Young microbes for adult obesity.

Abstract:

:Gut microbes are active participants of host metabolism. At birth, child physiology is committed towards healthiness or sickness depending, in part, on maternal condition (i.e. lean vs obesity) and delivery. Finally, changes from breastfeeding to solid food also account to define gut microbiota ecology in adulthood. Nowadays, alterations of gut microbiota, named dysbiosis, are acquired risk factors for multiple diseases, especially type 2 diabetes and obesity. Despite important evidence linking nutrition to dysbiosis to energetic dysmetabolism, molecular mechanisms for causality are still missing. That the status of gut microbiota of mother and child is crucial for future diseases is witnessed by adulthood overweight and obesity observed in children with dysbiosis. In this short review we highlight the importance of early life events related to the microbiota and their impact on future adult disease risk. Therefore, our effort to treat or prevent metabolic diseases should be addressed towards early or previous life steps, when microbial decisions are going to affect our metabolic fate.

journal_name

Pediatr Obes

journal_title

Pediatric obesity

authors

Serino M,Nicolas S,Trabelsi MS,Burcelin R,Blasco-Baque V

doi

10.1111/ijpo.12146

subject

Has Abstract

pub_date

2017-08-01 00:00:00

pages

e28-e32

issue

4

eissn

2047-6302

issn

2047-6310

journal_volume

12

pub_type

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