Abstract:
:Trace elements, like Cu, Zn, Fe, or Se, are important for the proper functioning of antioxidant enzymes. However, in excessive amounts, they can also act as pro-oxidants. Accordingly, trace elements influence redox-modulated signaling pathways, such as the Nrf2 pathway. Vice versa, Nrf2 target genes belong to the group of transport and metal binding proteins. In order to investigate whether Nrf2 directly regulates the systemic trace element status, we used mice to study the effect of a constitutive, whole-body Nrf2 knockout on the systemic status of Cu, Zn, Fe, and Se. As the loss of selenoproteins under Se-deprived conditions has been described to further enhance Nrf2 activity, we additionally analyzed the combination of Nrf2 knockout with feeding diets that provide either suboptimal, adequate, or supplemented amounts of Se. Experiments revealed that the Nrf2 knockout partially affected the trace element concentrations of Cu, Zn, Fe, or Se in the intestine, liver, and/or plasma. However, aside from Fe, the other three trace elements were only marginally modulated in an Nrf2-dependent manner. Selenium deficiency mainly resulted in increased plasma Zn levels. One putative mediator could be the metal regulatory transcription factor 1, which was up-regulated with an increasing Se supply and downregulated in Se-supplemented Nrf2 knockout mice.
journal_name
Nutrientsjournal_title
Nutrientsauthors
Schwarz M,Lossow K,Kopp JF,Schwerdtle T,Kipp APdoi
10.3390/nu11092112subject
Has Abstractpub_date
2019-09-05 00:00:00issue
9issn
2072-6643pii
nu11092112journal_volume
11pub_type
杂志文章相关文献
Nutrients文献大全abstract::Gluten cross-contamination in gluten-free food may jeopardize treatment of celiac patients. Considering the deficit of appropriate instruments to enable the implementation of safe production practices for gluten-free food, this study aimed to evaluate the application of a check-list elaborated for gluten cross-contami...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu10091274
更新日期:2018-09-10 00:00:00
abstract::Emerging laboratory and animal studies indicate that green tea inhibits development and progression of pancreatic cancer, but evidence from epidemiologic studies appears inconsistent and inconclusive. A meta-analysis summarizing published case-control and cohort studies was performed to evaluate the association of gre...
journal_title:Nutrients
pub_type: 杂志文章,meta分析
doi:10.3390/nu6114640
更新日期:2014-10-28 00:00:00
abstract::The aim of this study was to analyze the anthropometric characteristics and sport supplement (SS) consumption patterns of heavyweight and lightweight international rowers. Methods: The 13 heavyweights (11 males) and seven lightweights (five males) of the Spanish National Rowing Team were recruited for the study. Body ...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12123871
更新日期:2020-12-18 00:00:00
abstract::Athletes competing in ultra-endurance sports should manage nutritional issues, especially with regards to energy and fluid balance. An ultra-endurance race, considered a duration of at least 6 h, might induce the energy balance (i.e., energy deficit) in levels that could reach up to ~7000 kcal per day. Such a negative...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu10121995
更新日期:2018-12-16 00:00:00
abstract::Even though irritable bowel syndrome (IBS) has been known for more than 150 years, it still remains one of the research challenges of the 21st century. According to the current diagnostic Rome IV criteria, IBS is characterized by abdominal pain associated with defecation and/or a change in bowel habit, in the absence ...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu11092162
更新日期:2019-09-09 00:00:00
abstract::Probiotics have been rapidly developed for health promotion, but clinical validation of the effects on exercise physiology has been limited. In a previous study, Lactobacillus plantarum TWK10 (TWK10), isolated from Taiwanese pickled cabbage as a probiotic, was demonstrated to improve exercise performance in an animal ...
journal_title:Nutrients
pub_type: 杂志文章,随机对照试验
doi:10.3390/nu11112836
更新日期:2019-11-19 00:00:00
abstract::There is currently little information on changes in vitamin D status during pregnancy and its predictors. The aim was to study the determinants of change in vitamin D status during pregnancy and of vitamin D deficiency (<30 nmol/L) in early pregnancy. Blood was drawn in the first (T1) and third trimester (T3). Serum 2...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu8100655
更新日期:2016-10-22 00:00:00
abstract::Restricting animal-based products from diet may exert beneficial effects on weight status; however, less is known about such a diet and emotional health. Moreover, personality traits, for example high neuroticism, may contribute to restrictive eating habits and potentially confound diet-health associations. We aim to ...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12051492
更新日期:2020-05-20 00:00:00
abstract::The aim of this study was to investigate the effects of administration of a mixture of Humulus japonicus (MH) on longitudinal bone growth in normal Sprague Dawley (SD) rats. We measured the femur and tibia length, growth plate area, proliferation of chondrocytes, and expression of insulin-like growth factor-1 (IGF-I) ...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12092625
更新日期:2020-08-28 00:00:00
abstract::Poor dietary habits contribute to increased incidences of obesity and related co-morbidities, such as type 2 diabetes (T2D). The biological, genetic, and pathological implications of T2D, are commonly investigated using animal models induced by a dietary intervention. In spite of significant research contributions, an...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu12123650
更新日期:2020-11-27 00:00:00
abstract::The snacking prevalence, frequency of daily snack consumption, and the contribution of snacks to daily energy intake have substantially increased globally. The aim of this study was to examine the patterns of snack consumption among a representative sample of Canadians aged 2 and older. Nationally representative dieta...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11051152
更新日期:2019-05-23 00:00:00
abstract::Shifting of energy intake towards a later time in the day is associated with an increased risk of obesity in adults. However, there is a lack of data for adolescents. The aim of this study was to investigate adolescents eveningness in energy intake (EV) and its association with anthropometric indicators of nutritional...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12061710
更新日期:2020-06-07 00:00:00
abstract::Sociodemographic differences in dietary consumption were observed in different populations. The current study aimed to identify sociodemographic and lifestyle determinants of diet quality and to investigate the differences in diet quality between the three main language regions of Switzerland. Using data of the Swiss ...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11010126
更新日期:2019-01-09 00:00:00
abstract::The population of older adults is growing globally. This increase has led to an accumulation of chronic illnesses, so-called age-related diseases. Diet and nutrition are considered the main drivers of the global burden of diseases, and this situation applies especially to this population segment. It relates directly t...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11061275
更新日期:2019-06-05 00:00:00
abstract::Prader-Willi syndrome (PWS) is the most common genetic inherited obesity syndrome. Obesity-related complications, mostly related to chronic low-grade systemic inflammation (LGI), are the commonest cause of mortality and morbidity in PWS adults. Phase angle (PhA) is an easy tool to screen a state of LGI in healthy subj...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12072065
更新日期:2020-07-11 00:00:00
abstract:BACKGROUND:The C57BL/6 mouse fed a high fat diet is a common and valuable model in experimental studies of obesity and type 2 diabetes (T2D). Different high fat diets are used and in order to determine which diet produces a model most accurately resembling human T2D, they need to be compared head-to-head. METHODS:Four...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu4101367
更新日期:2012-09-28 00:00:00
abstract::Thiamine is a crucial cofactor involved in the maintenance of carbohydrate metabolism and participates in multiple cellular metabolic processes. Although thiamine can be obtained from various food sources, some common food groups are deficient in thiamine, and it can be denatured by high temperature and pH. Additional...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12092810
更新日期:2020-09-13 00:00:00
abstract::The prevalence of renal and cardiovascular disease (CVD) in patients with systemic lupus erythematosus (SLE) is higher than in general populations. Recently, a causal role of gut microbiota on the development of immune responses in SLE has been described. Probiotic consumption changes the composition of gut microbiota...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu11112676
更新日期:2019-11-05 00:00:00
abstract::Celiac disease (CD) is an autoimmune disorder triggered by the ingestion of gluten and affects approximately 1% of the global population. Currently, the only treatment available is lifelong strict adherence to a gluten-free diet (GFD). Chronic diseases such as CD affect patients and their family members' quality of li...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11102302
更新日期:2019-09-27 00:00:00
abstract::Gluten seems a potentially important determinant in type 1 diabetes (T1D) and type 2 diabetes (T2D). Intake of gluten, a major component of wheat, rye, and barley, affects the microbiota and increases the intestinal permeability. Moreover, studies have demonstrated that gluten peptides, after crossing the intestinal b...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu10111746
更新日期:2018-11-13 00:00:00
abstract::Home Artificial Nutrition (HAN) is a safe and efficacious technique that insures children's reintegration into the family, society and school. Epidemiological data on paediatric HAN in Italy are not available. AIM:to detect the prevalence and incidence of Home Parenteral Nutrition (HPN) and Home Enteral Nutrition (HE...
journal_title:Nutrients
pub_type: 杂志文章,多中心研究
doi:10.3390/nu10091311
更新日期:2018-09-16 00:00:00
abstract::Glycyrrhizic acid (GA) ameliorates many components of the metabolic syndrome, but its potential therapeutic use is marred by edema caused by inhibition of renal 11β-hydroxysteroid dehydrogenase 2 (11β-HSD2). We assessed whether 100 mg/kg per day GA administered orally could promote metabolic benefits without causing e...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu6114856
更新日期:2014-11-04 00:00:00
abstract:BACKGROUND:Malnutrition is associated with poor outcomes in patients with cancer, heart failure and chronic kidney disease. This study aimed to investigate the predictive value of the Controlling Nutritional Status (CONUT) score in coronary artery disease (CAD) patients. METHODS:We recruited a cohort of 3118 patients ...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12051295
更新日期:2020-05-02 00:00:00
abstract:BACKGROUND/OBJECTIVES:To compare the efficacy of a diet rich in natural folate and of two different folic acid supplementation protocols in subjects with "moderate" hyperhomocysteinemia, also taking into account C677T polymorphism of 5,10-methylenetetrahydrofolate reductase (MTHFR) gene. SUBJECTS/METHODS:We performed ...
journal_title:Nutrients
pub_type: 杂志文章,随机对照试验
doi:10.3390/nu5051531
更新日期:2013-05-08 00:00:00
abstract::Routine administration of trace elements is recognised as a standard of care in children requiring parenteral nutrition. However, there is a lack of global consensus regarding trace elements provision and dosing in pediatric parenteral nutrition. This review provides an overview of available evidence regarding trace e...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu10111819
更新日期:2018-11-21 00:00:00
abstract::Despite their low cost and high nutrient density, the contribution of eggs to nutrient intake and dietary quality among Mexican-American postpartum women has not been evaluated. Nutrient intake and dietary quality, as assessed by the Healthy Eating Index 2010 (HEI-2010), were measured in habitually sedentary overweigh...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu7105402
更新日期:2015-10-02 00:00:00
abstract::The fatty acid compositions of plasma lipids and cell membranes of certain tissues are modified by dietary fatty acid composition. Furthermore, many other factors (age, sex, ethnicity, health status, genes, and gene × diet interactions) affect the fatty acid composition of cell membranes or plasma lipid compartments. ...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu10111785
更新日期:2018-11-16 00:00:00
abstract::We determined the nutritional adequacy and overall quality of the diets of adult patients with eosinophilic esophagitis (EoE). Dietary intakes stratified by sex and age were compared to Dietary Reference Values (DRV). Overall diet quality was assessed by two independent Diet-Quality-Indices scores, the PANDiet and DHD...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu13010214
更新日期:2021-01-13 00:00:00
abstract::Both type 2 prediabetes/diabetes (T2DM) and new-onset prediabetes/diabetes after acute pancreatitis (NODAP) are characterized by impaired tissue sensitivity to insulin action. Although the outcomes of NODAP and T2DM are different, it is unknown whether drivers of insulin resistance are different in the two types of di...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12092883
更新日期:2020-09-21 00:00:00
abstract::Interpretive, front-of-pack (FOP) nutrition labels may encourage reformulation of packaged foods. We aimed to evaluate the effects of the Health Star Rating (HSR), a new voluntary interpretive FOP labelling system, on food reformulation in New Zealand. Annual surveys of packaged food and beverage labelling and composi...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu9080918
更新日期:2017-08-22 00:00:00