The Role of the Slc39a Family of Zinc Transporters in Zinc Homeostasis in Skin.

Abstract:

:The first manifestations that appear under zinc deficiency are skin defects such as dermatitis, alopecia, acne, eczema, dry, and scaling skin. Several genetic disorders including acrodermatitis enteropathica (also known as Danbolt-Closs syndrome) and Brandt's syndrome are highly related to zinc deficiency. However, the zinc-related molecular mechanisms underlying normal skin development and homeostasis, as well as the mechanism by which disturbed zinc homeostasis causes such skin disorders, are unknown. Recent genomic approaches have revealed the physiological importance of zinc transporters in skin formation and clarified their functional impairment in cutaneous pathogenesis. In this review, we provide an overview of the relationships between zinc deficiency and skin disorders, focusing on the roles of zinc transporters in the skin. We also discuss therapeutic outlooks and advantages of controlling zinc levels via zinc transporters to prevent cutaneous disorganization.

journal_name

Nutrients

journal_title

Nutrients

authors

Bin BH,Hojyo S,Seo J,Hara T,Takagishi T,Mishima K,Fukada T

doi

10.3390/nu10020219

subject

Has Abstract

pub_date

2018-02-16 00:00:00

issue

2

issn

2072-6643

pii

nu10020219

journal_volume

10

pub_type

杂志文章,评审
  • Studying the Relationship of Intermittent Fasting and β-Amyloid in Animal Model of Alzheimer's Disease: A Scoping Review.

    abstract::We examined the evidence for intermittent fasting (IF) as a preventative tool to influence β-amyloid in animal models of Alzheimer's disease (AD). A Scopus, Ovid, PubMed, and Web of Science (WoS), search yielded 29 results using the keywords "amyloid beta", "intermittent fasting", "intermittent caloric restriction", "...

    journal_title:Nutrients

    pub_type: 杂志文章,评审

    doi:10.3390/nu12103215

    authors: Nasaruddin ML,Syed Abd Halim SA,Kamaruzzaman MA

    更新日期:2020-10-21 00:00:00

  • A Review of Bioactive Factors in Human Breastmilk: A Focus on Prematurity.

    abstract::Preterm birth is an increasing worldwide problem. Prematurity is the second most common cause of death in children under 5 years of age. It is associated with a higher risk of several pathologies in the perinatal period and adulthood. Maternal milk, a complex fluid with several bioactive factors, is the best option fo...

    journal_title:Nutrients

    pub_type: 杂志文章,评审

    doi:10.3390/nu11061307

    authors: Gila-Diaz A,Arribas SM,Algara A,Martín-Cabrejas MA,López de Pablo ÁL,Sáenz de Pipaón M,Ramiro-Cortijo D

    更新日期:2019-06-10 00:00:00

  • Vitamin-D Receptor-Gene Polymorphisms Affect Quality of Life in Patients with Autoimmune Liver Diseases.

    abstract::Vitamin D deficiency has been associated with depressive symptoms and reduced physical functioning. The aim of the study was to characterize the relationship between polymorphisms of the vitamin D receptor (VDR) gene and the quality of life in patients with autoimmune hepatitis (AIH) and primary biliary cholangitis (P...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu12082244

    authors: Kempinska-Podhorodecka A,Adamowicz M,Chmielarz M,Janik MK,Milkiewicz P,Milkiewicz M

    更新日期:2020-07-27 00:00:00

  • Food-Based Social Enterprises and Asylum Seekers: The Food Justice Truck.

    abstract::People seeking asylum in high-income countries are vulnerable to food insecurity due to limited opportunities for social and economic participation. While charity organizations have long sought to provide food aid to those in need, the increasing number of people seeking this assistance requires alternatives. Using a ...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu10060756

    authors: McKay FH,Lippi K,Dunn M,Haines BC,Lindberg R

    更新日期:2018-06-12 00:00:00

  • DNA hypermethylation of the serotonin receptor type-2A gene is associated with a worse response to a weight loss intervention in subjects with metabolic syndrome.

    abstract::Understanding the regulation of gene activities depending on DNA methylation has been the subject of much recent study. However, although polymorphisms of the HTR2A gene have been associated with both obesity and psychiatric disorders, the role of HTR2A gene methylation in these illnesses remains uncertain. The aim of...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu6062387

    authors: Perez-Cornago A,Mansego ML,Zulet MA,Martinez JA

    更新日期:2014-06-23 00:00:00

  • Changes in Plasma Free Fatty Acids Associated with Type-2 Diabetes.

    abstract::Type 2 diabetes mellitus (T2DM) is associated with increased total plasma free fatty acid (FFA) concentrations and an elevated risk of cardiovascular disease. The exact mechanisms by which the plasma FFA profile of subjects with T2DM changes is unclear, but it is thought that dietary fats and changes to lipid metaboli...

    journal_title:Nutrients

    pub_type: 杂志文章,评审

    doi:10.3390/nu11092022

    authors: I S Sobczak A,A Blindauer C,J Stewart A

    更新日期:2019-08-28 00:00:00

  • Insights from space: potential role of diet in the spatial organization of chromosomes.

    abstract::We can now sequence and identify genome wide epigenetic patterns and perform a variety of "genomic experiments" within relatively short periods of time-ranging from days to weeks. Yet, despite these technological advances, we have a poor understanding of the inter-relationships between epigenetics, genome structure-fu...

    journal_title:Nutrients

    pub_type: 杂志文章,评审

    doi:10.3390/nu6125724

    authors: O'Sullivan JM,Doynova MD,Antony J,Pichlmuller F,Horsfield JA

    更新日期:2014-12-10 00:00:00

  • Protection of UVB-Induced Photoaging by Fuzhuan-Brick Tea Aqueous Extract via MAPKs/Nrf2-Mediated Down-Regulation of MMP-1.

    abstract::Ultraviolet B (UVB) irradiation is viewed as the principal inducer of skin photo-aging, associated with acceleration of collagen degradation and upregulation of matrix metalloproteinases (MMPs). The ethnic groups of southern/western China use Fuzhuan brick-tea (FBT) as a beverage and as a nutritional supplement. In th...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu11010060

    authors: Zhao P,Alam MB,Lee SH

    更新日期:2018-12-28 00:00:00

  • A Calorie-Restricted DASH Diet Reduces Body Fat and Maintains Muscle Strength in Obese Older Adults.

    abstract::This study examined the effect of the Dietary Approaches to Stop Hypertension (DASH) diet containing lean red meat on measures of body composition and muscle strength in a cohort of obese adults 65 and older; 36 males (n = 15) and females (n = 21) consumed 1800 kcal/day for 12 weeks under controlled feeding conditions...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu12010102

    authors: Perry CA,Van Guilder GP,Kauffman A,Hossain M

    更新日期:2019-12-30 00:00:00

  • Reducing Breast Cancer Recurrence: The Role of Dietary Polyphenolics.

    abstract::Evidence from numerous observational and clinical studies suggest that polyphenolic phytochemicals such as phenolic acids in olive oil, flavonols in tea, chocolate and grapes, and isoflavones in soy products reduce the risk of breast cancer. A dietary food pattern naturally rich in polyphenols is the Mediterranean die...

    journal_title:Nutrients

    pub_type: 杂志文章,评审

    doi:10.3390/nu8090547

    authors: Braakhuis AJ,Campion P,Bishop KS

    更新日期:2016-09-06 00:00:00

  • Effects of Rapid Weight Loss on Judo Athletes: A Systematic Review.

    abstract::Rapid weight loss (RWL) is commonly practiced among judo athletes. Although it helps them to gain the advantage over their lighter opponents, previous studies have shown that RWL can have a negative impact on the athlete's performance and overall well-being. This systematic review aimed to synthesize the evidence that...

    journal_title:Nutrients

    pub_type: 杂志文章,评审

    doi:10.3390/nu12051220

    authors: Lakicevic N,Roklicer R,Bianco A,Mani D,Paoli A,Trivic T,Ostojic SM,Milovancev A,Maksimovic N,Drid P

    更新日期:2020-04-26 00:00:00

  • Beta-Cryptoxanthin Inhibits Lipopolysaccharide-Induced Osteoclast Differentiation and Bone Resorption via the Suppression of Inhibitor of NF-κB Kinase Activity.

    abstract::Beta-cryptoxanthin (β-cry) is a typical carotenoid found abundantly in fruit and vegetables such as the Japanese mandarin orange, persimmon, papaya, paprika, and carrot, and exerts various biological activities (e.g., antioxidant effects). We previously reported that β-cry suppressed lipopolysaccharide (LPS)-induced o...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu11020368

    authors: Hirata N,Ichimaru R,Tominari T,Matsumoto C,Watanabe K,Taniguchi K,Hirata M,Ma S,Suzuki K,Grundler FMW,Miyaura C,Inada M

    更新日期:2019-02-10 00:00:00

  • Changing to a Low-Polyphenol Diet Alters Vascular Biomarkers in Healthy Men after Only Two Weeks.

    abstract::Bioactive dietary compounds play a critical role in health maintenance. The relation between bioactive compound intake and cardiovascular health-related biomarkers has been demonstrated in several studies, although mainly with participants who have altered biochemical parameters (high blood pressure, high cholesterol,...

    journal_title:Nutrients

    pub_type: 杂志文章,随机对照试验

    doi:10.3390/nu10111766

    authors: Hurtado-Barroso S,Quifer-Rada P,Rinaldi de Alvarenga JF,Pérez-Fernández S,Tresserra-Rimbau A,Lamuela-Raventos RM

    更新日期:2018-11-14 00:00:00

  • Nutritional strategies for the preservation of fat free mass at high altitude.

    abstract::Exposure to extreme altitude presents many physiological challenges. In addition to impaired physical and cognitive function, energy imbalance invariably occurs resulting in weight loss and body composition changes. Weight loss, and in particular, loss of fat free mass, combined with the inherent risks associated with...

    journal_title:Nutrients

    pub_type: 杂志文章,评审

    doi:10.3390/nu6020665

    authors: Wing-Gaia SL

    更新日期:2014-02-13 00:00:00

  • Thiamine Deficiency in Adolescents with Eating Disorders: A Prospective Cohort Study.

    abstract:BACKGROUND:Pediatric eating disorders (PED) patients are prone to nutritional deficiencies. Thiamine deficiency is well described in other malnutrition states but is not routinely screened for in PED. In the current study we evaluated the prevalence of thiamine deficiency among PED patients on their first admission to ...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu12051396

    authors: Bahat H,Reisler G,Brandriss N,Bar-Chaim A,Goldman M

    更新日期:2020-05-13 00:00:00

  • High Fat-High Fructose Diet-Induced Changes in the Gut Microbiota Associated with Dyslipidemia in Syrian Hamsters.

    abstract::Aim: The objective of this study was to characterize the early effects of high fructose diets (with and without high fat) on both the composition of the gut microbiota and lipid metabolism in Syrian hamsters, a reproducible preclinical model of diet-induced dyslipidemia. Methods: Eight-week-old male hamsters were fed ...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu12113557

    authors: Horne RG,Yu Y,Zhang R,Abdalqadir N,Rossi L,Surette M,Sherman PM,Adeli K

    更新日期:2020-11-20 00:00:00

  • Impacts of Maternal Nutrition on Vascularity of Nutrient Transferring Tissues during Gestation and Lactation.

    abstract::As the demand for food increases with exponential growth in the world population, it is imperative that we understand how to make livestock production as efficient as possible in the face of decreasing available natural resources. Moreover, it is important that livestock are able to meet their metabolic demands and su...

    journal_title:Nutrients

    pub_type: 杂志文章,评审

    doi:10.3390/nu7053497

    authors: Vonnahme KA,Lemley CO,Caton JS,Meyer AM

    更新日期:2015-05-13 00:00:00

  • A nutrient combination that can affect synapse formation.

    abstract::Brain neurons form synapses throughout the life span. This process is initiated by neuronal depolarization, however the numbers of synapses thus formed depend on brain levels of three key nutrients-uridine, the omega-3 fatty acid DHA, and choline. Given together, these nutrients accelerate formation of synaptic membra...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu6041701

    authors: Wurtman RJ

    更新日期:2014-04-23 00:00:00

  • The Role of Probiotics in Nonalcoholic Fatty Liver Disease: A New Insight into Therapeutic Strategies.

    abstract::Nonalcoholic fatty liver disease (NAFLD) encompasses a broad spectrum of pathological hepatic conditions ranging from simple steatosis to nonalcoholic steatohepatitis (NASH), which may predispose to liver cirrhosis and hepatocellular carcinoma (HCC). Due to the epidemic obesity, NAFLD is representing a global health i...

    journal_title:Nutrients

    pub_type: 杂志文章,评审

    doi:10.3390/nu11112642

    authors: Meroni M,Longo M,Dongiovanni P

    更新日期:2019-11-04 00:00:00

  • Compliance to Prenatal Iron and Folic Acid Supplement Use in Relation to Low Birth Weight in Lilongwe, Malawi.

    abstract::Prenatal iron and folic acid (IFA) supplements are offered free to all pregnant women in Malawi to reduce maternal anemia and improve birth outcomes. We investigated the association between self-reported compliance to IFA intake and risk of low birth weight (LBW). Pregnant women who attended Bwaila Maternity Wing of L...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu10091275

    authors: Chikakuda AT,Shin D,Comstock SS,Song S,Song WO

    更新日期:2018-09-10 00:00:00

  • Compound 18 Improves Glucose Tolerance in a Hepatocyte TGR5-dependent Manner in Mice.

    abstract::The bile acid receptor, TGR5, is a key regulator of glucose homeostasis, but the mechanisms by which TGR5 signaling improves glucose regulation are incompletely defined. In particular, TGR5 has an increasingly appreciated role in liver physiology and pathobiology; however, whether TGR5 signaling within the liver contr...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu12072124

    authors: Holter MM,Chirikjian MK,Briere DA,Maida A,Sloop KW,Schoonjans K,Cummings BP

    更新日期:2020-07-17 00:00:00

  • Modulation of Adenosine Receptors and Antioxidative Effect of Beer Extracts in in Vitro Models.

    abstract::The fight against neurodegenerative diseases is promoting the searching of nutrients, preferably of wide consumption, with proven effects on health. Beer is widely consumed and has potential benefits on health. In this work, three different extracts from dark beer (DB), non-alcoholic beer (NAB), and lager beer (LB) we...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu11061258

    authors: Alonso-Andrés P,Martín M,Albasanz JL

    更新日期:2019-06-03 00:00:00

  • Better Adherence to the Mediterranean Diet Could Mitigate the Adverse Consequences of Obesity on Cardiovascular Disease: The SUN Prospective Cohort.

    abstract::Strong observational evidence supports the association between obesity and cardiovascular events. In elderly high-risk subjects, the Mediterranean diet (MedDiet) was reported to counteract the adverse cardiovascular effects of adiposity. Whether this same attenuation is also present in younger subjects is not known. W...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu7115457

    authors: Eguaras S,Toledo E,Hernández-Hernández A,Cervantes S,Martínez-González MA

    更新日期:2015-11-05 00:00:00

  • The Relationship between Single Nucleotide Polymorphisms in Taste Receptor Genes, Taste Function and Dietary Intake in Preschool-Aged Children and Adults in the Guelph Family Health Study.

    abstract::Taste is a fundamental determinant of food selection, and inter-individual variations in taste perception may be important risk factors for poor eating habits and obesity. Characterizing differences in taste perception and their influences on dietary intake may lead to an improved understanding of obesity risk and a p...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu10080990

    authors: Chamoun E,Carroll NA,Duizer LM,Qi W,Feng Z,Darlington G,Duncan AM,Haines J,Ma DWL,Guelph Family Health Study.

    更新日期:2018-07-29 00:00:00

  • Exploration of the Association between Dietary Fiber Intake and Hypertension among U.S. Adults Using 2017 American College of Cardiology/American Heart Association Blood Pressure Guidelines: NHANES 2007⁻2014.

    abstract::This study aimed to explore the association between dietary fiber intake and hypertension risk using 2017 American College of Cardiology/American Heart Association Blood Pressure Guidelines. Data from the National Health and Nutrition Examination Survey 2007⁻2014 were used in this study. Dietary fiber data were obtain...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu10081091

    authors: Sun B,Shi X,Wang T,Zhang D

    更新日期:2018-08-15 00:00:00

  • Association between Dietary Inflammatory Index, C-Reactive Protein and Metabolic Syndrome: A Cross-Sectional Study.

    abstract::Increased prevalence of metabolic syndrome (MetS) has become a global major public health problem. Chronic low-grade inflammation associated with diet was found to play an import role in the development of MetS, although further studies are needed. The main purpose of this study was to explore the association between ...

    journal_title:Nutrients

    pub_type: 杂志文章,多中心研究

    doi:10.3390/nu10070831

    authors: Ren Z,Zhao A,Wang Y,Meng L,Szeto IM,Li T,Gong H,Tian Z,Zhang Y,Wang P

    更新日期:2018-06-27 00:00:00

  • A High Protein Calorie Restriction Diet Alters the Gut Microbiome in Obesity.

    abstract:BACKGROUND:High protein calorie restriction diets have shown clinical efficacy for obesity, but the mechanisms are not fully known. The intestinal microbiome is a mediator of obesity and preclinical data support an effect of high protein diet (HPD) on the gut microbiome of obesity, but there are few studies in humans. ...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu12103221

    authors: Dong TS,Luu K,Lagishetty V,Sedighian F,Woo SL,Dreskin BW,Katzka W,Chang C,Zhou Y,Arias-Jayo N,Yang J,Ahdoot A,Li Z,Pisegna JR,Jacobs JP

    更新日期:2020-10-21 00:00:00

  • The Effect of Parenteral or Oral Iron Supplementation on Fatigue, Sleep, Quality of Life and Restless Legs Syndrome in Iron-Deficient Blood Donors: A Secondary Analysis of the IronWoMan RCT.

    abstract::Background: Besides anemia, iron deficiency may cause more subtle symptoms, including the restless legs syndrome (RLS), the chronic fatigue syndrome (CFS) or sleeping disorders. Objective: The aim of this pre-planned secondary analysis of the IronWoMan randomized controlled trial (RCT) was to compare the frequency and...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu12051313

    authors: Macher S,Herster C,Holter M,Moritz M,Matzhold EM,Stojakovic T,Pieber TR,Schlenke P,Drexler C,Amrein K

    更新日期:2020-05-05 00:00:00

  • Vitamin D Receptor Polymorphisms in Sex-Frailty Paradox.

    abstract::The "male-female health-survival paradox" evidences that the survival advantage observed in women is linked to higher rates of disability and poor health status compared to men, a phenomenon also called the "sex-frailty paradox". The depletion of vitamin D seems to play a role in the fragilization of old persons, and ...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu12092714

    authors: Arosio B,Guerini FR,Costa AS,Dicitore A,Ferri E,Mari D,Torresani E,Clerici M,Cesari M,Vitale G

    更新日期:2020-09-05 00:00:00

  • Association of Iron Storage Markers with Metabolic Syndrome and Its Components in Chinese Rural 6-12 Years Old Children: The 2010-2012 China National Nutrition and Health Survey.

    abstract:BACKGROUND:Elevated ferritin, which is often used to represent iron storage, is known to increase the risk of metabolic syndrome (MetS) or its components, but its increase is affected by many factors. Therefore, it is necessary to analyze the relationship between other indicators of iron storage, and MetS and its compo...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu12051486

    authors: Zhang H,Wang L,Li S,Liu X,Li Y,He Y,Man Q,Yang L

    更新日期:2020-05-20 00:00:00