The role of vitamin D in hematologic disease and stem cell transplantation.

Abstract:

:Vitamin D is a steroid hormone with a broad range of biological effects ranging from the classical role as a mediator of calcium and phosphate balance to cellular differentiation and immune modulation. These effects impact normal and dysfunctional hematopoietic and immune function, which may allow an avenue for improved treatment and support of patients suffering from hematologic disorders. In this review, we will summarize the role of vitamin D in normal hematopoiesis, discuss ways in which vitamin D may improve outcomes, and discuss a potential role of vitamin D for treating hematologic disorders and modulating the immune system to improve the outcome of allogeneic stem cell transplant.

journal_name

Nutrients

journal_title

Nutrients

authors

Hall AC,Juckett MB

doi

10.3390/nu5062206

subject

Has Abstract

pub_date

2013-06-18 00:00:00

pages

2206-21

issue

6

issn

2072-6643

pii

nu5062206

journal_volume

5

pub_type

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