Abstract:
BACKGROUND:Infants born small-for-gestational-age (SGA) who develop post-natal weight catch-up are at risk for insulin resistance, central adiposity and cardiovascular disease in later life, even in the absence of overweight. OBJECTIVE:In young (age 3-6 years) non-obese SGA children, we assessed arterial health (as judged by intima-media thickness [IMT]) and abdominal fat distribution (subcutaneous, visceral, preperitoneal and hepatic components by magnetic resonance imaging [MRI] and/or ultrasound [US]) besides a selection of endocrine markers. METHODS:Comparisons of measures in SGA (n = 27) vs. appropriate-for-GA (AGA) children (n = 19) of similar height, weight and body mass index. Longitudinal outcomes (age 3-6 years) were carotid IMT (cIMT); fasting glucose, circulating insulin, IGF-I and high-molecular-weight (HMW) adiponectin; abdominal fat partitioning by US. Cross-sectional outcomes (age 6 years) were aortic IMT (aIMT) and abdominal fat partitioning by MRI. RESULTS:At 3 and 6 years, cIMT and IGF-I results were higher and HMW adiponectin lower in SGA than AGA children; at 6 years, SGA subjects had also a thicker aIMT and more pre-peritoneal and hepatic fat, and were less insulin sensitive (all P values between <0.05 and <0.0001). cIMT correlated positively with pre-peritoneal fat, particularly at 6 years. Post-SGA status and weight gain in early childhood (between 3 and 6 years) were independent predictors of cIMT at 6 years, explaining 48 % of its variance. CONCLUSION:SGA children aged 3-6 years were found to have a thicker intima- media and more pre-peritoneal and hepatic fat than AGA children of comparable size.
journal_name
Pediatr Obesjournal_title
Pediatric obesityauthors
Sebastiani G,Díaz M,Bassols J,Aragonés G,López-Bermejo A,de Zegher F,Ibáñez Ldoi
10.1111/ijpo.12053subject
Has Abstractpub_date
2016-08-01 00:00:00pages
251-7issue
4eissn
2047-6302issn
2047-6310journal_volume
11pub_type
杂志文章abstract:OBJECTIVE:The objective of this study was to investigate changes in volatile organic compounds (VOCs) in exhaled breath in overweight/obese children compared with their lean counterparts. STUDY DESIGN:Single exhaled breath was collected and analyzed per protocol using selective ion flow tube mass spectrometry (SIFT-MS...
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doi:10.1111/j.2047-6310.2012.00095.x
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章,meta分析
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pub_type: 杂志文章
doi:10.1111/ijpo.12150
更新日期:2017-10-01 00:00:00
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更新日期:2016-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2016-12-01 00:00:00
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pub_type: 杂志文章
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