Depressive symptoms are associated with fasting insulin resistance in obese youth.

Abstract:

BACKGROUND:In adults, depressive symptoms are positively associated with insulin resistance. OBJECTIVE:To determine whether an association exists between depressive symptoms and markers of insulin resistance in youth. METHODS:This study used a retrospective review of data from an obesity clinic. We evaluated the association between depressive symptoms (Children's Depression Inventory, CDI) and fasting insulin and homeostatic model assessment-insulin resistance (HOMA-IR) in obese youth (n = 207, age 10-18 years). Individuals with lower vs. higher CDI T-scores (<65 vs. ≥65) were compared; this cut-point is accepted as indicating the possibility of clinical depression. Multiple linear regression was used to evaluate relationships between CDI T-scores and insulin resistance. RESULTS:Fasting insulin and HOMA-IR values were 40% higher in patients with higher CDI T-scores (P = 0.04). After accounting for gender, race, age and body mass index, CDI T-score remained associated with HOMA-IR, although the strength of the association was small (b = 0.007, P = 0.049). CONCLUSIONS:Relationships between depressive symptoms and insulin resistance should be considered when evaluating obese youth.

journal_name

Pediatr Obes

journal_title

Pediatric obesity

authors

Hannon TS,Li Z,Tu W,Huber JN,Carroll AE,Lagges AM,Gupta S

doi

10.1111/ijpo.237

subject

Has Abstract

pub_date

2014-10-01 00:00:00

pages

e103-7

issue

5

eissn

2047-6302

issn

2047-6310

journal_volume

9

pub_type

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