Abstract:
OBJECTIVE:The objective of this study was to investigate changes in volatile organic compounds (VOCs) in exhaled breath in overweight/obese children compared with their lean counterparts. STUDY DESIGN:Single exhaled breath was collected and analyzed per protocol using selective ion flow tube mass spectrometry (SIFT-MS). RESULTS:Sixty overweight/obese children and 55 lean controls were included. Compared with the lean group, the obese group was significantly older (14.1 ± 2.8 vs. 12.1 ± 3.0 years), taller (164.8 ± 10.9 vs. 153.3 ± 17.1 cm) and more likely to be Caucasian (60% vs. 35.2%); P < 0.05 for all. A comparison of the SIFT-MS results of the obese group with the lean group revealed differences in concentration of more than 50 compounds. A panel of four VOCs can identify the presence of overweight/obesity with excellent accuracy. Further analysis revealed that breath isoprene, 1-decene, 1-octene, ammonia and hydrogen sulfide were significantly higher in the obese group compared with the lean group (P value < 0.01 for all). CONCLUSION:Obese children have a unique pattern of exhaled VOCs. Changes in VOCs observed in this study may help to gain insight into pathophysiological processes and pathways leading to the development of childhood obesity.
journal_name
Pediatr Obesjournal_title
Pediatric obesityauthors
Alkhouri N,Eng K,Cikach F,Patel N,Yan C,Brindle A,Rome E,Hanouneh I,Grove D,Lopez R,Hazen SL,Dweik RAdoi
10.1111/j.2047-6310.2014.221.xsubject
Has Abstractpub_date
2015-02-01 00:00:00pages
23-9issue
1eissn
2047-6302issn
2047-6310journal_volume
10pub_type
杂志文章abstract:BACKGROUND:Obesity is a global health concern but the United States has reported a leveling in obesity rates in the pediatric population. OBJECTIVE:To provide updated waist circumference (WC) percentile values, identify differences across time and discuss differences within the context of reported weight stabilization...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12150
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND:Increased consumption of sweetened beverages has previously been linked to the degree of childhood obesity. OBJECTIVE:The aim of the present study was to assess whether the intake of sweetened beverages, candy, snacks or fast food at baseline in a multidisciplinary childhood obesity treatment program was as...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12094
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:Child obesity is a growing public health concern. Excess weight in childhood is known to be associated with a high risk of obesity and obesity-related comorbidities in adulthood. OBJECTIVES:This study quantifies lifetime excess costs of overweight and obese adults in Germany taking the history of obesity in...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.278
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:In the USA, half of children are regularly cared for before or after school by someone other than a parent. OBJECTIVE:Describe the relationship between childcare arrangements and obesity among school-aged children. METHODS:Data are from the fifth-grade wave of the Early Childhood Longitudinal Study - Kinde...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12107
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND:There are no academic studies that characterize advertisements directed at children from the companies that signed the self-regulation. OBJECTIVE:The aim of this paper was to assess the extent and nature of food advertisements and the persuasive techniques used to market unhealthy food and beverages (UFB) t...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12144
更新日期:2017-08-01 00:00:00
abstract::Childhood obesity is associated with a pro-atherogenic phenotype contributing to increased cardiovascular disease (CVD) risk. This single-arm pilot study examined the effects of a lifestyle intervention on lipoprotein particle size and cholesterol distribution in obese Latino adolescents. Fifteen obese Latino adolesce...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/j.2047-6310.2013.00162.x
更新日期:2013-10-01 00:00:00
abstract:OBJECTIVE:To investigate the association of the neuropeptide Y (NPY) promoter polymorphism rs16147 with body mass index (BMI) during the course of development from infancy to adulthood. DESIGN:Longitudinal, prospective study of a German community sample. SUBJECTS:n = 306 young adults (139 males, 167 females). MEASUR...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/j.2047-6310.2012.00069.x
更新日期:2012-12-01 00:00:00
abstract:UNLABELLED:What is already known about this subject Circulating concentrations of branched-chain amino acids (BCAAs) can affect carbohydrate metabolism in skeletal muscle, and therefore may alter insulin sensitivity. BCAAs are elevated in adults with diet-induced obesity, and are associated with their future risk of ty...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/j.2047-6310.2012.00087.x
更新日期:2013-02-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to assess overweight and obesity status transition probabilities using first-order Markov transition models applied to elementary school children. METHOD:Complete longitudinal data across 11 assessments were available from 1494 elementary school children (from 7599 students in...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12025
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:Early life factors can programme future risk for cardiovascular disease. OBJECTIVES:We explored associations between adolescent adiponectin levels and concomitant metabolic alteration and also looked at the association between early life factors and adolescent adiponectin levels. METHODS:We studied a longi...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12212
更新日期:2018-05-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to examine the relationship between diet and inflammation, and adiposity in minority youth. DESIGN AND METHODS:The study was designed as a cross-sectional analysis of 142 overweight (≥85th body mass index percentile) Hispanic and African-American adolescents (14-18 years) with...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12017
更新日期:2016-02-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to establish, through measured height and weight, the prevalence of overweight and obesity in a representative sample of Maltese children aged 10-11 years. METHODS:Height and weight were measured in a sample, stratified by sex, region and type of school, of 874 year 6 children...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/j.2047-6310.2013.00191.x
更新日期:2013-10-01 00:00:00
abstract::This study's purpose was to examine changes in healthy and unhealthy items purchased following the implementation of traffic light and cartoon labelling in a small retail food venue (Café Bay) in a children's hospital in eastern North Carolina. Between October 2015 and March 2016, daily food and beverage sales from Ca...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12232
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:The incidence of type 2 diabetes mellitus (T2D) is increasing in youth, yet little is known about the underlying pathophysiology. Decreased insulin suppression of lipolysis and elevated non-esterified free fatty acid (NEFA) concentrations are known to be associated with insulin resistance and T2D in adults, ...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/j.2047-6310.2013.00189.x
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:Obesity is a risk factor for asthma. However, it is unclear if increased obesity prevalence contributed to rising childhood asthma prevalence. OBJECTIVE:To assess if population-level changes in weight status impacted asthma prevalence over time. METHODS:Using nationally representative 1988-2014 National He...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12246
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:Primary prevention of overweight is to be preferred above secondary prevention, which has shown moderate effectiveness. OBJECTIVE:To develop and internally validate a dynamic prediction model to identify young children in the general population, applicable at every age between birth and age 6, at high risk ...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12647
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:Previous studies have indicated that snacking is contributing to increased calorie intake of American children and that the energy density of snacks in US diets has increased in recent decades. OBJECTIVE:Examine short-term and long-term trends in the energy density and food sources of snacks for US children...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12220
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:The intrauterine environment is critical in the development of child obesity. OBJECTIVE:To investigate the association between maternal lipid levels during pregnancy and child weight status. METHODS:Maternal lipid levels (total cholesterol, high-density and low-density lipoprotein cholesterol, triglyceride...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12485
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND:The American Academy of Pediatrics calls for aggressive management of preterm infants to achieve body composition approximating that of the healthy infant in utero. Air displacement plethysmography (ADP) has been validated for assessment of body composition in preterm infants and could be used to monitor the...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/j.2047-6310.2013.00215.x
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:Childhood and adolescent obesity may lead to obesity and related complications in adulthood. Biomarkers of obesity can be useful for screening for obesity complications and promoting early intervention during school age. Thus, the metabolomic differences in obese children and adolescents should be investigat...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12114
更新日期:2017-04-01 00:00:00
abstract:OBJECTIVES:Sagittal diameter (SAD) has been reported to correlate to visceral fat and cardiovascular risk factors. SAD is measured with the individual lying down, halfway between the lower rib margin and the iliac crest; it represents the mid-height of the abdomen. The aim of this study was to validate SAD measured usi...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/j.2047-6310.2012.00095.x
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND:The effect of the patatin-like phospholipase domain containing 3 gene (PNPLA3) I148M polymorphism on the risk and severity of paediatric and adolescent nonalcoholic fatty liver disease (NAFLD) remains inconclusive. OBJECTIVES:We aimed to estimate the effect of this polymorphism not only on early-onset NAFLD...
journal_title:Pediatric obesity
pub_type: 杂志文章,meta分析
doi:10.1111/ijpo.12615
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:Insufficient information is available on the relationship between obesity and outcome of paediatric patients with acute pancreatitis. OBJECTIVES:This study aimed to investigate the effect of obesity on outcomes of paediatric patients with acute pancreatitis based on a national administrative database. METH...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12041
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:Reports comparing waist circumference (WC) measurements from young populations are scarce. OBJECTIVES:We compared two protocols for measuring waist circumference in a sample of youth with diabetes. METHODS:Participants were enrolled in the SEARCH for Diabetes in Youth Study (SEARCH). WC was measured at lea...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/j.2047-6310.2012.00088.x
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:The data regarding prospective associations between physical activity (PA) and adiposity in youth are inconsistent. OBJECTIVE:The objective of this study was to investigate associations between baseline levels of objectively measured PA and changes in adiposity over 2.5 years from mid-to-late adolescence. ...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12031
更新日期:2016-04-01 00:00:00
abstract:OBJECTIVE:This study investigated if levels of allostatic load (ALoad) differed according to race/ethnicity in children and if ALoad was associated with obesity-related measures. METHODS:A multiethnic sample of 307 children aged seven to 12 was evaluated, composed of 39% European American (EA), 35% African American (A...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12501
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:In adults, adherence to the Mediterranean diet has been inversely associated with cardiovascular risk, but the extent to which diet in pregnancy is associated with offspring adiposity is unclear. We aimed to investigate the association between adherence to Mediterranean diet in pregnancy and offspring cardio...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12191
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:Dietary factors seem to influence telomere length. Moreover, associations between changes in adiposity indices and telomere length (TL) have been found in intervention studies. OBJECTIVE:We evaluated changes in two diet quality indices and their association with TL in children with abdominal obesity in a 12...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12661
更新日期:2020-11-01 00:00:00
abstract:OBJECTIVES:The current cross-sectional study examined whether children who are overweight experience greater levels of parent-reported bullying behaviors and victimization using a national sample. Additionally, the relations among child (mental health), family (parent-child sharing of information), and contextual facto...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12516
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:In adults, depressive symptoms are positively associated with insulin resistance. OBJECTIVE:To determine whether an association exists between depressive symptoms and markers of insulin resistance in youth. METHODS:This study used a retrospective review of data from an obesity clinic. We evaluated the asso...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.237
更新日期:2014-10-01 00:00:00