Abstract:
UNLABELLED:What is already known about this subject Circulating concentrations of branched-chain amino acids (BCAAs) can affect carbohydrate metabolism in skeletal muscle, and therefore may alter insulin sensitivity. BCAAs are elevated in adults with diet-induced obesity, and are associated with their future risk of type 2 diabetes even after accounting for baseline clinical risk factors. What this study adds Increased concentrations of BCAAs are already present in young obese children and their metabolomic profiles are consistent with increased BCAA catabolism. Elevations in BCAAs in children are positively associated with insulin resistance measured 18 months later, independent of their initial body mass index. BACKGROUND:Branched-chain amino acid (BCAA) concentrations are elevated in response to overnutrition, and can affect both insulin sensitivity and secretion. Alterations in their metabolism may therefore play a role in the early pathogenesis of type 2 diabetes in overweight children. OBJECTIVE:To determine whether paediatric obesity is associated with elevations in fasting circulating concentrations of BCAAs (isoleucine, leucine and valine), and whether these elevations predict future insulin resistance. METHODS:Sixty-nine healthy subjects, ages 8-18 years, were enrolled as a cross-sectional cohort. A subset of subjects who were pre- or early-pubertal, ages 8-13 years, were enrolled in a prospective longitudinal cohort for 18 months (n = 17 with complete data). RESULTS:Elevations in the concentrations of BCAAs were significantly associated with body mass index (BMI) Z-score (Spearman's Rho 0.27, P = 0.03) in the cross-sectional cohort. In the subset of subjects that followed longitudinally, baseline BCAA concentrations were positively associated with homeostasis model assessment for insulin resistance measured 18 months later after controlling for baseline clinical factors including BMI Z-score, sex and pubertal stage (P = 0.046). CONCLUSIONS:Elevations in the concentrations of circulating BCAAs are significantly associated with obesity in children and adolescents, and may independently predict future insulin resistance.
journal_name
Pediatr Obesjournal_title
Pediatric obesityauthors
McCormack SE,Shaham O,McCarthy MA,Deik AA,Wang TJ,Gerszten RE,Clish CB,Mootha VK,Grinspoon SK,Fleischman Adoi
10.1111/j.2047-6310.2012.00087.xsubject
Has Abstractpub_date
2013-02-01 00:00:00pages
52-61issue
1eissn
2047-6302issn
2047-6310journal_volume
8pub_type
杂志文章abstract:BACKGROUND:Insufficient information is available on the relationship between obesity and outcome of paediatric patients with acute pancreatitis. OBJECTIVES:This study aimed to investigate the effect of obesity on outcomes of paediatric patients with acute pancreatitis based on a national administrative database. METH...
journal_title:Pediatric obesity
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journal_title:Pediatric obesity
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journal_title:Pediatric obesity
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更新日期:2017-12-01 00:00:00
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journal_title:Pediatric obesity
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journal_title:Pediatric obesity
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journal_title:Pediatric obesity
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更新日期:2016-12-01 00:00:00
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journal_title:Pediatric obesity
pub_type: 杂志文章
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更新日期:2020-09-01 00:00:00
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journal_title:Pediatric obesity
pub_type: 杂志文章
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journal_title:Pediatric obesity
pub_type: 杂志文章
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journal_title:Pediatric obesity
pub_type: 杂志文章,评审
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更新日期:2020-02-01 00:00:00
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journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.262
更新日期:2015-08-01 00:00:00
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journal_title:Pediatric obesity
pub_type: 杂志文章,随机对照试验
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更新日期:2018-04-01 00:00:00
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journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12701
更新日期:2021-01-01 00:00:00
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journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/j.2047-6310.2013.00191.x
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journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/j.2047-6310.2012.00095.x
更新日期:2013-04-01 00:00:00
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journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12497
更新日期:2019-05-01 00:00:00
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journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12105
更新日期:2017-02-01 00:00:00
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journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/j.2047-6310.2013.00189.x
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journal_title:Pediatric obesity
pub_type: 杂志文章
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journal_title:Pediatric obesity
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journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12031
更新日期:2016-04-01 00:00:00
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journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/j.2047-6310.2014.221.x
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journal_title:Pediatric obesity
pub_type: 杂志文章,评审
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更新日期:2015-12-01 00:00:00
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journal_title:Pediatric obesity
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journal_title:Pediatric obesity
pub_type: 杂志文章
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journal_title:Pediatric obesity
pub_type: 杂志文章
doi:10.1111/ijpo.12133
更新日期:2017-06-01 00:00:00
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journal_title:Pediatric obesity
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journal_title:Pediatric obesity
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