Abstract:
PURPOSE:Insulin responses to oral and intravenous glucose markedly differ by ethnicity. This study examined whether ethnic differences in pancreatic insulin secretion, hepatic insulin extraction and clearance explain these disparate findings in 35 obese African-American and 41 Latina girls (Tanner Stages: IV-V; ages: 14-18; body mass index percentile: 85.9-99.8%). METHODS:Pancreatic insulin secretion, hepatic insulin extraction and clearance were estimated by C-peptide and insulin modeling during an oral glucose tolerance test. Insulin sensitivity (SI), acute insulin response to glucose (AIRG ) and disposition index were derived from a frequently sampled intravenous glucose tolerance test. RESULTS:Compared to Latinas, obese African-American adolescents had lower pancreatic insulin secretion (21.3%; P < 0.01), glucose incremental area under the curve (IAUC) (41.7%, P = 0.02), C-peptide IAUC (25.1%, P < 0.01) and SI (33.7%; P < 0.01). There were no ethnic differences in hepatic insulin extraction and clearance (P's > 0.05). CONCLUSIONS:Compensatory mechanisms to insulin resistance do not appear to explain the ethnic differences in insulin responses to oral and intravenous glucose in obese African-American and Latina girls.
journal_name
Pediatr Obesjournal_title
Pediatric obesityauthors
Hasson RE,Adam TC,Davis JN,Watanabe RM,Goran MIdoi
10.1111/j.2047-6310.2013.00184.xsubject
Has Abstractpub_date
2013-12-01 00:00:00pages
e68-73issue
6eissn
2047-6302issn
2047-6310journal_volume
8pub_type
杂志文章abstract:BACKGROUND:In the USA, half of children are regularly cared for before or after school by someone other than a parent. OBJECTIVE:Describe the relationship between childcare arrangements and obesity among school-aged children. METHODS:Data are from the fifth-grade wave of the Early Childhood Longitudinal Study - Kinde...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12107
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND:Attention-deficit/hyperactivity disorder (ADHD) symptoms have been linked with eating behaviors and obesity adolescence and young adulthood. Yet, little is known about whether these associations occur during early childhood and few studies have examined these associations prospectively. OBJECTIVES:To assess...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12631
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND:Health Care Professionals struggle to initiate conversations about overweight in toddlerhood. A novel 3D body size scale (3D BSS) may facilitate engagement with this topic during pediatric appointments. OBJECTIVES:To explore barriers and facilitators to using the 3D BSS through a mixed-methods design. METH...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12715
更新日期:2021-02-01 00:00:00
abstract:BACKGROUND:Stepped-care approaches to weight loss have shown some success among adults. A 'stepped-down' version of the stepped-care approach to adolescent weight loss has never been evaluated. OBJECTIVES:We conducted a one-year randomized controlled trial to compare a stepped-down weight loss intervention versus enha...
journal_title:Pediatric obesity
pub_type: 杂志文章,随机对照试验
doi:10.1111/ijpo.12013
更新日期:2016-02-01 00:00:00
abstract:OBJECTIVES:Sagittal diameter (SAD) has been reported to correlate to visceral fat and cardiovascular risk factors. SAD is measured with the individual lying down, halfway between the lower rib margin and the iliac crest; it represents the mid-height of the abdomen. The aim of this study was to validate SAD measured usi...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/j.2047-6310.2012.00095.x
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND:Intestinal parasites, virus and bacterial infections are positively associated with obesity and adiposity in vitro and in animal models, but conclusive evidence of this relationship in humans is lacking. The aim of this cross-sectional study was to determine differences in adiposity between infected and non-...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12085
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:The effect of the patatin-like phospholipase domain containing 3 gene (PNPLA3) I148M polymorphism on the risk and severity of paediatric and adolescent nonalcoholic fatty liver disease (NAFLD) remains inconclusive. OBJECTIVES:We aimed to estimate the effect of this polymorphism not only on early-onset NAFLD...
journal_title:Pediatric obesity
pub_type: 杂志文章,meta分析
doi:10.1111/ijpo.12615
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:Dutch children's diets, like the diets of many children in Europe and the US are not balanced, do not contain enough vegetables and have been associated with a high prevalence of childhood obesity. Promoting children's vegetable intake is challenging. OBJECTIVE:We investigated the relative effectiveness of ...
journal_title:Pediatric obesity
pub_type: 杂志文章,多中心研究
doi:10.1111/ijpo.244
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:Early life factors can programme future risk for cardiovascular disease. OBJECTIVES:We explored associations between adolescent adiponectin levels and concomitant metabolic alteration and also looked at the association between early life factors and adolescent adiponectin levels. METHODS:We studied a longi...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12212
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND:Insufficient information is available on the relationship between obesity and outcome of paediatric patients with acute pancreatitis. OBJECTIVES:This study aimed to investigate the effect of obesity on outcomes of paediatric patients with acute pancreatitis based on a national administrative database. METH...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12041
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:Childhood and adolescent obesity may lead to obesity and related complications in adulthood. Biomarkers of obesity can be useful for screening for obesity complications and promoting early intervention during school age. Thus, the metabolomic differences in obese children and adolescents should be investigat...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12114
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND:The intrauterine environment is critical in the development of child obesity. OBJECTIVE:To investigate the association between maternal lipid levels during pregnancy and child weight status. METHODS:Maternal lipid levels (total cholesterol, high-density and low-density lipoprotein cholesterol, triglyceride...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12485
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND:Overt or subclinical hypothyroidism is a common finding in adult populations affected by non-alcoholic fatty liver disease (NAFLD). Currently, there are only sparse data available on the association of thyroid dysfunction and NAFLD in obese children and adolescents. OBJECTIVE:The study aims to investigate t...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12110
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND:Reports comparing waist circumference (WC) measurements from young populations are scarce. OBJECTIVES:We compared two protocols for measuring waist circumference in a sample of youth with diabetes. METHODS:Participants were enrolled in the SEARCH for Diabetes in Youth Study (SEARCH). WC was measured at lea...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/j.2047-6310.2012.00088.x
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:Few studies have assessed how well body mass index (BMI), waist circumference (WC), or waist to height ratio (WtHR) perform in identifying cardio-metabolic risk among youth. OBJECTIVE:The objective of this study was to evaluate the utility of BMI and WC percentiles and WtHR to distinguish adolescents with a...
journal_title:Pediatric obesity
pub_type: 杂志文章,随机对照试验
doi:10.1111/ijpo.267
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Previous studies have indicated that snacking is contributing to increased calorie intake of American children and that the energy density of snacks in US diets has increased in recent decades. OBJECTIVE:Examine short-term and long-term trends in the energy density and food sources of snacks for US children...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12220
更新日期:2018-04-01 00:00:00
abstract::Mobile health (mHealth) is a relatively nascent field, with a variety of technologies being explored and developed. Because of the explosive growth in this field, it is of interest to examine the design, development and efficacy of various interventions as research becomes available. This systematic review examines cu...
journal_title:Pediatric obesity
pub_type: 杂志文章,评审
doi:10.1111/ijpo.12002
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:In some previous studies direct associations between intake of soft drinks, sugar-sweetened beverages and adiposity have been reported. The majority of these studies were, however, conducted in the USA and it is uncertain if the results are applicable to non-US countries. OBJECTIVE:To assess the association...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/j.2047-6310.2013.00170.x
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND:Dietary factors seem to influence telomere length. Moreover, associations between changes in adiposity indices and telomere length (TL) have been found in intervention studies. OBJECTIVE:We evaluated changes in two diet quality indices and their association with TL in children with abdominal obesity in a 12...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12661
更新日期:2020-11-01 00:00:00
abstract::Childhood obesity is associated with a pro-atherogenic phenotype contributing to increased cardiovascular disease (CVD) risk. This single-arm pilot study examined the effects of a lifestyle intervention on lipoprotein particle size and cholesterol distribution in obese Latino adolescents. Fifteen obese Latino adolesce...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/j.2047-6310.2013.00162.x
更新日期:2013-10-01 00:00:00
abstract:OBJECTIVE:This study investigated if levels of allostatic load (ALoad) differed according to race/ethnicity in children and if ALoad was associated with obesity-related measures. METHODS:A multiethnic sample of 307 children aged seven to 12 was evaluated, composed of 39% European American (EA), 35% African American (A...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12501
更新日期:2019-06-01 00:00:00
abstract::Gut microbes are active participants of host metabolism. At birth, child physiology is committed towards healthiness or sickness depending, in part, on maternal condition (i.e. lean vs obesity) and delivery. Finally, changes from breastfeeding to solid food also account to define gut microbiota ecology in adulthood. N...
journal_title:Pediatric obesity
pub_type: 杂志文章,评审
doi:10.1111/ijpo.12146
更新日期:2017-08-01 00:00:00
abstract:OBJECTIVES:The objectives of this study were twofold - (i) to assess the agreement between self-reported waist circumference (SRWC) and assessor measured waist circumference (MWC) and (ii) to evaluate the diagnostic ability of SRWC for classifying (i) a clustering of cardiometabolic risk factors (CMRFs) and (ii) overwe...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/j.2047-6310.2011.00017.x
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND:Obesity is a risk factor for asthma. However, it is unclear if increased obesity prevalence contributed to rising childhood asthma prevalence. OBJECTIVE:To assess if population-level changes in weight status impacted asthma prevalence over time. METHODS:Using nationally representative 1988-2014 National He...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12246
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:Obesity is a global health concern but the United States has reported a leveling in obesity rates in the pediatric population. OBJECTIVE:To provide updated waist circumference (WC) percentile values, identify differences across time and discuss differences within the context of reported weight stabilization...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12150
更新日期:2017-10-01 00:00:00
abstract:OBJECTIVE:The objective of the study was to determine accuracy of the Tanita SC-240 body composition analyser to measure paediatric percent body fat (%BF). METHODS:Eighty-nine African-American and white 5-18-year-olds participated in this study. %BF was estimated by dual-energy X-ray absorptiometry (DXA) and by the Ta...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/j.2047-6310.2012.00122.x
更新日期:2013-04-01 00:00:00
abstract::The consumption of high-fructose corn syrup (HFCS) beverages has increased since the 1970s. At the same time, childhood obesity is on the rise, causing children to be at risk of heart disease, diabetes and other diseases. Healthcare providers have attributed childhood obesity to the consumption of HFCS in the form of ...
journal_title:Pediatric obesity
pub_type: 杂志文章,评审
doi:10.1111/j.2047-6310.2013.00173.x
更新日期:2013-08-01 00:00:00
abstract:OBJECTIVE:We examined the association between gestational weight gain (GWG) and offspring obesity at age 36 months. METHODS:Mother-infant dyads (n = 609) were followed from a first study visit (mean [standard deviation]: 18.8 [2.7] weeks gestation) to 36 months postpartum. Total GWG over the entire pregnancy was defin...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.262
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:Increases in portion size are thought by many to promote obesity in children. However, this relationship remains unclear. Here, we explore the extent to which a child's BMI is predicted both by parental beliefs about their child's ideal and maximum portion size and/or by the child's own beliefs. METHODS:Par...
journal_title:Pediatric obesity
pub_type: 杂志文章,随机对照试验
doi:10.1111/ijpo.12218
更新日期:2018-04-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to investigate changes in volatile organic compounds (VOCs) in exhaled breath in overweight/obese children compared with their lean counterparts. STUDY DESIGN:Single exhaled breath was collected and analyzed per protocol using selective ion flow tube mass spectrometry (SIFT-MS...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/j.2047-6310.2014.221.x
更新日期:2015-02-01 00:00:00