Abstract：
:Recommendations for zinc intake during childhood vary widely across Europe. The EURRECA project attempts to consolidate the basis for the definition of micronutrient requirements, taking into account relationships among intake, status and health outcomes, in order to harmonise these recommendations. Data on zinc intake and biomarkers of zinc status reported in randomised controlled trials (RCTs) can provide estimates of dose-response relationships which may be used for underpinning zinc reference values. This systematic review included all RCTs of apparently healthy children aged 1-17 years published by February 2010 which provided data on zinc intake and biomarkers of zinc status. An intake-status regression coefficient (β) was calculated for each individual study and calculated the overall pooled and SE (β) using random effects meta-analysis on a double log scale. The pooled dose-response relationship between zinc intake and zinc status indicated that a doubling of the zinc intake increased the serum/plasma zinc status by 9%. This evidence can be utilised, together with currently used balance studies and repletion/depletion studies, when setting zinc recommendations as a basis for nutrition policies.
journal_name
Nutrientsjournal_title
Nutrientsauthors
Moran VH,Stammers AL,Medina MW,Patel S,Dykes F,Souverein OW,Dullemeijer C,Pérez-Rodrigo C,Serra-Majem L,Nissensohn M,Lowe NMdoi
10.3390/nu4080841subject
Has Abstractpub_date
2012-08-01 00:00:00pages
841-58issue
8issn
2072-6643pii
nu4080841journal_volume
4pub_type
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