Abstract:
BACKGROUND:The incidence of childhood obesity and associated comorbidities are on an increasing trend worldwide. More than 340 million children and adolescents aged between 5 and 19 years old were overweight or had obesity in 2016, from which over 124 million children and adolescents (6% of girls and 8% of boys) had obesity. OBJECTIVE:To describe the relationship between pancreas steatosis, body fat and the risk of metabolic syndrome, insulin resistance in Hong Kong Chinese adolescents with both obesity and non-alcoholic fatty liver disease (NAFLD). METHODS:Fifty two adolescents with obesity and NAFLD were analysed (14-18 years), stratified into fatty and non-fatty pancreas groups using chemical shift encoded MRI-pancreas proton density fat fraction ≥5%. Pancreatic, abdominal subcutaneous adipose tissue (SAT)/visceral adipose tissue (VAT) volumes, biochemical and anthropometric parameters were measured. Mann-Whitney U test, multiple linear/binary logistic regression analyses and odds ratios were used. RESULTS:Fifty percent had fatty pancreas, 38% had metabolic syndrome and 81% had insulin resistance. Liver proton density fat fraction (PDFF) and VAT were independent predictors of insulin resistance (P = .006, .016). Pancreas and liver PDFF were both independent predictors of beta cells dysfunction (P = .015, .050) and metabolic syndrome (P = .021, .041). Presence of fatty pancreas in obesity was associated with insulin resistance (OR = 1.58, 95% CI = 0.39-6.4) and metabolic syndrome (OR = 1.70, 95% CI = 0.53-5.5). CONCLUSION:A significant causal relationship exists between fatty pancreas, fatty liver, body fat and the risk of developing metabolic syndrome and insulin resistance. KEY POINTS:Fatty pancreas is a common finding in adolescents with obesity, with a prevalence rate of 50% in this study cohort. Liver PDFF and VAT are independent predictors of insulin resistance while pancreas PDFF and liver PDFF are independent predictors of both beta cells dysfunction and metabolic syndrome. Presence of fatty pancreas at imaging should not be considered as a benign finding but rather as an imaging biomarker of emerging pancreatic metabolic and endocrine dysfunction.
journal_name
Pediatr Obesjournal_title
Pediatric obesityauthors
Chiyanika C,Chan DFY,Hui SCN,So HK,Deng M,Yeung DKW,Nelson EAS,Chu WCWdoi
10.1111/ijpo.12653subject
Has Abstractpub_date
2020-09-01 00:00:00pages
e12653issue
9eissn
2047-6302issn
2047-6310journal_volume
15pub_type
杂志文章abstract:BACKGROUND:The intrauterine environment is critical in the development of child obesity. OBJECTIVE:To investigate the association between maternal lipid levels during pregnancy and child weight status. METHODS:Maternal lipid levels (total cholesterol, high-density and low-density lipoprotein cholesterol, triglyceride...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12485
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND:The American Academy of Pediatrics calls for aggressive management of preterm infants to achieve body composition approximating that of the healthy infant in utero. Air displacement plethysmography (ADP) has been validated for assessment of body composition in preterm infants and could be used to monitor the...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/j.2047-6310.2013.00215.x
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:Insufficient information is available on the relationship between obesity and outcome of paediatric patients with acute pancreatitis. OBJECTIVES:This study aimed to investigate the effect of obesity on outcomes of paediatric patients with acute pancreatitis based on a national administrative database. METH...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12041
更新日期:2016-06-01 00:00:00
abstract::In order to examine sex-specific differences in the association of body mass index (BMI) and hypertension, we conducted a retrospective, cross-sectional study of 717 812 (402 914 men and 314 898 women) Israeli Jewish adolescents aged 16.0-19.99 years medically screened for military service. A diagnosis of hypertension...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12029
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:Child obesity is a growing public health concern. Excess weight in childhood is known to be associated with a high risk of obesity and obesity-related comorbidities in adulthood. OBJECTIVES:This study quantifies lifetime excess costs of overweight and obese adults in Germany taking the history of obesity in...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.278
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:Increases in portion size are thought by many to promote obesity in children. However, this relationship remains unclear. Here, we explore the extent to which a child's BMI is predicted both by parental beliefs about their child's ideal and maximum portion size and/or by the child's own beliefs. METHODS:Par...
journal_title:Pediatric obesity
pub_type: 杂志文章,随机对照试验
doi:10.1111/ijpo.12218
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:In adults, adherence to the Mediterranean diet has been inversely associated with cardiovascular risk, but the extent to which diet in pregnancy is associated with offspring adiposity is unclear. We aimed to investigate the association between adherence to Mediterranean diet in pregnancy and offspring cardio...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12191
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:Emerging adulthood is a critical time for excess weight gain. Risk can be masked if recommended overweight and obesity cut-points for Asians are not employed. OBJECTIVES:To determine the associations among sociodemographic factors and occurrence of overweight and obesity among normal weight 18-year olds. M...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12173
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:Pediatric obesity impacts on multiple domains of psychological health, including self-esteem and body image. OBJECTIVE:To determine the effect of multicomponent pediatric obesity treatment interventions on self-esteem and body image. METHODS:A systematic search of published literature up to June 2019 was u...
journal_title:Pediatric obesity
pub_type: 杂志文章,meta分析
doi:10.1111/ijpo.12600
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND:Early childhood temperament is increasingly recognized as an important attribute that may impact screen time use, outdoor play and childhood obesity. The relationship between temperament and nutrition in preschool children is less clear. OBJECTIVE:The objective of the study is to investigate if temperament ...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12161
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND/OBJECTIVE:We evaluated the prevalence of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) in 27 adolescents referred for weight loss surgery (WLS). RESULTS:On biopsy, 18 patients (66.7%) had NAFLD, and of those, 10 (37.0%) had NASH and 11 (40.7%) had fibrosis. Insulin, HbA1...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/j.2047-6310.2014.219.x
更新日期:2014-10-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to examine the relationship between diet and inflammation, and adiposity in minority youth. DESIGN AND METHODS:The study was designed as a cross-sectional analysis of 142 overweight (≥85th body mass index percentile) Hispanic and African-American adolescents (14-18 years) with...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12017
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:The Healthy Communities Study (HCS) was a national study of community programs and policies that aimed to address childhood obesity; it necessitated recruitment of a large sample of children from communities throughout the United States. OBJECTIVE:The HCS aimed to complete visits with an average of 45 child...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12455
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVE:To conduct a systematic review of the literature for strategies designed to reduce attrition in managing paediatric obesity. METHODS:We searched Ovid Medline (1946 to May 6, 2020), Ovid Embase (1974 to May 6, 2020), EBSCO CINAHL (inception to May 6, 2020), Elsevier Scopus (inception to April 14, 2020), and P...
journal_title:Pediatric obesity
pub_type: 杂志文章,评审
doi:10.1111/ijpo.12733
更新日期:2020-09-22 00:00:00
abstract:BACKGROUND:Non-alcoholic fatty liver disease (NAFLD), prediabetes and type 2 diabetes mellitus are known to be closely linked with obesity as early as during childhood. OBJECTIVES:The study aimed to determine the prevalence of prediabetes and T2DM in children with obesity with or without increased transaminases. METH...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12601
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:Attention-deficit/hyperactivity disorder (ADHD) symptoms have been linked with eating behaviors and obesity adolescence and young adulthood. Yet, little is known about whether these associations occur during early childhood and few studies have examined these associations prospectively. OBJECTIVES:To assess...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12631
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND:Dutch children's diets, like the diets of many children in Europe and the US are not balanced, do not contain enough vegetables and have been associated with a high prevalence of childhood obesity. Promoting children's vegetable intake is challenging. OBJECTIVE:We investigated the relative effectiveness of ...
journal_title:Pediatric obesity
pub_type: 杂志文章,多中心研究
doi:10.1111/ijpo.244
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:Few studies have assessed how well body mass index (BMI), waist circumference (WC), or waist to height ratio (WtHR) perform in identifying cardio-metabolic risk among youth. OBJECTIVE:The objective of this study was to evaluate the utility of BMI and WC percentiles and WtHR to distinguish adolescents with a...
journal_title:Pediatric obesity
pub_type: 杂志文章,随机对照试验
doi:10.1111/ijpo.267
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Overt or subclinical hypothyroidism is a common finding in adult populations affected by non-alcoholic fatty liver disease (NAFLD). Currently, there are only sparse data available on the association of thyroid dysfunction and NAFLD in obese children and adolescents. OBJECTIVE:The study aims to investigate t...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12110
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND:Children who frequently move have poorer behavioural, emotional, and overall health. For similar reasons, the experience of changing home may contextualize children's risk for obesity. Few studies have assessed the relationship between residential mobility and obesity; even fewer explore this relationship wi...
journal_title:Pediatric obesity
pub_type: 杂志文章,评审
doi:10.1111/ijpo.12576
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:Obesity is a risk factor for asthma. However, it is unclear if increased obesity prevalence contributed to rising childhood asthma prevalence. OBJECTIVE:To assess if population-level changes in weight status impacted asthma prevalence over time. METHODS:Using nationally representative 1988-2014 National He...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12246
更新日期:2018-06-01 00:00:00
abstract:OBJECTIVES:Sagittal diameter (SAD) has been reported to correlate to visceral fat and cardiovascular risk factors. SAD is measured with the individual lying down, halfway between the lower rib margin and the iliac crest; it represents the mid-height of the abdomen. The aim of this study was to validate SAD measured usi...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/j.2047-6310.2012.00095.x
更新日期:2013-04-01 00:00:00
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journal_title:Pediatric obesity
pub_type: 杂志文章,随机对照试验
doi:10.1111/ijpo.12013
更新日期:2016-02-01 00:00:00
abstract:PURPOSE:Insulin responses to oral and intravenous glucose markedly differ by ethnicity. This study examined whether ethnic differences in pancreatic insulin secretion, hepatic insulin extraction and clearance explain these disparate findings in 35 obese African-American and 41 Latina girls (Tanner Stages: IV-V; ages: 1...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/j.2047-6310.2013.00184.x
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:Health Care Professionals struggle to initiate conversations about overweight in toddlerhood. A novel 3D body size scale (3D BSS) may facilitate engagement with this topic during pediatric appointments. OBJECTIVES:To explore barriers and facilitators to using the 3D BSS through a mixed-methods design. METH...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12715
更新日期:2021-02-01 00:00:00
abstract:UNLABELLED:What is already known about this subject Circulating concentrations of branched-chain amino acids (BCAAs) can affect carbohydrate metabolism in skeletal muscle, and therefore may alter insulin sensitivity. BCAAs are elevated in adults with diet-induced obesity, and are associated with their future risk of ty...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/j.2047-6310.2012.00087.x
更新日期:2013-02-01 00:00:00
abstract:OBJECTIVE:Our aim is to determine the effect of paced eating, exposure to an educational programme that promotes healthy eating habits and allowing the satiety reflex to limit food intake in controlling weight gain in healthy adolescents. METHODS:Fifty-four healthy individuals consisting of 18 adolescent girls and 36 ...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12091
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:Primary prevention of overweight is to be preferred above secondary prevention, which has shown moderate effectiveness. OBJECTIVE:To develop and internally validate a dynamic prediction model to identify young children in the general population, applicable at every age between birth and age 6, at high risk ...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12647
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:Childhood and adolescent obesity may lead to obesity and related complications in adulthood. Biomarkers of obesity can be useful for screening for obesity complications and promoting early intervention during school age. Thus, the metabolomic differences in obese children and adolescents should be investigat...
journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12114
更新日期:2017-04-01 00:00:00
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journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/j.2047-6310.2011.00017.x
更新日期:2012-04-01 00:00:00