Breathprints of childhood obesity: changes in volatile organic compounds in obese children compared with lean controls.

Abstract:

OBJECTIVE:The objective of this study was to investigate changes in volatile organic compounds (VOCs) in exhaled breath in overweight/obese children compared with their lean counterparts. STUDY DESIGN:Single exhaled breath was collected and analyzed per protocol using selective ion flow tube mass spectrometry (SIFT-MS). RESULTS:Sixty overweight/obese children and 55 lean controls were included. Compared with the lean group, the obese group was significantly older (14.1 ± 2.8 vs. 12.1 ± 3.0 years), taller (164.8 ± 10.9 vs. 153.3 ± 17.1 cm) and more likely to be Caucasian (60% vs. 35.2%); P < 0.05 for all. A comparison of the SIFT-MS results of the obese group with the lean group revealed differences in concentration of more than 50 compounds. A panel of four VOCs can identify the presence of overweight/obesity with excellent accuracy. Further analysis revealed that breath isoprene, 1-decene, 1-octene, ammonia and hydrogen sulfide were significantly higher in the obese group compared with the lean group (P value < 0.01 for all). CONCLUSION:Obese children have a unique pattern of exhaled VOCs. Changes in VOCs observed in this study may help to gain insight into pathophysiological processes and pathways leading to the development of childhood obesity.

journal_name

Pediatr Obes

journal_title

Pediatric obesity

authors

Alkhouri N,Eng K,Cikach F,Patel N,Yan C,Brindle A,Rome E,Hanouneh I,Grove D,Lopez R,Hazen SL,Dweik RA

doi

10.1111/j.2047-6310.2014.221.x

subject

Has Abstract

pub_date

2015-02-01 00:00:00

pages

23-9

issue

1

eissn

2047-6302

issn

2047-6310

journal_volume

10

pub_type

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