Prevalence and outcome of non-alcoholic fatty liver disease in adolescents and young adults undergoing weight loss surgery.

Abstract:

BACKGROUND/OBJECTIVE:We evaluated the prevalence of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) in 27 adolescents referred for weight loss surgery (WLS). RESULTS:On biopsy, 18 patients (66.7%) had NAFLD, and of those, 10 (37.0%) had NASH and 11 (40.7%) had fibrosis. Insulin, HbA1C and homeostatic model assessment of insulin resistance (HOMA-IR) were significantly higher in patients with NASH than those without NASH. Following WLS, 40% of patients with NASH had persistently elevated aminotransferase levels despite weight loss. CONCLUSION:We found that NASH is underdiagnosed in adolescents referred for WLS, and that hyperinsulinaemia, HOMA-IR and HbA1c can aid in identifying high-risk patients.

journal_name

Pediatr Obes

journal_title

Pediatric obesity

authors

Corey KE,Stanley TL,Misdraji J,Scirica C,Pratt J,Hoppin A,Misra M

doi

10.1111/j.2047-6310.2014.219.x

subject

Has Abstract

pub_date

2014-10-01 00:00:00

pages

e91-3

issue

5

eissn

2047-6302

issn

2047-6310

journal_volume

9

pub_type

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