Abstract：
:Prader-Willi syndrome (PWS) is the most common genetic inherited obesity syndrome. Obesity-related complications, mostly related to chronic low-grade systemic inflammation (LGI), are the commonest cause of mortality and morbidity in PWS adults. Phase angle (PhA) is an easy tool to screen a state of LGI in healthy subjects and in subjects with obesity and is obtained from bioelectrical impedance analysis (BIA). The aim of this study was to validate the PhA in PWS adults as a potential biomarker of LGI. In this single-center, cross-sectional study, fifteen PWS adults (six males, aged 19-41 years, and body mass index (BMI) 31.0-68.0 Kg/m2) and fifteen control subjects matched by gender, age, and BMI were evaluated. PhA values were significantly lower (p < 0.001), while high-sensitivity C-reactive protein (hs-CRP) levels were significantly higher (p < 0.001) in PWS adults compared with controls (p < 0.001), without a gender difference in the latter. After adjustment for gender, BMI, and waist circumference, significant correlation was found between PhA and hs-CRP levels (r = -0.69, p = 0.01). At the ROC analysis, the threshold value of PhA predicting the highest hs-CRP levels above the median value was found at PhA ≤ 4.8° (p = 0.01; AUC, 0.82; standard error, 0.12; 95% CI, 0.58 to 1.00). These results suggest that PWS adults had a significant higher degree of LGI compared with their counterparts. Moreover, our finding suggest that PhA is a valid biomarker of LGI also in PWS adults.
journal_name
Nutrientsjournal_title
Nutrientsauthors
Barrea L,Pugliese G,de Alteriis G,Colao A,Savastano S,Muscogiuri Gdoi
10.3390/nu12072065subject
Has Abstractpub_date
2020-07-11 00:00:00issue
7issn
2072-6643pii
nu12072065journal_volume
12pub_type
杂志文章相关文献
Nutrients文献大全abstract：:We can now sequence and identify genome wide epigenetic patterns and perform a variety of "genomic experiments" within relatively short periods of time-ranging from days to weeks. Yet, despite these technological advances, we have a poor understanding of the inter-relationships between epigenetics, genome structure-fu...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu6125724
更新日期：2014-12-10 00:00:00
abstract：:The fatty acid (FA) composition of red blood cell (RBC) membrane phospholipids of cancer patients can reflect tumor status, dietary intakes, and cancer type or therapy. However, the characteristic membrane profiles have so far not yet defined as a potential biomarker to monitor disease evolution. The present work prov...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu10121853
更新日期：2018-12-01 00:00:00
abstract：:The aim was to evaluate whether the ingestion of a high protein diet containing dairy protein is associated with anthropometric indicators of adiposity and blood glucose. METHODS:A cross-sectional study was conducted with volunteers of 20-89 years of age who performed leisure physical activity. We assessed dietary in...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11061384
更新日期：2019-06-20 00:00:00
abstract：:Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are increased in plasma lipids and blood cell membranes in response to supplementation. Whilst arachidonic acid (AA) is correspondingly decreased, the effect on other fatty acids (FA) is less well described and there may be site-specific differences. In respon...
journal_title：Nutrients
pub_type： 杂志文章,随机对照试验
doi：10.3390/nu7085285
更新日期：2015-08-03 00:00:00
abstract：BACKGROUND:Choice of food is an imperative aspect of quality of life for residents in Residential Aged Care Homes (RACHs), where overall choice and control is diminished upon entering a home to receive care. The purpose of this study was to examine the current strategies of menu planning in a range of RACHs in Australi...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu7095354
更新日期：2015-09-09 00:00:00
abstract：:Keratoconjunctivitis sicca (KCS) or dry eye is a disease characterized by ocular surface symptoms. This study aimed to investigate the effectiveness of oral choline alfoscerate (CA) administration as a treatment for KCS. The medical records of dry eye patients who were refractory to topical eyedrops and then took oral...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12051526
更新日期：2020-05-23 00:00:00
abstract：:Malnutrition is very prevalent in geriatric patients with hip fracture. Nevertheless, its importance is not fully recognized. The objective of this paper is to review the impact of malnutrition and of nutritional treatment upon outcomes and mortality in older people with hip fracture. We searched the PubMed database f...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu10050555
更新日期：2018-04-30 00:00:00
abstract：:A target-based approach has been used to develop novel drugs in many therapeutic fields. In the final stage of intracellular signaling, transcription factor-DNA interactions are central to most biological processes and therefore represent a large and important class of targets for human therapeutics. Thus, we focused ...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu7115445
更新日期：2015-10-30 00:00:00
abstract：:This study assesses the impact of an integrated infant and young child feeding (IYCF) and micronutrient powder (MNP) intervention on children's risk of anemia and IYCF practices in Madagascar. Quantitative baseline and endline surveys were conducted in representative households with children 6-23 months from two distr...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu9060581
更新日期：2017-06-07 00:00:00
abstract：:Gastrodin (GAS), the main phenolic glycoside extracted from Gastrodia elata Blume, exhibited potential neuroprotective properties. Here we examined the protective effects of GAS against lead(Pb)-induced nerve injury in mice, and explores its underlying mechanisms. Our research findings revealed that GAS improved behav...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12061805
更新日期：2020-06-17 00:00:00
abstract：:Reducing salt intake is a cost-effective public health intervention to reduce the global burden of non-communicable disease (NCDs). Ultra-processed foods contribute ~80% of dietary salt in high income countries, and are becoming prominent in low-middle income countries. Instant noodle consumption is particularly high ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu9060612
更新日期：2017-06-16 00:00:00
abstract：:Impulsivity, particularly towards food, is a potential risk factor for increased energy intake and the development and maintenance of obesity in children. However, neuropsychological and neurophysiological indicators of general and food-specific impulsivity and their association with children's weight status are poorl...
journal_title：Nutrients
pub_type： 临床试验,杂志文章
doi：10.3390/nu10121983
更新日期：2018-12-15 00:00:00
abstract：:Elevated blood pressure affects a great part of the elderly population and is the leading risk factor for cardiovascular disease. New approaches have been taken in the fight against this growing problem, in the form of diets (Mediterranean, Dietary Approaches to Stop Hypertension (DASH) and intermittent fasting). Rece...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12061659
更新日期：2020-06-03 00:00:00
abstract：:Many inflammatory bowel disease (IBD) patients require surgical intervention due to limited pharmacological treatment options. Antibodies targeting α4ß7, a gut-homing integrin, are one of the most promising IBD treatments. As retinoic acid (RA) regulates expression of gut-homing proteins including α4ß7 integrin, we te...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12102927
更新日期：2020-09-24 00:00:00
abstract：:This study concerns obesity-related atherosclerosis, hyperlipidemia, and chronic inflammation. We studied the anti-obesity and anti-atherosclerosis effects of phenethyl isothiocyanate (PEITC) and explored their underlying mechanisms. We established an animal model of high fat/cholesterol-induced obesity in C57BL/6 mic...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12123657
更新日期：2020-11-27 00:00:00
abstract：:Chronic kidney disease (CKD) is increasingly recognized in pregnant patients. Three characteristics are associated with a risk of preterm delivery or small for gestational age babies; kidney function reduction, hypertension, and proteinuria. In pregnancy, the anti-proteinuric agents (ACE-angiotensin converting enzyme-...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu9070770
更新日期：2017-07-19 00:00:00
abstract：:Probiotics are linked to positive regulatory effects on the immune system. The aim of the study was to examine the association between the exposure of probiotics via dietary supplements or via infant formula by the age of 1 year and the development of celiac disease autoimmunity (CDA) and celiac disease among a cohort...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11081790
更新日期：2019-08-02 00:00:00
abstract：:Despite their low cost and high nutrient density, the contribution of eggs to nutrient intake and dietary quality among Mexican-American postpartum women has not been evaluated. Nutrient intake and dietary quality, as assessed by the Healthy Eating Index 2010 (HEI-2010), were measured in habitually sedentary overweigh...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu7105402
更新日期：2015-10-02 00:00:00
abstract：:Selenium is an essential trace element which is incorporated in the form of a rare amino acid, the selenocysteine, into an important group of proteins, the selenoproteins. Among the twenty-five selenoprotein genes identified to date, several have important cellular functions in antioxidant defense, cell signaling and ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11071524
更新日期：2019-07-04 00:00:00
abstract：:In adults, fermentation of high amylose maize starch (HAMS), a resistant starch (RS), has a prebiotic effect. Were such a capacity to exist in infants, intake of RS might programme the gut microbiota during a critical developmental period. This study aimed to determine if infant faecal inocula possess the capacity to ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11061345
更新日期：2019-06-14 00:00:00
abstract：:The first manifestations that appear under zinc deficiency are skin defects such as dermatitis, alopecia, acne, eczema, dry, and scaling skin. Several genetic disorders including acrodermatitis enteropathica (also known as Danbolt-Closs syndrome) and Brandt's syndrome are highly related to zinc deficiency. However, th...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu10020219
更新日期：2018-02-16 00:00:00
abstract：:Atopic dermatitis (AD) is a chronic inflammatory skin disease in humans. In this study, we evaluated the effects of a mixture (NCM 1921) of omega-3 butter, omega-3 beef tallow oil, omega-3 lard oil, caprylic acid, lauric acid, choline, and Fe on AD in 1-chloro-2,4-dinitrobenzene (DNCB)-treated NC/Nga mice. NCM 1921 si...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12010165
更新日期：2020-01-07 00:00:00
abstract：:Anthocyanin consumption is linked to benefits in obesity-related metabolic alterations and non-alcoholic fatty liver disease (NAFLD), though the functional role of delphinidin (Dp) is yet to be established. Therefore, this study examined the effects of Dp on metabolic alterations associated with NAFLD, and molecular m...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu10081060
更新日期：2018-08-10 00:00:00
abstract：:Workout capacity is energy-production driven. To produce peak metabolic power outputs, the organism predominantly relies more on anaerobic metabolism, but this undoubtedly has a negative and limiting impact on muscle function and performance. The aim of the study was to evaluate if an innovative polyphenol-based food ...
journal_title：Nutrients
pub_type： 杂志文章,随机对照试验
doi：10.3390/nu9040421
更新日期：2017-04-24 00:00:00
abstract：:Socioeconomic factors (SEF) can exert a great impact on food choices. However, limited data are available from the Spanish population. Our aim was to describe the influence of place of residence and habitat size on food group intakes. Data were obtained from the ANIBES study. A 3-day dietary record provided informatio...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu10040392
更新日期：2018-03-22 00:00:00
abstract：:As not much is known about the prevalence and predictors of nutritional deficiencies among vegans in the Czech Republic, we evaluated whether supplement use and duration of adherence to the vegan diet are associated with the risk of cobalamin and iron deficiencies. Associations between self-reported supplementation an...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11123019
更新日期：2019-12-10 00:00:00
abstract：:Aim: The objective of this study was to characterize the early effects of high fructose diets (with and without high fat) on both the composition of the gut microbiota and lipid metabolism in Syrian hamsters, a reproducible preclinical model of diet-induced dyslipidemia. Methods: Eight-week-old male hamsters were fed ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12113557
更新日期：2020-11-20 00:00:00
abstract：:Type-2 diabetes mellitus (T2DM) has become a major health problem worldwide. T2DM risk can be reduced with healthy dietary interventions, but the precise molecular underpinnings behind this association are still incompletely understood. We recently discovered that the expression profile of the splicing machinery is as...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12113528
更新日期：2020-11-17 00:00:00
abstract：BACKGROUND:To prevent malnutrition and food aspiration in children with chronic neuromuscular problems, enteral nutrition provided by gastrostomy is recommended. Long-term follow-up data about surgical and medical complications of PEG are available, but few papers have addressed all of the issues in the same series. M...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11071555
更新日期：2019-07-10 00:00:00
abstract：:Metabolic syndrome is a cluster of metabolic abnormalities characterized by obesity, insulin resistance, hypertension and dyslipidemia. Ferulic acid (FA) is the major phenolic compound found in rice oil and various fruits and vegetables. In this study, we examined the beneficial effects of FA in minimizing insulin res...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu7085283
更新日期：2015-08-04 00:00:00
