_title
Pediatric obesityauthors
Toledo-Corral CM,Alderete TL,Habre R,Berhane K,Lurmann FW,Weigensberg MJ,Goran MI,Gilliland FDdoi
10.1111/ijpo.12188subject
Has Abstractpub_date
2018-01-01 00:00:00pages
54-62issue
1eissn
2047-6302issn
2047-6310journal_volume
13pub_type
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journal_title:Pediatric obesity
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journal_title:Pediatric obesity
pub_type: 杂志文章,评审
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journal_title:Pediatric obesity
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journal_title:Pediatric obesity
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journal_title:Pediatric obesity
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journal_title:Pediatric obesity
pub_type: 杂志文章
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journal_title:Pediatric obesity
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journal_title:Pediatric obesity
pub_type: 杂志文章,随机对照试验
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更新日期:2014-06-01 00:00:00
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更新日期:2017-02-01 00:00:00
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journal_title:Pediatric obesity
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更新日期:2017-08-01 00:00:00
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journal_title:Pediatric obesity
pub_type: 杂志文章
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journal_title:Pediatric obesity
pub_type: 杂志文章
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更新日期:2020-11-01 00:00:00
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journal_title:Pediatric obesity
pub_type: 杂志文章
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更新日期:2020-09-01 00:00:00
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journal_title:Pediatric obesity
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更新日期:2012-02-01 00:00:00
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journal_title:Pediatric obesity
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