Abstract:
:Gluten seems a potentially important determinant in type 1 diabetes (T1D) and type 2 diabetes (T2D). Intake of gluten, a major component of wheat, rye, and barley, affects the microbiota and increases the intestinal permeability. Moreover, studies have demonstrated that gluten peptides, after crossing the intestinal barrier, lead to a more inflammatory milieu. Gluten peptides enter the pancreas where they affect the morphology and might induce beta-cell stress by enhancing glucose- and palmitate-stimulated insulin secretion. Interestingly, animal studies and a human study have demonstrated that a gluten-free (GF) diet during pregnancy reduces the risk of T1D. Evidence regarding the role of a GF diet in T2D is less clear. Some studies have linked intake of a GF diet to reduced obesity and T2D and suggested a role in reducing leptin- and insulin-resistance and increasing beta-cell volume. The current knowledge indicates that gluten, among many environmental factors, may be an aetiopathogenic factors for development of T1D and T2D. However, human intervention trials are needed to confirm this and the proposed mechanisms.
journal_name
Nutrientsjournal_title
Nutrientsauthors
Haupt-Jorgensen M,Holm LJ,Josefsen K,Buschard Kdoi
10.3390/nu10111746subject
Has Abstractpub_date
2018-11-13 00:00:00issue
11issn
2072-6643pii
nu10111746journal_volume
10pub_type
杂志文章,评审相关文献
Nutrients文献大全abstract::Glycerol monolaurate (GML) has potent antimicrobial and anti-inflammatory activities. The present study aimed to assess the dose-dependent antimicrobial-effects of GML on the gut microbiota, glucose and lipid metabolism and inflammatory response in C57BL/6 mice. Mice were fed on diets supplemented with GML at dose of ...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11091981
更新日期:2019-08-22 00:00:00
abstract::Reduction in cholesterol blood levels represents one of the therapeutic goals to achieve in order to reduce the occurrence of cardiovascular diseases. Commonly, this goal is attempted by promoting healthy lifestyle behaviors and low-fat diets. Recently, several nutraceuticals have been shown to possess cholesterol-low...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11010163
更新日期:2019-01-14 00:00:00
abstract::The objective of the present study is to investigate the relationships between body composition, nutritional profile, muscular fitness (MF) and bone health in a sample of children and adolescents from Colombia. Participants included 1118 children and adolescents (54.6% girls). Calcaneal broadband ultrasound attenuatio...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu9020106
更新日期:2017-02-03 00:00:00
abstract::Infants rely on their innate immune systems to protect them from infection. Human milk (HM) contains fatty acids (FAs) and monoacylglycerols that are known to exhibit antiviral and antibacterial properties in vitro. The specific fat content of HM may potentially affect the efficacy of this antimicrobial activity. This...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu9091034
更新日期:2017-09-19 00:00:00
abstract::Impulsivity, particularly towards food, is a potential risk factor for increased energy intake and the development and maintenance of obesity in children. However, neuropsychological and neurophysiological indicators of general and food-specific impulsivity and their association with children's weight status are poorl...
journal_title:Nutrients
pub_type: 临床试验,杂志文章
doi:10.3390/nu10121983
更新日期:2018-12-15 00:00:00
abstract::Obesity is a significant health problem world-wide, particularly in developed nations. Vitamin D deficiency is pandemic, and has been implicated in a wide variety of disease states. This paper seeks to examine the consistently reported relationship between obesity and low vitamin D concentrations, with reference to th...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu5030949
更新日期:2013-03-20 00:00:00
abstract::The synergies and cumulative effects among different foods and nutrients are what produce the benefits of a healthy dietary pattern. Diets and dietary patterns are a major environmental factor that we are exposed to several times a day. People can learn how to control this behavior in order to promote healthy living a...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu8040218
更新日期:2016-04-13 00:00:00
abstract::Age-related macular degeneration and retinitis pigmentosa are leading causes of blindness and share a pathological feature, which is photoreceptor degeneration. To date, the lack of a potential treatment to prevent such diseases has raised great concern. Photoreceptor degeneration can be accelerated by excessive light...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu10121991
更新日期:2018-12-15 00:00:00
abstract::G protein-coupled receptor 43/free fatty acid receptor 2 (GPR43/FFAR2) is essential for polymorphonuclear (PMN) recruitment. We investigated the expression of GPR43/FFAR2 in the colon from Crohn's disease patients and whether dietary fiber in enteral nutrition increases GPR43+ polymorphonuclear infiltration in mucosa....
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu7075223
更新日期:2015-07-01 00:00:00
abstract::Obesity in the postmenopausal period is associated with an increased risk of cardiovascular diseases in women. One of the key drivers of cardiovascular risk is endothelial dysfunction; thus, this is also a crucial point for studies on new therapeutic methods of cardioprotective properties. The aim of the current study...
journal_title:Nutrients
pub_type: 杂志文章,随机对照试验
doi:10.3390/nu10111672
更新日期:2018-11-05 00:00:00
abstract::Drug resistance is a major problem in the treatment of non-small-cell lung cancer (NSCLC). In this study, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis was performed to identify the differentially expressed genes in Adriamycin (ADR)-resistant NSCLC A549/ADR cells compared with parental A549 cells. Am...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu10121829
更新日期:2018-11-26 00:00:00
abstract::Celiac disease (CD) is an autoimmune disorder triggered by the ingestion of gluten and affects approximately 1% of the global population. Currently, the only treatment available is lifelong strict adherence to a gluten-free diet (GFD). Chronic diseases such as CD affect patients and their family members' quality of li...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11102302
更新日期:2019-09-27 00:00:00
abstract::In their study, Adams et al. [1] attempted to determine whether thirst perception could serve as a reliable marker of hydration status during 3 h of exercise where participants either dehydrated by 3% of their body mass or maintained euhydration through water intake, and following exercise where they either could not ...
journal_title:Nutrients
pub_type: 评论,杂志文章
doi:10.3390/nu12010215
更新日期:2020-01-14 00:00:00
abstract::Sweeteners are found in all types of foods, and their high consumption is associated with chronic degenerative diseases, such as diabetes and obesity, among others. A characterization was carried out of food products with sweeteners from the three biggest supermarkets at a national level; they were identified by the l...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu10030338
更新日期:2018-03-11 00:00:00
abstract::The mechanism by which high fat-diet induced obesity affects cardiac protein expression is unclear, and the extent to which this is modulated by prebiotic treatment is not known. These outcomes were assessed in rats initially fed a high-fat diet, then the top 40% weight gain group were randomly allocated to control (C...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12113404
更新日期:2020-11-05 00:00:00
abstract::Apolipoprotein E (ApoE) is a protein playing a pivotal role in lipid homeostasis since it regulates cholesterol, triglyceride and phospholipid metabolism in the blood and the brain. APOE gene regulates the expression of this protein and has three different alleles: ε2, ε3 and ε4. Carrying an APOE4 allele is recognised...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu6104452
更新日期:2014-10-20 00:00:00
abstract::Prenatal iron and folic acid (IFA) supplements are offered free to all pregnant women in Malawi to reduce maternal anemia and improve birth outcomes. We investigated the association between self-reported compliance to IFA intake and risk of low birth weight (LBW). Pregnant women who attended Bwaila Maternity Wing of L...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu10091275
更新日期:2018-09-10 00:00:00
abstract::Carotenoids are diet-dependent milk components that are important for the visual and cognitive development of an infant. This study determined β-carotene, lycopene and lutein + zeaxanthin in breastmilk and its associations with dietary intake from healthy Polish mothers in the first six months of lactation. Concentrat...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11010193
更新日期:2019-01-18 00:00:00
abstract::We examined the impact of APOE genotype on plasma lipids and glucose in a secondary analysis of data from a five-arm, randomised controlled, parallel dietary intervention trial ('RISCK' study), to investigate the impact of replacing saturated fatty acids (SFA) with either monounsaturated fat (MUFA) or carbohydrate of ...
journal_title:Nutrients
pub_type: 杂志文章,随机对照试验
doi:10.3390/nu10101524
更新日期:2018-10-17 00:00:00
abstract::Qualified health claims (QHC) describe diet-disease relationships and summarize the quality and strength of evidence for a claim. Companies assert that QHCs increase sales and take legal action to ensure claims reflect their interests. Yet, there is no empirical evidence that QHCs influence consumers. Using green tea ...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11040921
更新日期:2019-04-24 00:00:00
abstract::The mothers' nutritional literacy is an important determinant of child malnourishment. We assessed the effect of a smartphone-based maternal nutritional education programme for the complementary feeding of undernourished children under 3 years of age in a food-secure middle-income community. The study used a randomise...
journal_title:Nutrients
pub_type: 杂志文章,随机对照试验
doi:10.3390/nu12020587
更新日期:2020-02-24 00:00:00
abstract::Chronic hyperglycemia increases oxidative stress, activates inflammatory pathways and reduces nerve growth factor (NGF) among diabetic patients, which contribute to development of diabetic peripheral neuropathy (DPN). Tocotrienol-Rich Vitamin E (Tocovid) possesses potent antioxidant and anti-inflammatory properties wh...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12051522
更新日期:2020-05-23 00:00:00
abstract::Researchers have a range of animal models in which to study Nonalcoholic fatty liver disease (NAFLD). Induction of NAFLD by a high-fat diet in the C57BL/6 strain is the most widely used among mice. In this study, we review works that performed NAFLD induction by a high-fat diet using the C57BL/6 strain, focusing on ex...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu11123067
更新日期:2019-12-16 00:00:00
abstract::Mothers' own milk is the best source of nutrition for nearly all infants. Beyond somatic growth, breast milk as a biologic fluid has a variety of other benefits, including modulation of postnatal intestinal function, immune ontogeny, and brain development. Although breastfeeding is highly recommended, breastfeeding ma...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu8050279
更新日期:2016-05-11 00:00:00
abstract::The sex differences in malnutrition and hypertension during adolescence is largely inconclusive. There is also a paucity of data on the sex-specific correlates of malnutrition and hypertension for adolescents. Hence, this study aimed to assess the association between malnutrition, pre-hypertension/hypertension (PHH) a...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12092737
更新日期:2020-09-08 00:00:00
abstract::This cross-sectional study is aimed at assessing sodium (Na) and potassium (K) content and the molar Na:K ratios of the most commonly available ready-to-eat street foods in Tajikistan and Kyrgyzstan. Four different samples of each of these foods were collected and 62 food categories were evaluated through bromatologic...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu10010098
更新日期:2018-01-16 00:00:00
abstract::Atherosclerosis is related to fat accumulation in the arterial walls and vascular stiffening, and results in acute coronary syndrome which is commonly associated with acute myocardial infarction. Oxidative stress participates in the pathogenesis of atherosclerosis. Thus, the inclusion of food sources of dietary antiox...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu12030682
更新日期:2020-03-03 00:00:00
abstract::High sodium intake is estimated to cause approximately 3 million deaths per year worldwide. The estimated average sodium intake of 3.95 g/day far exceeds the recommended intake. Population sodium reduction should be a global priority, while simultaneously ensuring universal salt iodization. This article identifies hig...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu12092543
更新日期:2020-08-22 00:00:00
abstract::Background: Two different species of sage, Salvia officinalis and Salvia lavandulaefolia, have demonstrated activities in cognitive function during preclinical and clinical studies related to impaired health situations or single administration. Different memory processes have been described to be significantly and pos...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12061777
更新日期:2020-06-15 00:00:00
abstract::The prevalence of renal and cardiovascular disease (CVD) in patients with systemic lupus erythematosus (SLE) is higher than in general populations. Recently, a causal role of gut microbiota on the development of immune responses in SLE has been described. Probiotic consumption changes the composition of gut microbiota...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu11112676
更新日期:2019-11-05 00:00:00