Abstract:
BACKGROUND:The effect of the patatin-like phospholipase domain containing 3 gene (PNPLA3) I148M polymorphism on the risk and severity of paediatric and adolescent nonalcoholic fatty liver disease (NAFLD) remains inconclusive. OBJECTIVES:We aimed to estimate the effect of this polymorphism not only on early-onset NAFLD risk and severity but also on metabolic syndromes susceptibility. METHODS:A systematic literature search was performed to identify relevant datasets. The odds ratio of the dichotomic variables and the standardized mean difference of quantitative variables with corresponding 95% confidence intervals were calculated to assess the strength of the associations. RESULTS:Twenty-seven studies comprising 10 070 subjects were eligible. The summary effect showed that this polymorphism increased susceptibility to NAFLD development. Furthermore, it also indicated that nonalcoholic steatohepatitis (NASH) was more frequently observed in G allele carriers among paediatric and adolescent NAFLD patients. Moreover, the meta-analysis suggested that the variant was significantly associated with elevated liver damage indexes, including serum alanine transaminase, aspartate transaminase, gamma-glutamyltransferase concentrations, and liver fat content. However, the summary estimates for insulin resistance, lipid metabolism, and adiposity showed no significant associations. CONCLUSIONS:The PNPLA3 I148M polymorphism is associated with elevated early-onset NAFLD risk, severity, and liver damage but not with related metabolic syndromes.
journal_name
Pediatr Obesjournal_title
Pediatric obesityauthors
Li J,Hua W,Ji C,Rui J,Zhao Y,Xie C,Shi B,Yang Xdoi
10.1111/ijpo.12615subject
Has Abstractpub_date
2020-06-01 00:00:00pages
e12615issue
6eissn
2047-6302issn
2047-6310journal_volume
15pub_type
杂志文章,meta分析abstract:BACKGROUND:Insufficient information is available on the relationship between obesity and outcome of paediatric patients with acute pancreatitis. OBJECTIVES:This study aimed to investigate the effect of obesity on outcomes of paediatric patients with acute pancreatitis based on a national administrative database. METH...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12041
更新日期:2016-06-01 00:00:00
abstract::The association between total dietary fat intake and measures of body fatness in children with obesity remains inconsistent. This study aimed to determine whether dietary long-chain polyunsaturated fatty acids (LCPUFA) and LCPUFA status relate to body composition in children with obesity. Children (n = 63, 9.0 ± 0.2 y...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12689
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:Early childhood adiposity may have significant later health effects. This study examines the prevalence and recognition of obesity and severe obesity among preschool-aged children. METHODS:The electronic medical record was used to examine body mass index (BMI), height, sex and race/ethnicity in 42,559 child...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/j.2047-6310.2013.00154.x
更新日期:2014-06-01 00:00:00
abstract:BACKGROUND:In adults, depressive symptoms are positively associated with insulin resistance. OBJECTIVE:To determine whether an association exists between depressive symptoms and markers of insulin resistance in youth. METHODS:This study used a retrospective review of data from an obesity clinic. We evaluated the asso...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.237
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:Executive functioning (EF) difficulties may be associated with problems regulating eating behaviours. Few studies have evaluated this question in youth using diverse measures of EF or objective measures of energy intake. METHODS:The current study used neuropsychological tasks and a laboratory test meal to e...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12614
更新日期:2020-06-01 00:00:00
abstract:OBJECTIVE:The objective of the study was to determine accuracy of the Tanita SC-240 body composition analyser to measure paediatric percent body fat (%BF). METHODS:Eighty-nine African-American and white 5-18-year-olds participated in this study. %BF was estimated by dual-energy X-ray absorptiometry (DXA) and by the Ta...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/j.2047-6310.2012.00122.x
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND:Previous studies have indicated that snacking is contributing to increased calorie intake of American children and that the energy density of snacks in US diets has increased in recent decades. OBJECTIVE:Examine short-term and long-term trends in the energy density and food sources of snacks for US children...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12220
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND/OBJECTIVE:We evaluated the prevalence of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) in 27 adolescents referred for weight loss surgery (WLS). RESULTS:On biopsy, 18 patients (66.7%) had NAFLD, and of those, 10 (37.0%) had NASH and 11 (40.7%) had fibrosis. Insulin, HbA1...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/j.2047-6310.2014.219.x
更新日期:2014-10-01 00:00:00
abstract:OBJECTIVE:Our aim is to determine the effect of paced eating, exposure to an educational programme that promotes healthy eating habits and allowing the satiety reflex to limit food intake in controlling weight gain in healthy adolescents. METHODS:Fifty-four healthy individuals consisting of 18 adolescent girls and 36 ...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12091
更新日期:2016-12-01 00:00:00
abstract::Gut microbes are active participants of host metabolism. At birth, child physiology is committed towards healthiness or sickness depending, in part, on maternal condition (i.e. lean vs obesity) and delivery. Finally, changes from breastfeeding to solid food also account to define gut microbiota ecology in adulthood. N...
journal_title:Pediatric obesity
pub_type: 杂志文章,评审
doi:10.1111/ijpo.12146
更新日期:2017-08-01 00:00:00
abstract:OBJECTIVE:To conduct a systematic review of the literature for strategies designed to reduce attrition in managing paediatric obesity. METHODS:We searched Ovid Medline (1946 to May 6, 2020), Ovid Embase (1974 to May 6, 2020), EBSCO CINAHL (inception to May 6, 2020), Elsevier Scopus (inception to April 14, 2020), and P...
journal_title:Pediatric obesity
pub_type: 杂志文章,评审
doi:10.1111/ijpo.12733
更新日期:2020-09-22 00:00:00
abstract:BACKGROUND:Few studies have assessed how well body mass index (BMI), waist circumference (WC), or waist to height ratio (WtHR) perform in identifying cardio-metabolic risk among youth. OBJECTIVE:The objective of this study was to evaluate the utility of BMI and WC percentiles and WtHR to distinguish adolescents with a...
journal_title:Pediatric obesity
pub_type: 杂志文章,随机对照试验
doi:10.1111/ijpo.267
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:The prevalence of obesity in childhood is of high concern, especially in deprived populations. We explored trends in obesity following the introduction of a citywide strategy focused on preschool children. METHODS:Analysis of obesity prevalence using the National Child Measurement Programme 2009 to 2017 for...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12529
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND:Infants born small-for-gestational-age (SGA) who develop post-natal weight catch-up are at risk for insulin resistance, central adiposity and cardiovascular disease in later life, even in the absence of overweight. OBJECTIVE:In young (age 3-6 years) non-obese SGA children, we assessed arterial health (as ju...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12053
更新日期:2016-08-01 00:00:00
abstract:OBJECTIVE:To examine associations between consumption of low-calorie sweetened beverages (LCSBs), sugar, and total energy intake in children in the United States. METHODS:We used 24-hour dietary recalls from 7026 children enrolled in the National Health and Nutrition Examination Survey (NHANES) 2011 to 2016 to assess ...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12535
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:Stepped-care approaches to weight loss have shown some success among adults. A 'stepped-down' version of the stepped-care approach to adolescent weight loss has never been evaluated. OBJECTIVES:We conducted a one-year randomized controlled trial to compare a stepped-down weight loss intervention versus enha...
journal_title:Pediatric obesity
pub_type: 杂志文章,随机对照试验
doi:10.1111/ijpo.12013
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:Increased consumption of sweetened beverages has previously been linked to the degree of childhood obesity. OBJECTIVE:The aim of the present study was to assess whether the intake of sweetened beverages, candy, snacks or fast food at baseline in a multidisciplinary childhood obesity treatment program was as...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12094
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:The data regarding prospective associations between physical activity (PA) and adiposity in youth are inconsistent. OBJECTIVE:The objective of this study was to investigate associations between baseline levels of objectively measured PA and changes in adiposity over 2.5 years from mid-to-late adolescence. ...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12031
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:There are no academic studies that characterize advertisements directed at children from the companies that signed the self-regulation. OBJECTIVE:The aim of this paper was to assess the extent and nature of food advertisements and the persuasive techniques used to market unhealthy food and beverages (UFB) t...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12144
更新日期:2017-08-01 00:00:00
abstract:OBJECTIVES:Sagittal diameter (SAD) has been reported to correlate to visceral fat and cardiovascular risk factors. SAD is measured with the individual lying down, halfway between the lower rib margin and the iliac crest; it represents the mid-height of the abdomen. The aim of this study was to validate SAD measured usi...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/j.2047-6310.2012.00095.x
更新日期:2013-04-01 00:00:00
abstract:OBJECTIVE:This study aimed to examine physical activity (PA) patterns in children with autism spectrum disorder (ASD) as well as to address PA determinant factors by employing triaxial accelerometry. METHODS:In a school-based cross-sectional study of 80 children and adolescents with ASD (mean = 9.6, standard deviation...
journal_title:Pediatric obesity
pub_type: 杂志文章,多中心研究
doi:10.1111/j.2047-6310.2012.00101.x
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND:The incidence of type 2 diabetes mellitus (T2D) is increasing in youth, yet little is known about the underlying pathophysiology. Decreased insulin suppression of lipolysis and elevated non-esterified free fatty acid (NEFA) concentrations are known to be associated with insulin resistance and T2D in adults, ...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/j.2047-6310.2013.00189.x
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:Drink personalization (featuring names on bottle labels) has been used by soft drink companies to make their drinks attractive to children, potentially increasing consumption. To date, no publically available research has evaluated the influence of personalization on children's drink choices. OBJECTIVES:To ...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12193
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Genetic and epigenetic variations may be an important contributer to altered eating behaviors in childhood which may lead to weight gain and obesity later in life. OBJECTIVE:This study aimed to evaluate epigenetic as well as genetic associations with appetite in young children. SUBJECTS AND METHODS:Partici...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12010
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:Findings concerning nitric oxide (NO) in children and adolescents with obesity are scant. OBJECTIVE:This study examined the links of NO with obesity and psychological traits (ie, self-concept, anxiety, depression, anger and disruptive behaviour) in children and adolescents in Taiwan. METHODS:A total of 564...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12593
更新日期:2020-03-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to assess overweight and obesity status transition probabilities using first-order Markov transition models applied to elementary school children. METHOD:Complete longitudinal data across 11 assessments were available from 1494 elementary school children (from 7599 students in...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12025
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:The Healthy Communities Study (HCS) was a national study of community programs and policies that aimed to address childhood obesity; it necessitated recruitment of a large sample of children from communities throughout the United States. OBJECTIVE:The HCS aimed to complete visits with an average of 45 child...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12455
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:Attention-deficit/hyperactivity disorder (ADHD) symptoms have been linked with eating behaviors and obesity adolescence and young adulthood. Yet, little is known about whether these associations occur during early childhood and few studies have examined these associations prospectively. OBJECTIVES:To assess...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12631
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND:Non-alcoholic fatty liver disease (NAFLD), prediabetes and type 2 diabetes mellitus are known to be closely linked with obesity as early as during childhood. OBJECTIVES:The study aimed to determine the prevalence of prediabetes and T2DM in children with obesity with or without increased transaminases. METH...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12601
更新日期:2020-04-01 00:00:00
abstract:OBJECTIVE:To investigate the association of the neuropeptide Y (NPY) promoter polymorphism rs16147 with body mass index (BMI) during the course of development from infancy to adulthood. DESIGN:Longitudinal, prospective study of a German community sample. SUBJECTS:n = 306 young adults (139 males, 167 females). MEASUR...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/j.2047-6310.2012.00069.x
更新日期:2012-12-01 00:00:00