Abstract:
BACKGROUND:Genetic and epigenetic variations may be an important contributer to altered eating behaviors in childhood which may lead to weight gain and obesity later in life. OBJECTIVE:This study aimed to evaluate epigenetic as well as genetic associations with appetite in young children. SUBJECTS AND METHODS:Participants were 32 non-obese and 32 obese African-American children aged 5-6 years. Saliva was collected from each child, and RNA and DNA were extracted for analysis. Individuals were genotyped for eating- and obesity-associated single nucleotide polymorphisms in seven candidate genes (FTO, MAOA, SH2B1, LEPR, DNMT3B, BDNF and CCKAR), and DNA methylation levels were measured in the upstream promoter region of each. Transcript levels of MAOA and FTO were also assessed. The Children's Eating Behavior Questionnaire (CEBQ) was used to assess the aspects of appetite. Child obesity was assessed using measured height and weight, and percent body fat was measured by dual-energy X-ray absorptiometry. RESULTS:Food responsiveness was higher and satiety responsiveness was lower among obese than non-obese female children (P = 0.001 and P = 0.031), but did not differ among male children. Epigenetic analysis of the BDNF promoter revealed associations with altered satiety responsiveness among female children (P < 0.01). CONCLUSION:The findings provide new evidence of epigenetic associations with altered appetite among young African-American girls.
journal_name
Pediatr Obesjournal_title
Pediatric obesityauthors
Gardner KR,Sapienza C,Fisher JOdoi
10.1111/ijpo.12010subject
Has Abstractpub_date
2015-12-01 00:00:00pages
476-82issue
6eissn
2047-6302issn
2047-6310journal_volume
10pub_type
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